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Volumn 24, Issue 1, 2008, Pages 4-10

Gastrointestinal microbiology enters the metagenomics era

Author keywords

Crohn's disease; Culture independent analysis; Metagenomics; Phylogenetic analysis; rRNA gene; Ulcerative colitis

Indexed keywords

BACTERIUM CULTURE; CROHN DISEASE; DIARRHEA; DNA SEQUENCE; GENOMICS; HELICOBACTER PYLORI; ILEITIS; INTESTINE FLORA; MICROBIAL DIVERSITY; OBESITY; REVIEW; ULCERATIVE COLITIS;

EID: 36549028432     PISSN: 02671379     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOG.0b013e3282f2b0e8     Document Type: Review
Times cited : (338)

References (67)
  • 1
    • 0029845965 scopus 로고    scopus 로고
    • A model of host - microbial interactions in an open mammalian ecosystem
    • Bry L, Falk PG, Midtvedt T, Gordon JI. A model of host - microbial interactions in an open mammalian ecosystem. Science 1996; 273:1380-1383.
    • (1996) Science , vol.273 , pp. 1380-1383
    • Bry, L.1    Falk, P.G.2    Midtvedt, T.3    Gordon, J.I.4
  • 2
    • 0037180433 scopus 로고    scopus 로고
    • Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells
    • Stappenbeck TS, Hooper LV, Gordon JI. Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells. Proc Natl Acad Sci U S A 2002; 99:15451-15455.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 15451-15455
    • Stappenbeck, T.S.1    Hooper, L.V.2    Gordon, J.I.3
  • 3
    • 0036399823 scopus 로고    scopus 로고
    • How host - microbial interactions shape the nutrient environment of the mammalian intestine
    • Hooper LV, Midtvedt T, Gordon JI. How host - microbial interactions shape the nutrient environment of the mammalian intestine. Annu Rev Nutr 2002; 22:283-307.
    • (2002) Annu Rev Nutr , vol.22 , pp. 283-307
    • Hooper, L.V.1    Midtvedt, T.2    Gordon, J.I.3
  • 4
    • 3242664636 scopus 로고    scopus 로고
    • Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis
    • Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, et al. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 2004; 118:229-241.
    • (2004) Cell , vol.118 , pp. 229-241
    • Rakoff-Nahoum, S.1    Paglino, J.2    Eslami-Varzaneh, F.3
  • 5
    • 22144490199 scopus 로고    scopus 로고
    • An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system
    • Mazmanian SK, Liu CH, Tzianabos AO, Kasper DL. An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell 2005; 122:107-118.
    • (2005) Cell , vol.122 , pp. 107-118
    • Mazmanian, S.K.1    Liu, C.H.2    Tzianabos, A.O.3    Kasper, D.L.4
  • 6
    • 19544366408 scopus 로고    scopus 로고
    • Commensal gut bacteria: Mechanisms of immune modulation
    • Kelly D, Conway S, Aminov R. Commensal gut bacteria: mechanisms of immune modulation. Trends Immunol 2005; 26:326-333.
    • (2005) Trends Immunol , vol.26 , pp. 326-333
    • Kelly, D.1    Conway, S.2    Aminov, R.3
  • 7
    • 0017341656 scopus 로고
    • Microbial ecology of the gastrointestinal tract
    • Savage DC. Microbial ecology of the gastrointestinal tract. Annu Rev Microbiol 1977; 31:107-133.
    • (1977) Annu Rev Microbiol , vol.31 , pp. 107-133
    • Savage, D.C.1
  • 8
    • 0027215468 scopus 로고
    • The identification of uncultured microbial pathogens
    • Relman DA. The identification of uncultured microbial pathogens. J Infect Dis 1993; 168:1-8.
    • (1993) J Infect Dis , vol.168 , pp. 1-8
    • Relman, D.A.1
  • 9
    • 0031768678 scopus 로고    scopus 로고
    • Creating and maintaining the gastrointestinal ecosystem: What we know and need to know from gnotobiology
    • Falk PG, Hooper LV, Midtvedt T, Gordon JI. Creating and maintaining the gastrointestinal ecosystem: what we know and need to know from gnotobiology. Microbiol Mol Biol Rev 1998; 62:1157-1170.
