Nutrition of the critically Ill-A 21st-century perspective

Nutrients

Volumn 5, Issue 1, 2013, Pages 162-207

  Bengmark, Stig ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Advanced glycation end products (AGEs); Advanced lipoxidation end products (ALEs); Airways; Amnion; Antibiotics; Apoptosis; Barriers; Biological; Blood brain barrier; Casein; Chemotherapeutics; Critical care; Curcumin; Cytokines; Eco biologicals; Endothelium; Endotoxin; Enteral nutrition; Fat diet; Food habits of the chimpanzee; Fruits; Gluten; Greens; Growth; Growth factors; Gut; Health care; IGF 1; IL1; Infection; Inflammation; Insulinogenic; Lactobacillus; Lactobacillus paracasei; Lactobacillus plantarum; Leakage; Liver cirrhosis; Liver steatosis; LPS; Microbial translocation; Microbiome; Microbiota; Minerals; Mucosa; Neutrophils; NF b; Nutraceuticals; Nutrition; Obesity; Oral cavity; Osteoarthritis; Paleolithic lifestyle; Pancreatitis; Parenteral nutrition; Pharmaceuticals; Placenta; Plant fibers; Plaques; Prebiotics; Probiotic bacteria; Proteotoxins; Refined carbohydrate diet; Replication; Resveratrol; Skin; Stress; Surgery; TNF; Toll like; Transplantation; Trauma; Vagina; Vegetables; Western lifestyle; Zein

Indexed keywords

ANTIOXIDANT; CASEIN; COCONUT OIL; CYSTEINE; DOCOSAHEXAENOIC ACID; ENDOTOXIN; FRUCTOSE OLIGOSACCHARIDE; GLUTEN; HLA DR ANTIGEN; ICOSAPENTAENOIC ACID; MALONALDEHYDE; MALTODEXTRIN; MONOUNSATURATED FATTY ACID; MUSCLE PROTEIN; MYELOPEROXIDASE; NITRIC OXIDE; OLIVE OIL; OMEGA 3 FATTY ACID; PALM OIL; PLACEBO; PROBIOTIC AGENT; RETINOL; SYNBIOTIC AGENT; ZEIN;

ACINETOBACTER INFECTION; ACUTE PANCREATITIS; ATHEROSCLEROTIC PLAQUE; BRAIN DISEASE; CANDIDIASIS; CAUSE OF DEATH; CD4+ T LYMPHOCYTE; CHEST INFECTION; COLLOID; CRITICALLY ILL PATIENT; CRYSTALLOID; DISEASE SEVERITY; DRUG EFFICACY; ENTERIC FEEDING; ENTEROBACTERIACEAE INFECTION; ENTEROCOCCAL INFECTION; GENE TARGETING; HOMEOSTASIS; HOSPITAL INFECTION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IMMUNOPROPHYLAXIS; IMMUNOREACTIVITY; IMMUNOSUPPRESSIVE TREATMENT; INFECTION PREVENTION; INFECTION RISK; INTESTINE FLORA; KLEBSIELLA PNEUMONIAE INFECTION; LENGTH OF STAY; LIPID METABOLISM; LIVER CIRRHOSIS; LIVER TRANSPLANTATION; MORBIDITY; NEUTROPHIL CHEMOTAXIS; NONHUMAN; NUTRITIONAL ASSESSMENT; OUTCOME ASSESSMENT; PARENTERAL NUTRITION; PERSONAL EXPERIENCE; POSTOPERATIVE INFECTION; PROTEUS INFECTION; PSEUDOMONAS INFECTION; QUALITY OF LIFE; REVIEW; RISK ASSESSMENT; STAPHYLOCOCCUS INFECTION; SURGICAL INFECTION; URINARY TRACT INFECTION; VAGINITIS;

EID: 84872856585     PISSN: 20726643     EISSN: None     Source Type: Journal    
DOI: 10.3390/nu5010162     Document Type: Review

References (186)

1. Kumar, G.; Kumar, N.; Taneja, A.; Kaleekal, T.; Tarima, S.; McGinley, E.; Jimenez, E.; Mohan, A.; Khan, R.A.; Whittle, J.; Jacobs, E.; Nanchal, R. Nationwide trends of severe sepsis in the twenty first century (2000-2007). Chest 2011, 140, 1223-1231.
2. Hall, M.J.; Williams, S.J.; DeFrances, C.J.; Golosinsky, A. Inpatient care for septicemia or sepsis: A challenge for patients and hospitals. Available online: http://www.cdc.gov/nchs/data/databriefs/db62.pdf (accessed on 16 November 2012).
3. Vincent, J.L. Increasing awareness of sepsis: World Sepsis Day. Crit. Care 2012, 16, 152.
4. Guggenbichler, J.P.; Assadian, O.; Boeswald, M.; Kramer, A. Incidence and clinical implication of nosocomial infections associated with implantable biomaterials-catheters, ventilator-associated pneumonia, urinary tract infections. GMS Krankenhhyg. Interdiszip. 2011, 6, 1.
5. Weiser, T.G.; Regenbogen, S.E.; Thompson, K.D.; Haynes, A.B.; Lipsitz, S.R.; Berry W.R.; Gawande, A.A. An estimation of the global volume of surgery: A modelling strategy based on available data. Lancet 2008, 372, 139-144.
6. Pearse, R.M.; Moreno, R.P.; Bauer, P.; Pelosi, P.; Metnitz, P.; Spies, C.; Vallet, B.; Vincent, J.L.; Hoeft, A.; Rhodes, A.; et al. Mortality after surgery in Europe: A 7 day cohort study. Lancet 2012, 380, 1059-1065.
7. Khuri, S.F.; Henderson, W.G.; DePalma, R.G.; Mosca, C.; Healey, N.A.; Kumbhani, D.J. Determinants of long-term survival after major surgery and the adverse effect of postoperative complications. Ann. Surg. 2005, 242, 326-341.
8. Pearse, R.M.; Harrison, D.A.; James, P.; Watson, D.; Hinds, C.; Rhodes, A.; Grounds, R.M.; Bennett, E.D. Identification and characterisation of the high-risk surgical population in the United Kingdom. Crit. Care 2006, 10, R81.
9. Jhanji, S.; Thomas, B.; Ely, A.; Watson, D.; Hinds, C.J.; Pearse, R.M. Mortality and utilisation of critical care resources amongst high-risk surgical patients in a large NHS trust. Anaesthesia 2008, 63, 695-700.
10. Findlay, G.; Goodwin, A.; Protopappa, K.; Smith, N.; Mason, M. Knowing the Risk: A Review of the Peri-Operative Care of Surgical Patients; National Confidential Enquiry into Patient Outcome and Death: London, UK, 2011.
11. Head, J.; Ferrie, J.E.; Alexanderson, K.; Westerlund, H.; Vahtera, J.; Kivimaki, M. Diagnosis-specific sickness absence as a predictor of mortality: the Whitehall II prospective cohort study. BMJ 2008, 337, a1469.
