A murine IL-4 receptor antagonist that inhibits IL-4- and IL-13-induced responses prevents antigen-induced airway eosinophilia and airway hyperresponsiveness

Journal of Immunology

Volumn 166, Issue 9, 2001, Pages 5792-5800

  Tomkinson, A ^a   Duez, C ^a   Cieslewicz, G ^a   Pratt, J C ^a   Joetham, A ^a   Shanafelt, M C ^a   Gundel, R ^a   Gelfand, E W ^a  

^a NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIASTHMATIC AGENT; ANTIINFLAMMATORY AGENT; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR;

ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRONCHUS HYPERREACTIVITY; EOSINOPHILIA; FEMALE; GENE MUTATION; LUNG LAVAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR AFFINITY; SIGNAL TRANSDUCTION;

EID: 0035340763     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.9.5792     Document Type: Article

References (68)

1. + T cells, eosinophils, and mast cells in bronchial biopsies obtained from atopic and nonatopic (intrinsic) asthmatics
2. IL-13 expression at the sites of allergen challenge in patients with asthma
3. Interleukin-13 and interleukin-4 are coexpressed in atopic asthma
4. The related cytokines interleukin-13 and interleukin-4 are distinguished by differential production and differential effects on T lymphocytes
5. + T lymphocytes prevents antigen-induced airway hyperreactivity and pulmonary eosinophilia
6. A novel T cell-regulated mechanism modulating allergen-induced airways hyperreactivity in BALB/c mice independently of IL-4 and IL-5
7. Requirements for allergen-induced airway hyperreactivity in T and B cell-deficient mice
8. IL-4-independent induction of airway hyperresponsiveness by Th2, but not Th1 cells
9. Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation
10. Recombinant human interleukin 5 is a selective activator of human eosinophil function
11. Purified interleukin 5 supports the terminal differentiation and proliferation of murine eosinophilic precursors
12. Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model
13. Disruption of the murine IL-4 gene blocks Th2 cytokine responses
14. + T cells, analyzed at the single-cell level
15. The role of IL-13 and its receptor in allergy and inflammatory responses
16. Impaired development of Th2 cells in IL-13-deficient mice
17. IL-4 is required to generate and sustain in vivo IgE responses
18. Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells
19. Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell function
20. Interleukin-13 alters the activation state of murine macrophages in vitro: Comparison with interleukin-4 and interferon-γ
21. Role of interleukin-4 and vascular cell adhesion molecule-1 in selective eosinophil migration into the airways in allergic asthma
22. IL-13 selectively induces vascular cell adhesion molecule-1 expression in human endothelial cells
23. A novel role for murine IL-4 in vivo: Induction of MUC5AC gene expression and mucin hypersecretion
24. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
25. Interleukin-4 is required for the induction of lung Th2 mucosal immunity
26. Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity
27. Aeroallergen-induced eosinophilic inflammation, lung damage, and airways hyperreactivity in mice can occur independently of IL-4 and allergen-specific immunoglobulins
28. Soluble IL-4 receptor inhibits airway inflammation following allergen challenge in a mouse model of asthma
29. Interleukin-13: Central mediator of allergic asthma
30. Requirement for IL-13 independently of IL-4 in experimental asthma
31. The IL-4 receptor: Signaling mechanisms and biologic functions
32. An antagonistic mutant of interleukin-4 fails to recruit γc into the receptor complex: Characterization by specific crosslinking
33. Design of human interleukin-4 antagonists inhibiting interleukin-4-dependent and interleukin-13-dependent responses in T-cells and B-cells with high efficiency
34. Specific antagonism of type I IL-4 receptor with a mutated form of murine IL-4
35. Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction
36. A murine interleukin-4 antagonistic mutant protein completely inhibits interleukin-4-induced cell proliferation, differentiation, and signal transduction
37. An antagonistic IL-4 mutant prevents type I allergy in the mouse: Inhibition of the IL-4/IL-13 receptor system completely abrogates humoral immune response to allergen and development of allergic symptoms in vivo
38. Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography
39. Antiinterleukin-5 antibody prevents airway hyperresponsiveness in a murine model of airway sensitization
40. An interleukin-4-induced transcription factor: IL-4 Stat
41. STF-IL-4: A novel IL-4-induced signal transducing factor
42. Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-13 but are not required for mitogenesis
43. Differential regulation of the Janus kinase-STAT pathway and biologic function of IL-13 in primary human NK and T cells: A comparative study with IL-4
44. Interleukin-13 is a potent activator of JAK3 and STAT6 in cells expressing interleukin-2 receptor-γ and interleukin-4 receptor-α
45. Cloning of the human IL-13Rα1 chain and reconstitution with the IL4Rα of a functional IL-4/IL-13 receptor complex
46. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene
47. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells
48. Interleukin (IL)-4-independent induction of immunoglobulin (Ig)E, and perturbation of T cell development in transgenic mice expressing IL-13
49. Mouse IL-13 enhances antibody production in vivo and acts directly on B cells in vitro to increase survival and hence antibody production
50. An interleukin 4 (IL-4) mutant protein inhibits both IL-4 or IL-13-induced human immunoglobulin G4 (IgG4) and IgE synthesis and B cell proliferation: Support for a common component shared by IL-4 and IL-13 receptors
51. Interleukin-4 receptor blockade prevents airway responses induced by antigen challenge in mice
52. Mechanisms of allergic pulmonary eosinophilia in the mouse
53. Pathology of asthma
54. Lung inflammation and epithelial changes in a murine model of atopic asthma
55. The failure of STAT6-deficient mice to develop airway eosinophilia and airway hyperresponsiveness is overcome by interleukin-5
56. Induction of airway mucus production by T helper 2 (Th2) cells: A critical role for interleukin 4 in cell recruitment but not mucus production
57. Asthma: Morphologic-physiologic interactions
58. Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production
59. TNF-α mediates recruitment of neutrophils and eosinophils during airway inflammation
60. Impaired IL-13-mediated functions of macrophages in STAT6-deficient mice
61. STAT6 is required for the anti-inflammatory activity of interleukin-4 in mouse peritoneal macrophages
62. + T cells through IL-12 produced by Listeria-induced macrophages
63. Superinduction of low affinity IgE receptors on murine B lymphocytes by lipopolysaccharide and IL-4
64. CD23/IgE-mediated regulation of the specific antibody response in vivo
65. Attenuation of allergic airway inflammation in IL-4 deficient mice
66. Mast cell activation enhances airway responsiveness to methacholine in the mouse
67. Development of eosinophilic airway inflammation and airway hyperresponsiveness in mast cell-deficient mice
68. Allergen-specific IgE and IL-5 are essential for the development of airway hyperresponsiveness