Eotaxin and asthma

Current Opinion in Pharmacology

Volumn 1, Issue 3, 2001, Pages 248-253

  Pease, James E ^a   Williams, Timothy J ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Antagonists; Asthma; Chemokine Receptors; Chemokines; Eotaxin; Immunology; Inflammation; Molecular Medicine; Pharmacology

Indexed keywords

BETA CHEMOKINE; CC CHEMOKINE RECEPTOR 3; CHEMOKINE RECEPTOR; EOSINOPHIL CHEMOTACTIC FACTOR; EOTAXIN;

ANIMAL; ASTHMA; DRUG ANTAGONISM; DRUG EFFECT; EOSINOPHIL; HUMAN; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW;

ANIMALS; ASTHMA; CHEMOKINES, CC; CHEMOTACTIC FACTORS, EOSINOPHIL; EOSINOPHILS; HUMANS; RECEPTORS, CHEMOKINE;

EID: 0035376745     PISSN: 14714892     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4892(01)00044-3     Document Type: Review

References (58)

1. Gleich G.J., Adolphson C.R., Kita H. The eosinophil and asthma. Busse W.W., Holgate S.T. Asthma and Rhinitis. 2 :2000;429-470 Blackwell Science Ltd, Oxford.
2. Zlotnik A., Yoshie O. Chemokines a new classification system and their role in immunity. Immunity. 12:2000;121-127. See annotation to Murphy et al. [3•].
3. Murphy P.M., Baggiolini M., Charo I.F., Hebert C.A., Horuk R., Matsushima K., Miller L.H., Oppenheim J.J., Power C.A. International union of pharmacology. XXII. Nomenclature for chemokine receptors. Pharmacol Rev. 52:2000;145-176. These are both excellent reviews of chemokines [2•] and chemokine receptors [3•], which introduce the standard nomenclature for both families of proteins.
4. Jose P.J., Griffiths-Johnson D.A., Collins P.D., Walsh D.T., Moqbel R., Totty N.F., Truong O., Hsuan J.J., Williams T.J. Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea-pig model of allergic airways inflammation. J Exp Med. 179:1994;881-887.
5. Jose P.J., Adcock I.M., Griffiths-Johnson D.A., Berkman N., Wells T.N.C., Williams T.J., Power C.A. Eotaxin: cloning of an eosinophil chemoattractant cytokine and increased mRNA expression in allergen-challenged guinea-pig lungs. Biochem Biophys Res Commun. 205:1994;788-794.
6. Ponath P.D., Qin S., Ringler D.J., Clark-Lewis I., Wang J., Kassam N., Smith H., ShI X., Gonzalo J.-A., Newman W., et al. Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding and functional properties suggest a mechanism for the selective recruitment of eosinophils. J Clin Invest. 97:1996;604-612.
7. Rothenberg M.E., Luster A.D., Leder P. Murine eotaxin: an eosinophil chemoattractant inducible in endothelial cells and in interleukin 4-induced tumor suppression. Proc Natl Acad Sci USA. 92:1995;8960-8964.
8. Humbles A.A., Conroy D.M., Marleau S., Rankin S.M., Palframan R.T., Proudfoot A.E.I., Wells T.N.C., Li D., Jeffery P.K., Griffiths-Johnson D.A., et al. Kinetics of eotaxin generation and its relationship to eosinophil accumulation in allergic airways disease: analysis in a guinea pig model in vivo. J Exp Med. 186:1997;601-612.
9. Li D., Wang D., Griffiths-Johnson D.A., Wells T.N.C., Williams T.J., Jose P.J., Jeffery P.K. Eotaxin protein and gene expression in guinea pig lungs: constitutive expression and upregulation after allergen challenge. Eur Respir J. 10:1997;1946-1954.
10. Collins P.D., Marleau S., Griffiths-Johnson D.A., Jose P.J., Williams T.J. Co-operation between interleukin-5 and the chemokine eotaxin to induce eosinophil accumulation in vivo. J Exp Med. 182:1995;1169-1174.
11. Palframan R.T., Collins P.D., Williams T.J., Rankin S.M. Eotaxin induces a rapid release of eosinophils and their progenitors from the bone marrow. Blood. 91:1998;2240-2248.
12. Palframan R.T., Collins P.D., Severs N.J., Rothery S., Williams T.J., Rankin S.M. Mechanisms of acute eosinophil mobilization from the bone marrow stimulated by interleukin 5: the role of specific adhesion molecules and phosphatidylinositol 3-kinase. J Exp Med. 188:1998;1621-1632.
