MEDI-563, a humanized anti-IL-5 receptor α mAb with enhanced antibody-dependent cell-mediated cytotoxicity function

Journal of Allergy and Clinical Immunology

Volumn 125, Issue 6, 2010, Pages

  Kolbeck, Roland ^a   Kozhich, Alexander ^a   Koike, Masamichi ^b   Peng, Li ^a   Andersson, Cecilia K ^c   Damschroder, Melissa M ^a   Reed, Jennifer L ^a   Woods, Robert ^a   Dall'Acqua, William W ^a   Stephens, Geoffrey L ^a   Erjefalt, Jonas S ^c   Bjermer, Leif ^d   Humbles, Alison A ^a   Gossage, David ^a   Wu, Herren ^a   Kiener, Peter A ^a   Spitalny, George L ^b   Mackay, Charles R ^e   Molfino, Nestor A ^a   Coyle, Anthony J ^a  

^a MEDIMMUNE   (United States)

^b KYOWA HAKKO KOGYO CO LTD   (Japan)

^c LUND UNIVERSITY   (Sweden)

^d LUND UNIVERSITY HOSPITAL   (Sweden)

^e GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

antibody dependent cell mediated cytotoxicity; Asthma; basophil; eosinophil; Fc RIII ; IL 5; IL 5 receptor; monoclonal antibody

Indexed keywords

EPITOPE; FC RECEPTOR; FC RECEPTOR IIIA; INTERLEUKIN 5; INTERLEUKIN 5 RECEPTOR ALPHA; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY MEDI 563; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ARTICLE; ASTHMA; BASOPHIL; BINDING AFFINITY; BINDING SITE; CELL INFILTRATION; CELL MATURATION; CELL MOTILITY; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG TARGETING; EMBRYO; EOSINOPHIL; EOSINOPHILIA; FEMALE; HUMAN; HUMAN CELL; INHIBITION KINETICS; MALE; NONHUMAN; PRIMATE; PRIORITY JOURNAL; PROTEIN BINDING; RESPIRATORY TRACT MUCOSA; SITE DIRECTED MUTAGENESIS; SURFACE PLASMON RESONANCE;

EID: 77952733788     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2010.04.004     Document Type: Article

References (45)

