Blockade of CD49d (α4 integrin) on intrapulmonary but not circulating leukocytes inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma

Journal of Clinical Investigation

Volumn 100, Issue 12, 1997, Pages 3083-3092

  Henderson Jr , William R ^a   Chi, Emil Y ^a   Albert, Richard K ^a   Chu, Shi Jye ^a   Lamm, Wayne J E ^a   Rochon, Yvan ^a   Jonas, Mechthild ^a   Christie, Pandora E ^a   Harlan, John M ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Eosinophil; Interleukin 4; Interleukin 5; Mucus; Very late antigen 4

Indexed keywords

ALPHA4 INTEGRIN; BETA1 INTEGRIN; INTEGRIN; INTERLEUKIN 4; INTERLEUKIN 5; METHACHOLINE; MONOCLONAL ANTIBODY CD49D; THY ANTIGEN; UNCLASSIFIED DRUG; ALLERGEN; BRONCHOCONSTRICTING AGENT; LEUKOCYTE ANTIGEN; METHACHOLINE CHLORIDE; MONOCLONAL ANTIBODY; OVALBUMIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; BRONCHITIS; BRONCHUS HYPERREACTIVITY; CONTROLLED STUDY; EFFECTOR CELL; EOSINOPHILIA; FEMALE; IMMUNOCYTOCHEMISTRY; LEUKOCYTE; LUNG FUNCTION TEST; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; BAGG ALBINO MOUSE; CELL MOTION; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DRUG EFFECT; EOSINOPHIL; HUMAN; IMMUNOLOGY; LUNG; METABOLISM; PATHOLOGY; PHYSIOLOGY; RESPIRATORY TRACT ALLERGY; TH2 CELL;

ALLERGENS; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ASTHMA; BRONCHOCONSTRICTOR AGENTS; CELL MOVEMENT; DISEASE MODELS, ANIMAL; EOSINOPHILS; FEMALE; HUMANS; INTEGRIN ALPHA4; LEUKOCYTES; LUNG; METHACHOLINE CHLORIDE; MICE; MICE, INBRED BALB C; OVALBUMIN; RESPIRATORY HYPERSENSITIVITY; TH2 CELLS;

EID: 0031573520     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119863     Document Type: Article

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