-
1
-
-
39749182234
-
Apoptosis: controlled demolition at the cellular level
-
Taylor R.C., et al. Apoptosis: controlled demolition at the cellular level. Nat. Rev. Mol. Cell Biol. 2008, 9:231-234.
-
(2008)
Nat. Rev. Mol. Cell Biol.
, vol.9
, pp. 231-234
-
-
Taylor, R.C.1
-
2
-
-
44349111132
-
Caspase activity mediates the differentiation of embryonic stem cells
-
Fujita J., et al. Caspase activity mediates the differentiation of embryonic stem cells. Cell Stem Cell 2008, 2:595-601.
-
(2008)
Cell Stem Cell
, vol.2
, pp. 595-601
-
-
Fujita, J.1
-
3
-
-
52149095957
-
Mutation of a self-processing site in caspase-8 compromises its apoptotic but not its nonapoptotic functions in bacterial artificial chromosome-transgenic mice
-
Kang T.B., et al. Mutation of a self-processing site in caspase-8 compromises its apoptotic but not its nonapoptotic functions in bacterial artificial chromosome-transgenic mice. J. Immunol. 2008, 181:2522-2532.
-
(2008)
J. Immunol.
, vol.181
, pp. 2522-2532
-
-
Kang, T.B.1
-
4
-
-
0038284956
-
Caspase-mediated processing of the Drosophila NF-kappaB factor Relish
-
Stoven S., et al. Caspase-mediated processing of the Drosophila NF-kappaB factor Relish. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:5991-5996.
-
(2003)
Proc. Natl. Acad. Sci. U.S.A.
, vol.100
, pp. 5991-5996
-
-
Stoven, S.1
-
5
-
-
40449097257
-
The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response
-
Muruve D.A., et al. The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response. Nature 2008, 452:103-107.
-
(2008)
Nature
, vol.452
, pp. 103-107
-
-
Muruve, D.A.1
-
6
-
-
66749174867
-
The inflammasomes: guardians of the body
-
Martinon F., et al. The inflammasomes: guardians of the body. Annu. Rev. Immunol. 2009, 27:229-265.
-
(2009)
Annu. Rev. Immunol.
, vol.27
, pp. 229-265
-
-
Martinon, F.1
-
7
-
-
63649145255
-
AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
-
Fernandes-Alnemri T., et al. AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature 2009, 458:509-513.
-
(2009)
Nature
, vol.458
, pp. 509-513
-
-
Fernandes-Alnemri, T.1
-
8
-
-
63649133278
-
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
-
Hornung V., et al. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 2009, 458:514-518.
-
(2009)
Nature
, vol.458
, pp. 514-518
-
-
Hornung, V.1
-
9
-
-
60749136484
-
An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome
-
Bürckstümmer T., et al. An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat. Immunol. 2009, 10:266-272.
-
(2009)
Nat. Immunol.
, vol.10
, pp. 266-272
-
-
Bürckstümmer, T.1
-
10
-
-
79956061094
-
IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi sarcoma-associated herpesvirus infection
-
Kerur N., et al. IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi sarcoma-associated herpesvirus infection. Cell Host Microbe 2011, 9:363-375.
-
(2011)
Cell Host Microbe
, vol.9
, pp. 363-375
-
-
Kerur, N.1
-
11
-
-
74049126045
-
Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production
-
Poeck H., et al. Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production. Nat. Immunol. 2010, 11:63-69.
-
(2010)
Nat. Immunol.
, vol.11
, pp. 63-69
-
-
Poeck, H.1
-
12
-
-
69549119940
-
Molecular mechanisms involved in inflammasome activation
-
Bryant C., Fitzgerald K.A. Molecular mechanisms involved in inflammasome activation. Trends Cell Biol. 2009, 19:455-464.
-
(2009)
Trends Cell Biol.
, vol.19
, pp. 455-464
-
-
Bryant, C.1
Fitzgerald, K.A.2
-
13
-
-
47849085872
-
The NALP3 inflammasome is involved in the innate immune response to amyloid-beta
-
Halle A., et al. The NALP3 inflammasome is involved in the innate immune response to amyloid-beta. Nat. Immunol. 2008, 9:857-865.
-
(2008)
Nat. Immunol.
, vol.9
, pp. 857-865
-
-
Halle, A.1
-
14
-
-
43249125839
-
Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica
-
Dostert C., et al. Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science 2008, 320:674-677.