1. Ayars G.H., Altman L.C., Gleich G.J., Loegering D.A., and Baker C.B. Eosinophil- and eosinophil granule-mediated pneumocyte injury. J Allergy Clin Immunol 76 (1985) 595-604
2. Gleich G.J. The eosinophil and bronchial asthma: current understanding. J Allergy Clin Immunol 85 (1990) 422-436
3. Shaw R.J., Walsh G.M., Cromwell O., Moqbel R., Spry C.J., and Kay A.B. Activated human eosinophils generate SRS-A leukotrienes following IgG-dependent stimulation. Nature 316 (1985) 150-152
4. Gundel R.H., Letts L.G., and Gleich G.J. Human eosinophil major basic protein induces airway constriction and airway hyperresponsiveness in primates. J Clin Invest 87 (1991) 1470-1473
5. Coyle A.J., Ackerman S.J., Burch R., Proud D., and Irvin C.G. Human eosinophil-granule major basic protein and synthetic polycations induce airway hyperresponsiveness in vivo dependent on bradykinin generation. J Clin Invest 95 (1995) 1735-1740
6. Hogan S.P., Rosenberg H.F., Moqbel R., Phipps S., Foster P.S., Lacy P., et al. Eosinophils: biological properties and role in health and disease. Clin Exp Allergy 38 (2008) 709-750
7. Sehmi R., Wood L.J., Watson R., Foley R., Hamid Q., O'Byrne P.M., et al. Allergen-induced increases in IL-5 receptor alpha-subunit expression on bone marrow-derived CD34+ cells from asthmatic subjects. A novel marker of progenitor cell commitment towards eosinophilic differentiation. J Clin Invest 100 (1997) 2466-2475
8. Ochensberger B., Tassera L., Bifrare D., Rihs S., and Dahinden C.A. Regulation of cytokine expression and leukotriene formation in human basophils by growth factors, chemokines and chemotactic agonists. Eur J Immunol 29 (1999) 11-22
9. Murata Y., Takaki S., Migita M., Kikuchi Y., Tominaga A., and Takatsu K. Molecular cloning and expression of the human interleukin 5 receptor. J Exp Med 175 (1992) 341-351
10. Migita M., Yamaguchi N., Mita S., Higuchi S., Hitoshi Y., Yoshida Y., et al. Characterization of the human IL-5 receptors on eosinophils. Cell Immunol 133 (1991) 484-497
11. Hamelmann E., Oshiba A., Loader J., Larsen G.L., Gleich G., Lee J., et al. Antiinterleukin-5 antibody prevents airway hyperresponsiveness in a murine model of airway sensitization. Am J Respir Crit Care Med 155 (1997) 819-825
12. Mauser P.J., Pitman A.M., Fernandez X., Foran S.K., Adams III G.K., Kreutner W., et al. Effects of an antibody to interleukin-5 in a monkey model of asthma. Am J Respir Crit Care Med 152 (1995) 467-472
13. Bousquet J., Chanez P., Lacoste J.Y., Barneon G., Ghavanian N., Enander I., et al. Eosinophilic inflammation in asthma. N Engl J Med 323 (1990) 1033-1039
14. Leckie M.J., Ten B.A., Khan J., Diamant Z., O'Connor B.J., Walls C.M., et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 356 (2000) 2144-2148
15. Kips J.C., O'Connor B.J., Langley S.J., Woodcock A., Kerstjens H.A., Postma D.S., et al. Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: a pilot study. Am J Respir Crit Care Med 167 (2003) 1655-1659
16. Haldar P., Brightling C.E., Hargadon B., Gupta S., Monteiro W., Sousa A., et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med 360 (2009) 973-984
17. Nair P., Pizzichini M.M., Kjarsgaard M., Inman M.D., Efthimiadis A., Pizzichini E., et al. Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. N Engl J Med 360 (2009) 985-993
18. Flood-Page P.T., Menzies-Gow A.N., Kay A.B., and Robinson D.S. Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway. Am J Respir Crit Care Med 167 (2003) 199-204
19. Koike M., Nakamura K., Furuya A., Iida A., Anazawa H., Takatsu K., et al. Establishment of humanized anti-interleukin-5 receptor alpha chain monoclonal antibodies having a potent neutralizing activity. Hum Antibodies 18 (2009) 17-27
20. Ishino T., Pasut G., Scibek J., and Chaiken I. Kinetic interaction analysis of human interleukin 5 receptor alpha mutants reveals a unique binding topology and charge distribution for cytokine recognition. J Biol Chem 279 (2004) 9547-9556
21. Shields R.L., Lai J., Keck R., O'Connell L.Y., Hong K., Meng Y.G., et al. Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human Fcgamma RIII and antibody-dependent cellular toxicity. J Biol Chem 277 (2002) 26733-26740
22. Shinkawa T., Nakamura K., Yamane N., Shoji-Hosaka E., Kanda Y., Sakurada M., et al. The absence of fucose but not the presence of galactose or bisecting N-acetylglucosamine of human IgG1 complex-type oligosaccharides shows the critical role of enhancing antibody-dependent cellular cytotoxicity. J Biol Chem 278 (2003) 3466-3473