12. Jencks, S.F.; Williams, M.V.; Coleman, E.A. Rehospitalizations among patients in the Medicare fee-for-service program. N. Engl. J. Med. 2009, 360, 1418-1428.
13. Derogar, M.; Orsini, N.; Sadr-Azodi, O.; Lagergren, P. Influence of major postoperative complications on health-related quality of life among long-term survivors of esophageal cancer surgery. J. Clin. Oncol. 2012, 30, 1615-1619.
14. Dombrovskiy, V.Y.; Martin, A.A.; Sunderram, J.; Paz, H.L. Facing the challenge: Decreasing case fatality rates in severe sepsis despite increasing hospitalizations. Crit. Care Med. 2005, 33, 2555-2562.
15. Dombrovskiy, V.Y.; Martin, A.A.; Sunderram, J.; Paz, H.L. Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: A trend analysis from 1993 to 2003. Crit. Care Med. 2007, 35, 1244-1250.
16. Vogel, T.R.; Dombrovskiy, V.Y.; Carson, J.L.; Graham, A.M.; Lowry, S.F. Postoperative sepsis in the United States. Ann. Surg. 2010, 252, 1065-1071.
17. Arias, E.; Smith, B.L. Deaths: Preliminary data for 2001. Natl. Vital Stat. Rep. 2003, 51, 1-44.
18. Angus, D.C.; Linde-Zwirble, W.T.; Lidicker, J.; Clermont, G.; Carcillo, J.; Pinsky, M.R. Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome and associated costs of care. Crit. Care Med. 2001, 29, 1303-1310.
19. Elias, A.C.; Matsuo, T.; Grion, C.M.; Cardoso, L.T.; Verri, P.H. Incidence and risk factors for sepsis in surgical patients: A cohort study. J. Crit. Care 2012, 27, 159-166.
20. Beghetto, M.G.; Victorino, J.; Teixeira, L.; de Azevedo, M.J. Parenteral nutrition as a risk factor or central venous catheter-related infection. JPEN J. Parenter. Enteral Nutr. 2005, 29, 367-373.
21. Wren, S.M.; Ahmed, N.; Jamal, A.; Safadi, B.Y. Preoperative oral antibiotics in colorectal surgery increase the rate of Clostridium difficile colitis. Arch. Surg. 2005, 140, 752-756.
22. Bucher, P.; Gervaz, P.; Soravia, C.; Mermillod, B.; Erne, M.; Morel, P. Randomized clinical trial of mechanical bowel preparation versus no preparation before elective left-sided colorectal surgery. Br. J. Surg. 2005, 92, 409-414.
23. Bucher, P.; Gervaz, P.; Egger, J.F.; Soravia, C.; Morel, P. Morphologic alterations associated with mechanical bowel preparation before elective colorectal surgery: A randomized trial. Dis. Colon Rectum 2006, 49, 109-112.
24. Wunsch, H.; Linde-Zwirble, W.T.; Angus, D.C.; Hartman, M.E.; Milbrandt, E.B.; Kahn, J.M. The epidemiology of mechanical ventilation use in the United States. Crit. Care Med. 2010, 38, 1947-1953.
25. Haskel, Y.; Xu, D.; Lu, Q.; Deitch, E. Elemental diet-induced bacterial translocation can be hormonally modulated. Ann. Surg. 1993, 217, 634-642.
26. Deitch, E.; Xu, D.; Naruhn, M.B.; Deitch, D.C.; Lu, Q.; Mario, A.A. Elemental diet and IV-TPN-induced bacterial translocation is associated with loss of intestinal mucosal barrier function against bacteria. Ann. Surg. 1995, 221, 299-307.
27. Herndon, D.N.; Barrow, R.E.; Stein, M.; Linares, H.; Rutan, T.C.; Rutan, R.; Abston, S. Increased mortality with intravenous supplemental feeding in severely burned patients. J. Burn Care. Rehabil. 1989, 10, 309-313.
28. Lange, H. Multiorgan dysfunction syndrome: how water might contribute to its progression. J. Cell. Mol. Med. 2002, 6, 653-660.
29. Lobo, D.N.; Bostock, K.A.; Neal, K.R.; Perkins, A.C.; Rowlands, B.J.; Allison, S.P. Effect of salt and water balance on recovery of gastrointestinal function after elective colonic resection: a randomised controlled trial. Lancet 2002, 359, 1812-1818.
30. Macafee, D.A.L.; Allison, S.P.; Lobo, D.N. Some interactions between gastrointestinal function and fluid and electrolyte homeostasis. Curr. Opin. Clin. Nutr. Metab. Care 2005, 8, 197-203.
31. Wan, J.M.F.; Teo, T.C.; Babayan, V.K.; Blackburn, G.L. Invited comment: Lipids and the development of immune dysfunction and infection. JPEN J. Parenter. Enteral Nutr. 1988, 12, 43S-52S.
32. Van der Poll, T.; Coyle, S.M.; Levi, M.; Boermeester, M.A.; Braxton, C.C.; Jansen, P.; Hack, C.E.; Lowry, S.F. Fat emulsion infusion potentiates coagulation activation during human endotoxemia. Thrombosis Heamostasis 1996, 75, 83-86.
33. Lin, B.F.; Huang, C.C.; Chiang, B.L.; Jeng, S.J. Dietary fat influences Ia antigen expression, cytokines and prostaglandin E2 production in immune cells in autoimmune-prone NZBxNZW F1 mice. Br. J. Nutr. 1996, 75, 711-722.
34. Umpierrez, G.E.; Isaacs, S.D.; Bazargan, N.; You, X.; Thaler, L.M.; Kitabchi, A.E. Hyperglycemia: An independent marker of in-hospital mortality in patients with undiagnosed diabetes. J. Clin. Endocrinol. Metab. 2002, 87, 978-962.
35. Mesotten, D.; Van den Berghe, G. Clinical potential of insulin therapy in critically ill patients. Drugs 2003, 63, 625-636.
36. Mesotten, D.; van den Berghe, G. Glycemic targets and approaches to management of the patient with critical illness. Curr. Diab. Rep. 2012, 12, 101-107.
37. Bulger, E.M. 7.5% saline and 7.5% saline/6% dextran for hypovolemic shock. J. Trauma 2011, 70, S27-S29.
38. Reinhart, K.; Perner, A.; Sprung, C.L.; Jaeschke, R.; Schortgen, F.; Johan Groeneveld, A.B.; Beale, R.; Hartog, C.S. European Society of Intensive Care Medicine. Consensus statement of the ESICM task force on colloid volume therapy in critically ill patients. Intensive Care Med. 2012, 38, 368-383.
39. Elmér, O.; Göransson, G.; Saku, M.; Bengmark, S. Influence of physiological saline, dextran 70, hydroxyethyl starch, degraded gelatin, and fat emulsion solutions on screen filtration pressure. Eur. Surg. Res. 1977, 9, 85-95.