    • (1998) Microbiol Mol Biol Rev , vol.62 , pp. 1157-1170
    • Falk, P.G.1    Hooper, L.V.2    Midtvedt, T.3    Gordon, J.I.4
  • 11
    • 0035139428 scopus 로고    scopus 로고
    • Molecular - phylogenetic analyses of human gastrointestinal microbiota
    • Frank DN, Pace NR. Molecular - phylogenetic analyses of human gastrointestinal microbiota. Curr Opin Gastroenterol 2001; 17:52-57.
    • (2001) Curr Opin Gastroenterol , vol.17 , pp. 52-57
    • Frank, D.N.1    Pace, N.R.2
  • 12
    • 10344227692 scopus 로고    scopus 로고
    • Metagenomics: Application of genomics to uncultured microorganisms
    • Handelsman J. Metagenomics: application of genomics to uncultured microorganisms. Microbiol Mol Biol Rev 2004; 68:669-685.
    • (2004) Microbiol Mol Biol Rev , vol.68 , pp. 669-685
    • Handelsman, J.1
  • 13
    • 0942279586 scopus 로고    scopus 로고
    • Molecular ecological analysis of the gastrointestinal microbiota: A review
    • Zoetendal EG, Collier CT, Koike S, et al. Molecular ecological analysis of the gastrointestinal microbiota: a review. J Nutr 2004; 134:465-472.
    • (2004) J Nutr , vol.134 , pp. 465-472
    • Zoetendal, E.G.1    Collier, C.T.2    Koike, S.3
  • 14
    • 15544369658 scopus 로고    scopus 로고
    • Host - bacterial mutualism in the human intestine
    • Backhed F, Ley RE, Sonnenburg JL, et al. Host - bacterial mutualism in the human intestine. Science 2005; 307:1915-1920.
    • (2005) Science , vol.307 , pp. 1915-1920
    • Backhed, F.1    Ley, R.E.2    Sonnenburg, J.L.3
  • 16
    • 0034665853 scopus 로고    scopus 로고
    • Bacterial rhodopsin: Evidence for a new type of phototrophy in the sea
    • Beja O, Aravind L, Koonin EV, et al. Bacterial rhodopsin: evidence for a new type of phototrophy in the sea. Science 2000; 289:1902-1906.
    • (2000) Science , vol.289 , pp. 1902-1906
    • Beja, O.1    Aravind, L.2    Koonin, E.V.3
  • 17
    • 0034554741 scopus 로고    scopus 로고
    • Construction and analysis of bacterial artificial chromosome libraries from a marine microbial assemblage
    • Beja O, Suzuki MT, Koonin EV, et al. Construction and analysis of bacterial artificial chromosome libraries from a marine microbial assemblage. Environ Microbiol 2000; 2:516-529.
    • (2000) Environ Microbiol , vol.2 , pp. 516-529
    • Beja, O.1    Suzuki, M.T.2    Koonin, E.V.3
  • 18
    • 0032976553 scopus 로고    scopus 로고
    • Identification and characterization of a flagellin gene from the endosymbiont of the hydrothermal vent tubeworm Riftia pachyptila
    • Millikan DS, Felbeck H, Stein JL. Identification and characterization of a flagellin gene from the endosymbiont of the hydrothermal vent tubeworm Riftia pachyptila. Appl Environ Microbiol 1999; 65:3129-3133.
    • (1999) Appl Environ Microbiol , vol.65 , pp. 3129-3133
    • Millikan, D.S.1    Felbeck, H.2    Stein, J.L.3
  • 19
    • 18844481269 scopus 로고    scopus 로고
    • Cloning the soil metagenome: A strategy for accessing the genetic and functional diversity of uncultured microorganisms
    • Rondon MR, August PR, Bettermann AD, et al. Cloning the soil metagenome: a strategy for accessing the genetic and functional diversity of uncultured microorganisms. Appl Environ Microbiol 2000; 66:2541-2547.
    • (2000) Appl Environ Microbiol , vol.66 , pp. 2541-2547
    • Rondon, M.R.1    August, P.R.2    Bettermann, A.D.3
  • 20
    • 1542377296 scopus 로고    scopus 로고
    • Community structure and metabolism through reconstruction of microbial genomes from the environment
    • Tyson GW, Chapman J, Hugenholtz P, et al. Community structure and metabolism through reconstruction of microbial genomes from the environment. Nature 2004; 428:37-43.
    • (2004) Nature , vol.428 , pp. 37-43
    • Tyson, G.W.1    Chapman, J.2    Hugenholtz, P.3
  • 21
    • 20244376755 scopus 로고    scopus 로고
    • Comparative metagenomics of microbial communities
    • Tringe SG, von Mering C, Kobayashi A, et al. Comparative metagenomics of microbial communities. Science 2005; 308:554-557.
