Inhibitory receptors on eosinophils: A direct hit to a possible Achilles heel?

Journal of Allergy and Clinical Immunology

Volumn 119, Issue 6, 2007, Pages 1382-1387

  Munitz, Ariel ^a   Levi Schaffer, Francesca ^a  

^a Faculty of Medicine   (Israel)

Author keywords

Eosinophil; inhibitory receptors; IRp60 CD300a; ITIM

Indexed keywords

ALLERGY; ASTHMA; CELL ACTIVATION; EOSINOPHIL; IMMUNOREGULATION; INFLAMMATION; NATURAL KILLER CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW;

AMINO ACID MOTIFS; ANIMALS; DRUG DELIVERY SYSTEMS; EOSINOPHILS; HUMANS; IMMUNOSUPPRESSION; RECEPTORS, IMMUNOLOGIC;

EID: 34249798165     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2007.01.031     Document Type: Review

References (37)

1. Ravetch J.V., and Lanier L.L. Immune inhibitory receptors. Science 290 (2000) 84-89
2. Clynes R., Maizes J.S., Guinamard R., Ono M., Takai T., and Ravetch J.V. Modulation of immune complex-induced inflammation in vivo by the coordinate expression of activation and inhibitory Fc receptors. J Exp Med 189 (1999) 179-185
3. O'Keefe T.L., Williams G.T., Batista F.D., and Neuberger M.S. Deficiency in CD22, a B cell-specific inhibitory receptor, is sufficient to predispose to development of high affinity autoantibodies. J Exp Med 189 (1999) 1307-1313
4. Kumar V., and McNerney M.E. A new self: MHC-class-I-independent natural-killer-cell self-tolerance. Nat Rev Immunol 5 (2005) 363-374
5. Katz H.R. Inhibitory receptors and allergy. Curr Opin Immunol 14 (2002) 698-704
6. Eissmann P., Beauchamp L., Wooters J., Tilton J.C., Long E.O., and Watzl C. Molecular basis for positive and negative signaling by the natural killer cell receptor 2B4 (CD244). Blood 105 (2005) 4722-4729
7. Zhang S., and Phillips J.H. Identification of tyrosine residues crucial for CD200R-mediated inhibition of mast cell activation. J Leukoc Biol 79 (2006) 363-368
8. Barrow A.D., and Trowsdale J. You say ITAM and I say ITIM, let's call the whole thing off: the ambiguity of immunoreceptor signalling. Eur J Immunol 36 (2006) 1646-1653
9. Pasquier B., Launay P., Kanamaru Y., Moura I.C., Pfirsch S., Ruffie C., et al. Identification of FcalphaRI as an inhibitory receptor that controls inflammation: dual role of FcRgamma ITAM. Immunity 22 (2005) 31-42
10. Barrow A.D., Astoul E., Floto A., Brooke G., Relou I.A., Jennings N.S., et al. Cutting edge: TREM-like transcript-1, a platelet immunoreceptor tyrosine-based inhibition motif encoding costimulatory immunoreceptor that enhances, rather than inhibits, calcium signaling via SHP-2. J Immunol 172 (2004) 5838-5842
11. Rothenberg M.E., and Hogan S.P. The eosinophil. Annu Rev Immunol 24 (2006) 147-174
12. Munitz A., Bachelet I., Eliashar R., Moretta A., Moretta L., and Levi-Schaffer F. The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils. Blood 107 (2006) 1996-2003
13. Tedla N., Bandeira-Melo C., Tassinari P., Sloane D.E., Samplaski M., Cosman D., et al. Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7. Proc Natl Acad Sci U S A 100 (2003) 1174-1179
14. Munday J., Kerr S., Ni J., Cornish A.L., Zhang J.Q., Nicoll G., et al. Identification, characterization and leucocyte expression of Siglec-10, a novel human sialic acid-binding receptor. Biochem J 355 (2001) 489-497
15. Nutku E., Hudson S.A., and Bochner B.S. Mechanism of Siglec-8-induced human eosinophil apoptosis: role of caspases and mitochondrial injury. Biochem Biophys Res Commun 336 (2005) 918-924
16. Nutku E., Aizawa H., Hudson S.A., and Bochner B.S. Ligation of Siglec-8: a selective mechanism for induction of human eosinophil apoptosis. Blood 101 (2003) 5014-5020
17. Bochner B.S., Alvarez R.A., Mehta P., Bovin N.V., Blixt O., White J.R., et al. Glycan array screening reveals a candidate ligand for Siglec-8. J Biol Chem 280 (2005) 4307-4312
18. Mingari M.C., Vitale C., Romagnani C., Falco M., and Moretta L. p75/AIRM1 and CD33, two sialoadhesin receptors that regulate the proliferation or the survival of normal and leukemic myeloid cells. Immunol Rev 181 (2001) 260-268
