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Volumn 14, Issue 3, 2012, Pages 197-206

PAX7-FKHR fusion gene inhibits myogenic differentiation via NF-kappaB upregulation

Author keywords

ARMS; NF kappaB; PAX7 FKHR; PI3K AKT

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE 4; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MYOD1 PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

EID: 84860739005     PISSN: 1699048X     EISSN: 16993055     Source Type: Journal    
DOI: 10.1007/s12094-012-0784-4     Document Type: Article
Times cited : (15)

References (38)
  • 2
    • 0037102443 scopus 로고    scopus 로고
    • Genetic heterogeneity in the alveolar rhabdomyosarcoma subset without typical gene fusions
    • Barr FG, Qualman SJ, Macris MH et al (2002). Genetic heterogeneity in the alveolar rhabdomyosarcoma subset without typical gene fusions. Cancer Res 62:4704-4710
    • (2002) Cancer Res , vol.62 , pp. 4704-4710
    • Barr, F.G.1    Qualman, S.J.2    MacRis, M.H.3
  • 3
    • 0035839886 scopus 로고    scopus 로고
    • Gene fusions involving PAX and FOX family members in alveolar rhabdomyosarcoma
    • DOI 10.1038/sj.onc.1204599
    • Barr FG (2001) Gene fusions involving PAX and FOX family members in alveolar rhabdomyosarcoma. Oncogene 20:5736-5746 (Pubitemid 32928111)
    • (2001) Oncogene , vol.20 , Issue.40 REV. ISS. 4 , pp. 5736-5746
    • Barr, F.G.1
  • 4
    • 0029154584 scopus 로고
    • Wild type PAX3 protein and the PAX3FKHR fusion protein of alveolar rhabdomyosarcoma contain potent, structurally distinct transcriptional activation domains
    • Bennicelli JL, Fredericks WJ, Wilson RB et al (1995) Wild type PAX3 protein and the PAX3FKHR fusion protein of alveolar rhabdomyosarcoma contain potent, structurally distinct transcriptional activation domains. Oncogene 11:119-130
    • (1995) Oncogene , vol.11 , pp. 119-130
    • Bennicelli, J.L.1    Fredericks, W.J.2    Wilson, R.B.3
  • 5
    • 0034737605 scopus 로고    scopus 로고
    • The COOH-terminal transactivation domain plays a key role in regulating the in vitro and in vivo function of Pax3 homeodomain
    • DOI 10.1074/jbc.275.13.9854
    • Cao Y, Wang C (2000) The COOH-terminal transactivation domain plays a key role in regulating the in vitro and in vivo function of Pax3 homeodomain. J Biol Chem 275:9854-9862 (Pubitemid 30185222)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.13 , pp. 9854-9862
    • Cao, Y.1    Wang, C.2
  • 6
    • 53049083206 scopus 로고    scopus 로고
    • Mouse mesenchymal stem cells expressing PAXFKHR form alveolar rhabdomyosarcomas by cooperating with secondary mutations
    • Ren YX, Finckenstein FG, Abdueva DA (2008) Mouse mesenchymal stem cells expressing PAXFKHR form alveolar rhabdomyosarcomas by cooperating with secondary mutations. Cancer Res 68:6587-6597
    • (2008) Cancer Res , vol.68 , pp. 6587-6597
    • Ren, Y.X.1    Finckenstein, F.G.2    Abdueva, D.A.3
  • 7
    • 0037742405 scopus 로고    scopus 로고
    • Ewing tumor fusion proteins block the differentiation of pluripotent marrow stromal cells
    • Torchia EC, Jaishankar S, Baker SJ (2003) Ewing tumor fusion proteins block the differentiation of pluripotent marrow stromal cells. Cancer Res 63: 3464-3468 (Pubitemid 36793021)
    • (2003) Cancer Research , vol.63 , Issue.13 , pp. 3464-3468
    • Torchia, E.C.1    Jaishankar, S.2    Baker, S.J.3
  • 8
    • 34548446433 scopus 로고    scopus 로고
    • Sarcomas: Genetics, signalling, and cellular origins. Part I: The fellowship of TET
    • DOI 10.1002/path.2209
    • Riggi N, Cironi L, Suva ML et al (2007) Sarcomas: genetics, signalling, and cellular origins. Part 1: The fellowship of TET. J Pathol 213:4-20 (Pubitemid 47354561)
    • (2007) Journal of Pathology , vol.213 , Issue.1 , pp. 4-20
    • Riggi, N.1    Cironi, L.2    Suva, M.-L.3    Stamenkovic, I.4
  • 10
    • 0036234459 scopus 로고    scopus 로고
    • Missing pieces in the NF-kappaB puzzle
    • Ghosh S, Karin M (2002) Missing pieces in the NF-kappaB puzzle. Cell 109[Suppl]:S81-96
    • (2002) Cell , vol.109 , Issue.SUPPL.