    • (2005) Science , vol.308 , pp. 554-557
    • Tringe, S.G.1    von Mering, C.2    Kobayashi, A.3
  • 22
    • 33744804299 scopus 로고    scopus 로고
    • Gill SR, Pop M, Deboy RT, et al. Metagenomic analysis of the human distal gut microbiome. Science 2006; 312:1355-1359. This metagenomic analysis of the fecal microbial communities of two healthy adults entailed sequencing around 78 million basepairs of randomly cloned bacterial genes. Bioinformatic analysis revealed enrichment in genes involved in several aspects of metabolism.
    • Gill SR, Pop M, Deboy RT, et al. Metagenomic analysis of the human distal gut microbiome. Science 2006; 312:1355-1359. This metagenomic analysis of the fecal microbial communities of two healthy adults entailed sequencing around 78 million basepairs of randomly cloned bacterial genes. Bioinformatic analysis revealed enrichment in genes involved in several aspects of metabolism.
  • 23
    • 2942624056 scopus 로고    scopus 로고
    • Quantification of intestinal bacterial populations by real-time PCR with a universal primer set and minor groove binder probes: A global approach to the enteric flora
    • Ott SJ, Musfeldt M, Ullmann U, et al. Quantification of intestinal bacterial populations by real-time PCR with a universal primer set and minor groove binder probes: a global approach to the enteric flora. J Clin Microbiol 2004; 42:2566-2572.
    • (2004) J Clin Microbiol , vol.42 , pp. 2566-2572
    • Ott, S.J.1    Musfeldt, M.2    Ullmann, U.3
  • 24
    • 23744452926 scopus 로고    scopus 로고
    • Characterisation of intestinal bacteria in infant stools using real-time PCR and northern hybridisation analyses
    • Hopkins MJ, Macfarlane GT, Furrie E, et al. Characterisation of intestinal bacteria in infant stools using real-time PCR and northern hybridisation analyses. FEMS Microbiol Ecol 2005; 54:77-85.
    • (2005) FEMS Microbiol Ecol , vol.54 , pp. 77-85
    • Hopkins, M.J.1    Macfarlane, G.T.2    Furrie, E.3
  • 25
    • 35348857386 scopus 로고    scopus 로고
    • Frank DN, St Amand AL, Feldman RA, et al. Molecular - phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc Natl Acad Sci U S A 2007; 104:13780-13785. Metagenomic analysis of human IBD-associated microbial communities, which demonstrated imbalances in selected Crohn's and ulcerative colitis patients. Relative to controls, these individuals were characterized by loss of commensal organisms of the bacterial phyla Bacteroidetes and Firmicutes.
    • Frank DN, St Amand AL, Feldman RA, et al. Molecular - phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc Natl Acad Sci U S A 2007; 104:13780-13785. Metagenomic analysis of human IBD-associated microbial communities, which demonstrated imbalances in selected Crohn's and ulcerative colitis patients. Relative to controls, these individuals were characterized by loss of commensal organisms of the bacterial phyla Bacteroidetes and Firmicutes.
  • 26
    • 0037401015 scopus 로고    scopus 로고
    • Detection of bacterial pathogens in environmental samples using DNA microarrays
    • Call DR, Borucki MK, Loge FJ. Detection of bacterial pathogens in environmental samples using DNA microarrays. J Microbiol Methods 2003; 53:235-243.
    • (2003) J Microbiol Methods , vol.53 , pp. 235-243
    • Call, D.R.1    Borucki, M.K.2    Loge, F.J.3
  • 27
    • 31544436089 scopus 로고    scopus 로고
    • Rapid quantitative profiling of complex microbial populations
    • Palmer C, Bik EM, Eisen MB, et al. Rapid quantitative profiling of complex microbial populations. Nucleic Acids Res 2006; 34:e5.
    • (2006) Nucleic Acids Res , vol.34
    • Palmer, C.1    Bik, E.M.2    Eisen, M.B.3
  • 28
    • 17144420448 scopus 로고    scopus 로고
    • Rapid quantification and taxonomic classification of environmental DNA from both prokaryotic and eukaryotic origins using a microarray
    • Desantis TZ, Stone CE, Murray SR, et al. Rapid quantification and taxonomic classification of environmental DNA from both prokaryotic and eukaryotic origins using a microarray. FEMS Microbiol Lett 2005; 245:271-278.