40. Zoucas, E.; Göransson, G.; Bengmark, S. Colloid-induced changes in bleeding following liver resection in the rat. Res. Exp. Med. (Berl.) 1984, 184, 251-258.
41. Andersson, R.; Alwmark, A.; Bengmark, S. Influence of dextran on pneumococcal septicemia in splenic artery-ligated or splenectomized rats. Res. Exp. Med. (Berl.) 1987, 187, 423-427.
42. Andersson, R.; Tranberg, K.G.; Alwmark, A.; Bengmark, S. Factors influencing the outcome of E. coli peritonitis in rats. Acta Chir. Scand. 1989, 155, 155-157.
43. Perner, A.; Haase, N.; Guttormsen, A.B.; Tenhunen, J.; Klemenzson, G.; Aneman, A.; Madsen, K.R.; Møller, M.H.; Elkjær, J.M.; Poulsen, L.M. et al. Hydroxyethyl Starch 130/0.42 versus Hydroxyethyl Starch 130/0.42 versus Ringer's Acetate in Severe Sepsis. N. Engl. J. Med. 2012, 367, 124-134.
44. Sandström, R.; Drott, C.; Hyltander, A.; Arfvidsson, B.; Schersten, T.; Wickström, I.; Lundholm, K. The effect of postoperative intravenous feeding (TPN) on outcome following major surgery evaluated in a randomized study. Ann. Surg. 1993, 217, 185-195.
45. Heslin, M.J.; Latkany, L.; Leung, D.; Brooks, A.D.; Hochwald, S.N.; Pisters, P.W.; Shike, M.; Brennan, M.F. A prospective randomized trial of early enteral feeding after resection of upper gastrointestinal malignancy. Ann. Surg. 1997, 226, 567-580.
46. Haskel, Y.; Xu, D.; Lu, Q.; Deitch, E. Bombesin protects against bacterial translocation induced by three commercially available liquid enteral diets: a prospective, randomized, multigroup trial. Crit. Care Med. 1994, 22, 108-113.
47. Haskel, Y.; Xu, D.; Lu, Q.; Deitch, E. The modulatory role of gut hormones in elemental diet and intravenous total parenteral nutrition-induced bacterial translocation in rats. JPEN J. Parenter. Enteral Nutr. 1994, 18, 159-166.
48. Slotwinski, R.; Olszewski, W.L.; Slotkowski, M.; Lech, G.; Zaleska, M.; Slotwinska, S.; Krasnodebski, W.I. Can the interleukin-1 receptor antagonist (IL-1ra) be a marker of anti-inflammatory response to enteral immunonutrition in malnourished patients after pancreaticoduodenectomy? J. Pancreas 2007, 8, 759-769.
49. Oz, H.S.; Chen, T.S.; Neuman, M. Nutrition intervention: A strategy against systemic inflammatory syndrome. JPEN J. Parenter. Enteral Nutr. 2009, 33, 380-389.
50. Kaido, T.; Ogura, Y.; Ogawa, K.; Hata, K.; Yoshizawa, A.; Yagi, S.; Uemoto, S. Effects of post-transplant enteral nutrition with an immunomodulating diet containing hydrolyzed whey peptide after liver transplantation. World J. Surg. 2012, 36, 1666-1671.
51. Menges, T.; Engel, J.; Welters, I.; Wagner, R.M.; Little, S.; Ruwoldt, R.; Wollbrueck, M.; Hempelmann, G. Changes in blood lymphocyte populations after multiple trauma. Crit. Care Med. 1999, 27, 733-740.
52. Zahorec, R. Ratio of neutrophil to lymphocyte counts-rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl. Lek. Listy 2001, 102, 5-14.
53. Kalff, C.; Carlos, T.M.; Schraut, W.H.; Billiar, T.R.; Simmons, R.L.; Bauer, A.J. Surgically induced leukocytic infiltrates within the rat intestinal muscularis mediate postoperative ileus. Gastroenterology 1999, 117, 378-387.
54. De Jonge, W.J.; Van den Wungaard, R.M.; The, F.O.; Ter Bek, M.L.; Bennink, R.J.; Tytgat, G.N.J. Postoperative ileus is maintained by intestinal immune infiltrates that activate inhibitory neural pathways in mice. Gastroenterology 2003, 125, 1137-1147.
55. Kubes, P.; Hunter, J.; Granger, D.N. Ischemia/reperfusion induced feline intestinal dysfunction: importance of granulocyte recruitment. Gastroenterology 1992, 103, 807-812.
56. Wei, L.; Wei, H.; Frenkel, K. Sensitivity to tumor promotion of SENCAR and C57BL/6J mice correlates with oxidative events and DNA damage. Carcinogenesis 1993, 14, 841-847.
57. Steinberg, K.P.; Milberg, J.A.; Martin, T.A.; Maunder, R.J.; Cockrill, B.A.; Hudson, L.D. Evolution of bronchoalveolar cell populations in the adult respiratory distress syndrome. Am. J. Respir. Crit. Care Med. 1994, 150, 113-122.
58. Sookhai, S.; Wang, J.H.; McCourt, M.; Di Wu, Q.; Kirwan, H.D.; Redmond, H.P. A novel mechanism for attenuating neutrophil-mediated lung injury in vivo. Surg. Forum 1999, 50, 205-208.
59. Ho, J.S.; Buchweitz, J.P.; Roth, R.A.; Ganey, P.E. Identification of factors from rat neutrophil responsible for cytotoxicity to isolated hepatocytes. J. Leukoc. Biol. 1996, 59, 716-724.
60. Lowell, C.A.; Bertin, G. Resistance to endotoxic shock and reduced neutrophil migration in mice deficient for the Src-family kinases Hck and Fgr. Proc. Natl. Acad. Sci. USA 1998, 95, 7580-7584.
61. Goris, R.J.; Boekholtz, W.K.; van Bebber, I.P.; Nuytinck, J.K.; Schillings, P.H. Multiple-organ failure and sepsis without bacteria. An experimental model. Arch. Surg. 1986, 121, 897-901.
62. Wilson, M.R.; Choudhury, S.; Takata, M. Pulmonary inflammation induced by high-stretch ventilation is mediated by tumor necrosis factor signaling in mice. Am. J. Physiol. Lung Cell Mol. Physiol. 2005, 288, L599-L607.
63. Rassias, A.J.; Marrin, C.A.S.; Arruda, J.; Whalen, P.K.; Beach, M.; Yeager, M.P. Insulin infusion improves neutrophil function in diabetic cardiac surgery patients. Anaesth. Analg. 1999, 88, 1011-1016.
64. O ́brien, G.; Shields, C.J.; Winter, D.C.; Dillin, J.P.; Kirwan, W.O.; Redmont, H.P. Cyclooxygenase-2 plays a central role in the genesis of pancreatitis and associated lung injury. Hepatobil. Pancreat. Dis. Int. 2005, 4, 126-129.
65. Bengmark, S. Control of systemic inflammation and chronic disease-the use of turmeric and curcumenoids. In Nutrigenomics and Proteonomics in Health and Disease. Food Factors and Gene Interaction; Mine, Y., Miyashita, K., Shahidi, F., Eds.; Wiley-Blackwell: Chichester, West Sussex, UK, 2009; pp. 161-180.