13. Ying S., Robinson D.S., Meng Q., Rottman J., Kennedy R., Ringler D.J., Mackay C.R., Daugherty B.L., Springer M.S., Durham S.R., et al. Enhanced expression of eotaxin and CCR3 mRNA and protein in atopic asthma. Association with airway hyperresponsiveness and predominant co-localization of eotaxin mRNA to bronchial epithelial and endothelial cells. Eur J Immunol. 27:1997;3507-3516.
14. Ying S., Meng Q., Zeibecoglou K., Robinson D.S., MacFarlane A., Humbert M., Kay A.B. Eosinophil chemotactic chemokines (eotaxin, eotaxin-2, RANTES, monocyte chemoattractant protein-3 (MCP-3), and MCP-4), and C-C chemokine receptor 3 expression in bronchial biopsies from atopic and nonatopic (intrinsic) asthmatics. J Immunol. 163:1999;6321-6329.
15. Zeibecoglou K., MacFarlane A.J., Ying S., Meng Q., Pavord I., Barnes N.C., Robinson D.S., Kay A.B. Increases in eotaxin-positive cells in induced sputum from atopic asthmatic subjects after inhalational allergen challenge. Allergy. 54:1999;730-735.
16. Yamada H., Yamaguchi M., Yamamoto K., Nakajima T., Hirai K., Morita Y., Sano Y. Eotaxin in induced sputum of asthmatics: relationship with eosinophils and eosinophil cationic protein in sputum. Allergy. 55:2000;392-397.
17. Lemiere C., Chaboilliez S., Trudeau C., Taha R., Maghni K., Martin J.G., Hamid Q. Characterization of airway inflammation after repeated exposures to occupational agents. J Allergy Clin Immunol. 106:2000;1163-1170.
18. Nakamura H., Weiss S.T., Israel E., Luster A.D., Drazen J.M., Lilly C.M. Eotaxin and impaired lung function in asthma. Am J Respir Crit Care Med. 160:1999;1952-1956.
19. Lilly C.M., Woodruff P.G., Camargo C.A.J., Nakamura H., Drazen J.M., Nadel E.S., Hanrahan J.P. Elevated plasma eotaxin levels in patients with acute asthma. J Allergy Clin Immunol. 104:1999;786-790.
20. Maclean J.A., Ownbey R., Luster A.D. T cell-dependent regulation of eotaxin in antigen-induced pulmonary eosinophilia. J Exp Med. 184:1996;1461-1469.
21. Hein H., Schluter C., Kulke R., Christophers E., Schroder J.-M., Bartels J. Genomic organisation, sequence, and transcriptional regulation of the human eotaxin gene. Biochem Biophys Res Commun. 237:1997;537-542.
22. Teran L.M., Mochizuki M., Bartels J., Valencia E.L., Nakajima T., Hirai K., Schroder J.M. Th1- and Th2-type cytokines regulate the expression and production of eotaxin and RANTES by human lung fibroblasts. Am J Respir Cell Mol Biol. 20:1999;777-786.
23. Stellato C., Matsukura S., Fal A., White J., Beck L.A., Proud D., Schleimer R.P. Differential regulation of epithelial-derived C-C chemokine expression by IL-4 and the glucocorticoid budesonide. J Immunol. 163:1999;5624-5632.
24. Matsukura S., Stellato C., Plitt J.R., Bickel C., Miura K., Georas S.N., Casolaro V., Schleimer R.P. Activation of eotaxin gene transcription by NF-κB and STAT6 in human airway epithelial cells. J Immunol. 163:1999;6876-6883.
25. Wills-Karp M., Luyimbazi J., Xu X., Schofield B., Neben T.Y., Karp C.L., Donaldson D.D. Interleukin-13: central mediator of allergic asthma. Science. 282:1998;2258-2261.
26. Zhu Z., Homer R.J., Wang Z., Chen Q., Geba G.P., Wang J., Zhang Y., Elias J.A. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest. 103:1999;779-788.
27. Li L., Xia Y., Nguyen A., Lai Y.H., Feng L., Mosmann T.R., Lo D. Effects of Th2 cytokines on chemokine expression in the lung: IL-13 potently induces eotaxin expression by airway epithelial cells. J Immunol. 162:1999;2477-2487.
28. Nickel R., Barnes K.C., Sengler C.A., Casolaro V., Friedhoff R., Weber P., Naidu R.P., Carabello L., Ehrlich E., Litt J., et al. Evidence for linkage of chemokine polymorphisms to asthma in populations of African descent. J Allergy Clin Immunol. 103:1999;S174.
