Medulloblastoma: Signalling a change in treatment

Lancet Oncology

Volumn 5, Issue 4, 2004, Pages 209-218

  Gilbertson, Richard J ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOPLATIN; CISPLATIN; CYCLOPHOSPHAMIDE; CYTARABINE; CYTOTOXIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 3; EPIDERMAL GROWTH FACTOR RECEPTOR 4; ERLOTINIB; ETOPOSIDE; GEFITINIB; IFOSFAMIDE; LOMUSTINE; METHOTREXATE; PREDNISOLONE; PROTEIN TYROSINE KINASE INHIBITOR; SONIC HEDGEHOG PROTEIN; TOPOTECAN; VINCRISTINE; WNT PROTEIN;

AGE; CANCER CLASSIFICATION; CANCER COMBINATION CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURVIVAL; CARCINOGENESIS; CHILD CARE; CHILDHOOD CANCER; CLINICAL TRIAL; DISEASE SEVERITY; DRUG TARGETING; GENE MUTATION; HISTOPATHOLOGY; HUMAN; MEDULLOBLASTOMA; MULTIMODALITY CANCER THERAPY; NEUROSURGERY; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; RISK MANAGEMENT; SIGNAL TRANSDUCTION; TREATMENT OUTCOME;

CEREBELLAR NEOPLASMS; HEDGEHOG PROTEINS; HUMANS; MEDULLOBLASTOMA; PROGNOSIS; PROTO-ONCOGENE PROTEINS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RISK FACTORS; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; WNT PROTEINS; ZEBRAFISH PROTEINS;

EID: 1642307767     PISSN: 14702045     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1470-2045(04)01424-X     Document Type: Review

References (75)