-
(2008)
Science
, vol.320
, pp. 674-677
-
-
Dostert, C.1
-
15
-
-
75649096002
-
Thioredoxin-interacting protein links oxidative stress to inflammasome activation
-
Zhou R., et al. Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat. Immunol. 2010, 11:136-140.
-
(2010)
Nat. Immunol.
, vol.11
, pp. 136-140
-
-
Zhou, R.1
-
16
-
-
77956958947
-
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1b in type 2 diabetes
-
Masters S.L., et al. Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1b in type 2 diabetes. Nat. Immunol. 2010, 11:897-904.
-
(2010)
Nat. Immunol.
, vol.11
, pp. 897-904
-
-
Masters, S.L.1
-
17
-
-
79551584144
-
Hyperglycemia activates caspase-1 and TXNIP-mediated IL-1beta transcription in human adipose tissue
-
Koenen T.B., et al. Hyperglycemia activates caspase-1 and TXNIP-mediated IL-1beta transcription in human adipose tissue. Diabetes 2011, 60:517-524.
-
(2011)
Diabetes
, vol.60
, pp. 517-524
-
-
Koenen, T.B.1
-
18
-
-
77954312028
-
Inflammasome activation. The missing link: how the inflammasome senses oxidative stress
-
Jin C., Flavell R.A. Inflammasome activation. The missing link: how the inflammasome senses oxidative stress. Immunol. Cell Biol. 2010, 88:510-512.
-
(2010)
Immunol. Cell Biol.
, vol.88
, pp. 510-512
-
-
Jin, C.1
Flavell, R.A.2
-
19
-
-
81355146675
-
Interplay between redox status and inflammasome activation
-
Rubartelli A., et al. Interplay between redox status and inflammasome activation. Trends Immunol. 2011, 32:559-566.
-
(2011)
Trends Immunol.
, vol.32
, pp. 559-566
-
-
Rubartelli, A.1
-
20
-
-
80053379974
-
Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity
-
Kofoed E.M., Vance R.E. Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity. Nature 2011, 477:592-595.
-
(2011)
Nature
, vol.477
, pp. 592-595
-
-
Kofoed, E.M.1
Vance, R.E.2
-
21
-
-
80053349020
-
The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus
-
Zhao Y., et al. The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus. Nature 2011, 477:596-600.
-
(2011)
Nature
, vol.477
, pp. 596-600
-
-
Zhao, Y.1
-
22
-
-
84860225554
-
GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals
-
Shenoy A.R., et al. GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals. Science 2012, 336:481-485.
-
(2012)
Science
, vol.336
, pp. 481-485
-
-
Shenoy, A.R.1
-
23
-
-
84867861468
-
Phosphorylation of NLRC4 is critical for inflammasome activation
-
Qu Y., et al. Phosphorylation of NLRC4 is critical for inflammasome activation. Nature 2012, 490:539-542.
-
(2012)
Nature
, vol.490
, pp. 539-542
-
-
Qu, Y.1
-
24
-
-
84865511926
-
Novel role of PKR in inflammasome activation and HMGB1 release
-
Lu B., et al. Novel role of PKR in inflammasome activation and HMGB1 release. Nature 2012, 488:670-674.
-
(2012)
Nature
, vol.488
, pp. 670-674
-
-
Lu, B.1
-
25
-
-
0343852938
-
Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways
-
Wong A.H., et al. Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways. EMBO J. 1997, 16:1291-1304.
-
(1997)
EMBO J.
, vol.16
, pp. 1291-1304
-
-
Wong, A.H.1
-
26
-
-
84861442790
-
Regulation of actin dynamics by protein kinase R control of gelsolin enforces basal innate immune defense
-
Irving A.T., et al. Regulation of actin dynamics by protein kinase R control of gelsolin enforces basal innate immune defense. Immunity 2012, 36:795-806.
-
(2012)
Immunity
, vol.36
, pp. 795-806
-
-
Irving, A.T.1
-
27
-
-
79957576718
-
NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis
-
Elinav E., et al. NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell 2011, 145:745-757.
-
(2011)
Cell
, vol.145
, pp. 745-757
-
-
Elinav, E.1
-
28
-
-
84858796861
-
An NLRP7-containing inflammasome mediates recognition of microbial lipopeptides in human macrophages
-
Khare S., et al. An NLRP7-containing inflammasome mediates recognition of microbial lipopeptides in human macrophages. Immunity 2012, 36:464-476.