29. Ponath P.D., Qin S., Post T.W., Wang J., Wu L., Gerard N.P., Newman W., Gerard C., Mackay C.R. Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils. J Exp Med. 183:1996;2437-2448.
30. Gao J.-L., Sen A.I., Kitaura M., Yoshie O., Rothenberg M.E., Murphy P.M., Luster A.D. Identification of a mouse eosinophil receptor for the CC chemokine eotaxin. Biochem Biophys Res Commun. 223:1996;679-684.
31. Sabroe I., Conroy D.M., Gerard N.P., Li Y., Collins P.D., Post T.W., Jose P.J., Williams T.J., Gerard C., Ponath P.D. Cloning and characterisation of the guinea pig eosinophil eotaxin receptor, CCR3: blockade using a monoclonal antibody in vivo. J Immunol. 161:1998;6139-6147.
32. Uguccioni M., Mackay C.R., Ochensberger B., Loetscher P., Rhis S., LaRosa G.J., Rao P., Ponath P.D., Baggiolini M., Dahinden C.A. High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines. J Clin Invest. 100:1997;1137-1143.
33. Sallusto F., Mackay C.R., Lanzavecchia A. Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells. Science. 277:1997;2005-2007.
34. Boehme S.A., Sullivan S.K., Crowe P.D., Santos M., Conlon P.J., Sriramarao P., Bacon K.B. Activation of mitogen-activated protein kinase regulates eotaxin-induced eosinophil migration. J Immunol. 163:1999;1611-1618.
35. Kampen G.T., Stafford S., Adachi T., Jinquan T., Quan S., Grant J.A., Skov P.S., Poulsen L.K., Alam R. Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases. Blood. 95:2000;1911-1917.
36. Zeibecoglou K., Ying S., Yamada T., North J., Burman J., Bungre J., Meng Q., Kay A.B., Robinson D.S. Increased mature and immature CCR3 messenger RNA+ eosinophils in bone marrow from patients with atopic asthma compared with atopic and nonatopic control subjects. J Allergy Clin Immunol. 103:1999;99-106.
37. Patel V.P., Kreider B.L., Li Y., Li H., Leung K., Salcedo T., Nardelli B., Pippalla V., Gentz S., Thotakura R., et al. Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors. J Exp Med. 185:1997;1163-1172.
38. White J.R., Imburgia C., Dul E., Appelbaum E., O'Donnell K., O'Shannessy D.J., Brawner M., Fornwald J., Adamou J., Elshourbagy N.A., et al. Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils. J Leukoc Biol. 62:1997;667-675.
39. Forssmann U., Uguccioni M., Loetscher P., Dahinden C.A., Langen H., Thelen M., Baggiolini M. Eotaxin-2, a novel CC chemokine that is selective for the chemokine receptor CCR3, and acts like eotaxin on human eosinophil and basophil leukocytes. J Exp Med. 185:1997;2171-2176.
40. Kitaura M., Suzuki N., Imai T., Takagi S., Suzuki R., Nakajima T., Hirai K., Nomiyama H., Yoshie O. Molecular cloning of a novel human CC chemokine (eotaxin-3) that is a functional ligand of CC chemokine receptor 3. J Biol Chem. 274:1999;27975-27980.
41. Shinkai A., Yoshisue H., Koike M., Shoji E., Nakagawa S., Saito A., Takeda T., Imabeppu S., Kato Y., Hanai N., et al. A novel human CC chemokine, eotaxin-3, which is expressed in IL-4-stimulated vascular endothelial cells, exhibits potent activity toward eosinophils. J Immunol. 163:1999;1602-1610.
42. Rothenberg M.E., MacLean J.A., Pearlman E., Luster A.D., Leder P. Targeted disruption of the chemokine eotaxin partially reduces antigen-induced tissue eosinophilia. J Exp Med. 185:1997;785-790.
43. Yang Y., Loy J., Ryseck R.P., Carrasco D., Bravo R. Antigen-induced eosinophilic lung inflammation develops in mice deficient in chemokine eotaxin. Blood. 92:1998;3912-3923.
44. Gonzalo J.-A., Lloyd C.M., Wen D., Albar J.P., Wells T.N.C., Proudfoot A., Martinez A.C., Dorf M., Bjerke T., Coyle A.J., et al. The coordinated action of CC chemokines in the lung orchestrates allergic inflammation and airways hyperresponsiveness. J Exp Med. 188:1998;157-167.