    • Ghosh, S.1    Karin, M.2
  • 11
  • 12
    • 54549119169 scopus 로고    scopus 로고
    • NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcoma
    • Wang H, Garzon R, Sun H et al (2008) NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcoma. Cancer Cell 14:369-381
    • (2008) Cancer Cell , vol.14 , pp. 369-381
    • Wang, H.1    Garzon, R.2    Sun, H.3
  • 14
    • 0028840711 scopus 로고
    • Detection of chimeric transcripts in desmoplastic small round cell tumor and related developmental tumors by reverse transcriptase polymerase chain reaction. A speci? c diagnostic assay
    • de Alava E, Ladanyi M, Rosai J et al (1995) Detection of chimeric transcripts in desmoplastic small round cell tumor and related developmental tumors by reverse transcriptase polymerase chain reaction. A speci? c diagnostic assay. Am J Pathol 147:1584-1591
    • (1995) Am J Pathol , vol.147 , pp. 1584-1591
    • De Alava, E.1    Ladanyi, M.2    Rosai, J.3
  • 15
    • 79958232040 scopus 로고    scopus 로고
    • Alternate Pax3 and Pax7 C-terminal isoforms in myogenic differentiation and sarcomagenesis
    • Charytonowicz E, Matushansky I, Castillo-Martin M et al (2011) Alternate Pax3 and Pax7 C-terminal isoforms in myogenic differentiation and sarcomagenesis. Clin Trans Oncol 13:194-203
    • (2011) Clin Trans Oncol , vol.13 , pp. 194-203
    • Charytonowicz, E.1    Matushansky, I.2    Castillo-Martin, M.3
  • 16
    • 52949120373 scopus 로고    scopus 로고
    • Inactivation of NF-kappaB by proteasome inhibition contributes to increased apoptosis induced by histone deacetylase inhibitors in human breast cancer cells
    • Domingo-Domenech J, Pippa R, Tapia M et al (2008) Inactivation of NF-kappaB by proteasome inhibition contributes to increased apoptosis induced by histone deacetylase inhibitors in human breast cancer cells. Breast Cancer Res Treat 112: 53-62
    • (2008) Breast Cancer Res Treat , vol.112 , pp. 53-62
    • Domingo-Domenech, J.1    Pippa, R.2    Tapia, M.3
  • 17
    • 77955495968 scopus 로고    scopus 로고
    • LY294002 may overcome 5-FU resistance via down-regulation of activated p-AKT in Epstein-Barr viruspositive gastric cancer cells
    • Shin JY, Kim JO, Lee SK et al (2010) LY294002 may overcome 5-FU resistance via down-regulation of activated p-AKT in Epstein-Barr viruspositive gastric cancer cells. BMC Cancer 10:425
    • (2010) BMC Cancer , vol.10 , pp. 425
    • Shin, J.Y.1    Kim, J.O.2    Lee, S.K.3
  • 19
    • 42649130645 scopus 로고    scopus 로고
    • Pax3 activation promotes the differentiation of mesenchymal stem cells toward the myogenic lineage
    • Gang EJ, Bosnakovski D, Simsek T et al (2008) Pax3 activation promotes the differentiation of mesenchymal stem cells toward the myogenic lineage. Exp Cell Res 314:1721-1733
    • (2008) Exp Cell Res , vol.314 , pp. 1721-1733
    • Gang, E.J.1    Bosnakovski, D.2    Simsek, T.3
  • 20
    • 33746924453 scopus 로고    scopus 로고
    • Expression of the FUS-CHOP fusion protein in primary mesenchymal progenitor cells gives rise to a model of myxoid liposarcoma
    • DOI 10.1158/0008-5472.CAN-05-3979
    • Riggi N, Cironi L, Provero P et al (2006) Expression of the FUS-CHOP fusion protein in primary mesenchymal progenitor cells gives rise to a model of myxoid liposarcoma. Cancer Res 66: 7016-7023 (Pubitemid 44197677)
