Tricyclic sulfonamides incorporating benzothiopyrano[4,3-c]pyrazole and pyridothiopyrano[4,3-c]pyrazole effectively inhibit α- And β-carbonic anhydrase: X-ray crystallography and solution investigations on 15 isoforms

Journal of Medicinal Chemistry

Volumn 55, Issue 22, 2012, Pages 9619-9629

  Marini, Anna M ^a   Maresca, Alfonso ^b   Aggarwal, Mayank ^c   Orlandini, Elisabetta ^a   Nencetti, Susanna ^a   Da Settimo, Federico ^a   Salerno, Silvia ^a   Simorini, Francesca ^a   La Motta, Concettina ^a   Taliani, Sabrina ^a   Nuti, Elisa ^a   Scozzafava, Andrea ^b   McKenna, Robert ^c   Rossello, Armando ^a   Supuran, Claudiu T ^b  

^a UNIVERSITY OF PISA   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

^c UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; BENZOTHIOPYRANO[4,3 C]PYRAZOLE; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE III; CARBONATE DEHYDRATASE IV; CARBONATE DEHYDRATASE IX; CARBONATE DEHYDRATASE V; CARBONATE DEHYDRATASE VA; CARBONATE DEHYDRATASE VB; CARBONATE DEHYDRATASE XII; CARBONATE DEHYDRATASE XIII; CARBONATE DEHYDRATASE XIV; CELECOXIB; PYRAZOLE DERIVATIVE; PYRIDOTHIOPYRANO[4,3 C]PYRAZOLE; RV3273 ENZYME; RV3588C ENZYME; SULFONAMIDE; UNCLASSIFIED DRUG; VALDECOXIB;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG INHIBITION; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SPECIFICITY; HUMAN; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HUMANS; ISOENZYMES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN CONFORMATION; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 84870021422     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300878g     Document Type: Article

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