Cyclopamine treatment of full-blown Hh/Ptch-associated RMS partially inhibits Hh/Ptch signaling, but not tumor growth

Molecular Carcinogenesis

Volumn 47, Issue 5, 2008, Pages 361-372

  Ecke, Ines ^a   Rosenberger, Albert ^a   Obenauer, Silvia ^a   Dullin, Christian ^a   Aberger, Fritz ^b   Kimmina, Sarah ^a   Schweyer, Stefan ^a   Hahn, Heidi ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b UNIVERSITY OF SALZBURG   (Austria)

Author keywords

Full blown tumors; Hedgehog signaling; In vivo application of cyclopamine; Patched mutation; Rhabdomyosarcoma

Indexed keywords

CYCLOPAMINE; DOXORUBICIN; IOTROLAN; PROTEIN PATCHED 1; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; ANTINEOPLASTIC ANTIBIOTIC; CELL SURFACE RECEPTOR; GLI PROTEIN, MOUSE; IGF2 PROTEIN, MOUSE; KRUPPEL LIKE FACTOR; MESSENGER RNA; PATCHED RECEPTORS; SOMATOMEDIN B; VERATRUM ALKALOID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; GENE AMPLIFICATION; GENE EXPRESSION; GROWTH INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RHABDOMYOSARCOMA; SIGNAL TRANSDUCTION; TUMOR GROWTH; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CELL STRAIN 3T3; GENE EXPRESSION PROFILING; GENETICS; HUMAN; MALE; MEDULLOBLASTOMA; METABOLISM; PATHOLOGY; PHYSIOLOGY; PROSTATE TUMOR; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SURVIVAL RATE; WESTERN BLOTTING;

ERINACEIDAE; MUS; VERATRUM CALIFORNICUM;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BLOTTING, WESTERN; CELL PROLIFERATION; DOXORUBICIN; GENE EXPRESSION PROFILING; HEDGEHOG PROTEINS; HUMANS; INSULIN-LIKE GROWTH FACTOR II; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MALE; MEDULLOBLASTOMA; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; NIH 3T3 CELLS; PROSTATIC NEOPLASMS; RECEPTORS, CELL SURFACE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RHABDOMYOSARCOMA; RNA, MESSENGER; SIGNAL TRANSDUCTION; SURVIVAL RATE; VERATRUM ALKALOIDS;

EID: 42949106939     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.20394     Document Type: Article

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