66. Lee, J.C.; Kinniry, P.A.; Arguiri, E.; Serota, M.; Kanterakis, S.; Chatterjee, S.; Solomides, C.C.; Javvadi, P.; Koumenis, C.; Cengel, K.A.; Christofidou-Solomidou, M. Dietary curcumin increases antioxidant defenses in lung, ameliorates radiation-induced pulmonary fibrosis, and improves survival in mice. Radiat. Res. 2010, 173, 590-601.
67. Landi-Librandi, A.P.; Caleiro Seixas Azzolini, A.E.; de Oliveira, C.A.; Lucisano-Valim, Y.M. Inhibitory activity of liposomal flavonoids during oxidative metabolism of human neutrophils upon stimulation with immune complexes and phorbol ester. Drug Deliv. 2012, 19, 177-187.
68. Bengmark, S. Synbiotics in human Medicine. In Therapeutic Microbiology: Probiotics and Related Strategies; Versalovic, J., Wilson, M., Eds.; ASM Press: Washington, DC, USA, 2008; pp. 307-321.
69. Bengmark, S. Gut microbiota, immune development and function. Pharmacol. Res. 2012, doi:10.1016/j.phrs.2012.09.002.
70. Ilkgul, O.; Aydede, H.; Erhan, Y.; Surucuoglu, S.; Gazi, H.; Vatansever, S.; Taneli, F.; Ulman, C.; Kose, C.; Bengmark, S. Subcutaneous administration of live lactobacillus prevents sepsis-induced lung organ failure in rats. Br. J. Int. Care 2005, 15, 52-57.
71. Tok, D.; Ilkgul, O.; Bengmark, S.; Aydede, H.; Erhan, Y.; Taneli, F.; Ulman, C.; Vatansever, S.; Kose, C.; Ok, G. Pretreatment with pro- and synbiotics reduces peritonitis-induced acute lung injury in rats. J. Trauma 2007, 62, 880-885.
72. Shimizu, K.; Ogura, H.; Goto, M.; Asahara, T.; Nomoto, K.; Morotomi, M.; Yoshiya, K.; Matsushima, A.; Sumi, Y.; Kuwagata, Y.; Tanaka, H.; Shimazu, T.; Sugimoto, H. Altered gut flora and environment in patients with severe SIRS. J. Trauma 2006, 60, 126-133.
73. Shimizu, K.; Ogura, H.; Asahara, T.; Nomoto, K.; Morotomi, M.; Nakahori, Y.; Osuka, A.; Yamano, S.; Goto, M.; Matsushima, A.; Tasaki, O.; Kuwagata, Y.; Sugimoto, H. Gastrointestinal dysmotility is associated with altered gut flora and septic mortality in patients with severe systemic inflammatory response syndrome: A preliminary study. Neurogastroenterol. Motil. 2011, 23, 330-335.
74. Shimizu, K.; Ogura, H.; Goto, M.; Asahara, T.; Nomoto, K.; Morotomi, M.; Matsushima, A.; Tasaki, O.; Fujita, K.; Hosotsubo, H.; Kuwagata, Y.; Tanaka, H.; Shimazu, T.; Sugimoto, H. Synbiotics decrease the incidence of septic complications in patients with severe SIRS: A preliminary report. Dig. Dis. Sci. 2009, 54, 1071-1078.
75. Neish, A. Microbes in gastrointestinal health and disease. Gastroenterology 2009, 136, 65-80.
76. Frank, D.N.; Pace, N.R. Gastrointestinal microbiology enters the metagenomics era. Curr. Opin. Gastroenterol. 2008, 24, 4-10.
77. Arumugam, M.; Raes, J.; Pelletier, E.; Le Paslier, D.; Yamada, T.; Mende, D.R.; Fernandes, G.R.; Tap, J.; Bruls, T.; Batto, J.M. et al. Enterotypes of the human gut microbiome. Nature 2011, 473, 174-180.
78. Ursell, L.K.; Clemente, J.C.; Rideout, J.R.; Gevers, D.; Caporaso, J.G.; Knight, R. The interpersonal and intrapersonal diversity of human-associated microbiota in key body sites. J. Allergy Clin. Immunol. 2012, 129, 1204-1208.
79. Clemente, J.C.; Ursell, L.K.; Parfrey, L.W.; Knight, R. The impact of the gut microbiota on human health: an integrative view. Cell 2012, 148, 1258-1270.
80. Ley, R.E.; Hamady, M.; Lozupone, C.; Turnbaugh, P.J.; Ramey, R.R.; Bircher, J.S.; Schlegel, M.L.; Tucker, T.A.; Schrenzel, M.D.; Knight, R.; Gordon, J.I. Evolution of mammals and their gut microbes. Science 2008, 320, 1647-1651.
81. Muegge, B.D.; Kuczynski, J.; Knights, D.; Clemente, J.C.; Gonzalez, A.; Fontana, L.; Henrissat, B.; Knight, R.; Gordon, J.I. Diet drives convergence in gut microbiome functions across mammalian phylogeny and within humans. Science 2011, 332, 970-974.
82. Wu, G.D.; Chen, J.; Hoffmann, C.; Bittinger, K.; Chen, Y.Y.; Keilbaugh, S.A.; Bewtra, M.; Knights, D.; Walters, W.A.; Knight, R. et al. Linking long-term dietary patterns with gut microbial enterotypes. Science 2011, 334, 105-108.
83. Matafome, P.; Santos-Silva, D.; Crisóstomo, J.; Rodrigues, T.; Rodrigues, L.; Sena, C.M.; Pereira, P.; Seiça, R. Methylglyoxal causes structural and functional alterations in adipose tissue independently of obesity. Arch. Physiol. Biochem. 2012, 118, 58-68.
84. Sekirov, I.; Russel, S.L.; Antunes, C.M.; Finlay, B.B. Gut microbiota in health and disease. Physiol. Rev. 2010, 90, 859-904.
85. Tap, J.; Mondot, S.; Levenez, F.; Pelletier, E.; Caron, C.; Furet, J.P.; Ugarte, E.; Muñoz-Tamayo, R.; Paslier, D.L.; Nalin, R.; Dore, J.; Leclerc, M. Towards the human intestinal microbiota phylogenetic core. Environ. Microbiol. 2009, 11, 2574-2584.
86. Håkansson, Å.; Molin, G. Gut microbiota and inflammation. Nutrients 2011, 3, 637-382.
87. Stearns, J.C.; Lynch, M.D.J.; Senadheera, D.B.; Tenenbaum, H.C.; Goldberg, M.B.; Cvitkovitch, D.G.; Croitoru, K.; Moreno-Hagelsieb, G.; Neufeld, J.D. Bacterial biogeography of the human digestive tract. Sci. Rep. 2011, 1, 170.