-
(2012)
Immunity
, vol.36
, pp. 464-476
-
-
Khare, S.1
-
29
-
-
78651393239
-
A role for mitochondria in NLRP3 inflammasome activation
-
Zhou R., et al. A role for mitochondria in NLRP3 inflammasome activation. Nature 2011, 469:221-225.
-
(2011)
Nature
, vol.469
, pp. 221-225
-
-
Zhou, R.1
-
30
-
-
84862777872
-
Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis
-
Shimada K., et al. Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity 2012, 36:401-414.
-
(2012)
Immunity
, vol.36
, pp. 401-414
-
-
Shimada, K.1
-
31
-
-
79951642032
-
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
-
Nakahira K., et al. Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat. Immunol. 2011, 12:222-230.
-
(2011)
Nat. Immunol.
, vol.12
, pp. 222-230
-
-
Nakahira, K.1
-
32
-
-
56249090667
-
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production
-
Saitoh T., et al. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature 2008, 456:264-268.
-
(2008)
Nature
, vol.456
, pp. 264-268
-
-
Saitoh, T.1
-
33
-
-
84857195479
-
Activation of autophagy by inflammatory signals limits IL-1b production by targeting ubiquitinated inflammasomes for destruction
-
Shi C.S., et al. Activation of autophagy by inflammatory signals limits IL-1b production by targeting ubiquitinated inflammasomes for destruction. Nat. Immunol. 2012, 13:255-263.
-
(2012)
Nat. Immunol.
, vol.13
, pp. 255-263
-
-
Shi, C.S.1
-
34
-
-
80055021939
-
Adenovirus type 5 rupture of lysosomes leads to cathepsin B-dependent mitochondrial stress and production of reactive oxygen species
-
McGuire K.A., et al. Adenovirus type 5 rupture of lysosomes leads to cathepsin B-dependent mitochondrial stress and production of reactive oxygen species. J. Virol. 2011, 85:10806-10813.
-
(2011)
J. Virol.
, vol.85
, pp. 10806-10813
-
-
McGuire, K.A.1
-
35
-
-
47849097202
-
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
-
Hornung V., et al. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat. Immunol. 2008, 9:847-856.
-
(2008)
Nat. Immunol.
, vol.9
, pp. 847-856
-
-
Hornung, V.1
-
36
-
-
84866156921
-
Encephalomyocarditis virus viroporin 2B activates NLRP3 inflammasome
-
Ito M., et al. Encephalomyocarditis virus viroporin 2B activates NLRP3 inflammasome. PLoS Pathog. 2012, 8:e1002857.
-
(2012)
PLoS Pathog.
, vol.8
-
-
Ito, M.1
-
37
-
-
0030715323
-
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
-
Li P., et al. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 1997, 91:479-489.
-
(1997)
Cell
, vol.91
, pp. 479-489
-
-
Li, P.1
-
38
-
-
77956095537
-
Mitochondria and cell death: outer membrane permeabilization and beyond
-
Tait S.W., Green D.R. Mitochondria and cell death: outer membrane permeabilization and beyond. Nat. Rev. Mol. Cell Biol. 2010, 11:621-632.
-
(2010)
Nat. Rev. Mol. Cell Biol.
, vol.11
, pp. 621-632
-
-
Tait, S.W.1
Green, D.R.2
-
39
-
-
84857175933
-
Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1?. via a noncanonical caspase-8 inflammasome
-
Gringhuis S.I., et al. Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1?. via a noncanonical caspase-8 inflammasome. Nat. Immunol. 2012, 13:246-254.
-
(2012)
Nat. Immunol.
, vol.13
, pp. 246-254
-
-
Gringhuis, S.I.1
-
40
-
-
51049100571
-
Stimulation of Toll-like receptor 3 and 4 induces interleukin-1beta maturation by caspase-8
-
Maelfait J., et al. Stimulation of Toll-like receptor 3 and 4 induces interleukin-1beta maturation by caspase-8. J. Exp. Med. 2008, 205:1967-1973.
-
(2008)
J. Exp. Med.
, vol.205
, pp. 1967-1973
-
-
Maelfait, J.1
-
41
-
-
84866087868
-
-
AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages. Cell Death Differ. (in press)
-
Pierini, R. et al. (2012) AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages. Cell Death Differ. (in press).