    • (2006) Cancer Research , vol.66 , Issue.14 , pp. 7016-7023
    • Riggi, N.1    Cironi, L.2    Provero, P.3    Suva, M.-L.4    Stehle, J.-C.5    Baumer, K.6    Guillou, L.7    Stamenkovic, I.8
  • 22
    • 0030271387 scopus 로고    scopus 로고
    • NF-kappa B: Ten years after
    • Baeuerle PA, Baltimore D (1996) NF-kappa B: ten years after. Cell 87:13-20
    • (1996) Cell , vol.87 , pp. 13-20
    • Baeuerle, P.A.1    Baltimore, D.2
  • 23
    • 34250898562 scopus 로고    scopus 로고
    • NF-κB as a potential molecular target for cancer therapy
    • Lee CH, Jeon YT, Kim SH et al (2007) NFkappaB as a potential molecular target for cancer therapy. Biofactors 29:19-35 (Pubitemid 46985299)
    • (2007) BioFactors , vol.29 , Issue.1 , pp. 19-35
    • Lee, C.H.1    Jeon, Y.-T.2    Kim, S.-H.3    Song, Y.-S.4
  • 24
    • 0037119428 scopus 로고    scopus 로고
    • Akt is a downstream target of NF-kappa B
    • Meng F, Liu L, Chin PC et al (2002) Akt is a downstream target of NF-kappa B. J Biol Chem 2: 29674-29680
    • (2002) J Biol Chem , vol.2 , pp. 29674-29680
    • Meng, F.1    Liu, L.2    Chin, P.C.3
  • 25
    • 0034528405 scopus 로고    scopus 로고
    • Myogenic differentiation requires signalling through both phosphatidylinositol 3-kinase and p38 MAP kinase
    • DOI 10.1016/S0898-6568(00)00120-0, PII S0898656800001200
    • Li Y, Jiang B, Ensign WY et al (2000) Myogenic differentiation requires signalling through both phosphatidylinositol 3-kinase and p38 MAP kinase. Cell Signal 12:751-757 (Pubitemid 32056343)
    • (2000) Cellular Signalling , vol.12 , Issue.11-12 , pp. 751-757
    • Li, Y.1    Jiang, B.-H.2    Ensign Jr., W.Y.3    Vogt, P.K.4    Han, J.5
  • 26
    • 0034870176 scopus 로고    scopus 로고
    • LY 294002, an inhibitor of phosphatidylinositol 3-kinase, inhibits GH-mediated expression of the IGF-I gene in rat hepatocytes
    • DOI 10.1210/en.142.9.3980
    • Shoba LN, Newman M, Liu W et al (2001) LY 294002, an inhibitor of phosphatidylinositol 3-kinase, inhibits GH-mediated expression of the IGF-I gene in rat hepatocytes. Endocrinology 142: 3980-3986 (Pubitemid 32802671)
    • (2001) Endocrinology , vol.142 , Issue.9 , pp. 3980-3986
    • Shoba, L.N.N.1    Newman, M.2    Liu, W.3    Lowe Jr., W.L.4
  • 27
    • 0034730251 scopus 로고    scopus 로고
    • NF-kappaB-induced loss of MyoD messenger RNA: Possible role in muscle decay and cachexia
    • Guttridge DC, Mayo MW, Madrid LV et al (2000) NF-kappaB-induced loss of MyoD messenger RNA: possible role in muscle decay and cachexia. Science 289:2363-2366
    • (2000) Science , vol.289 , pp. 2363-2366
    • Guttridge, D.C.1    Mayo, M.W.2    Madrid, L.V.3
  • 29
    • 0033572867 scopus 로고    scopus 로고
    • 1 cdk kinase activity by MyoD promotes myoblast cell cycle withdrawal and terminal differentiation
    • Zhang JM, Zhao X, Wei Q et al (1999) Direct inhibition of G(1) cdk kinase activity by MyoD promotes myoblast cell cycle withdrawal and terminal differentiation. EMBO J 18:6983-6993 (Pubitemid 30000451)
    • (1999) EMBO Journal , vol.18 , Issue.24 , pp. 6983-6993
    • Zhang, J.-M.1    Zhao, X.2    Wei, Q.3    Paterson, B.M.4
  • 30
    • 69249230769 scopus 로고    scopus 로고
    • Mammalian cell-cycle regulation: Several Cdks, numerous cyclins and diverse compensatory mechanisms
