Interplay between redox status and inflammasome activation

Trends in Immunology

Volumn 32, Issue 12, 2011, Pages 559-566

  Rubartelli, Anna ^a   Gattorno, Marco ^b   Netea, Mihai G ^c   Dinarello, Charles A ^d  

^a UNIVERSITY OF GENOA   (Italy)

^b G GASLINI INSTITUTE   (Italy)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^d UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIOXIDANT; CARRIER PROTEINS AND BINDING PROTEINS; CRYOPYRIN; GLUTATHIONE; INFLAMMASOME; INTERLEUKIN 1; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; NLRP12 PROTEIN; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; OXIDIZING AGENT; REACTIVE OXYGEN METABOLITE; TOLL LIKE RECEPTOR; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

BONE MARROW CELL; CYTOKINE PRODUCTION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; INFLAMMATORY CELL; LEUKEMIA CELL; MACROPHAGE; MONOCYTE; OXIDATION; OXIDATION REDUCTION POTENTIAL; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; HUMANS; INFLAMMASOMES; INTERLEUKIN-1BETA; OXIDATION-REDUCTION; PHENOTYPE; RECEPTORS, CELL SURFACE;

EID: 81355146675     PISSN: 14714906     EISSN: 14714981     Source Type: Journal    
DOI: 10.1016/j.it.2011.08.005     Document Type: Review

References (56)