    • (2005) FEMS Microbiol Lett , vol.245 , pp. 271-278
    • Desantis, T.Z.1    Stone, C.E.2    Murray, S.R.3
  • 29
    • 0036018472 scopus 로고    scopus 로고
    • Sequence-specific identification of 18 pathogenic microorganisms using microarray technology
    • Wilson WJ, Strout CL, DeSantis TZ, et al. Sequence-specific identification of 18 pathogenic microorganisms using microarray technology. Mol Cell Probes 2002; 16:119-127.
    • (2002) Mol Cell Probes , vol.16 , pp. 119-127
    • Wilson, W.J.1    Strout, C.L.2    DeSantis, T.Z.3
  • 30
    • 0036245011 scopus 로고    scopus 로고
    • High-density microarray of small-subunit ribosomal DNA probes
    • Wilson KH, Wilson WJ, Radosevich JL, et al. High-density microarray of small-subunit ribosomal DNA probes. Appl Environ Microbiol 2002; 68:2535-2541.
    • (2002) Appl Environ Microbiol , vol.68 , pp. 2535-2541
    • Wilson, K.H.1    Wilson, W.J.2    Radosevich, J.L.3
  • 31
    • 0037031130 scopus 로고    scopus 로고
    • Design and evaluation of oligonucleotide-microarray method for the detection of human intestinal bacteria in fecal samples
    • Wang RF, Beggs ML, Robertson LH, Cerniglia CE. Design and evaluation of oligonucleotide-microarray method for the detection of human intestinal bacteria in fecal samples. FEMS Microbiol Lett 2002; 213:175-182.
    • (2002) FEMS Microbiol Lett , vol.213 , pp. 175-182
    • Wang, R.F.1    Beggs, M.L.2    Robertson, L.H.3    Cerniglia, C.E.4
  • 32
    • 0033966699 scopus 로고    scopus 로고
    • Comparison of viable cell counts and fluorescence in situ hybridization using specific rRNA-based probes for the quantification of human fecal bacteria
    • Harmsen HJ, Gibson GR, Elfferich P, et al. Comparison of viable cell counts and fluorescence in situ hybridization using specific rRNA-based probes for the quantification of human fecal bacteria. FEMS Microbiol Lett 2000; 183:125-129.
    • (2000) FEMS Microbiol Lett , vol.183 , pp. 125-129
    • Harmsen, H.J.1    Gibson, G.R.2    Elfferich, P.3
  • 33
    • 0032735725 scopus 로고    scopus 로고
    • Effects of inulin on faecal bifidobacteria in human subjects
    • Kruse HP, Kleessen B, Blaut M. Effects of inulin on faecal bifidobacteria in human subjects. Br J Nutr 1999; 82:375-382.
    • (1999) Br J Nutr , vol.82 , pp. 375-382
    • Kruse, H.P.1    Kleessen, B.2    Blaut, M.3
  • 34
    • 0034129592 scopus 로고    scopus 로고
    • Analysis of the fecal microflora of human subjects consuming a probiotic product containing Lactobacillus rhamnosus DR20
    • Tannock GW, Munro K, Harmsen HJ, et al. Analysis of the fecal microflora of human subjects consuming a probiotic product containing Lactobacillus rhamnosus DR20. Appl Environ Microbiol 2000; 66:2578-2588.
    • (2000) Appl Environ Microbiol , vol.66 , pp. 2578-2588
    • Tannock, G.W.1    Munro, K.2    Harmsen, H.J.3
  • 35
    • 0030624615 scopus 로고    scopus 로고
    • 16S ribosomal RNA-targeted oligonucleotide probes for monitoring of intestinal tract bacteria
    • Welling GW, Elfferich P, Raangs GC, et al. 16S ribosomal RNA-targeted oligonucleotide probes for monitoring of intestinal tract bacteria. Scand J Gastroenterol Suppl 1997; 222:17-19.
    • (1997) Scand J Gastroenterol Suppl , vol.222 , pp. 17-19
    • Welling, G.W.1    Elfferich, P.2    Raangs, G.C.3
  • 36
    • 0032755259 scopus 로고    scopus 로고
    • Direct analysis of genes encoding 16S rRNA from complex communities reveals many novel molecular species within the human gut
    • Suau A, Bonnet R, Sutren M, et al. Direct analysis of genes encoding 16S rRNA from complex communities reveals many novel molecular species within the human gut. Appl Environ Microbiol 1999; 65:4799-4807.