45. Lloyd C.M., Delany T., Nguyen T., Tian J., Martinez A.C., Coyle A.J., Gutierrez-Ramos J.-C. CC Chemokine receptor (CCR)3/eotaxin is followed by CCR4/monocyte-derived chemokine in mediating pulmonary T helper lymphocyte type 2 recruitment after serial antigen challenge in vivo. J Exp Med. 191:2000;265-273. This elegant study employed the adoptive transfer of antigen-specific T-lymphocytes to show that eotaxin mediates the early phase recruitment of allergen-specific T-lymphocytes to the lung in a mouse model of airways inflammation.
46. + lymphocytes) is necessary for eosinophil degranulation and the development of airways hyperreactivity.
47. Campbell E.M., Kunkel S.L., Strieter R.M., Lukacs N.W. Temporal role of chemokines in a murine model of cockroach allergen-induced airway hyperreactivity and eosinophilia. J Immunol. 161:1998;7047-7053.
48. -/- mice during chronic fungal allergic airway disease. J Immunol. 165:2000;1564-1572.
49. -/- mice. J Immunol. 165:2000;2603-2611.
50. Zimmermann N., Hogan S.P., Mishra A., Brandt E.B., Bodette T.R., Pope S.M., Finkelman F.D., Rothenberg M.E. Murine eotaxin-2: a constitutive eosinophil chemokine induced by allergen challenge and IL-4 overexpression. J Immunol. 165:2000;5839-5846. A recent paper which describes the identification and preliminary characterisation of murine eotaxin-2 and suggests that only two eotaxin analogues are encoded within the mouse genome.
51. Saunders J., Tarby C.M. Opportunities for novel therapeutic agents acting at chemokine receptors. Drug Discov Today. 4:1999;80-92.
52. Heath H., Qin S., Wu L., LaRosa G., Kassam N., Ponath P.D., Mackay C.R. Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody. J Clin Invest. 99:1997;178-184.
53. Weng Y., Siciliano S.J., Waldburger K.E., Sirotina-Meisher A., Staruch M.J., Daugherty B.L., Gould S.L., Springer M.S., DeMartino J.A. Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors. J Biol Chem. 273:1998;18288-18291. See annotation to Loetscher et al. [54•].
54. Loetscher P., Pellegrino A., Gong J.H., Mattioli I., Loetscher M., Bardi G., Baggiolini M., Clark-Lewis I. The ligands of CXC chemokine receptor 3, I-TAC, Mig and IP10, are natural antagonists for CCR3. J Biol Chem. 276:2001;2986-2991. These two articles [53•,54•] demonstrate that although eotaxin (to the best of our knowledge) only signals via CCR3, it can bind to another chemokine receptor, CXCR3, and act as an antagonist. Similarly, CXCR3 ligands can act as antagonists of CCR3. These findings led both laboratories to conclude that Th1-associated chemokines may act, in part, by antagonising Th2-associated chemokine receptors and vice versa.
55. Sabroe I., Peck M.J., van Keulen B.J., Jorritsma A., Simmons G., Clapham P.R., Williams T.J., Pease J.E. A small molecule antagonist of the chemokine receptors CCR1 and CCR3: potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry. J Biol Chem. 275:2000;25985-25992. See annotation to White et al. [56••].
56. White J.R., Lee J.M., Dede K., Imburgia C.S., Jurewicz A.J., Chan G., Fornwold J.A., Dhanak D., Christmann L.T., Darcy M.G., et al. Identification of potent, selective non-peptide CCR3 antagonist that inhibits eotaxin-, eotaxin-2 and MCP-4 induced eosinophil migration. J Biol Chem. 275:2000;36626-36631. Both papers [55••,56••] describe potent small-molecule antagonists of CCR3, which are potent inhibitors of eotaxin-induced functions of eosinophils.
57. Mirzadegan T., Diehl F., Ebi B., Bhakta S., Polsky I., McCarley D., Mulkin S.M., Weatherhead G.S., LaPierre J.M., Dankwardt J., et al. Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle. J Biol Chem. 275:2000;25562-25571.
58. Dragic T., Trkola A., Thompson D.A., Cormier E.G., Kajumo F.A., Maxwell E., Lin S.W., Ying W., Smith S.O., Sakmar T.P., et al. A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5. Proc Natl Acad Sci USA. 97:2000;5639-5644.