Role of the Hedgehog/Patched signaling pathway in oncogenesis: A new polymorphism in the PTCH gene in ovarian fibroma

Annals of the New York Academy of Sciences

Volumn 1030, Issue , 2004, Pages 134-143

  Levanat, Sonja ^a   Musani, Vesna ^a   Komar, Arijana ^a   Oreskovic S ^b  

^a RUDER BO KOVI INSTITUTE   (Croatia)

^b UNIVERSITY OF ZAGREB   (Croatia)

Author keywords

GLI1; Hedgehog Patched signaling; Ovarian dermoids; Ovarian fibromas; PTCH; PTCH polymorphisms; SHH; SMO

Indexed keywords

MEMBRANE PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1;

CARCINOGENESIS; CONFERENCE PAPER; CONTROLLED STUDY; DNA POLYMORPHISM; FIBROMA; GENE EXPRESSION; GENE LOCUS; GENE OVEREXPRESSION; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; OVARY FIBROMA; OVARY TERATOMA; OVARY TUMOR; SIGNAL TRANSDUCTION;

ERINACEIDAE;

EID: 15044360576     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1329.017     Document Type: Conference Paper

References (16)

1. HAHN, H., C. WICKING, C. ZAPHIROPOULOS, et al. 1996. Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell 85: 841-851.
2. LEVANAT, S., R.J. GORLIN, S. FALLET, et al. 1996. A two hit model for developmental defects in Gorlin syndrome. Nat. Genet. 12: 85-87.
3. LEVANAT, S., B. PAVELIĆ, I. CRNIĆ, et al. 2000. Involvement of PTCH gene in various noninflammatory cysts. J. Mol. Med. 78: 140-146.
4. INGHAM, P.W. 1998. The patched aene in development and cancer. Curr. Opin. Genet. Dev. 8: 88-94.
5. PASCA DI MAGLIANO, M. & M. HEBROK. 2003. Hedgehog signaling in cancer formation and maintenance. Nat. Rev. 3: 903-911.
6. REGL, G., G.W. NEIL, T. EICHBERGER, et al. 2002. Human GLI2 and GLI1 are part of a positive feedback mechanism in basal cell carcinoma. Oncogene 21: 5529-5539.
7. MULLOR, J.L., P. SANCHEZ & A. RUIZ. 2002. Pathway and consequences: hedgehog signaling in human disease. Trends Cell Biol. 12: 562-569.
8. PIETSCH, T., A. WAHA, J. KRAUS, et al. 1997. Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched. Cancer Res. 57: 2085-2088.
9. LEVANAT, S., M. ŠITUM, I. CRNIĆ, et al. 2003. Alterations in CDKN2A locus as potential indicator of melanoma predisposition in relatives of non-familial melanoma cases. Croat. Med. J. 44: 418-424.
10. MITCHELL, L.G., A. BODENTEICH & C.R. MERRIL. 1996. Use of silver staining to detect nucleic acids. Methods Mol. Biol. 58: 97-103.
11. TOJO, M., H. KIYOSAWA, K. IWATSUKI, et al. 2002. Expression of a sonic hedgehog signal transducer, hedgehog-interacting protein, by human basal cell carcinoma. Br. J. Dermatol. 146: 69-73.
12. KALLASY, M., R. TOFTGARD, M. UEDA, et al. 1997. Patched-(ptch) associated preferential expression of smoothened in human basal cell carcinoma of the skin. Cancer Res. 57: 4731-4735.
13. EKLUND, E.K., E. LINDSTROM, A.B. UNDEN, et al. 1998. Mutation analysis of the human homologue of Drosophila patched and xeroderma pigmentosum complementation group A genes in squamous cell carcinomas of the skin. Mol. Carcinogenesis 21: 87-92.
14. DONG, J., M.R. GAILANI, S.L. POMEKOY, et al. 2000. Identilication of PATCHED mutations in medulloblastomas by direct sequencing. Hum. Mutat. 16: 89-90.
15. EVANS, T., W. BOONCHAI, S. SHANLEY, et al. 2000. The spectrum of patched mutations in a collection of Australian basal cell carcinomas. Hum. Mutat. 16: 43-48.
16. HASENPUSCH-THEIL, K., V. BATAILLE, J. LAEHDETIE, et al. 1997. Gorlin syndrome: identification of 4 novel germ-line mutations of the human patched (PTCH) gene. Hum. Mutat. Mutations in Brief Online #137. 〈http://journals. wiley.com/1059-7794〉 (1999.06.18)