메뉴 건너뛰기




Volumn 57, Issue 6, 2011, Pages 930-938

Hedgehog pathway activity in pediatric embryonal rhabdomyosarcoma and undifferentiated sarcoma: A report from the Children's Oncology Group

Author keywords

GLI; Gorlin's syndrome; Hedgehog; Rhabdomyosarcoma; Undifferentiated sarcoma

Indexed keywords

PROTEIN PATCHED; RNA; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1;

EID: 80052655551     PISSN: 15455009     EISSN: 15455017     Source Type: Journal    
DOI: 10.1002/pbc.23174     Document Type: Article
Times cited : (62)

References (27)
  • 1
    • 0035577854 scopus 로고    scopus 로고
    • Hedgehog signaling in animal development: Paradigms and principles
    • Ingham PW, McMahon AP. Hedgehog signaling in animal development: Paradigms and principles. Genes Dev 2001; 15: 3059-3087.
    • (2001) Genes Dev , vol.15 , pp. 3059-3087
    • Ingham, P.W.1    McMahon, A.P.2
  • 2
    • 0026023193 scopus 로고
    • The zinc finger protein GLI transforms primary cells in cooperation with adenovirus E1A
    • Ruppert JM, Vogelstein B, Kinzler KW. The zinc finger protein GLI transforms primary cells in cooperation with adenovirus E1A. Mol Cell Biol 1991; 11: 1724-1728.
    • (1991) Mol Cell Biol , vol.11 , pp. 1724-1728
    • Ruppert, J.M.1    Vogelstein, B.2    Kinzler, K.W.3
  • 3
    • 0031837454 scopus 로고    scopus 로고
    • A. Rhabdomyosarcoma and radiation hypersensitivity in a mouse model of Gorlin Syndrome
    • Hahn HW, Zimmer L, Hall AM, et al. A. Rhabdomyosarcoma and radiation hypersensitivity in a mouse model of Gorlin Syndrome. Nat Med 1998; 4: 619-622.
    • (1998) Nat Med , vol.4 , pp. 619-622
    • Hahn, H.W.1    Zimmer, L.2    Hall, A.M.3
  • 4
    • 0023222358 scopus 로고
    • Nevoid basal-cell carcinoma syndrome
    • Gorlin R. Nevoid basal-cell carcinoma syndrome. Medicine 1987; 66: 98-113.
    • (1987) Medicine , vol.66 , pp. 98-113
    • Gorlin, R.1
  • 5
    • 0020626816 scopus 로고
    • Case report: Nasopharyngeal rhabdomyosarcoma and Gorlin's Naevoid basal cell carcinoma syndrome
    • Beddis IR, Mott MG, Bullimore J. Case report: Nasopharyngeal rhabdomyosarcoma and Gorlin's Naevoid basal cell carcinoma syndrome. Med Pediatr Oncol 1983; 11: 178-179.
    • (1983) Med Pediatr Oncol , vol.11 , pp. 178-179
    • Beddis, I.R.1    Mott, M.G.2    Bullimore, J.3
  • 6
    • 18244374534 scopus 로고    scopus 로고
    • Genomic gains and losses are similar in genetic and histologic subsets of rhabdomyosarcoma, whereas amplification predominates in embryonal with anaplasia and alveolar subtypes
    • Bridge JA, Liu J, Qualman SJ, et al. Genomic gains and losses are similar in genetic and histologic subsets of rhabdomyosarcoma, whereas amplification predominates in embryonal with anaplasia and alveolar subtypes. Genes Chromosomes Cancer 2002; 33: 310-321.
    • (2002) Genes Chromosomes Cancer , vol.33 , pp. 310-321
    • Bridge, J.A.1    Liu, J.2    Qualman, S.J.3
  • 7
    • 29744463531 scopus 로고    scopus 로고
    • Deregulation of the hedgehog signalling pathway: A possible role for the PTCH and SUFU genes in human rhabdomyoma and rhabdomyosarcoma development
    • Tostar U, Malm CJ, Meis-Kindblom JM, et al. Deregulation of the hedgehog signalling pathway: A possible role for the PTCH and SUFU genes in human rhabdomyoma and rhabdomyosarcoma development. J Pathol 2006; 208: 17-25.
    • (2006) J Pathol , vol.208 , pp. 17-25
    • Tostar, U.1    Malm, C.J.2    Meis-Kindblom, J.M.3
  • 8
    • 78649814616 scopus 로고    scopus 로고
    • Activation of the hedgehog pathway confers a poor prognosis in embryonal and fusion gene-negative alveolar rhabdomyosarcoma
