Structural analysis of charge discrimination in the binding of inhibitors to human carbonic anhydrases I and II

Journal of the American Chemical Society

Volumn 129, Issue 17, 2007, Pages 5528-5537

  Srivastava, D K ^a   Jude, Kevin M ^b   Banerjee, Abir L ^a   Haldar, Manas ^a   Manokaran, Sumathra ^a   Kooren, Joel ^a   Mallik, Sanku ^a   Christianson, David W ^b  

^a NORTH DAKOTA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDES; CHARGE TRANSFER; CONFORMATIONS; MOLECULAR DYNAMICS; STRUCTURAL ANALYSIS;

BENZENESULFONAMIDE; CARBONIC ANHYDRASES; CHARGE DISCRIMINATION;

ENZYMES;

BENZENESULFONAMIDE DERIVATIVE; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE II; CARBOXYLIC ACID DERIVATIVE; ENZYME INHIBITOR; FUNCTIONAL GROUP;

AMIDATION; ARTICLE; BINDING AFFINITY; BINDING SITE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME BINDING; ESTERIFICATION; HYDROGEN BOND; MICROCALORIMETRY; MOLECULAR RECOGNITION; PROTEIN INTERACTION; STRUCTURE ANALYSIS; SYNTHESIS; X RAY ANALYSIS;

CALORIMETRY; CARBONIC ANHYDRASE I; CARBONIC ANHYDRASE II; CARBONIC ANHYDRASE INHIBITORS; CRYSTALLOGRAPHY, X-RAY; HUMANS; INDICATORS AND REAGENTS; KINETICS; MODELS, MOLECULAR; PROTEIN BINDING; SPECTROMETRY, FLUORESCENCE; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; THERMODYNAMICS;

EID: 34247854899     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja068359w     Document Type: Article

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