Mesenchymal Stem Cell Features of Ewing Tumors

Cancer Cell

Volumn 11, Issue 5, 2007, Pages 421-429

  Tirode, Franck ^a,b   Laud Duval, Karine ^a,b   Prieur, Alexandre ^a,b   Delorme, Bruno ^c,d   Charbord, Pierre ^c,d   Delattre, Olivier ^a,b  

^a INSTITUT CURIE   (France)

^b INSTITUT CURIE   (France)

^c INSERM   (France)

^d UNIVERSITÉ DE TOURS   (France)

Author keywords

STEMCELL

Indexed keywords

RNA BINDING PROTEIN EWS; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR FLI 1; TRANSCRIPTION FACTOR RUNX2; TRANSCRIPTION FACTOR SOX9;

ADIPOGENESIS; ARTICLE; CANCER CELL CULTURE; CELL DIFFERENTIATION; CELL LINEAGE; COMPUTER MODEL; CONTROLLED STUDY; EWING SARCOMA; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; MESENCHYMAL STEM CELL; MICROARRAY ANALYSIS; PRIORITY JOURNAL;

EID: 34247570879     PISSN: 15356108     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ccr.2007.02.027     Document Type: Article

References (44)

1. Arvand A., and Denny C.T. Biology of EWS/ETS fusions in Ewing's family tumors. Oncogene 20 (2001) 5747-5754
2. Basch M.L., Bronner-Fraser M., and Garcia-Castro M.I. Specification of the neural crest occurs during gastrulation and requires Pax7. Nature 441 (2006) 218-222
3. Boquest A.C., Shahdadfar A., Fronsdal K., Sigurjonsson O., Tunheim S.H., Collas P., and Brinchmann J.E. Isolation and transcription profiling of purified uncultured human stromal stem cells: Alteration of gene expression after in vitro cell culture. Mol. Biol. Cell 16 (2005) 1131-1141
4. Brown L.A., Rodaway A.R., Schilling T.F., Jowett T., Ingham P.W., Patient R.K., and Sharrocks A.D. Insights into early vasculogenesis revealed by expression of the ETS-domain transcription factor Fli-1 in wild-type and mutant zebrafish embryos. Mech. Dev. 90 (2000) 237-252
5. Castillero-Trejo Y., Eliazer S., Xiang L., Richardson J.A., and Ilaria Jr. R.L. Expression of the EWS/FLI-1 oncogene in murine primary bone-derived cells Results in EWS/FLI-1-dependent, ewing sarcoma-like tumors. Cancer Res. 65 (2005) 8698-8705
6. Cavazzana A.O., Miser J.S., Jefferson J., and Triche T.J. Experimental evidence for a neural origin of Ewing's sarcoma of bone. Am. J. Pathol. 127 (1987) 507-518
7. Chansky H.A., Barahmand-Pour F., Mei Q., Kahn-Farooqi W., Zielinska-Kwiatkowska A., Blackburn M., Chansky K., Conrad III E.U., Bruckner J.D., Greenlee T.K., and Yang L. Targeting of EWS/FLI-1 by RNA interference attenuates the tumor phenotype of Ewing's sarcoma cells in vitro. J. Orthop. Res. 22 (2004) 910-917
8. Covas D.T., Piccinato C.E., Orellana M.D., Siufi J.L., Silva Jr. W.A., Proto-Siqueira R., Rizzatti E.G., Neder L., Silva A.R., Rocha V., and Zago M.A. Mesenchymal stem cells can be obtained from the human saphena vein. Exp. Cell Res. 309 (2005) 340-344
9. Dauphinot L., De Oliveira C., Melot T., Sevenet N., Thomas V., Weissman B.E., and Delattre O. Analysis of the expression of cell cycle regulators in Ewing cell lines: EWS-FLI-1 modulates p57KIP2and c-Myc expression. Oncogene 20 (2001) 3258-3265
10. Delattre O., Zucman J., Plougastel B., Desmaze C., Melot T., Peter M., Kovar H., Joubert I., de Jong P., Rouleau G., et al. Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours. Nature 359 (1992) 162-165
11. Dennis J.E., and Charbord P. Origin and differentiation of human and murine stroma. Stem Cells 20 (2002) 205-214