88. Ekberg, H. Colorectal liver cancer, resection and regional chemotherapy. In Bulletin from Department of Surgery; Lund University: Lund, Sweden, 1986; pp. 1-76.
89. Ekberg, H.; Tranberg, K.G.; Andersson, R.; Jeppsson, B.; Bengmark, S. Major liver resection: Perioperative course and management. Surgery 1986, 100, 1-8.
90. Gustafsson, B.E. The physiological importance of the colonic microflora. Scand. J. Gastroenterol. 1982, 77, S117-S131.
91. Gilliland, S.E.; Speck, M.L. Antagonistic action of Lactobacillus acidophilus towards intestinal and food-borne pathogens in associative cultures. J. Food Prot. 1977, 40, 820-823.
92. Johansson, M.L.; Molin, G.; Jeppsson, B.; Nobaek, S.; Ahrné, S.; Bengmark, S. Administration of different Lactobacillus strains in fermented oatmeal soup: in vivo colonization of human intestinal mucosa and effect on the indigenous flora. Appl. Environ. Microbiol. 1993, 59, 15-20.
93. Molin, G.; Andersson, R.; Ahrné, S.; Lönner, C.; Marklinder, I.; Johansson, M.L.; Jeppsson, B.; Bengmark, S. Effect of fermented oatmeal soup on the cholesterol level and the Lactobacillus colonization of rat intestinal mucosa. Antonie Van Leeuwenhoek 1992, 61, 167-173.
94. Molin, G.; Jeppsson, B.; Johansson, M.L.; Ahrné, S.; Nobaek, S.; Ståhl, M.; Bengmark, S. Numerical taxonomy of Lactobacillus spp. associated with healthy and diseased mucosa of the human intestines. J. Appl. Bacteriol. 1993, 74, 314-323.
95. Ljungh, Å.; Lan, J.G.; Yamagisawa, N. Isolation, selection and characteristics of Lactobacillus paracasei ssp. paracasei isolate F19. Microb. Ecol. Health Dis. 2002, 3, S4-S6.
96. Kruszewska, K.; Lan, J.; Lorca, G.; Yanagisawa, N.; Marklinder, I.; Ljungh, Å. Selection of lactic acid bacteria as probiotic strains by in vitro tests. Microecol. Ther. 2002, 29, 37-51.
97. Rayes, N.; Hansen, S.; Seehöfer, D.; Müller, A.R.; Serke, S.; Bengmark, S.; Neuhaus, P. Early enteral supply of fiber and Lactobacilli versus conventional nutrition: a controlled trial in patients with major abdominal surgery. Nutrition 2002, 18, 609-615.
98. Rayes, N.; Seehöfer, D.; Theruvath, T.; Mogl, M.; Langrehr, J.M.; Nüssler, N.C.; Bengmark, S.; Neuhaus, P. Effect of enteral nutrition and synbiotics on bacterial infection rates after pylorus-preserving pancreatoduodenectomy: a randomized, double-blind trial. Ann. Surg. 2007, 246, 36-41.
99. Han, C.M. Medical School, Zhejiang University, Hangzhou, China. Personal communication, 2012.
100. Rayes, N.; Seehöfer, D.; Hansen, S.; Boucsein, K.; Müller, A.R.; Serke, S.; Bengmark, S.; Neuhaus, P. Early enteral supply of lactobacillus and fiber versus selective bowel decontamination: A controlled trial in liver transplant recipients. Transplantation 2002, 74, 123-127.
101. Rayes, N.; Seehöfer, D.; Theruvath, T.; Schiller, R.A.; Langrehr, J.M.; Jonas, S.; Bengmark, S.; Neuhaus, P. Supply of pre- and probiotics reduces bacterial infection rates after liver transplantation-a randomized, double-blind trial. Am. J. Transplant. 2005, 5, 125-130.
102. Spindler-Vesel, A.; Bengmark, S.; Vovk, I.; Cerovic, O.; Kompan, L. Synbiotics, pre-biotics, glutamine, or peptide in early enteral nutrition: a randomized study in trauma patients. JPEN J. Parenter. Enteral Nutr. 2007, 31, 119-126.
103. Kotzampassi, K.; Giamerellos-Bourboulis, E.J.; Voudouris, A.; Kazamias, P.; Eleftheriadis, E. Benefits of Synbiotic 2000 Forte in critically ill trauma patients-early results of a randomized controlled trial. World J. Surg. 2006, 30, 1848-1855.
104. Giamarellos-Bourboulis, E.J.; Bengmark, S.; Kanellakopoulou, K.; Kotzampassi, K. Pro- and synbiotics to control inflammation and infection in patients with multiple injuries. J. Trauma 2009, 67, 815-818.
105. Koutelidakis, I.M.; Bezirtzoglou, E.; Giamarellos-Bourboulis, E.J.; Grosomanidis, V.; Kotzampassi, K. Impact of synbiotics on the intestinal flora of critically ill patients with multiple injuries. Int. J. Antimicrob. Agents 2010, 36, 90-91,
106. Oláh, A.; Belágyi, T.; Issekutz, Á.; Gamal, M.E.; Bengmark, S. Early enteral nutrition with specific lactobacillus and fibre reduces sepsis in severe acute pancreatitis. Br. J. Surg. 2002, 89, 1103-1107.
107. Oláh, A.; Belágyi, T.; Pótó, L.; Romics, L., Jr.; Bengmark, S. Synbiotic control of inflammation and infection in severe acute pancreatitis, a prospective randomized double blind study. Hepatogastroenterology 2007, 54, 590-594.
108. Plaudis, H.; Pupelis, G.; Zeiza, K.; Boka, V. Early Low Volume Oral Synbiotic/Prebiotic Supplemented Enteral Stimulation of the Gut in Patients with Severe Acute Pancreatitis: A Prospective Feasibility Study. Acta Chir. Belg. 2012, 112, 131-138.
109. Butterworth, R.F. Hepatic encephalopathy: A central neuroinflammator1 disorder? Hepatology 2011, 53, 1372-1376.
110. Eutamene, H.; Bueno, L. Role of probiotics in correcting abnormalities of colonic flora induced by stress. Gut 2007, 56, 1495-1497.
111. Ait-Belgnaoui, A.; Durand, H.; Cartier, C.; Chaumaz, G.; Eutamene, H.; Ferrier, L.; Houdeau, E.; Fioramonti, J.; Bueno, L.; Theodorou, V. Prevention of gut leakiness by a probiotic treatment leads to attenuated HPA response to an acute psychological stress in rats. Psychoneuroendocrinoloy 2012, 37, 1885-1895.
112. Liu, Q.; Duan, Z.P.; Ha, D.K.; Bengmark, S.; Kurtovic, J.; Riordan, S.M. Synbiotic modulation of gut flora: effect on minimal hepatic encephalopathy in patients with cirrhosis. Hepatology 2004, 39, 1441-1449.
113. Riordan, S.M.; Skinner, N.A.; McIver, C.J.; Liu, Q.; Bengmark, S.; Bihari, D.; Visvanathan, K. Synbiotic-associated improvement in liver function in cirrhotic patients: Relation to changes in circulating cytokine messenger RNA and protein levels. Microb. Ecol. Health Dis. 2007, 19, 7-16.