    • (1999) Appl Environ Microbiol , vol.65 , pp. 4799-4807
    • Suau, A.1    Bonnet, R.2    Sutren, M.3
  • 37
    • 0029900986 scopus 로고    scopus 로고
    • Human colonic biota studied by ribosomal DNA sequence analysis
    • Wilson KH, Blitchington RB. Human colonic biota studied by ribosomal DNA sequence analysis. Appl Environ Microbiol 1996; 62:2273-2278.
    • (1996) Appl Environ Microbiol , vol.62 , pp. 2273-2278
    • Wilson, K.H.1    Blitchington, R.B.2
  • 38
    • 0036185771 scopus 로고    scopus 로고
    • Assessment of microbial diversity in human colonic samples by 16S rDNA sequence analysis
    • Hold GL, Pryde SE, Russell VJ, et al. Assessment of microbial diversity in human colonic samples by 16S rDNA sequence analysis. FEMS Microbiol Ecol 2002; 39:33-39.
    • (2002) FEMS Microbiol Ecol , vol.39 , pp. 33-39
    • Hold, G.L.1    Pryde, S.E.2    Russell, V.J.3
  • 39
    • 20544444045 scopus 로고    scopus 로고
    • Diversity of the human intestinal microbial flora
    • Eckburg PB, Bik EM, Bernstein CN, et al. Diversity of the human intestinal microbial flora. Science 2005; 308:1635-1638.
    • (2005) Science , vol.308 , pp. 1635-1638
    • Eckburg, P.B.1    Bik, E.M.2    Bernstein, C.N.3
  • 40
    • 33845901507 scopus 로고    scopus 로고
    • Ley RE, Turnbaugh PJ, Klein S, Gordon JI. Microbial ecology: human gut microbes associated with obesity. Nature 2006; 444:1022-1023. The authors examined the impact of diet on gastrointestinal microbiota. Microbial communities associated with obese individuals were enriched in the bacterial phylum Firmicutes, relative to nonobese individuals. Treatment of obese individuals with a low-calorie diet shifted their microbiotas to the nonobese state.
    • Ley RE, Turnbaugh PJ, Klein S, Gordon JI. Microbial ecology: human gut microbes associated with obesity. Nature 2006; 444:1022-1023. The authors examined the impact of diet on gastrointestinal microbiota. Microbial communities associated with obese individuals were enriched in the bacterial phylum Firmicutes, relative to nonobese individuals. Treatment of obese individuals with a low-calorie diet shifted their microbiotas to the nonobese state.
  • 41
    • 31444449652 scopus 로고    scopus 로고
    • Bik EM, Eckburg PB, Gill SR, et al. Molecular analysis of the bacterial microbiota in the human stomach. Proc Natl Acad Sci U S A 2006; 103:732-737. This study revealed much unanticipated diversity in the microbial communities that inhabit the healthy adult human stomach.
    • Bik EM, Eckburg PB, Gill SR, et al. Molecular analysis of the bacterial microbiota in the human stomach. Proc Natl Acad Sci U S A 2006; 103:732-737. This study revealed much unanticipated diversity in the microbial communities that inhabit the healthy adult human stomach.
  • 42
    • 27644574002 scopus 로고    scopus 로고
    • Molecular analysis of jejunal, ileal, caecal and recto-sigmoidal human colonic microbiota using 16S rRNA gene libraries and terminal restriction fragment length polymorphism
    • Hayashi H, Takahashi R, Nishi T, et al. Molecular analysis of jejunal, ileal, caecal and recto-sigmoidal human colonic microbiota using 16S rRNA gene libraries and terminal restriction fragment length polymorphism. J Med Microbiol 2005; 54:1093-1101.
    • (2005) J Med Microbiol , vol.54 , pp. 1093-1101
    • Hayashi, H.1    Takahashi, R.2    Nishi, T.3
  • 43
    • 0036024611 scopus 로고    scopus 로고
    • Phylogenetic analysis of the human gut microbiota using 16S rDNA clone libraries and strictly anaerobic culture-based methods
    • Hayashi H, Sakamoto M, Benno Y. Phylogenetic analysis of the human gut microbiota using 16S rDNA clone libraries and strictly anaerobic culture-based methods. Microbiol Immunol 2002; 46:535-548.