12. Eliazer S., Spencer J., Ye D., Olson E., and Ilaria Jr. R.L. Alteration of mesodermal cell differentiation by EWS/FLI-1, the oncogene implicated in Ewing's sarcoma. Mol. Cell. Biol. 23 (2003) 482-492
13. Ewing J. Diffuse endothelioma of bone. Proc. New York Pathol. Soc. 21 (1921) 17-24
14. Friedenstein A.J., Gorskaja J.F., and Kulagina N.N. Fibroblast precursors in normal and irradiated mouse hematopoietic organs. Exp. Hematol. 4 (1976) 267-274
15. Gregory C.A., Prockop D.J., and Spees J.L. Non-hematopoietic bone marrow stem cells: Molecular control of expansion and differentiation. Exp. Cell Res. 306 (2005) 330-335
16. Hu-Lieskovan S., Zhang J., Wu L., Shimada H., Schofield D.E., and Triche T.J. EWS-FLI1 fusion protein up-regulates critical genes in neural crest development and is responsible for the observed phenotype of Ewing's family of tumors. Cancer Res. 65 (2005) 4633-4644
17. Izadpanah R., Joswig T., Tsien F., Dufour J., Kirijan J.C., and Bunnell B.A. Characterization of multipotent mesenchymal stem cells from the bone marrow of rhesus macaques. Stem Cells Dev. 14 (2005) 440-451
18. Janknecht R. EWS-ETS oncoproteins: The linchpins of Ewing tumors. Gene 363 (2005) 1-14
19. Johnstone B., Hering T.M., Caplan A.I., Goldberg V.M., and Yoo J.U. In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells. Exp. Cell Res. 238 (1998) 265-272
20. Kiepe D., Ciarmatori S., Haarmann A., and Tonshoff B. Differential expression of IGF system components in proliferating vs. differentiating growth plate chondrocytes: The functional role of IGFBP-5. Am. J. Physiol. 290 (2006) E363-E371
21. Noguera R., Navarro S., Peydro-Olaya A., and Llombart-Bosch A. Patterns of differentiation in extraosseous Ewing's sarcoma cells. An in vitro study. Cancer 73 (1994) 616-624
22. Oshima Y., Kawaguchi S., Nagoya S., Wada T., Kokai Y., Ikeda T., Nogami S., Oya T., and Hirayama Y. Abdominal small round cell tumor with osteoid and EWS/FLI1. Hum. Pathol. 35 (2004) 773-775
23. Oswald J., Boxberger S., Jorgensen B., Feldmann S., Ehninger G., Bornhauser M., and Werner C. Mesenchymal stem cells can be differentiated into endothelial cells in vitro. Stem Cells 22 (2004) 377-384
24. Parkinson H., Sarkans U., Shojatalab M., Abeygunawardena N., Contrino S., Coulson R., Farne A., Lara G.G., Holloway E., Kapushesky M., et al. ArrayExpress-A public repository for microarray gene expression data at the EBI. Nucleic Acids Res. 33 (2005) D553-D555
25. Pittenger M.F., Mackay A.M., Beck S.C., Jaiswal R.K., Douglas R., Mosca J.D., Moorman M.A., Simonetti D.W., Craig S., and Marshak D.R. Multilineage potential of adult human mesenchymal stem cells. Science 284 (1999) 143-147
26. Prieur A., Tirode F., Cohen P., and Delattre O. EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3. Mol. Cell. Biol. 24 (2004) 7275-7283
27. R Development Core Team. R: A language and environment for statistical computing (2006), R Foundation for Statistical Computing, Vienna, Austria. http://www.R-project.org
28. Riggi N., Cironi L., Provero P., Suva M.L., Kaloulis K., Garcia-Echeverria C., Hoffmann F., Trumpp A., and Stamenkovic I. Development of Ewing's sarcoma from primary bone marrow-derived mesenchymal progenitor cells. Cancer Res. 65 (2005) 11459-11468
29. Rorie C.J., Thomas V.D., Chen P., Pierce H.H., O'Bryan J.P., and Weissman B.E. The Ews/Fli-1 fusion gene switches the differentiation program of neuroblastomas to Ewing sarcoma/peripheral primitive neuroectodermal tumors. Cancer Res. 64 (2004) 1266-1277
