Structure and Inhibition of the CO2-Sensing Carbonic Anhydrase Can2 from the Pathogenic Fungus Cryptococcus neoformans

Journal of Molecular Biology

Volumn 385, Issue 4, 2009, Pages 1207-1220

  Schlicker, Christine ^a   Hall, Rebecca A ^b   Vullo, Daniela ^c   Middelhaufe, Sabine ^a   Gertz, Melanie ^a   Supuran, Claudiu T ^c   Mühlschlegel, Fritz A ^b   Steegborn, Clemens ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b UNIVERSITY OF KENT   (United Kingdom)

^c UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Cryptococcus neoformans; crystal structure; inhibition; sulfonamide; class carbonic anhydrase

Indexed keywords

4 (2 AMINO PYRIMIDIN 4 YL)BENZENESULFONAMIDE; 4 (4 SULFANILYLAMINOETHYL)BENZENESULFONAMIDE; 4 AMINO 6 CHLORO BENZENE 1,3 DISULFONAMIDE; 4 HYDROXYETHYLBENZENESULFONAMIDE; 4 METHYLBENZENESULFONAMIDE; ACETAZOLAMIDE; BENZOLAMIDE; BRINZOLAMIDE; CARBON DIOXIDE; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE INHIBITOR; CARZENIDE; CELECOXIB; CHLORAZOLAMIDE; DICLOFENAMIDE; DORZOLAMIDE; ETHOXZOLAMIDE; INDISULAM; MAFENIDE; METHAZOLAMIDE; ORTHANILAMIDE; SACCHARIN; SULFANILAMIDE; SULFONAMIDE; SULPIRIDE; SULTIAME; TOPIRAMATE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALDECOXIB; ZONISAMIDE; ACETIC ACID DERIVATIVE; CARBONATE DEHYDRATASE; FUNGAL PROTEIN; MUTANT PROTEIN; SULFAMIC ACID; SULFONIC ACID DERIVATIVE;

AMINO TERMINAL SEQUENCE; ARTICLE; CANDIDA ALBICANS; CRYPTOCOCCUS NEOFORMANS; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME STRUCTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETIC COMPLEMENTATION; METABOLISM; MOLECULAR GENETICS; PROTEIN SECONDARY STRUCTURE; SEQUENCE ALIGNMENT; STATIC ELECTRICITY; X RAY CRYSTALLOGRAPHY;

CANDIDA ALBICANS; FILOBASIDIELLA NEOFORMANS; FUNGI;

ACETATES; AMINO ACID SEQUENCE; CANDIDA ALBICANS; CARBON DIOXIDE; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; CATALYTIC DOMAIN; CRYPTOCOCCUS NEOFORMANS; CRYSTALLOGRAPHY, X-RAY; FUNGAL PROTEINS; GENETIC COMPLEMENTATION TEST; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; PROTEIN STRUCTURE, SECONDARY; SEQUENCE ALIGNMENT; STATIC ELECTRICITY; SULFONAMIDES; SULFONIC ACIDS;

EID: 58149330109     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2008.11.037     Document Type: Article

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