1. Legler JM Ries LA Smith MA et al. Cancer surveillance series [corrected]: brain and other central nervous system cancers: recent trends in incidence and mortality J Natl Cancer Inst 91 1999 1382-1390
2. Palmer SL Goloubeva O Reddick WE et al. Patterns of intellectual development among survivors of pediatric medulloblastoma: a longitudinal analysis J Clin Oncol 19 2001 2302-2308
3. Freeman CR Taylor RE Kortmann RD Carrie C. Radiotherapy for medulloblastoma in children: a perspective on current international clinical research efforts Med Pediatr Oncol 39 2002 99-108
4. Gurney JG Kadan-Lottick NS Packer RJ et al. Endocrine and cardiovascular late effects among adult survivors of childhood brain tumors: Childhood Cancer Survivor Study Cancer 97 2003 663-673
5. Ris MD Packer R Goldwein J et al. Intellectual outcome after reduced-dose radiation therapy plus adjuvant chemotherapy for medulloblastoma: a Children's Cancer Group study J Clin Oncol 19 2001 3470-3476
6. Kleihues P Louis DN Scheithauer BW et al. The WHO classification of tumors of the nervous system J Neuropathol Exp Neurol 61 2002 215-229
7. Ellison D. Classifying the medulloblastoma: insights from morphology and molecular genetics Neuropathol Appl Neurobiol 28 2002 257-282
8. Eberhart CG Kepner JL Goldthwaite PT et al. Histopathologic grading of medulloblastomas: a Pediatric Oncology Group study Cancer 94 2002 552-560
9. Kortmann RD Kuhl J Timmermann B et al. Postoperative neoadjuvant chemotherapy before radiotherapy as compared to immediate radiotherapy followed by maintenance chemotherapy in the treatment of medulloblastoma in childhood: results of the German prospective randomized trial HIT '91 Int J Radiat Oncol Biol Phys 46 2000 269-279
10. Zeltzer PM Boyett JM Finlay JL et al. Metastasis stage, adjuvant treatment, and residual tumor are prognostic factors for medulloblastoma in children: conclusions from the Children's Cancer Group 921 randomized phase III study J Clin Oncol 17 1999 832-845
11. Heideman RL. Overview of the treatment of infant central nervous system tumors: medulloblastoma as a model J Pediatr Hematol Oncol 23 2001 268-271
12. Biegel JA Kalpana G Knudsen ES et al. The role of INI1 and the SWI/SNF complex in the development of rhabdoid tumors: meeting summary from the workshop on childhood atypical teratoid/rhabdoid tumors Cancer Res 62 2002 323-328
13. Eberhart CG Cohen KJ Tihan T et al. Medulloblastomas with systemic metastases: evaluation of tumor histopathology and clinical behaviour in 23 patients J Pediatr Hematol Oncol 25 2003 198-203
14. Taylor RE Bailey CC Robinson K et al. Results of a randomized study of preradiation chemotherapy versus radiotherapy alone for nonmetastatic medulloblastoma: the International Society of Paediatric Oncology/UK Children's Cancer Study Group PNET-3 Study J Clin Oncol 21 2003 1581-1591
15. Packer RJ Goldwein J Nicholson HS et al. Treatment of children with medulloblastomas with reduced-dose craniospinal radiation therapy and adjuvant chemotherapy: a Children's Cancer Group Study J Clin Oncol 17 1999 2127-2136
16. Strother D Ashley D Kellie SJ et al. Feasibility of four consecutive high-dose chemotherapy cycles with stem-cell rescue for patients with newly diagnosed medulloblastoma or supratentorial primitive neuroectodermal tumor after craniospinal radiotherapy: results of a collaborative study J Clin Oncol 19 2001 2696-2704
17. Thomas PR Deutsch M Kepner JL et al. Low-stage medulloblastoma: final analysis of trial comparing standard-dose with reduced-dose neuraxis irradiation J Clin Oncol 18 2000 3004-3011
18. Ellison DW Clifford SC Gajjar A Gilbertson RJ. What's new in neuro-oncology? Recent advances in medulloblastoma Eur J Paediatr Neurol 7 2003 53-66
19. Packer RJ Sutton LN Elterman R et al. Outcome for children with medulloblastoma treated with radiation and cisplatin, CCNU, and vincristine chemotherapy J Neurosurg 81 1994 690-698
20. Kalderon D. Similarities between the Hedgehog and WNT signalling pathways Trends Cell Biol 12 2002 523-531
21. Henderson BR Fagotto F. The ins and outs of APC and beta-catenin nuclear transport EMBO Rep 3 2002 834-839
22. Polakis P. Wnt signaling and cancer Genes Dev 14 2000 1837-1851
23. Zurawel RH Chiappa SA Allen C Raffel C. Sporadic medulloblastomas contain oncogenic beta-catenin mutations Cancer Res 58 1998 896-899
24. Huang H Mahler-Araujo BM Sankila A et al. APC mutations in sporadic medulloblastomas Am J Pathol 156 2000 433-437
25. Koch A Waha A Tonn JC et al. Somatic mutations of WNT/wingless signalling pathway components in primitive neuroectodermal tumors Int J Cancer 93 2001 445-449
26. Eberhart CG Tihan T Burger PC. Nuclear localization and mutation of beta-catenin in medulloblastomas J Neuropathol Exp Neurol 59 2000 333-337
27. Baeza N Masuoka J Kleihues P Ohgaki H. AXIN1 mutations but not deletions in cerebellar medulloblastomas Oncogene 22 2003 632-636
28. Yokota N Nishizawa S Ohta S et al. Role of Wnt pathway in medulloblastoma oncogenesis Int J Cancer 101 2002 198-201
29. Kang DE Soriano S Xia X et al. Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis Cell 110 2002 751-762
30. Hamilton SR Liu B Parsons RE et al. The molecular basis of Turcot's syndrome N Engl J Med 332 1995 839-847
31. Taipale J Beachy PA. The Hedgehog and Wnt signalling pathways in cancer Nature 411 2001 349-354
32. Ruiz IAA Palma V Dahmane N. Hedgehog-Gli signalling and the growth of the brain Nat Rev Neurosci 3 2002 24-33
33. McMahon AP Ingham PW Tabin CJ. Developmental roles and clinical significance of hedgehog signaling Curr Top Dev Biol 53 2003 1-114
34. Ruiz I Altaba A Sanchez P Dahmane N. Gli and hedgehog in cancer: tumours, embryos and stem cells Nat Rev Cancer 2 2002 361-372
35. Taipale J Cooper MK Maiti T Beachy PA. Patched acts catalytically to suppress the activity of Smoothened Nature 418 2002 892-897