19. Vitale C., Romagnani C., Falco M., Ponte M., Vitale M., Moretta A., et al. Engagement of p75/AIRM1 or CD33 inhibits the proliferation of normal or leukemic myeloid cells. Proc Natl Acad Sci U S A 96 (1999) 15091-15096
20. Munitz A., Bachelet I., Fraenkel S., Katz G., Mandelboim O., Simon H.U., et al. 2B4 (CD244) is expressed and functional on human eosinophils. J Immunol 174 (2005) 110-118
21. Fulkerson P.C., Zimmermann N., Brandt E.B., Muntel E.E., Doepker M.P., Kavanaugh J.L., et al. Negative regulation of eosinophil recruitment to the lung by the chemokine monokine induced by IFN-gamma (Mig, CXCL9). Proc Natl Acad Sci U S A 101 (2004) 1987-1992
22. Fulkerson P.C., Zhu H., Williams D.A., Zimmermann N., and Rothenberg M.E. CXCL9 inhibits eosinophil responses by a CCR3- and Rac2-dependent mechanism. Blood 106 (2005) 436-443
23. Kim C.H., Qu C.K., Hangoc G., Cooper S., Anzai N., Feng G.S., et al. Abnormal chemokine-induced responses of immature and mature hematopoietic cells from motheaten mice implicate the protein tyrosine phosphatase SHP-1 in chemokine responses. J Exp Med 190 (1999) 681-690
24. Zhang H., Meng F., Chu C.L., Takai T., and Lowell C.A. The Src family kinases Hck and Fgr negatively regulate neutrophil and dendritic cell chemokine signaling via PIR-B. Immunity 22 (2005) 235-246
25. Elsner J., Hochstetter R., Spiekermann K., and Kapp A. Surface and mRNA expression of the CD52 antigen by human eosinophils but not by neutrophils. Blood 88 (1996) 4684-4693
26. Sanz L., Blanco B., and Alvarez-Vallina L. Antibodies and gene therapy: teaching old 'magic bullets' new tricks. Trends Immunol 25 (2004) 85-91
27. Yoshida S., Kobayashi T., Matsuoka H., Seki C., Gosnell W.L., Chang S.P., et al. T-cell activation and cytokine production via a bispecific single-chain antibody fragment targeted to blood-stage malaria parasites. Blood 101 (2003) 2300-2306
28. Weiner L.M., Clark J.I., Davey M., Li W.S., Garcia de Palazzo I., Ring D.B., et al. Phase I trial of 2B1, a bispecific monoclonal antibody targeting c-erbB-2 and Fc gamma RIII. Cancer Res 55 (1995) 4586-4593
29. Weiner L.M., Clark J.I., Ring D.B., and Alpaugh R.K. Clinical development of 2B1, a bispecific murine monoclonal antibody targeting c-erbB-2 and Fc gamma RIII. J Hematother 4 (1995) 453-456
30. James N.D., Atherton P.J., Jones J., Howie A.J., Tchekmedyian S., and Curnow R.T. A phase II study of the bispecific antibody MDX-H210 (anti-HER2 x CD64) with GM-CSF in HER2+ advanced prostate cancer. Br J Cancer 85 (2001) 152-156
31. Repp R., van Ojik H.H., Valerius T., Groenewegen G., Wieland G., Oetzel C., et al. Phase I clinical trial of the bispecific antibody MDX-H210 (anti-FcgammaRI x anti-HER-2/neu) in combination with Filgrastim (G-CSF) for treatment of advanced breast cancer. Br J Cancer 89 (2003) 2234-2243
32. van Ojik H.H., Repp R., Groenewegen G., Valerius T., and van de Winkel J.G. Clinical evaluation of the bispecific antibody MDX-H210 (anti-Fc gamma RI x anti-HER-2/neu) in combination with granulocyte-colony-stimulating factor (filgrastim) for treatment of advanced breast cancer. Cancer Immunol Immunother 45 (1997) 207-209
33. Tam S.W., Demissie S., Thomas D., and Daeron M. A bispecific antibody against human IgE and human FcgammaRII that inhibits antigen-induced histamine release by human mast cells and basophils. Allergy 59 (2004) 772-780
34. Zhu D., Kepley C.L., Zhang M., Zhang K., and Saxon A. A novel human immunoglobulin Fc gamma Fc epsilon bifunctional fusion protein inhibits Fc epsilon RI-mediated degranulation. Nat Med 8 (2002) 518-521
35. Zhu D., Kepley C.L., Zhang K., Terada T., Yamada T., and Saxon A. A chimeric human-cat fusion protein blocks cat-induced allergy. Nat Med 11 (2005) 446-449
36. Munitz A., Bachelet I., Levi-Schaffer F., and Daeron M. Reversal of airway inflammation and remodeling in asthma by a bispecific antibody fragment linking CCR3 to CD300a. J Allergy Clin Immunol 118 (2006) 1082-1089
37. Rosenberg H.F., and Domachowske J.B. Eosinophils, eosinophil ribonucleases, and their role in host defense against respiratory virus pathogens. J Leukoc Biol 70 (2001) 691-698