-
(2012)
-
-
Pierini, R.1
-
42
-
-
80455176839
-
Non-canonical inflammasome activation targets caspase-11
-
Kayagaki N., et al. Non-canonical inflammasome activation targets caspase-11. Nature 2011, 479:117-121.
-
(2011)
Nature
, vol.479
, pp. 117-121
-
-
Kayagaki, N.1
-
43
-
-
84864600268
-
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by Gram-negative bacteria
-
Rathinam V.A., et al. TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by Gram-negative bacteria. Cell 2012, 150:606-619.
-
(2012)
Cell
, vol.150
, pp. 606-619
-
-
Rathinam, V.A.1
-
44
-
-
0034704161
-
Expression analysis of the human caspase-1 subfamily reveals specific regulation of the CASP5 gene by lipopolysaccharide and interferon-gamma
-
Lin X.Y., et al. Expression analysis of the human caspase-1 subfamily reveals specific regulation of the CASP5 gene by lipopolysaccharide and interferon-gamma. J. Biol. Chem. 2000, 275:39920-39926.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 39920-39926
-
-
Lin, X.Y.1
-
45
-
-
2542457495
-
Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory disease
-
Martinon F., Tschopp J. Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory disease. Cell 2004, 117:561-574.
-
(2004)
Cell
, vol.117
, pp. 561-574
-
-
Martinon, F.1
Tschopp, J.2
-
46
-
-
0036671894
-
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
-
Martinon F., et al. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol. Cell 2002, 10:417-426.
-
(2002)
Mol. Cell
, vol.10
, pp. 417-426
-
-
Martinon, F.1
-
47
-
-
84856832054
-
Caspase-4 is required for activation of inflammasomes
-
Sollberger G., et al. Caspase-4 is required for activation of inflammasomes. J. Immunol. 2012, 188:1992-2000.
-
(2012)
J. Immunol.
, vol.188
, pp. 1992-2000
-
-
Sollberger, G.1
-
48
-
-
84864292536
-
Caspase-11 promotes the fusion of phagosomes harboring pathogenic bacteria with lysosomes by modulating actin polymerization
-
Akhter A., et al. Caspase-11 promotes the fusion of phagosomes harboring pathogenic bacteria with lysosomes by modulating actin polymerization. Immunity 2012, 37:35-47.
-
(2012)
Immunity
, vol.37
, pp. 35-47
-
-
Akhter, A.1
-
49
-
-
0029005646
-
A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells
-
Faucheu C., et al. A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells. EMBO J. 1995, 14:1914-1922.
-
(1995)
EMBO J.
, vol.14
, pp. 1914-1922
-
-
Faucheu, C.1
-
50
-
-
84867333450
-
Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1
-
Broz P., et al. Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1. Nature 2012, 490:288-291.
-
(2012)
Nature
, vol.490
, pp. 288-291
-
-
Broz, P.1
-
51
-
-
84859464225
-
An inactivating caspase 11 passenger mutation originating from the 129 murine strain in mice targeted for c-IAP1
-
Kenneth N.S., et al. An inactivating caspase 11 passenger mutation originating from the 129 murine strain in mice targeted for c-IAP1. Biochem. J. 2012, 443:355-359.
-
(2012)
Biochem. J.
, vol.443
, pp. 355-359
-
-
Kenneth, N.S.1
-
52
-
-
77951628300
-
Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo
-
Mayer-Barber K.D., et al. Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo. J. Immunol. 2010, 184:3326-3330.
-
(2010)
J. Immunol.
, vol.184
, pp. 3326-3330
-
-
Mayer-Barber, K.D.1
-
53
-
-
84857166396
-
A new path to IL-1b production controlled by caspase-8
-
Dupaul-Chicoine J., Saleh M. A new path to IL-1b production controlled by caspase-8. Nat. Immunol. 2012, 13:211-212.
-
(2012)
Nat. Immunol.
, vol.13
, pp. 211-212
-
-
Dupaul-Chicoine, J.1
Saleh, M.2
-
54
-
-
77954930632
-
IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer
-
Gyrd-Hansen M., Meier P. IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer. Nat. Rev. Cancer 2010, 10:561-574.
-
(2010)
Nat. Rev. Cancer
, vol.10
, pp. 561-574
-
-
Gyrd-Hansen, M.1
Meier, P.2
-
55
-
-
55949118522
-
Inactivation of effector caspases through nondegradative polyubiquitylation
-
Ditzel M., et al. Inactivation of effector caspases through nondegradative polyubiquitylation. Mol. Cell 2008, 32:540-553.