    • (2002) Microbiol Immunol , vol.46 , pp. 535-548
    • Hayashi, H.1    Sakamoto, M.2    Benno, Y.3
  • 44
    • 33750956239 scopus 로고    scopus 로고
    • Gophna U, Sommerfeld K, Gophna S, et al. Differences between tissue-associated intestinal microfloras of patients with Crohn's disease and ulcerative colitis. J Clin Microbiol 2006; 44:4136-4141. Reports the loss of normally prevalent commensal phyla in patients with inflammatory bowel disease.
    • Gophna U, Sommerfeld K, Gophna S, et al. Differences between tissue-associated intestinal microfloras of patients with Crohn's disease and ulcerative colitis. J Clin Microbiol 2006; 44:4136-4141. Reports the loss of normally prevalent commensal phyla in patients with inflammatory bowel disease.
  • 45
    • 30944466824 scopus 로고    scopus 로고
    • Manichanh C, Rigottier-Gois L, Bonnaud E, et al. Reduced diversity of faecal microbiota in Crohn's disease revealed by a metagenomic approach. Gut 2006; 55:205-211. Reports the loss of normally prevalent commensal phyla in patients with inflammatory bowel disease.
    • Manichanh C, Rigottier-Gois L, Bonnaud E, et al. Reduced diversity of faecal microbiota in Crohn's disease revealed by a metagenomic approach. Gut 2006; 55:205-211. Reports the loss of normally prevalent commensal phyla in patients with inflammatory bowel disease.
  • 46
    • 0033857550 scopus 로고    scopus 로고
    • Profiling of bacterial flora in gastric biopsies from patients with Helicobacter pylori-associated gastritis and histologically normal control individuals by temperature gradient gel electrophoresis and 16S rDNA sequence analysis
    • Monstein HJ, Tiveljung A, Kraft CH, et al. Profiling of bacterial flora in gastric biopsies from patients with Helicobacter pylori-associated gastritis and histologically normal control individuals by temperature gradient gel electrophoresis and 16S rDNA sequence analysis. J Med Microbiol 2000; 49:817-822.
    • (2000) J Med Microbiol , vol.49 , pp. 817-822
    • Monstein, H.J.1    Tiveljung, A.2    Kraft, C.H.3
  • 47
    • 0028028182 scopus 로고
    • Taxonomic note: A place for DNA-DNA reassociation and 16S rRNA sequence analysis in the present species definition in bacteriology
    • Stackebrandt E, Goebel BM. Taxonomic note: a place for DNA-DNA reassociation and 16S rRNA sequence analysis in the present species definition in bacteriology. Int J Syst Bacteriol 1994; 44:846-849.
    • (1994) Int J Syst Bacteriol , vol.44 , pp. 846-849
    • Stackebrandt, E.1    Goebel, B.M.2
  • 48
    • 0036300743 scopus 로고    scopus 로고
    • Mucosa-associated bacteria in the human gastrointestinal tract are uniformly distributed along the colon and differ from the community recovered from feces
    • Zoetendal EG, von Wright A, Vilpponen-Salmela T, et al. Mucosa-associated bacteria in the human gastrointestinal tract are uniformly distributed along the colon and differ from the community recovered from feces. Appl Environ Microbiol 2002; 68:3401-3407.
    • (2002) Appl Environ Microbiol , vol.68 , pp. 3401-3407
    • Zoetendal, E.G.1    von Wright, A.2    Vilpponen-Salmela, T.3
  • 49
    • 18944401261 scopus 로고    scopus 로고
    • Biodiversity of the mucosa-associated microbiota is stable along the distal digestive tract in healthy individuals and patients with IBD
    • Lepage P, Seksik P, Sutren M, et al. Biodiversity of the mucosa-associated microbiota is stable along the distal digestive tract in healthy individuals and patients with IBD. Inflamm Bowel Dis 2005; 11:473-480.
    • (2005) Inflamm Bowel Dis , vol.11 , pp. 473-480
    • Lepage, P.1    Seksik, P.2    Sutren, M.3
  • 50
    • 33645110636 scopus 로고    scopus 로고
    • Molecular characterization of the bacteria adherent to human colorectal mucosa
    • Green GL, Brostoff J, Hudspith B, et al. Molecular characterization of the bacteria adherent to human colorectal mucosa. J Appl Microbiol 2006; 100:460-469.