36. Hahn H Wicking C Zaphiropoulous PG et al. Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome Cell 85 1996 841-851
37. Taylor MD Liu L Raffel C et al. Mutations in SUFU predispose to medulloblastoma Nat Genet 31 2002 306-310
38. Raffel C Jenkins RB Frederick L et al. Sporadic medulloblastomas contain PTCH mutations Cancer Res 57 1997 842-845
39. Pietsch T Waha A Koch A et al. Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched Cancer Res 57 1997 2085-2088
40. Reifenberger J Wolter M Weber RG et al. Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system Cancer Res 58 1998 1798-1803
41. Wolter M Reifenberger J Sommer C et al. Mutations in the human homologue of the Drosophila segment polarity gene patched (PTCH) in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system Cancer Res 57 1997 2581-2585
42. Vorechovsky I Tingby O Hartman M et al. Somatic mutations in the human homologue of Drosophila patched in primitive neuroectodermal tumours Oncogene 15 1997 361-366
43. Kenney AM Cole MD Rowitch DH. Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors Development 130 2003 15-28
44. Oliver TG Grasfeder LL Carroll AL et al. Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursors Proc Natl Acad Sci USA 100 2003 7331-7336
45. Wetmore C Eberhart DE Curran T. Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched Cancer Res 61 2001 513-516
46. Berman DM Karhadkar SS Hallahan AR et al. Medulloblastoma growth inhibition by hedgehog pathway blockade Science 297 2002 1559-1561
47. Goodrich LV Milenkovic L Higgins KM Scott MP. Altered neural cell fates and medulloblastoma in mouse patched mutants Science 277 1997 1109-1113
48. Wetmore C Eberhart DE Curran T. The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ-line mutation of patched Cancer Res 60 2000 2239-2246
49. Weiner HL Bakst R Hurlbert MS et al. Induction of medulloblastomas in mice by sonic hedgehog, independent of Gli1 Cancer Res 62 2002 6385-6389
50. Yarden Y Sliwkowski MX. Untangling the ErbB signalling network Nat Rev Mol Cell Biol 2 2001 127-137
51. Weiner DB Liu J Cohen JA et al. A point mutation in the neu oncogene mimics ligand induction of receptor aggregation Nature 339 1989 230-231
52. Padhy LC Shih C Cowing D et al. Identification of a phosphoprotein specifically induced by the transforming DNA of rat neuroblastomas Cell 28 1982 865-871
53. Muller WJ Sinn E Pattengale PK et al. Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene Cell 54 1988 105-115
54. Segatto O King CR Pierce JH. Different structural alterations upregulate in vitro tyrosine kinase activity and transforming potency of the erbB-2 gene Mol Cell Biol 8 1988 5570-5574
55. Guy CT Webster MA Schaller M et al. Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease Proc Natl Acad Sci USA 89 1992 10578-10582
56. Gilbertson RJ Perry RH Kelly PJ et al. Prognostic significance of HER2 and HER4 coexpression in childhood medulloblastoma Cancer Res 57 1997 3272-3280
57. Gilbertson R Wickramasinghe C Hernan R et al. Clinical and molecular stratification of disease risk in medulloblastoma Br J Cancer 85 2001 705-712
58. Gajjar A, Hernan R, Kocak M, et al. Clinical, histopathological and molecular markers of prognosis: toward a new disease risk stratification system for medulloblastoma. J Clin Oncol (in press).
59. Gilbertson RJ Clifford SC MacMeekin W et al. Expression of the ErbB-neuregulin signaling network during human cerebellar development: implications for the biology of medulloblastoma Cancer Res 58 1998 3932-3941
60. Zhou BP Liao Y Xia W et al. Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells Nat Cell Biol 3 2001 245-252
61. Zhou BP Liao Y Xia W et al. HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation Nat Cell Biol 3 2001 973-982
62. Laughner E Taghavi P Chiles K et al. HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression Mol Cell Biol 21 2001 3995-4004
63. Calabrese C Frank A Maclean K Gilbertson R. Medulloblastoma sensitivity to 17-allylamino-17-demethoxygeldanamycin requires MEK/ERK J Biol Chem 278 2003 24951-24959
64. Hernan R Fasheh R Calabrese C et al. ERBB2 upregulates S100A4 and several other prometastatic genes in medulloblastoma Cancer Res 63 2003 140-148
65. Tong WM Ohgaki H Huang H et al. Null mutation of DNA strand break-binding molecule poly(ADP-ribose) polymerase causes medulloblastomas in p53(-/-) mice Am J Pathol 162 2003 343-352
66. Lee Y McKinnon PJ. DNA ligase IV suppresses medulloblastoma formation Cancer Res 62 2002 6395-6399
67. Marino S Vooijs M van Der Gulden H et al. Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum Genes Dev 14 2000 994-1004
68. Wang J Pham-Mitchell N Schindler C Campbell IL. Dysregulated sonic hedgehog signaling and medulloblastoma consequent to IFN-alpha-stimulated STAT2-independent production of IFN-gamma in the brain J Clin Invest 112 2003 535-543
69. MacDonald TJ Brown KM LaFleur B et al. Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease Nat Genet 29 2001 143-152
70. Pomeroy SL Tamayo P Gaasenbeek M et al. Prediction of central nervous system embryonal tumour outcome based on gene expression Nature 415 2002 436-442
71. Gilbertson RJ Clifford SC. PDGFRB is overexpressed in metastatic medulloblastoma Nat Genet 35 2003 197-198
72. Lee Y Miller HL Jensen P et al. A molecular fingerprint for medulloblastoma Cancer Res 63 2003 5428-5437
73. Chen JK Taipale J Cooper MK Beachy PA. Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened Genes Dev 16 2002 2743-2748
74. Schroeder JA Adriance MC McConnell EJ et al. ErbB-beta-catenin complexes are associated with human infiltrating ductal breast and murine mammary tumor virus (MMTV)-Wnt-1 and MMTV-c-Neu transgenic carcinomas J Biol Chem 277 2002 22692-22698
75. Meng X Poon R Zhang X et al. Suppressor of fused negatively regulates beta-catenin signaling J Biol Chem 276 2001 40113-40119