30. Saeed A.I., Sharov V., White J., Li J., Liang W., Bhagabati N., Braisted J., Klapa M., Currier T., Thiagarajan M., et al. TM4: A free, open-source system for microarray data management and analysis. Biotechniques 34 (2003) 374-378
31. Schuetz A.N., Rubin B.P., Goldblum J.R., Shehata B., Weiss S.W., Liu W., Wick M.R., and Folpe A.L. Intercellular junctions in Ewing sarcoma/primitive neuroectodermal tumor: Additional evidence of epithelial differentiation. Mod. Pathol. 18 (2005) 1403-1410
32. Schutze N., Noth U., Schneidereit J., Hendrich C., and Jakob F. Differential expression of CCN-family members in primary human bone marrow-derived mesenchymal stem cells during osteogenic, chondrogenic and adipogenic differentiation. Cell Commun. Signal. 3 (2005) 5
33. Scintu F., Reali C., Pillai R., Badiali M., Sanna M.A., Argiolu F., Ristaldi M.S., and Sogos V. Differentiation of human bone marrow stem cells into cells with a neural phenotype: Diverse effects of two specific treatments. BMC Neurosci. 7 (2006) 14
34. Smith R., Owen L.A., Trem D.J., Wong J.S., Whangbo J.S., Golub T.R., and Lessnick S.L. Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma. Cancer Cell 9 (2006) 405-416
35. Staege M.S., Hutter C., Neumann I., Foja S., Hattenhorst U.E., Hansen G., Afar D., and Burdach S.E. DNA microarrays reveal relationship of Ewing family tumors to both endothelial and fetal neural crest-derived cells and define novel targets. Cancer Res. 64 (2004) 8213-8221
36. Su A.I., Wiltshire T., Batalov S., Lapp H., Ching K.A., Block D., Zhang J., Soden R., Hayakawa M., Kreiman G., et al. A gene atlas of the mouse and human protein-encoding transcriptomes. Proc. Natl. Acad. Sci. USA 101 (2004) 6062-6067
37. Torchia E.C., Jaishankar S., and Baker S.J. Ewing tumor fusion proteins block the differentiation of pluripotent marrow stromal cells. Cancer Res. 63 (2003) 3464-3468
38. Tusher V.G., Tibshirani R., and Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc. Natl. Acad. Sci. USA 98 (2001) 5116-5121
39. van de Wetering M., Oving I., Muncan V., Pon Fong M.T., Brantjes H., van Leenen D., Holstege F.C., Brummelkamp T.R., Agami R., and Clevers H. Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector. EMBO Rep. 4 (2003) 609-615
40. van der Horst G., van der Werf S.M., Farih-Sips H., van Bezooijen R.L., Lowik C.W., and Karperien M. Downregulation of Wnt signaling by increased expression of Dickkopf-1 and -2 is a prerequisite for late-stage osteoblast differentiation of KS483 cells. J. Bone Miner. Res. 20 (2005) 1867-1877
41. van der Schaft D.W., Hillen F., Pauwels P., Kirschmann D.A., Castermans K., Egbrink M.G., Tran M.G., Sciot R., Hauben E., Hogendoorn P.C., et al. Tumor cell plasticity in Ewing sarcoma, an alternative circulatory system stimulated by hypoxia. Cancer Res. 65 (2005) 11520-11528
42. Woodbury D., Schwarz E.J., Prockop D.J., and Black I.B. Adult rat and human bone marrow stromal cells differentiate into neurons. J. Neurosci. Res. 61 (2000) 364-370
43. Woodbury D., Reynolds K., and Black I.B. Adult bone marrow stromal stem cells express germline, ectodermal, endodermal, and mesodermal genes prior to neurogenesis. J. Neurosci. Res. 69 (2002) 908-917
44. Zucman J., Melot T., Desmaze C., Ghysdael J., Plougastel B., Peter M., Zucker J.M., Triche T.J., Sheer D., Turc-Carel C., et al. Combinatorial generation of variable fusion proteins in the Ewing family of tumours. EMBO J. 12 (1993) 4481-4487