-
(2008)
Mol. Cell
, vol.32
, pp. 540-553
-
-
Ditzel, M.1
-
56
-
-
80053439574
-
Drosophila IAP1-mediated ubiquitylation controls activation of the initiator caspase DRONC independent of protein degradation
-
Lee T.V., et al. Drosophila IAP1-mediated ubiquitylation controls activation of the initiator caspase DRONC independent of protein degradation. PLoS Genet. 2011, 7:e1002261.
-
(2011)
PLoS Genet.
, vol.7
-
-
Lee, T.V.1
-
57
-
-
79959539790
-
Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death
-
Vucic D., et al. Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death. Nat. Rev. Mol. Cell Biol. 2011, 12:439-452.
-
(2011)
Nat. Rev. Mol. Cell Biol.
, vol.12
, pp. 439-452
-
-
Vucic, D.1
-
58
-
-
65549160961
-
The CULt of caspase-8 ubiquitination
-
Békés M., Salvesen G.S. The CULt of caspase-8 ubiquitination. Cell 2009, 137:604-606.
-
(2009)
Cell
, vol.137
, pp. 604-606
-
-
Békés, M.1
Salvesen, G.S.2
-
59
-
-
84255178199
-
Cellular inhibitors of apoptosis proteins cIAP1 and cIAP2 are required for efficient caspase-1 activation by the inflammasome
-
Labbé K., et al. Cellular inhibitors of apoptosis proteins cIAP1 and cIAP2 are required for efficient caspase-1 activation by the inflammasome. Immunity 2011, 35:897-907.
-
(2011)
Immunity
, vol.35
, pp. 897-907
-
-
Labbé, K.1
-
60
-
-
65549085701
-
Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling
-
Jin Z., et al. Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling. Cell 2009, 137:721-735.
-
(2009)
Cell
, vol.137
, pp. 721-735
-
-
Jin, Z.1
-
61
-
-
84862189464
-
Ubiquitylation of the initiator caspase DREDD is required for innate immune signalling
-
Meinander A., et al. Ubiquitylation of the initiator caspase DREDD is required for innate immune signalling. EMBO J. 2012, 31:2770-2783.
-
(2012)
EMBO J.
, vol.31
, pp. 2770-2783
-
-
Meinander, A.1
-
62
-
-
79955484976
-
The spatial and temporal organization of ubiquitin networks
-
Grabbe C., et al. The spatial and temporal organization of ubiquitin networks. Nat. Rev. Mol. Cell Biol. 2011, 12:295-307.
-
(2011)
Nat. Rev. Mol. Cell Biol.
, vol.12
, pp. 295-307
-
-
Grabbe, C.1
-
63
-
-
80052754179
-
Caspase-1 promiscuity is counterbalanced by rapid inactivation of processed enzyme
-
Walsh J.G., et al. Caspase-1 promiscuity is counterbalanced by rapid inactivation of processed enzyme. J. Biol. Chem. 2011, 286:32513-32524.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 32513-32524
-
-
Walsh, J.G.1
-
64
-
-
84863009653
-
Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9
-
Fombonne J., et al. Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:10510-10515.
-
(2012)
Proc. Natl. Acad. Sci. U.S.A.
, vol.109
, pp. 10510-10515
-
-
Fombonne, J.1
-
65
-
-
79960224920
-
Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2
-
Darding M., et al. Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2. Cell Death Differ. 2011, 18:1376-1386.
-
(2011)
Cell Death Differ.
, vol.18
, pp. 1376-1386
-
-
Darding, M.1
-
66
-
-
84857404572
-
Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation
-
Vince J.E., et al. Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation. Immunity 2011, 36:215-227.
-
(2011)
Immunity
, vol.36
, pp. 215-227
-
-
Vince, J.E.1
-
67
-
-
79960921946
-
The ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs
-
Tenev T., et al. The ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs. Mol. Cell 2011, 43:432-448.
-
(2011)
Mol. Cell
, vol.43
, pp. 432-448
-
-
Tenev, T.1
-
68
-
-
82455212812
-
'Necrosome'-induced inflammation: must cells die for it?
-
Wallach D., et al. 'Necrosome'-induced inflammation: must cells die for it?. Trends Immunol. 2011, 32:505-509.
-
(2011)
Trends Immunol.