114. Bengmark, S. Bio-ecological control of chronic liver disease and encephalopathy. Metab. Brain Dis. 2009, 24, 223-236.
115. Brenchley, J.M.; Price, D.A.; Schacker, T.W.; Asher, T.E.; Silvestri, G.; Rao, S.; Kazzaz, Z.; Bornstein, E.; Lambotte, O.; Altmann, D. et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat. Med. 2006, 12, 1365-1371.
116. Gori, A.; Tincati, C.; Rizzardini, G.; Torti, C.; Quirino, T.; Haarman, M.; Amor, K.B.; van Schaik, J.; Vriesema, A.; Knol, J. et al. Early impairment of gut function and gut flora supporting a role for alteration of gastrointestinal mucosa in human immunodeficiency virus pathogenesis. J. Clin. Microbiol. 2008, 46, 757.
117. Ellis, C.L.; Ma, C.M.; Mann, S.K.; Li, S.C.; Wu, J.; Knight, T.H.; Yotter, T.; Hayes, T.L.; Maniar, A.H.; Troia-Cancio, P.V. et al. Molecular characterization of stool microbiota in HIV-infected subjects by panbacterial and order-level 16S Ribosomal DNA (rDNA) quantification and correlations with immune activation. J. Acquir. Immune Defic. Syndr. 2011, 57, 363-370.
118. Cunningham-Rundles, S.; Ahrné, S.; Johann-Liang, R.; Abuav, R.; Dunn-Navarra, A.M.; Grassey, C.; Bengmark, S.; Cervia, J.S. Effect of probiotic bacteria on microbial host defense, growth, and immune function in human immunodeficiency virus type-1 infection. Nutrients 2011, 3, 1042-1070.
119. Hummelen, R.; Changalucha, J.; Butamanya, N.L.; Cook, A.; Habbema, J.D.; Reid, G. Lactobacillus rhamnosus GR-1 and L. reuteri RC-14 to prevent or cure bacterial vaginosis among women with HIV. Int. J. Gynaecol. Obstet. 2010, 111, 245-248.
120. Hummelen, R.; Changalucha, J.; Butamanya, N.L.; Koyama, T.E.; Cook, A.; Habbema, J.D.; Reid, G. Effect of 25 weeks probiotic supplementation on immune function of HIV patients. Gut Microbes 2011, 2, 80-85.
121. Hummelen, R.; Hemsworth, J.; Changalucha, J.; Butamanya, N.L.; Hekmat, S.; Habbema, J.D.; Reid, G. Effect of micronutrient and probiotic fortified yogurt on immune-function of anti-retroviral therapy naive HIV patients. Nutrients 2011, 3, 897-909.
122. Schunter, M.; Chu, H.; Hayes, T.L.; McConnell, D.L.; Crawford, S.S.; Luciw, P.A.; Bengmark, S.; Asmuth, D.M.; Brown, J.; Bevins, C.L. et al. Randomized Pilot Trial of a Synbiotic Dietary Supplement in Chronic HIV-1 Infection. BMC Complement Altern. Med. 2012, 12, 84.
123. Calvano, S.E.; Xiao, W.; Richards, D.R.; Felciano, R.M.; Baker, H.V.; Cho, R.J.; Chen, R.O.; Brownstein, B.H.; Cobb, J.P.; Tschoeke, S.K. et al. A network-based analysis of systemic inflammation in humans. Nature 2005, 13, 1032-1037.
124. Loza, M.J.; McCall, C.E.; Li, L.; Isaacs, W.B.; Xu, J.; Chang, B.L. Assembly of inflammation-related genes for pathway-focused genetic analysis. PLoS One 2007, 2, e1035.
125. Seok, J.; Xiao, W.; Moldawer, L.L.; Davis, R.W.; Covert, M.W. A dynamic network of transcription in LPS-treated human subjects. BMC Syst. Biol. 2009, 3, 78.
126. Burcelin, R.; Serino, M.; Chabo, C.; Blasco-Baque, V.; Amar, J. Gut microbiota and diabetes: from pathogenesis to therapeutic perspective. Acta Diabetol. 2011, 48, 257-273.
127. Festi, D.; Schiumerini, R.; Birtolo, C.; Marzi, L.; Montrone, L.; Scaioli, E.; Di Biase, A.R.; Colecchia, A. Gut microbiota and its pathophysiology in disease paradigms. Dig. Dis. 2011, 29, 518-524.
128. Leavy, O. Inflammation: Trauma kicks up a storm. Nat. Rev. Immunol. 2011, 12, 3.
129. London, N.R.; Zhu, W.; Bozza, F.A.; Smith, M.C.; Greif, D.M.; Sorensen, L.K.; Chen, L.; Kaminoh, Y.; Chan, A.C.; Passi, S.F. et al. Targeting Robo4-dependent Slit signaling to survive the cytokine storm in sepsis and influenza. Sci. Transl. Med. 2010, 2, 23ra19.
130. Thomas, E.L.; Saeed, N.; Hajnal, J.V.; Goldstone, A.P.; Frost, G.; Bell, J.D. Magnetic resonance imaging of total body fat. J. Appl. Physiol. 1998, 85, 1778-1785.
131. Alessi, M.C.; Peiretti, F.; Morange, P.; Henry, M.; Nalbone, G.; Juhan-Vague, I. Production of plasminogen activator inhibitor 1 by human adipose tissue: Possible link between visceral fat accumulation and vascular disease. Diabetes 1997, 46, 860-867.
132. Almersjö, O.; Bengmark, S.; Engevik, L.; Kerstell, J.; Svanborg, A. Serum lipids after extensive liver resection in man. Acta Hepatosplenol. 1968, 15, 1-12.
133. Bengmark, S. Liver steatosis and liver resection. Digestion 1969, 2, 304-311.
134. Henao-Mejia, J.; Elinav, E.; Jin, C.; Hao, L.; Mehal, W.Z.; Strowig, T.; Thaiss, C.A.; Kau, A.L.; Eisenbarth, S.C.; Jurczak, M.J. et al. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 2012, 482, 179-185.
135. Bengmark, S.; Olsson, R.; Svanborg, A. Fat infiltration after partial hepatectomy, changes in glycerides, cholesterol and phospholipids in the residual liver of the rat. Acta Hepatosplenol. 1964, 11, 276-285.
136. Girish, C.; Pradhan, S.C. Hepatoprotective activities of picroliv, curcumin, and ellagic acid compared to silymarin on carbon-tetrachloride-induced liver toxicity in mice. J. Pharmacol. Pharmacother. 2012, 3, 149-155.
137. Xu, R.Y.; Wan, Y.P.; Fang, Q.Y.; Lu, W.; Cai, W. Supplementation with probiotics modifies gut flora and attenuates liver fat accumulation in rat nonalcoholic fatty liver disease model. J. Clin. Biochem. Nutr. 2012, 50, 72-77.
