Serendipitous fragment-based drug discovery: Ketogenic diet metabolites and statins effectively inhibit several carbonic anhydrases

Chemical Communications

Volumn 48, Issue 29, 2012, Pages 3551-3553

  Parkkila, Seppo ^a   Vullo, Daniela ^b   Maresca, Alfonso ^b   Carta, Fabrizio ^b   Scozzafava, Andrea ^b   Supuran, Claudiu T ^b  

^a TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXY 3 METHYL GLUTARYL COENZYME A REDUCTASE; 3 HYDROXYBUTYRIC ACID; ACETAZOLAMIDE; ACETOACETIC ACID; ANTICONVULSIVE AGENT; ANTINEOPLASTIC AGENT; ANTIOBESITY AGENT; ATORVASTATIN; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE III; CARBONATE DEHYDRATASE IV; CARBONATE DEHYDRATASE IX; CARBONATE DEHYDRATASE V; CARBONATE DEHYDRATASE XII; FLUINDOSTATIN; HARKOSERIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ISOENZYME; PHENOBARBITAL; ROSUVASTATIN; TOPIRAMATE; UNCLASSIFIED DRUG; ZONISAMIDE;

ARTICLE; CARCINOGENESIS; CHOLESTEROL SYNTHESIS; ENZYME INHIBITION; EPILEPTOGENESIS; HUMAN; KETOGENIC DIET; LIPOGENESIS; METABOLITE; MITOCHONDRION;

EID: 84858403123     PISSN: 13597345     EISSN: 1364548X     Source Type: Journal    
DOI: 10.1039/c2cc30359k     Document Type: Article

References (25)

1. E. H. Kossoff, B. A. Zupec-Kania, J. M. Rho, J. Child Neurol., 2009, 24, 979.
2. J. Freeman, P. Veggiotti, G. Lanzi, A. Tagliabue, E. Perucca, Epilepsy Res., 2006, 68, 145.
3. M. J. MacDonald, M. J. Longacre, S. W. Stoker, M. Kendrick, A. Thonpho, L. J. Brown, N. M. Hasan, S. Jitrapakdee, T. Fukao, M. S. Hanson, L. A. Fernandez, J. Odorico, J. Biol. Chem., 2011, 286, 18383.
4. C. T. Supuran and J. Y. Winum, in Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural, and Disease Applications, ed. C. T. Supuran and J. Y. Winum, Wiley, Hoboken, 2009, pp. 3-12.
5. G. De Simone, C. T. Supuran, J. Inorg. Biochem., 2012, doi:10.1016/j.jinorgbio.2011.11.017.
6. A. Innocenti, D. Vullo, A. Scozzafava, J. R. Casey, C. T. Supuran, Bioorg. Med. Chem. Lett., 2005, 15, 573-578.
7. F. Carta, A. Innocenti, R. A. Hall, F. A. Mühlschlegel, A. Scozzafava, C. T. Supuran, Bioorg. Med. Chem. Lett., 2011, 21, 2521.
8. C. T. Supuran, Nat. Rev. Drug Discovery, 2008, 7, 168.
9. K. K. Ray, S. R. K. Seshasai, S. Erqou, P. Sever, J. W. Jukema, I. Ford, N. Sattar, Arch. Intern. Med., 2010, 170, 1024.
10. A. Endo, J. Lipid Res., 1992, 33, 1569.
11. A. Casini, J. Antel, F. Abbate, A. Scozzafava, S. David, H. Waldeck, S. Schäfer, C. T. Supuran, Bioorg. Med. Chem. Lett., 2003, 13, 841.
12. G. De Simone, A. Di Fiore, V. Menchise, C. Pedone, J. Antel, A. Casini, A. Scozzafava, M. Wurl, C. T. Supuran, Bioorg. Med. Chem. Lett., 2005, 15, 2315.
13. C. Temperini, A. Innocenti, A. Scozzafava, S. Parkkila, C. T. Supuran, J. Med. Chem., 2010, 53, 850.
14. P. F. Morrison, P. L. Pyzik, R. Hamdy, A. L. Hartman, E. H. Kossoff, Epilepsia, 2009, 50, 1999.
15. M. Bardou, A. Barkun, M. Martel, Gut, 2010, 59, 1572.
16. Y. H. Chen, B. Feng, Z. W. Chen, Exp. Clin. Endocrinol. Diabetes, 2012, 120, 116.
17. D. Neri, C. T. Supuran, Nat. Rev. Drug Discovery, 2011, 10, 767.
18. T. O. Price, V. Eranki, W. A. Banks, N. Ercal, G. N. Shah, Endocrinology, 2012, 153, 362.
19. R. G. Khalifah, J. Biol. Chem., 1971, 246, 2561.
20. C. T. Supuran, A. Di Fiore, G. De Simone, Expert Opin. Emerging Drugs, 2008, 13, 383.
21. F. Pacchiano, M. Aggarwal, B. S. Avvaru, A. H. Robbins, A. Scozzafava, R. McKenna, C. T. Supuran, Chem. Commun., 2010, 46, 8371.
22. A. Maresca, C. Temperini, H. Vu, N. B. Pham, S. A. Poulsen, A. Scozzafava, R. J. Quinn, C. T. Supuran, J. Am. Chem. Soc., 2009, 131, 3057.
23. G. De Simone, A. Scozzafava, C. T. Supuran, Chem. Biol. Drug Des., 2009, 74, 317.
24. A. Di Fiore, A. Maresca, V. Alterio, C. T. Supuran, G. De Simone, Chem. Commun., 2011, 47, 11636.
25. F. Carta, M. Aggarwal, A. Maresca, A. Scozzafava, R. McKenna, C. T. Supuran, Chem. Commun., 2012, 48, 1868.