Molecular characterization of Patched-associated rhabdomyosarcoma

Journal of Pathology

Volumn 200, Issue 3, 2003, Pages 348-356

  Kappler, Roland ^a,b,c   Calzada Wack, Julia ^a,b   Schnitzbauer, Udo ^a,b   Koleva, Milena ^c   Herwig, Astrid ^c   Piontek, Guido ^a   Graedler, Florian ^b   Adamski, Jerzy ^b   Heinzmann, Ulrich ^b   Schlegel, Jürgen ^a   Hemmerlein, Bernhard ^c   Quintanilla Martinez, Leticia ^b   Hahn, Heidi ^a,b,c  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Apoptosis; Gene expression; Microarray; Murine model system; Patched; Rhabdomyosarcoma

Indexed keywords

GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; ONCOPROTEIN; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN P27; SOMATOMEDIN B; SONIC HEDGEHOG PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BASAL CELL CARCINOMA; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA MICROARRAY; DROSOPHILA; ENZYME ACTIVATION; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GENE MUTATION; GENETIC TRANSCRIPTION; HETEROZYGOSITY; MEDULLOBLASTOMA; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTO ONCOGENE; RHABDOMYOSARCOMA; SEQUENCE HOMOLOGY; TUMOR CELL;

ANIMALS; APOPTOSIS; BLOTTING, NORTHERN; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; DNA, NEOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MICE; MICROSCOPY, ELECTRON; MUSCLE, SKELETAL; MUTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RHABDOMYOSARCOMA; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 0038686690     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/path.1361     Document Type: Article

References (32)

1. Wicking C, Smyth I, Bale A. The hedgehog signalling pathway in tumorigenesis and development. Oncogene 1999; 18: 7844-7851.
2. Johnson RL, Rothman AL, Xie J, et al. Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science 1996; 272: 1668-1671.
3. Hahn H, Wicking C, Zaphiropoulous PG, et al. Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell 1996; 85: 841-851.
4. Gorlin RJ. Nevoid basal-cell carcinoma syndrome. Medicine (Baltimore) 1987; 66: 98-113.
5. Toftgard R. Hedgehog signalling in cancer. Cell Mol Life Sci 2000; 57: 1720-1731.
6. Aszterbaum M, Epstein J, Oro A, et al. Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice. Nature Med 1999; 5: 1285-1291.
7. Goodrich LV, Milenkovic L, Higgins KM, Scott MP. Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 1997; 277: 1109-1113.
8. Hahn H, Wojnowski L, Zimmer AM, Hall J, Miller G, Zimmer A. Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome. Nature Med 1998; 4: 619-622.
9. Hahn H, Wojnowski L, Specht K, et al. Patched target Igf2 is indispensable for the formation of medulloblastoma and rhabdomyosarcoma. J Biol Chem 2000; 275: 28 341-28 344.
10. Schlegel J, Piontek G, Budde B, Neff F, Kraus A. The Akt/protein kinase B-dependent anti-apoptotic pathway and the mitogen-activated protein kinase cascade are alternatively activated in human glioblastoma multiforme. Cancer Lett 2000; 158: 103-108.
11. Ansari B, Coates PJ, Greenstein BD, Hall PA. In situ end-labelling detects DNA strand breaks in apoptosis and other physiological and pathological states. J Pathol 1993; 170: 1-8.
12. Kirschner LS, Carney JA, Pack SD, et al. Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the Carney complex. Nature Genet 2000; 26: 89-92.
13. Maass N, Hojo T, Zhang M, Sager R, Jonat W, Nagasaki K. Maspin - a novel protease inhibitor with tumor- suppressing activity in breast cancer. Acta Oncol 2000; 39: 931-934.
14. Sellar GC, Li L, Watt KP, et al. BARX2 induces cadherin 6 expression and is a functional suppressor of ovarian cancer progression. Cancer Res 2001; 61: 6977-6981.
15. Hornigold N, Devlin J, Davies AM, Aveyard JS, Habuchi T, Knowles MA. Mutation of the 9q34 gene TSC1 in sporadic bladder cancer. Oncogene 1999; 18: 2657-2661.
16. Shridhar R, Shridhar V, Rivard S, et al. Mutations in the arginine-rich protein gene in lung, breast, and prostate cancers, and in squamous cell carcinoma of the head and neck. Cancer Res 1996; 56: 5576-5578.
17. Tanaka M, Adzuma K, Iwami M, Yoshimoto K, Monden Y, Itakura M. Human calgizzarin; one colorectal cancer-related gene selected by a large scale random cDNA sequencing and northern blot analysis. Cancer Lett 1995; 89: 195-200.
18. Werner H, Le Roith D. New concepts in regulation and function of the insulin-like growth factors: implications for understanding normal growth and neoplasia. Cell Mol Life Sci 2000; 57: 932-942.
19. Friedman E, Gejman PV, Martin GA, McCormick F. Nonsense mutations in the C-terminal SH2 region of the GTPase activating protein (GAP) gene in human tumours. Nature Genet 1993; 5: 242-247.
20. Casci T, Vinos J, Freeman M. Sprouty, an intracellular inhibitor of Ras signaling. Cell 1999; 96: 655-665.
21. Skorski T, Bellacosa A, Nieborowska-Skorska M, et al. Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway. EMBO J 1997; 16: 6151-6161.
22. Vanhaesebroeck B, Alessi DR. The PI3K-PDK1 connection: more than just a road to PKB. Biochem J 2000; 346(Pt 3): 561-576.
23. May P, May E. Twenty years of p53 research: structural and functional aspects of the p53 protein. Oncogene 1999; 18: 7621-7636.
24. Lee MH, Yang HY. Negative regulators of cyclin-dependent kinases and their roles in cancers. Cell Mol Life Sci 2001; 58: 1907-1922.
25. Merlino G, Helman LJ. Rhabdomyosarcoma - working out the pathways. Oncogene 1999; 18: 5340-5348.
26. Anderson J, Gordon A, Pritchard-Jones K, Shipley J. Genes, chromosomes, and rhabdomyosarcoma. Genes Chromosomes Cancer 1999; 26: 275-285.
27. Morrione A, Valentinis B, Xu SQ, et al. Insulin-like growth factor II stimulates cell proliferation through the insulin receptor. Proc Natl Acad Sci USA 1997; 94: 3777-3782.
28. Ruiz i Altaba A, Sanchez P, Dahmane N. Gli and hedgehog in cancer: tumours, embryos and stem cells. Nat Rev Cancer 2002; 2: 361-372.
29. Hamm RL, McDonnell T. Gli-1 and gli-3 function to antagonistically regulate bcl-2: the connection between the shh pathway and apoptosis. 2002 AACR Annual Meeting: Proceeding Online: http//aacr02.agora.com/planner/default.asp. Abstracts number 542.
30. Wexler LH, Helman LJ. Rhabdomyosarcoma and the indifferentiated sarcomas. Principles and Practice of Pediatric Oncology (3rd edn). Raven-Lippincott: Philadelphia, 1997.
31. El-Badry OM, Minniti C, Kohn EC, Houghton PJ, Daughaday WH, Helman LJ. Insulin-like growth factor II acts as an autocrine growth and motility factor in human rhabdomyosarcoma tumors. Cell Growth Differ 1990; 1: 325-331.
32. Pressey JG, Barr FG. Sonic hedgehog pathway activation in rhabdomyosarcoma. 2002 AACR Annual Meeting: Proceeding Online: http//aacr02.agora.com/planner/default.asp. Abstract number 4494.