Phenylethynylbenzenesulfonamide regioisomers strongly and selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic isoforms i and II

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 19, 2011, Pages 5892-5896

  Knaus, Edward E ^a   Innocenti, Alessio ^b   Scozzafava, Andrea ^b   Supuran, Claudiu T ^b  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Alkynylsulfonamide; Antitumor lead; Carbonic anhydrase; Isoform selective inhibitor; Isoforms I, II, IX, XII

Indexed keywords

ACETAZOLAMIDE; BENZENESULFONAMIDE DERIVATIVE; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE INHIBITOR; CARBONATE DEHYDRATASE IX; CARBONATE DEHYDRATASE XII; CELECOXIB; DICLOFENAMIDE; PHENYLETHYNYLBENZENESULFONAMIDE DERIVATIVE; SULFANILAMIDE; UNCLASSIFIED DRUG; VALDECOXIB;

ARTICLE; DRUG ACTIVITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; STEREOISOMERISM;

ANTIGENS, NEOPLASM; CARBONIC ANHYDRASE I; CARBONIC ANHYDRASE II; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; CYTOSOL; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; ISOENZYMES; MOLECULAR TARGETED THERAPY; NEOPLASMS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 80052564922     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.07.090     Document Type: Article

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