    • (2006) J Appl Microbiol , vol.100 , pp. 460-469
    • Green, G.L.1    Brostoff, J.2    Hudspith, B.3
  • 51
    • 0036709733 scopus 로고    scopus 로고
    • Intestinal flora during the first months of life: New perspectives
    • Edwards CA, Parrett AM. Intestinal flora during the first months of life: new perspectives. Br J Nutr 2002; 88 (Suppl 1):S11-S18.
    • (2002) Br J Nutr , vol.88 , Issue.SUPPL. 1
    • Edwards, C.A.1    Parrett, A.M.2
  • 52
    • 34547129847 scopus 로고    scopus 로고
    • Development of the human infant intestinal microbiota
    • An extremely detailed examination of microbial succession in healthy newborns
    • Palmer C, Bik EM, Digiulio DB, et al. Development of the human infant intestinal microbiota. PLoS Biol 2007; 5:e177. An extremely detailed examination of microbial succession in healthy newborns.
    • (2007) PLoS Biol , vol.5
    • Palmer, C.1    Bik, E.M.2    Digiulio, D.B.3
  • 53
    • 0028135495 scopus 로고
    • Paneth cell differentiation in the developing intestine of normal and transgenic mice
    • Bry L, Falk P, Huttner K, et al. Paneth cell differentiation in the developing intestine of normal and transgenic mice. Proc Natl Acad Sci U S A 1994; 91:10335-10339.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 10335-10339
    • Bry, L.1    Falk, P.2    Huttner, K.3
  • 54
    • 0035793372 scopus 로고    scopus 로고
    • Molecular analysis of commensal host - microbial relationships in the intestine
    • Hooper LV, Wong MH, Thelin A, et al. Molecular analysis of commensal host - microbial relationships in the intestine. Science 2001; 291:881-884.
    • (2001) Science , vol.291 , pp. 881-884
    • Hooper, L.V.1    Wong, M.H.2    Thelin, A.3
  • 56
    • 0036917143 scopus 로고    scopus 로고
    • Fecal microbial diversity in a strict vegetarian as determined by molecular analysis and cultivation
    • Hayashi H, Sakamoto M, Benno Y. Fecal microbial diversity in a strict vegetarian as determined by molecular analysis and cultivation. Microbiol Immunol 2002; 46:819-831.
    • (2002) Microbiol Immunol , vol.46 , pp. 819-831
    • Hayashi, H.1    Sakamoto, M.2    Benno, Y.3
  • 57
    • 9644267200 scopus 로고    scopus 로고
    • Impact of consumption of oligosaccharide-containing biscuits on the fecal microbiota of humans
    • Tannock GW, Munro K, Bibiloni R, et al. Impact of consumption of oligosaccharide-containing biscuits on the fecal microbiota of humans. Appl Environ Microbiol 2004; 70:2129-2136.
    • (2004) Appl Environ Microbiol , vol.70 , pp. 2129-2136
    • Tannock, G.W.1    Munro, K.2    Bibiloni, R.3
  • 58
    • 11144238567 scopus 로고    scopus 로고
    • Microbiological effects of consuming a synbiotic containing Bifidobacterium bifidum, Bifidobacterium lactis, and oligofructose in elderly persons, determined by real-time polymerase chain reaction and counting of viable bacteria
    • Bartosch S, Woodmansey EJ, Paterson JC, et al. Microbiological effects of consuming a synbiotic containing Bifidobacterium bifidum, Bifidobacterium lactis, and oligofructose in elderly persons, determined by real-time polymerase chain reaction and counting of viable bacteria. Clin Infect Dis 2005; 40:28-37.
    • (2005) Clin Infect Dis , vol.40 , pp. 28-37
    • Bartosch, S.1    Woodmansey, E.J.2    Paterson, J.C.3
  • 59
    • 1542513850 scopus 로고    scopus 로고
    • Antibiotic-associated diarrhea accompanied by large-scale alterations in the composition of the fecal microbiota
    • Young VB, Schmidt TM. Antibiotic-associated diarrhea accompanied by large-scale alterations in the composition of the fecal microbiota. J Clin Microbiol 2004; 42:1203-1206.
    • (2004) J Clin Microbiol , vol.42 , pp. 1203-1206
    • Young, V.B.1    Schmidt, T.M.2
  • 60
    • 0025939784 scopus 로고
    • The assessment of faecal flora in patients with inflammatory bowel disease by a simplified bacteriological technique
    • Giaffer MH, Holdsworth CD, Duerden BI. The assessment of faecal flora in patients with inflammatory bowel disease by a simplified bacteriological technique. J Med Microbiol 1991; 35:238-241.