23. Rogers K.A., Scinicariello F., and Attanasio R. IgG Fc receptor III homologues in nonhuman primate species: genetic characterization and ligand interactions. J Immunol 177 (2006) 3848-3856
24. Ravetch J.V., and Bolland S. IgG Fc receptors. Annu Rev Immunol 19 (2001) 275-290
25. Busse W.W., Katial R., Gossage D., Sari S., Wang B., Kolbeck R., et al. Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti-IL-5 receptor α antibody, in a phase I study of subjects with mild asthma. J Allergy Clin Immunol 125 (2010) 1237-1244
26. Rothenberg M.E., Owen Jr. W.F., Silberstein D.S., Woods J., Soberman R.J., Austen K.F., et al. Human eosinophils have prolonged survival, enhanced functional properties, and become hypodense when exposed to human interleukin 3. J Clin Invest 81 (1988) 1986-1992
27. Lopez A.F., Elliott M.J., Woodcock J., and Vadas M.A. GM-CSF, IL-3 and IL-5: cross-competition on human haemopoietic cells. Immunol Today 13 (1992) 495-500
28. Gleich G.J., and Adolphson C.R. The eosinophilic leukocyte: structure and function. Adv Immunol 39 (1986) 177-253
29. Walsh G.M. Eosinophil granule proteins and their role in disease. Curr Opin Hematol 8 (2001) 28-33
30. Frigas E., Loegering D.A., and Gleich G.J. Cytotoxic effects of the guinea pig eosinophil major basic protein on tracheal epithelium. Lab Invest 42 (1980) 35-43
31. Hastie A.T., Loegering D.A., Gleich G.J., and Kueppers F. The effect of purified human eosinophil major basic protein on mammalian ciliary activity. Am Rev Respir Dis 135 (1987) 848-853
32. Durack D.T., Sumi S.M., and Klebanoff S.J. Neurotoxicity of human eosinophils. Proc Natl Acad Sci U S A 76 (1979) 1443-1447
33. Erjefalt J.S., and Persson C.G. New aspects of degranulation and fates of airway mucosal eosinophils. Am J Respir Crit Care Med 161 (2000) 2074-2085
34. Ravetch J.V., and Kinet J.P. Fc receptors. Annu Rev Immunol 9 (1991) 457-492
35. Nimmerjahn F., and Ravetch J.V. Fcgamma receptors: old friends and new family members. Immunity 24 (2006) 19-28
36. Juhlin L., and Michaëlsson G. A new syndrome characterised by absence of eosinophils and basophils. Lancet 1 (1977) 1233-1235
37. Mitchell E.B., Platts-Mills T.A., Pereira R.S., Malkovska V., and Webster A.D. Acquired basophil and eosinophil deficiency in a patient with hypogammaglobulinaemia associated with thymoma. Clin Lab Haematol 5 (1983) 253-257
38. Liu L.Y., Sedgwick J.B., Bates M.E., Vrtis R.F., Gern J.E., Kita H., et al. Decreased expression of membrane IL-5 receptor alpha on human eosinophils: I. Loss of membrane IL-5 receptor alpha on airway eosinophils and increased soluble IL-5 receptor alpha in the airway after allergen challenge. J Immunol 169 (2002) 6452-6458
39. Liu L.Y., Sedgwick J.B., Bates M.E., Vrtis R.F., Gern J.E., Kita H., et al. Decreased expression of membrane IL-5 receptor alpha on human eosinophils: II. IL-5 down-modulates its receptor via a proteinase-mediated process. J Immunol 169 (2002) 6459-6466
40. Gregory B., Kirchem A., Phipps S., Gevaert P., Pridgeon C., Rankin S.M., et al. Differential regulation of human eosinophil IL-3, IL-5, and GM-CSF receptor alpha-chain expression by cytokines: IL-3, IL-5, and GM-CSF down-regulate IL-5 receptor alpha expression with loss of IL-5 responsiveness, but up-regulate IL-3 receptor alpha expression. J Immunol 170 (2003) 5359-5366
41. Hellman C., Lonnkvist K., Hedlin G., Hallden G., and Lundahl J. Down-regulated IL-5 receptor expression on peripheral blood eosinophils from budesonide-treated children with asthma. Allergy 57 (2002) 323-328
42. Yoshimura-Uchiyama C., Yamaguchi M., Nagase H., Fujisawa T., Ra C., Matsushima K., et al. Comparative effects of basophil-directed growth factors. Biochem Biophys Res Commun 302 (2003) 201-206
43. Mukai K., Matsuoka K., Taya C., Suzuki H., Yokozeki H., Nishioka K., et al. Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells. Immunity 23 (2005) 191-202
44. Gauvreau G.M., Lee J.M., Watson R.M., Irani A.M., Schwartz L.B., and O'Byrne P.M. Increased numbers of both airway basophils and mast cells in sputum after allergen inhalation challenge of atopic asthmatics. Am J Respir Crit Care Med 161 (2000) 1473-1478
45. Dahl C., Hoffmann H.J., Saito H., and Schiotz P.O. Human mast cells express receptors for IL-3, IL-5 and GM-CSF; a partial map of receptors on human mast cells cultured in vitro. Allergy 59 (2004) 1087-1096