, vol.32
, pp. 505-509
-
-
Wallach, D.1
-
69
-
-
84867902828
-
Modulation of immune signalling by inhibitors of apoptosis
-
Beug S.T., et al. Modulation of immune signalling by inhibitors of apoptosis. Trends Immunol. 2012, 33:535-545.
-
(2012)
Trends Immunol.
, vol.33
, pp. 535-545
-
-
Beug, S.T.1
-
70
-
-
84857433477
-
Inhibitors of apoptosis proteins and IL-1b: a tangled relationship
-
Ciraci C., Sutterwala F.S. Inhibitors of apoptosis proteins and IL-1b: a tangled relationship. Immunity 2012, 36:155-157.
-
(2012)
Immunity
, vol.36
, pp. 155-157
-
-
Ciraci, C.1
Sutterwala, F.S.2
-
71
-
-
78449269290
-
Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria
-
Miao E.A., et al. Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria. Nat. Immunol. 2010, 11:1136-1142.
-
(2010)
Nat. Immunol.
, vol.11
, pp. 1136-1142
-
-
Miao, E.A.1
-
72
-
-
84860668802
-
Lethal inflammasome activation by a multidrug-resistant pathobiont upon antibiotic disruption of the microbiota
-
Ayres J.S., et al. Lethal inflammasome activation by a multidrug-resistant pathobiont upon antibiotic disruption of the microbiota. Nat. Med. 2012, 18:799-806.
-
(2012)
Nat. Med.
, vol.18
, pp. 799-806
-
-
Ayres, J.S.1
-
73
-
-
67349124914
-
Immunogenic and tolerogenic cell death
-
Green D.R., et al. Immunogenic and tolerogenic cell death. Nat. Rev. Immunol. 2009, 9:353-363.
-
(2009)
Nat. Rev. Immunol.
, vol.9
, pp. 353-363
-
-
Green, D.R.1
-
74
-
-
84861435630
-
A perspective on mammalian caspases as positive and negative regulators of inflammation
-
Martin S.J., et al. A perspective on mammalian caspases as positive and negative regulators of inflammation. Mol. Cell 2012, 46:387-397.
-
(2012)
Mol. Cell
, vol.46
, pp. 387-397
-
-
Martin, S.J.1
-
75
-
-
68249137289
-
Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases
-
Lüthi A.U., et al. Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases. Immunity 2009, 31:84-98.
-
(2009)
Immunity
, vol.31
, pp. 84-98
-
-
Lüthi, A.U.1
-
76
-
-
46749136790
-
Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein
-
Kazama H., et al. Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein. Immunity 2008, 29:21-32.
-
(2008)
Immunity
, vol.29
, pp. 21-32
-
-
Kazama, H.1
-
77
-
-
80052845560
-
Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis
-
Günther C., et al. Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis. Nature 2011, 477:335-339.
-
(2011)
Nature
, vol.477
, pp. 335-339
-
-
Günther, C.1
-
78
-
-
70350484946
-
Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease
-
Kovalenko A., et al. Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease. J. Exp. Med. 2009, 206:2161-2177.
-
(2009)
J. Exp. Med.
, vol.206
, pp. 2161-2177
-
-
Kovalenko, A.1
-
79
-
-
68049092912
-
RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway
-
Chiu Y.H., et al. RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. Cell 2009, 138:576-591.
-
(2009)
Cell
, vol.138
, pp. 576-591
-
-
Chiu, Y.H.1
-
80
-
-
79952770123
-
RIG-I RNA helicase activation of IRF3 transcription factor is negatively regulated by caspase-8-mediated cleavage of the RIP1 protein
-
Rajput A., et al. RIG-I RNA helicase activation of IRF3 transcription factor is negatively regulated by caspase-8-mediated cleavage of the RIP1 protein. Immunity 2011, 34:340-351.
-
(2011)
Immunity
, vol.34
, pp. 340-351
-
-
Rajput, A.1
-
81
-
-
80052989433
-
Caspase-8-mediated cleavage inhibits IRF-3 protein by facilitating its proteasome-mediated degradation
-
Sears N., et al. Caspase-8-mediated cleavage inhibits IRF-3 protein by facilitating its proteasome-mediated degradation. J. Biol. Chem. 2011, 286:33037-33044.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 33037-33044
-
-
Sears, N.1
-
82
-
-
79952811804
-
RIP3 mediates the embryonic lethality of caspase-8-deficient mice
-
Kaiser W.J., et al. RIP3 mediates the embryonic lethality of caspase-8-deficient mice. Nature 2011, 471:368-372.