138. Seehofer, D.; Schirmeier, A.; Bengmark, S.; Cho, S.Y.; Koch, M.; Lederer, A.; Rayes, N.; Menger, M.D.; Neuhaus, P.; Nüssler, A.K. Curcumin attenuates oxidative stress and inflammatory response in the early phase after partial hepatectomy with simultaneous intraabdominal infection in rats. J. Surg. Res. 2010, 159, 497-502.
139. Kuo, J.J.; Chang, H.H.; Tsai, T.H.; Lee, T.Y. Positive effect of curcumin on inflammation and mitochondrial dysfunction in obese mice with liver steatosis. Int. J. Mol. Med. 2012, 30, 673-679.
140. Müller-Ladner, U.; Pap, T.; Gay, R.E.; Neidhart, M.; Gay, S. Mechanisms of disease: the molecular and cellular basis of joint destruction in rheumatoid arthritis. Nat. Clin. Pract. Rheumatol. 2005, 1, 102-110.
141. Simmonds, R.E.; Foxwell, B.M. Signalling, inflammation and arthritis NF-κB and its relevance to arthritis and inflammation. Rheumatology 2008, 47, 584-590.
142. Perrier, C.; Rutgeerts, P. Cytokine blockade in inflammatory bowel diseases. Immunotherapy 2011, 3, 1341-1352.
143. Mancini, G.B.; Baker, S.; Bergeron, J.; Fitchett, D.; Frohlich, J.; Genest, J.; Gupta, M.; Hegele, R.A.; Ng, D.; Pope, J. Diagnosis, prevention, and management of statin adverse effects and intolerance: proceedings of a Canadian Working Group Consensus Conference. Can. J. Cardiol. 2011, 27, 635-662.
144. Aggarwal, B.B.; Sethi, G.; Baladandayuthapani, V.; Krishnan, S.; Shishodia, S. Targeting cell signaling pathways for drug discovery: an old lock needs a new key. J. Cell. Biochem. 2007, 102, 580-592.
145. Bengmark, S. Advanced glycation and lipoxidation end products-amplifiers of inflammation: The role of food. JPEN J. Parenter. Enteral Nutr. 2007, 31, 430-440.
146. Bengmark, S. AGE, ALE RAGE and disease-a foods perspective. In Handbook of Prebiotic and Probiotic Ingredients: Health Benefits and Food Applications; Cho, S.S., Finocchiaro, T., Eds.; CRC Press, Taylor and Francis Group: Boca Raton, FL, USA, 2010; pp. 139-162.
147. Bengmark, S. Modified Amino Acid-Based Molecules: Accumulation and Health Implications. In Amino Acids in Human Nutrition and Health; Mello, J.F.D., Ed.; CABI: Wallingford, UK, 2011; pp. 382-405.
148. Vanschoonbeek, K.; Lansink, M.; van Laere, K.M.; Senden, J.M.; Verdijk, L.B.; van Loon, L.J. Slowly digestible carbohydrate sources can be used to attenuate the postprandial glycemic response to the ingestion of diabetes-specific enteral formulas. Diabetes Educ. 2009, 35, 631-640.
149. Martindale, R.G.; DeLegge, M.; McClave, S.; Monroe, C.; Smith, V.; Kiraly, L. Nutrition delivery for obese ICU patients: Delivery issues, lack of guidelines, and missed opportunities. JPEN J. Parenter. Enteral Nutr. 2011, 35, S80-S87.
150. Miner-Williams, W.; Deglaire, A.; Benamouzig, R.; Fuller, M.F.; Tomé, D.; Moughan, P.J. Endogenous proteins in terminal ileal digesta of adult subjects fed a casein-based diet. Am. J. Clin. Nutr. 2012, 96, 508-515.
151. Veldhorst, M.A.; Nieuwenhuizen, A.G.; Hochstenbach-Waelen, A.; Westerterp, K.R.; Engelen, M.P.; Deutz, N.E.; Westerterp-Plantenga, M.S. A breakfast with alpha-lactalbumin, gelatin, or gelatin + TRP lowers energy intake at lunch compared with a breakfast with casein, soy, whey, or whey-GMP. Clin. Nutr. 2009, 28, 147-155.
152. Ang, M.; Müller, A.S.; Wagenlehner, F.; Pilatz, A.; Linn, T. Combining protein and carbohydrate increases postprandial insulin levels but does not improve glucose response in patients with type 2 diabetes. Metabolism 2012, 61, 1696-1702.
153. Liu, X.; Murali, S.G.; Holst, J.J.; Ney, D.M. Whey protein potentiates the intestinotrophic action of glucagon-like peptide-2 in parenterally fed rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2009, 297, R1554-R1562.
154. Tang, J.E.; Moore, D.R.; Kujbida, G.W.; Tarnopolsky, M.A.; Phillips, S.M. Ingestion of whey hydrolysate, casein, or soy protein isolate: effects on mixed muscle protein synthesis at rest and following resistance exercise in young men. J. Appl. Physiol. 2009, 107, 987-992.
155. Morifuji, M.; Sakai, K.; Sugiura, K. Dietary whey protein modulates liver glycogen level and glycoregulatory enzyme activities in exercise-trained rats. Exp. Biol. Med. (Maywood) 2005, 230, 23-30.
156. Ebaid, H.; Salem, A.; Sayed, A.; Metwalli, A. Whey protein enhances normal inflammatory responses during cutaneous wound healing in diabetic rats. Lipids Health Dis. 2011, 10, 235.
157. Hoppe, C.; Mølgaard, C.; Dalum, C.; Vaag, A.; Michaelsen, K.F. Differential effects of casein versus whey on fasting plasma levels of insulin, IGF-1 and IGF-1/IGFBP-3: results from a randomized 7-day supplementation study in prepubertal boys. Eur. J. Clin. Nutr. 2009, 63, 1076-1083.
158. Graf, S.; Egert, S.; Heer, M. Effects of whey protein supplements on metabolism: Evidence from human intervention studies. Curr. Opin. Clin. Nutr. Metab. Care 2011, 14, 569-580.
159. Yang, L.; Chen, J.H.; Xu, T.; Zhou, A.S.; Yang, H.K. Rice protein improves oxidative stress by regulating glutathione metabolism and attenuating oxidative damage to lipids and proteins in rats. Life Sci. 2012, 91, 389-394.
160. Alvarez-Jubete, L.; Arendt, E.K.; Gallagher, E. Nutritive value and chemical composition of pseudocereals as gluten-free ingredients. Int. J. Food Sci. Nutr. 2009, 60, S240-S257.
161. Chintagari, N.R.; Liu, L. GABA receptor ameliorates ventilator-induced lung injury in rats by improving alveolar fluid clearance. Crit. Care 2012, 16, R55.
162. Schep, L.J.; Knudsen, K.; Slaughter, R.J.; Vale, J.A.; Mégarbane, B. The clinical toxicology of γ-hydroxybutyrate, γ-butyrolactone and 1,4-butanediol. Clin. Toxicol. 2012, 5, 458-470.