1. Dinarello C.A. Immunological and inflammatory functions of the interleukin-1 family. Annu. Rev. Immunol. 2009, 27:519-550.
2. Bauernfeind F., et al. Inflammasomes: current understanding and open questions. Cell. Mol. Life Sci. 2011, 68:765-783.
3. Agostini L., et al. NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity 2004, 20:319-325.
4. Tschopp J., Schroder K. NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?. Nat. Rev. Immunol. 2010, 10:210-215.
5. Auron P.E., et al. Nucleotide sequence of human monocyte interleukin 1 precursor cDNA. Proc. Natl. Acad. Sci. U.S.A. 1984, 81:7907-7911.
6. Rubartelli A., et al. A novel secretory pathway for interleukin-1 beta, a protein lacking a signal sequence. EMBO J. 1990, 9:1503-1510.
7. Perregaux D., et al. IL-1 beta maturation: evidence that mature cytokine formation can be induced specifically by nigericin. J. Immunol. 1992, 149:1294-1303.
8. Perregaux D., Gabel C.A. Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity. J. Biol. Chem. 1994, 269:15195-15203.
9. Ferrari D., et al. Extracellular ATP triggers IL-1 beta release by activating the purinergic P2Z receptor of human macrophages. J. Immunol. 1997, 159:1451-1458.
10. Piccini A., et al. ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1beta and IL-18 secretion in an autocrine way. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:8067-8072.
11. Pfeiffer Z.A., et al. Nucleotide receptor signaling in murine macrophages is linked to reactive oxygen species generation. Free Radic. Biol. Med. 2007, 42:1506-1516.
12. Hewinson J., et al. A key role for redox signaling in rapid P2X7 receptor-induced IL-1 beta processing in human monocytes. J. Immunol. 2008, 180:8410-8420.
13. Cruz C.M., et al. ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages. J. Biol. Chem. 2007, 282:2871-2879.
14. Dostert C., et al. Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science 2008, 320:674-677.
15. Meissner F., et al. Superoxide dismutase 1 regulates caspase-1 and endotoxic shock. Nat. Immunol. 2008, 9:866-872.
16. Hornung V., et al. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat. Immunol. 2008, 9:847-856.
17. Meissner F., et al. Inflammasome activation in NADPH oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease. Blood 2010, 116:1570-1573.
18. Van Bruggen R., et al. Human NLRP3 inflammasome activation is Nox1-4 independent. Blood 2010, 115:5398-5400.
19. van de Veerdonk F., et al. Reactive oxygen species-independent activation of the IL-1beta inflammasome in cells from patients with chronic granulomatous disease. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:3030-3033.
20. Freigang S., et al. Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis. Eur. J. Immunol. 2011, 41:2040-2051.
21. Zhou R., et al. Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat. Immunol. 2010, 11:136-140.
22. Masters S.L., et al. Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1beta in type 2 diabetes. Nat. Immunol. 2010, 11:897-904.
23. Tassi S., et al. Pathogen-induced interleukin-1beta processing and secretion is regulated by a biphasic redox response. J. Immunol. 2009, 183:1456-1462.
24. Carta S., et al. The rate of Interleukin-1beta secretion in different myeloid cells varies with the extent of redox response to Toll-like receptor triggering. J. Biol. Chem. 2011, 286:27069-27080.
25. Bauernfeind F., et al. Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome. J. Immunol. 2011, 187:613-617.
26. Zhou R., et al. A role for mitochondria in NLRP3 inflammasome activation. Nature 2011, 346:221-225.
27. Carta S., et al. DAMPs and inflammatory processes: the role of redox in the different outcomes. J. Leukoc. Biol. 2009, 86:549-555.
28. Angelini G., et al. Antigen-presenting dendritic cells provide the reducing extracellular microenvironment required for T lymphocyte activation. Proc. Natl. Acad. Sci. U.S.A. 2002, 99:1491-1496.
29. Sido B., et al. A prominent role for mucosal cystine/cysteine metabolism in intestinal immunoregulation. Gastroenterology 2008, 134:179-191.
30. Yan Z., et al. Extracellular redox modulation by regulatory T cells. Nat. Chem. Biol. 2009, 5:721-723.
31. Conrad M., Sato H. The oxidative stress-inducible cystine/glutamate antiporter, system x (c) (-): cystine supplier and beyond. Amino Acids 2011, 10.1007/s00726-011-0867-5.
32. Simons J.F., et al. BiP/Kar2p serves as a molecular chaperone during carboxypeptidase Y folding in yeast. J. Cell Biol. 1995, 130:41-49.
33. Trotter E.W., Grant C.M. Thioredoxins are required for protection against a reductive stress in the yeast Saccharomyces cerevisiae. Mol. Microbiol. 2002, 46:869-878.
34. Rajasekaran N.S., et al. Human alpha B-crystallin mutation causes oxido-reductive stress and protein aggregation cardiomyopathy in mice. Cell 2007, 130:427-439.
35. You W., et al. Cardiac-specific expression of heat shock protein 27 attenuated endotoxin-induced cardiac dysfunction and mortality in mice through a PI3K/Akt-dependent mechanism. Shock 2009, 32:108-117.
36. Netea M.G., et al. Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages. Blood 2009, 113:2324-2335.
37. Masters S.L. Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease. Annu. Rev. Immunol. 2009, 27:621-668.
38. Gattorno M., et al. Pattern of interleukin-1beta secretion in response to lipopolysaccharide and ATP before and after interleukin-1 blockade in patients with CIAS1 mutations. Arthritis Rheum. 2007, 56:3138-3148.
39. Tassi S., et al. Altered redox state of monocytes from cryopyrin-associated periodic syndromes causes accelerated IL-1beta secretion. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:9789-9794.
40. Jéru I., et al. Mutations in NALP12 cause hereditary periodic fever syndromes. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:1614-1619.
41. Borghini S., et al. Clinical presentation and pathogenesis of cold-induced autoinflammatory disease in a family with recurrence of an NLRP12 mutation. Arthritis Rheum. 2011, 63:830-839.
42. Jackson S.H., et al. The p47phox mouse knock-out model of chronic granulomatous disease. J. Exp. Med. 1995, 182:751-758.
43. Lehtinen M.K., et al. Cystatin B deficiency sensitizes neurons to oxidative stress in progressive myoclonus epilepsy, EPM1. J. Neurosci. 2009, 29:5910-5915.
44. Villani G.R., et al. Mucopolysaccharidosis IIIB: oxidative damage and cytotoxic cell involvement in the neuronal pathogenesis. Brain Res. 2009, 1279:99-108.
45. Luciani A., et al. Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition. Nat. Cell Biol. 2010, 12:863-875.
46. Aksentijevich I., et al. An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist. N. Engl. J. Med. 2009, 360:2426-2437.
47. Andrei C., et al. The secretory route of the leaderless protein interleukin 1beta involves exocytosis of endolysosome-related vesicles. Mol. Biol. Cell 1999, 10:1463-1475.
48. Andrei C., et al. Phospholipases C and A2 control lysosome-mediated IL-1 beta secretion: Implications for inflammatory processes. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:9745-9750.
49. Mariathasan S., et al. Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 2006, 440:228-232.
50. Souvannavong V., Adam A. Macrophages from C3H/HeJ mice require an additional step to produce monokines: synergistic effects of silica and poly(I:C) in the release of interleukin 1. J. Leukoc. Biol. 1990, 48:183-192.
51. Franchi L., et al. Differential requirement of P2X7 receptor and intracellular K+ for caspase-1 activation induced by intracellular and extracellular bacteria. J. Biol. Chem. 2007, 282:18810-18818.
52. Ferrari D., et al. The P2X7 receptor: a key player in IL-1 processing and release. J. Immunol. 2006, 176:3877-3883.
53. Walev I., et al. Potassium-inhibited processing of IL-1 beta in human monocytes. EMBO J. 1995, 14:1607-1614.
54. MacKenzie A., et al. Rapid secretion of interleukin-1beta by microvesicle shedding. Immunity 2001, 15:825-835.
55. Qu Y., et al. Nonclassical IL-1 beta secretion stimulated by P2X7 receptors is dependent on inflammasome activation and correlated with exosome release in murine macrophages. J. Immunol. 2007, 179:1913-1925.
56. Lushchak V.I. Adaptive response to oxidative stress: Bacteria, fungi, plants and animals. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2011, 153:175-190.