Role of prostaglandin D2 receptor CRTH2 in sustained eosinophil accumulation in the airways of mice with chronic asthma

International Archives of Allergy and Immunology

Volumn 155, Issue SUPPL. 1, 2011, Pages 6-11

  Kagawa, Shizuko ^a   Fukunaga, Koichi ^a   Oguma, Tsuyoshi ^a   Suzuki, Yusuke ^a   Shiomi, Tetsuya ^a   Sayama, Koichi ^a   Kimura, Tokuhiro ^a   Hirai, Hiroyuki ^c   Nagata, Kinya ^c   Nakamura, Masataka ^b   Asano, Koichiro ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c BML   (Japan)

Author keywords

Airway responsiveness, remodeling; Eosinophils; Lung; Mucus

Indexed keywords

G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR CRTH2; INTERLEUKIN 13; OVALBUMIN; PROSTAGLANDIN D2; UNCLASSIFIED DRUG; DIAGNOSTIC AGENT; IMMUNOGLOBULIN RECEPTOR; INTERLEUKIN 5; METHACHOLINE CHLORIDE; MUCIN; PROSTAGLANDIN D2 RECEPTOR; PROSTAGLANDIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ASTHMA; CONFERENCE PAPER; CONTROLLED STUDY; EOSINOPHIL; INFLAMMATION; INFLAMMATORY CELL; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; WILD TYPE; ANIMAL; ARTICLE; BAGG ALBINO MOUSE; BRONCHUS HYPERREACTIVITY; CHEMISTRY; CYTOLOGY; GENETICS; GOBLET CELL; IMMUNOLOGY; LOEFFLER PNEUMONIA; LUNG; LUNG LAVAGE; METABOLISM; MOUSE MUTANT; PATHOLOGY; PATHOPHYSIOLOGY; VACCINATION;

ANIMALS; ASTHMA; BRONCHIAL HYPERREACTIVITY; BRONCHOALVEOLAR LAVAGE FLUID; EOSINOPHILS; GOBLET CELLS; INTERLEUKIN-13; INTERLEUKIN-5; LUNG; MALE; METHACHOLINE CHLORIDE; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MUCINS; OVALBUMIN; PULMONARY EOSINOPHILIA; RECEPTORS, IMMUNOLOGIC; RECEPTORS, PROSTAGLANDIN; VACCINATION;

EID: 79958162505     PISSN: 10182438     EISSN: 14230097     Source Type: Journal    
DOI: 10.1159/000327257     Document Type: Conference Paper

References (18)

1. Brusselle GG, Kips JC, Tavernier JH, van der Heyden JG, Cuvelier CA, Pauwels RA, Bluethmann H: Attenuation of allergic airway inflammation in IL-4 deficient mice. Clin Exp Allergy 1994;24:73-80. (Pubitemid 24210819)
2. Kobayashi T, Miura T, Haba T, Sato M, Serizawa I, Nagai H, Ishizaka K: An essential role of mast cells in the development of airway hyperresponsiveness in a murine asthma model. J Immunol 2000;164:3855-3861. (Pubitemid 30169844)
3. Williams CM, Galli SJ: Mast cells can amplify airway reactivity and features of chronic inflammation in an asthma model in mice. J Exp Med 2000;192:455-462. (Pubitemid 30629171)
4. Masuda T, Tanaka H, Komai M, Nagao K, Ishizaki M, Kajiwara D, Nagai H: Mast cells play a partial role in allergen-induced subepithelial fibrosis in a murine model of allergic asthma. Clin Exp Allergy 2003;33:705-713. (Pubitemid 36629698)
5. Reuter S, Heinz A, Sieren M, Wiewrodt R, Gelfand EW, Stassen M, Buhl R, Taube C: Mast cell-derived tumour necrosis factor is essential for allergic airway disease. Eur Respir J 2008;31:773-782.
6. Yu M, Tsai M, Tam SY, Jones C, Zehnder J, Galli SJ: Mast cells can promote the development of multiple features of chronic asthma in mice. J Clin Invest 2006;116:1633-1641.
7. Okayama Y, Ra C, Saito H: Role of mast cells in airway remodeling. Curr Opin Immunol 2007;19:687-693. (Pubitemid 350236804)
8. 2-induced eosinophilic airway inflammation is mediated by CRTH2 receptor. J Pharmacol Exp Ther 2005;312:954-960.
9. 2/CRTH2 pathway mediates double-stranded RNA-induced enhancement of allergic airway inflammation. J Immunol 2008;180:541-549.
10. Gervais FG, Cruz RP, Chateauneuf A, Gale S, Sawyer N, Nantel F, Metters KM, O'neill GP: Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP. J Allergy Clin Immunol 2001;108:982-988. (Pubitemid 33151552)
11. 2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. J Exp Med 2001;193:255-261.
12. 2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor. Blood 2001;98:1942-1948.
13. Nagata K, Hirai H, Tanaka K, Ogawa K, Aso T, Sugamura K, Nakamura M, Takano S: CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor(s). FEBS Lett 1999;459:195-199. (Pubitemid 29475029)
14. Parameswaran K, Radford K, Fanat A, Stephen J, Bonnans C, Levy BD, Janssen LJ, Cox PG: Modulation of human airway smooth muscle migration by lipid mediators and Th-2 cytokines. Am J Respir Cell Mol Biol 2007;37:240-247. (Pubitemid 47255007)
15. Stebbins KJ, Broadhead AR, Baccei CS, Scott JM, Truong YP, Coate H, Stock NS, Santini AM, Fagan P, Prodanovich P, Bain G, Stearns BA, King CD, Hutchinson JH, Prasit P, Evans JF, Lorrain DS: Pharmacological blockade of the DP2 receptor inhibits cigarette smoke-induced inflammation, mucus cell metaplasia, and epithelial hyperplasia in the mouse lung. J Pharmacol Exp Ther 2010;332:764-775.
16. Ohta S, Oda N, Yokoe T, Tanaka A, Yamamoto Y, Watanabe Y, Minoguchi K, Ohnishi T, Hirose T, Nagase H, Ohta K, Adachi M: Effect of tiotropium bromide on airway inflammation and remodelling in a mouse model of asthma. Clin Exp Allergy 2010;40:1266-1275.
17. Chevalier E, Stock J, Fisher T, Dupont M, Fric M, Fargeau H, Leport M, Soler S, Fabien S, Pruniaux MP, Fink M, Bertrand CP, McNeish J, Li B: Chemoattractant receptor-homologous molecule expressed on Th2 cells plays a restricting role on IL-5 production and eosinophil recruitment. J Immunol 2005;175:2056-2060. (Pubitemid 41113809)
18. 2 plays an essential role in chronic allergic inflammation of the skin via CRTH2 receptor. J Immunol 2006;177:2621-2629.