-
(2011)
Nature
, vol.471
, pp. 368-372
-
-
Kaiser, W.J.1
-
83
-
-
80755132824
-
The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation
-
Bonnet M.C., et al. The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation. Immunity 2011, 35:572-582.
-
(2011)
Immunity
, vol.35
, pp. 572-582
-
-
Bonnet, M.C.1
-
84
-
-
80052850704
-
FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation
-
Welz P.S., et al. FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation. Nature 2011, 477:330-334.
-
(2011)
Nature
, vol.477
, pp. 330-334
-
-
Welz, P.S.1
-
85
-
-
79952810024
-
Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis
-
Oberst A., et al. Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis. Nature 2011, 471:363-367.
-
(2011)
Nature
, vol.471
, pp. 363-367
-
-
Oberst, A.1
-
86
-
-
84856160569
-
Caspase 8 inhibits programmed necrosis by processing CYLD
-
O'Donnell M.A., et al. Caspase 8 inhibits programmed necrosis by processing CYLD. Nat. Cell Biol. 2011, 13:1437-1442.
-
(2011)
Nat. Cell Biol.
, vol.13
, pp. 1437-1442
-
-
O'Donnell, M.A.1
-
87
-
-
0041967054
-
The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination
-
Kovalenko A., et al. The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination. Nature 2003, 424:801-805.
-
(2003)
Nature
, vol.424
, pp. 801-805
-
-
Kovalenko, A.1
-
88
-
-
34548437549
-
Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase domain
-
Feng S., et al. Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase domain. Cell. Signal. 2007, 19:2056-2067.
-
(2007)
Cell. Signal.
, vol.19
, pp. 2056-2067
-
-
Feng, S.1
-
89
-
-
0037160117
-
The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex
-
Micheau O., et al. The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex. J. Biol. Chem. 2002, 277:45162-45171.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 45162-45171
-
-
Micheau, O.1
-
90
-
-
76149104286
-
Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment
-
Geserick P., et al. Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment. J. Cell Biol. 2009, 187:1037-1054.
-
(2009)
J. Cell Biol.
, vol.187
, pp. 1037-1054
-
-
Geserick, P.1
-
91
-
-
79960922705
-
CIAPs block ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms
-
Feoktistova M., et al. cIAPs block ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol. Cell 2011, 43:449-463.
-
(2011)
Mol. Cell
, vol.43
, pp. 449-463
-
-
Feoktistova, M.1
-
92
-
-
80053580530
-
RIPK-dependent necrosis and its regulation by caspases: a mystery in five acts
-
Green D.R., et al. RIPK-dependent necrosis and its regulation by caspases: a mystery in five acts. Mol. Cell 2011, 44:9-16.
-
(2011)
Mol. Cell
, vol.44
, pp. 9-16
-
-
Green, D.R.1
-
93
-
-
79960110569
-
Programmed necrosis from molecules to health and disease
-
Galluzzi L., et al. Programmed necrosis from molecules to health and disease. Int. Rev. Cell Mol. Biol. 2011, 289:1-35.
-
(2011)
Int. Rev. Cell Mol. Biol.
, vol.289
, pp. 1-35
-
-
Galluzzi, L.1
-
94
-
-
84856231635
-
Viral infection and the evolution of caspase 8-regulated apoptotic and necrotic death pathways
-
Mocarski E.S., et al. Viral infection and the evolution of caspase 8-regulated apoptotic and necrotic death pathways. Nat. Rev. Immunol. 2011, 12:79-88.
-
(2011)
Nat. Rev. Immunol.
, vol.12
, pp. 79-88
-
-
Mocarski, E.S.1
-
95
-
-
66449133280
-
Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation
-
Cho Y.S., et al. Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell 2009, 137:1112-1123.
-
(2009)
Cell
, vol.137
, pp. 1112-1123
-
-
Cho, Y.S.1
-
96
-
-
77954593965
-
Virus inhibition of RIP3-dependent necrosis
-
Upton J.W., et al. Virus inhibition of RIP3-dependent necrosis. Cell Host Microbe 2010, 7:302-313.
-
(2010)
Cell Host Microbe
, vol.7
, pp. 302-313
-
-
Upton, J.W.1
|