163. Coda, R.; Rizzello, C.G.; Gobbetti, M. Use of sourdough fermentation and pseudo-cereals and leguminous flours for the making of a functional bread enriched of gamma-aminobutyric acid (GABA). Int. J. Food Microbiol. 2010, 137, 236-245.
164. Coda, R.; Di Cagno, R.; Rizzello, C.G.; Nionelli, L.; Edema, M.O.; Gobbetti, M. Utilization of African grains for sourdough bread making. J. Food Sci. 2011, 76, M329-M335.
165. Han, Y.Y.; Lai, S.L.; Ko, W.J.; Chou, C.H.; Lai, H.S. Effects of fish oil on inflammatory modulation in surgical intensive care unit patients. Nutr. Clin. Pract. 2012, 27, 91-98.
166. Versleijen, M.W.; Roelofs, H.M.; Rombouts, C.; Hermans, P.W.; Noakes, P.S.; Calder, P.C.; Wanten, G.J. Short-term infusion of a fish oil-based lipid emulsion modulates fatty acid status, but not immune function or (anti)oxidant balance: a randomized cross-over study. Eur. J. Clin. Invest. 2012, 42, 290-302.
167. Levy, B.D. Resolvins and protectins: Natural pharmacophores for resolution biology. Prostaglandins Leukot. Essent. Fatty Acids 2010, 82, 327-332,
168. Ott, J.; Hiesgen, C.; Mayer, K. Lipids in critical care medicine. Prostaglandins Leukot. Essent. Fatty Acids 2011, 85, 267-273.
169. van der Meij, B.S.; van Bokhorst-de van der Schueren, M.A.; Langius, J.A.; Brouwer, I.A.; van Leeuwen, P.A. n-3 PUFAs in cancer, surgery, and critical care: A systematic review on clinical effects, incorporation, and washout of oral or enteral compared with parenteral supplementation. Am. J. Clin. Nutr. 2011, 94, 1248-1265.
170. Rice, T.W.; Wheeler, A.P.; Thompson, B.T.; deBoisblanc, B.P.; Steingrub, J.; Rock, P.; NIH NHLBI Acute Respiratory Distress Syndrome Network of Investigators. Enteral omega-3 fatty acid, gamma-linolenic acid, and antioxidant supplementation in acute lung injury. JAMA 2011, 306, 1574-1581.
171. Wang, J.; Yu, J.C.; Kang, W.M.; Ma, Z.Q. Superiority of a fish oil-enriched emulsion to medium-chain triacylglycerols/long-chain triacylglycerols in gastrointestinal surgery patients: A randomized clinical trial. Nutrtion 2012, 28, 623-629.
172. Umpierrez, G.E.; Spiegelman, R.; Zhao, V.; Smiley, D.D.; Pinzon, I.; Griffith, D.P.; Peng, L.; Morris, T.; Luo, M.; Garcia, H.; Thomas, C.; Newton, C.A.; Ziegler, T.R. A double-blind, randomized clinical trial comparing soybean oil-based versus olive oil-based lipid emulsions in adult medical-surgical intensive care unit patients requiring parenteral nutrition. Crit. Care Med. 2012, 40, 1792-1798.
173. Siqueira, J.; Smiley, D.; Newton, C.; Le, N.A.; Gosmanov, A.R.; Spiegelman, R.; Peng, L.; Osteen, S.J.; Jones, D.P.; Quyyumi, A.A.; Ziegler, T.R.; Umpierrez, G.E. Substitution of standard soybean oil with olive oil-based lipid emulsion in parenteral nutrition: comparison of vascular, metabolic, and inflammatory effects. J. Clin. Endocrinol. Metab. 2011, 96, 3207-3216.
174. Unlu, N.Z.; Bohn, T.; Clinton, S.K.; Schwartz, S.J. Carotenoid absorption from salad and salsa by humans is enhanced by the addition of avocado or avocado oil. J. Nutr. 2005, 135, 431-436.
175. Boileau, C.; Martel-Pelletier, J.; Caron, J.; Msika, P.; Guillou, G.B.; Baudouin, C. Protective effects of total fraction of avocado/soybean unsaponifiables on the structural changes in experimental dog osteoarthritis: inhibition of nitric oxide synthase and matrix metalloproteinase-13. Arthritis Res. Ther. 2009, 11, R41.
176. Oguntibeju, O.O.; Esterhuyse, A.J.; Truter, E.J. Red palm oil: nutritional, physiological and therapeutic roles in improving human wellbeing and quality of life. Br. J. Biomed. Sci. 2009, 66, 216-222.
177. Sen, C.K.; Rink, C.; Khanna, S. Palm oil-derived natural vitamin E alpha-tocotrienol in brain health and disease. J. Am. Coll. Nutr. 2010, 29, S314-S323.
178. Takeuchi, H.; Sekine, S.; Kojima, K.; Aoyama, T. The application of medium-chain fatty acids: edible oil with a suppressing effect on body fat accumulation. Asia Pac. J. Clin. Nutr. 2008, 17, S320-S323.
179. Wu, S.J.; Liu, P.L.; Ng, L.T. Tocotrienol-rich fraction of palm oil exhibits anti-inflammatory property by suppressing the expression of inflammatory mediators in human monocytic cells. Mol. Nutr. Food Res. 2008, 52, 921-929.
180. Esterhuyse, A.J.; Du Toit, E.F.; Van Rooyen, J. Dietary Red Palm Oil supplementation protects against the consequences of global ischaemia in the isolated perfused rat heart. Asia Pac. J. Clin. Nutr. 2005, 14, 1-7.
181. Esterhuyse, A.J.; Du Toit, E.F.; Benadè, A.J.S.; van Rooyen, J. Dietary Red Palm Oil improves reperfusion cardiac function in the isolated perfused rat heart of animals fed a high cholesterol diet. Prostaglandins Leukot. Essent. Fatty Acids 2005, 72, 153-161.
182. van Rooyen, J.; Esterhuyse, A.J.; Engelbrecht, A.M.; du Toit, E.F. Health benefits of a natural carotenoid rich oil: a proposed mechanism of protection against ischaemia/reperfusion injury. Asia Pac. J. Clin. Nutr. 2008, 17, S316-S319.
183. Desbois, A.P.; Smith, V.J. Antibacterial free fatty acids: Activities, mechanisms of action and biotechnological potential. Appl. Microbiol. Biotechnol. 2010, 85, 1629-1642.
184. Descotes, J. Immunotoxicology: Role in the safety assessment of drugs. Drug Saf. 2005, 28, 127-136.
185. Boutenko, V. Green for Life; North Atlantic Books: Berkeley, CA, USA, 2010.
186. Iapichino, G.; Callegari, M.L.; Marzorati, S.; Cigada, M.; Corbella, D.; Ferrari, S.; Morelli, L. Impact of antibiotics on the gut microbiota of critically ill patients. J. Med. Microbiol. 2008, 57, 1007-1014.