    • (1991) J Med Microbiol , vol.35 , pp. 238-241
    • Giaffer, M.H.1    Holdsworth, C.D.2    Duerden, B.I.3
  • 61
    • 0019818169 scopus 로고
    • Relation between concentrations of metronidazole and Bacteroides spp in faeces of patients with Crohn's disease and healthy individuals
    • Krook A, Lindstrom B, Kjellander J, et al. Relation between concentrations of metronidazole and Bacteroides spp in faeces of patients with Crohn's disease and healthy individuals. J Clin Pathol 1981; 34:645-650.
    • (1981) J Clin Pathol , vol.34 , pp. 645-650
    • Krook, A.1    Lindstrom, B.2    Kjellander, J.3
  • 62
    • 0024157187 scopus 로고
    • The obligate anaerobic faecal flora of patients with Crohn's disease and their first-degree relatives
    • Van de Merwe JP, Schroder AM, Wensick F, Hazenberg MP. The obligate anaerobic faecal flora of patients with Crohn's disease and their first-degree relatives. Scand J Gastroenterol 1988; 23:1125-1131.
    • (1988) Scand J Gastroenterol , vol.23 , pp. 1125-1131
    • Van de Merwe, J.P.1    Schroder, A.M.2    Wensick, F.3    Hazenberg, M.P.4
  • 63
    • 0037302961 scopus 로고    scopus 로고
    • Alterations of the dominant faecal bacterial groups in patients with Crohn's disease of the colon
    • Seksik P, Rigottier-Gois L, Gramet G, et al. Alterations of the dominant faecal bacterial groups in patients with Crohn's disease of the colon. Gut 2003; 52:237-242.
    • (2003) Gut , vol.52 , pp. 237-242
    • Seksik, P.1    Rigottier-Gois, L.2    Gramet, G.3
  • 64
    • 4644231021 scopus 로고    scopus 로고
    • Molecular inventory of faecal microflora in patients with Crohn's disease
    • Mangin I, Bonnet R, Seksik P, et al. Molecular inventory of faecal microflora in patients with Crohn's disease. FEMS Micro Ecol 2004; 50:25-36.
    • (2004) FEMS Micro Ecol , vol.50 , pp. 25-36
    • Mangin, I.1    Bonnet, R.2    Seksik, P.3
  • 65
    • 9144260143 scopus 로고    scopus 로고
    • Ribosomal DNA sequence analysis of mucosa-associated bacteria in Crohn's disease
    • Prindiville T, Cantrell M, Wilson KH. Ribosomal DNA sequence analysis of mucosa-associated bacteria in Crohn's disease. Inflamm Bowel Dis 2004; 10:824-833.
    • (2004) Inflamm Bowel Dis , vol.10 , pp. 824-833
    • Prindiville, T.1    Cantrell, M.2    Wilson, K.H.3
  • 66
    • 33750932588 scopus 로고    scopus 로고
    • Culture-independent analyses of temporal variation of the dominant fecal microbiota and targeted bacterial subgroups in Crohn's disease
    • Scanlan PD, Shanahan F, O'Mahony C, Marchesi JR. Culture-independent analyses of temporal variation of the dominant fecal microbiota and targeted bacterial subgroups in Crohn's disease. J Clin Microbiol 2006; 44:3980-3988.
    • (2006) J Clin Microbiol , vol.44 , pp. 3980-3988
    • Scanlan, P.D.1    Shanahan, F.2    O'Mahony, C.3    Marchesi, J.R.4
  • 67
    • 33947157141 scopus 로고    scopus 로고
    • Dysbiosis in pouchitis: Evidence of unique microfloral patterns in pouch inflammation
    • An initial examination of pouch inflammation following surgery for ulcerative colitis reveals an enrichment of several microbial groups, relative to noninflammed controls
    • Komanduri S, Gillevet PM, Sikaroodi M, et al. Dysbiosis in pouchitis: evidence of unique microfloral patterns in pouch inflammation. Clin Gastroenterol Hepatol 2007; 5:352-360. An initial examination of pouch inflammation following surgery for ulcerative colitis reveals an enrichment of several microbial groups, relative to noninflammed controls.
    • (2007) Clin Gastroenterol Hepatol , vol.5 , pp. 352-360
    • Komanduri, S.1    Gillevet, P.M.2    Sikaroodi, M.3


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