Prevailing importance of the hedgehog signaling pathway and the potential for treatment advancement in sarcoma

Pharmacology and Therapeutics

Volumn 136, Issue 2, 2012, Pages 153-168

  Kelleher, Fergal C ^a   Cain, Jason E ^b   Healy, Joan M ^c   Watkins, D Neil ^b   Thomas, David M ^a  

^a PETER MACCALLUM CANCER CENTRE   (Australia)

^b HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c ST VINCENT S UNIVERSITY HOSPITAL   (Ireland)

Author keywords

Chondrosarcoma; Hedgehog signaling; Patched; Sarcoma; Smoothened; Vismodegib

Indexed keywords

BMS 833923; CYCLOPAMINE; LEQ 506; ONCOPROTEIN; PF 04449913; SARIDEGIB; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; SONIDEGIB; TRANSCRIPTION FACTOR GLI1; UNCLASSIFIED DRUG; VISMODEGIB;

APOPTOSIS; BASAL CELL CARCINOMA; CARTILAGE CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; CHONDROSARCOMA; CONNECTIVE TISSUE TUMOR; CORRELATION COEFFICIENT; EPIPHYSIS PLATE; EWING SARCOMA; FIBROMA; GENE EXPRESSION; GROWTH PLATE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MEDULLOBLASTOMA; MESENCHYMAL STEM CELL; NONHUMAN; OSTEOSARCOMA; OVARY TUMOR; PRIORITY JOURNAL; PROGNOSIS; REVIEW; RHABDOMYOSARCOMA; SARCOMA; SIGNAL TRANSDUCTION;

ANILIDES; ANIMALS; APOPTOSIS; BASAL CELL NEVUS SYNDROME; CARCINOMA, BASAL CELL; CHONDROSARCOMA; HEDGEHOG PROTEINS; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MEDULLOBLASTOMA; MESENCHYMAL STROMAL CELLS; OSTEOSARCOMA; PYRIDINES; SARCOMA; SIGNAL TRANSDUCTION;

EID: 84867332609     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2012.08.004     Document Type: Review

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