    • Satyanarayana A, Kaldis P (2009) Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms. Oncogene 28:2925-2939
    • (2009) Oncogene , vol.28 , pp. 2925-2939
    • Satyanarayana, A.1    Kaldis, P.2
  • 31
    • 0033558347 scopus 로고    scopus 로고
    • Coupling of the cell cycle and myogenesis through the cyclin D1-dependent interaction of MyoD with cdk4
    • DOI 10.1093/emboj/18.4.926
    • Zhang JM, Wei Q, Zhao X et al (1999) Coupling of the cell cycle and myogenesis through the cyclin D1-dependent interaction of MyoD with cdk4. EMBO J 18:926-933 (Pubitemid 29082272)
    • (1999) EMBO Journal , vol.18 , Issue.4 , pp. 926-933
    • Zhang, J.-M.1    Wei, Q.2    Zhao, X.3    Paterson, B.M.4
  • 32
    • 77957680199 scopus 로고    scopus 로고
    • Regulation of promyogenic signal transduction by cell-cell contact and adhesion
    • Krauss RS (2010) Regulation of promyogenic signal transduction by cell-cell contact and adhesion. Exp Cell Res 316:3042-3049
    • (2010) Exp Cell Res , vol.316 , pp. 3042-3049
    • Krauss, R.S.1
  • 34
    • 67349218119 scopus 로고    scopus 로고
    • Alveolar rhabdomyosarcoma: Is the cell of origin a mesenchymal stem cell?
    • Charytonowicz E, Cordon-Cardo C, Matushansky I et al (2009) Alveolar rhabdomyosarcoma: is the cell of origin a mesenchymal stem cell? Cancer Lett 279:126-136
    • (2009) Cancer Lett , vol.279 , pp. 126-136
    • Charytonowicz, E.1    Cordon-Cardo, C.2    Matushansky, I.3
  • 35
    • 0025944330 scopus 로고
    • Muscle-speci? c gene expression in rhabdomyosarcomas and stages of human fetal skeletal muscle development
    • Tonin PN, Scrable H, Shimada H et al (1991) Muscle-speci? c gene expression in rhabdomyosarcomas and stages of human fetal skeletal muscle development. Cancer Res 51:5100-5106
    • (1991) Cancer Res , vol.51 , pp. 5100-5106
    • Tonin, P.N.1    Scrable, H.2    Shimada, H.3
  • 36
    • 0011227194 scopus 로고
    • Basic fibroblast growth factor in human rhabdomyosarcoma cells: Implications for the proliferation and neovascularization of myoblast-derived tumors
    • DOI 10.1073/pnas.84.3.842
    • Schweigerer L, Neufeld G, Mergia A et al (1987) Basic fibroblast growth factor in human rhabdomyosarcoma cells: implications for the proliferation and neovascularization of myoblast-derived tumors. Proc Natl Acad Sci U S A 84:842-846 (Pubitemid 17033903)
    • (1987) Proceedings of the National Academy of Sciences of the United States of America , vol.84 , Issue.3 , pp. 842-846
    • Schweigerer, L.1    Neufeld, G.2    Mergia, A.3
  • 37
    • 70449450426 scopus 로고    scopus 로고
    • Identi? cation of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models
    • Taylor JG, Cheuk AT, Tsang PS et al (2009) Identi? cation of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models. J Clin Invest 119: 3395-3407
    • (2009) J Clin Invest , vol.119 , pp. 3395-3407
    • Taylor, J.G.1    Cheuk, A.T.2    Tsang, P.S.3
  • 38
    • 68549119132 scopus 로고    scopus 로고
    • Regulation of skeletal muscle stem cell behavior by Pax3 and Pax7
    • Lagha M, Sato T, Bajard L et al (2008) Regulation of skeletal muscle stem cell behavior by Pax3 and Pax7. Cold Spring Harb Symp Quant Biol 73: 307-315
    • (2008) Cold Spring Harb Symp Quant Biol , vol.73 , pp. 307-315
    • Lagha, M.1    Sato, T.2    Bajard, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.