    • Zibat A, Missiaglia E, Rosenberger A, et al. Activation of the hedgehog pathway confers a poor prognosis in embryonal and fusion gene-negative alveolar rhabdomyosarcoma. Oncogene 29: 6323-6330.
    • Oncogene , vol.29 , pp. 6323-6330
    • Zibat, A.1    Missiaglia, E.2    Rosenberger, A.3
  • 9
    • 0033590605 scopus 로고    scopus 로고
    • A frequent activated smoothened mutation in sporadic basal cell carcinomas
    • Lam CW, Xie J, To KF, et al. A frequent activated smoothened mutation in sporadic basal cell carcinomas. Oncogene 1999; 18: 833-836.
    • (1999) Oncogene , vol.18 , pp. 833-836
    • Lam, C.W.1    Xie, J.2    To, K.F.3
  • 10
    • 33845382806 scopus 로고
    • Nonparametric estimation from incomplete observations
    • Kaplan E, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958; 53: 457-481.
    • (1958) J Am Stat Assoc , vol.53 , pp. 457-481
    • Kaplan, E.1    Meier, P.2
  • 11
    • 0013886333 scopus 로고
    • Evaluation of survival data and two new rank order statistics arising in its consideration
    • Mantel N. Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep 1966; 50: 163-170.
    • (1966) Cancer Chemother Rep , vol.50 , pp. 163-170
    • Mantel, N.1
  • 12
    • 77955362243 scopus 로고    scopus 로고
    • Hedgehog controls neural stem cells through p53-independent regulation of Nanog
    • Po A, Ferretti E, Miele E, et al. Hedgehog controls neural stem cells through p53-independent regulation of Nanog. EMBO J 29: 2646-2658.
    • EMBO J , vol.29 , pp. 2646-2658
    • Po, A.1    Ferretti, E.2    Miele, E.3
  • 13
    • 0029330813 scopus 로고
    • The Gorlin syndrome gene: A tumor suppressor active in basal cell carcinogenesis and embryonic development
    • Bale AE, Gailani MR, Leffell DJ. The Gorlin syndrome gene: A tumor suppressor active in basal cell carcinogenesis and embryonic development. Proc Assoc Am Physicians 1995; 107: 253-257.
    • (1995) Proc Assoc Am Physicians , vol.107 , pp. 253-257
    • Bale, A.E.1    Gailani, M.R.2    Leffell, D.J.3
  • 14
    • 0037165140 scopus 로고    scopus 로고
    • Prediction of central nervous system embryonal tumour outcome based on gene expression
    • Pomeroy SL, Tamayo P, Gaasenbeek M, et al. Prediction of central nervous system embryonal tumour outcome based on gene expression. Nature 2002; 415: 436-442.
    • (2002) Nature , vol.415 , pp. 436-442
    • Pomeroy, S.L.1    Tamayo, P.2    Gaasenbeek, M.3
  • 15
    • 0242268525 scopus 로고    scopus 로고
    • Widespread requirement for hedgehog ligand stimulation in growth of digestive tract tumours
    • Berman DM, Karhadkar SS, Maitra A, et al. Widespread requirement for hedgehog ligand stimulation in growth of digestive tract tumours. Nature 2003; 425: 846-851.
    • (2003) Nature , vol.425 , pp. 846-851
    • Berman, D.M.1    Karhadkar, S.S.2    Maitra, A.3
  • 16
    • 0037085379 scopus 로고    scopus 로고
    • Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation
    • Yoon JW, Kita Y, Frank DJ, et al. Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation. J Biol Chem 2002; 277: 5548-5555.
    • (2002) J Biol Chem , vol.277 , pp. 5548-5555
    • Yoon, J.W.1    Kita, Y.2    Frank, D.J.3
  • 17
    • 0034088133 scopus 로고    scopus 로고
    • Novel genomic imbalances in embryonal rhabdomyosarcoma revealed by comparative genomic hybridization and fluorescence in situ hybridization: An intergroup rhabdomyosarcoma study
    • Bridge JA, Liu J, Weibolt V, et al. Novel genomic imbalances in embryonal rhabdomyosarcoma revealed by comparative genomic hybridization and fluorescence in situ hybridization: An intergroup rhabdomyosarcoma study. Genes Chromosomes Cancer 2000; 27: 337-344.
    • (2000) Genes Chromosomes Cancer , vol.27 , pp. 337-344
    • Bridge, J.A.1    Liu, J.2    Weibolt, V.3
  • 18
    • 68049128117 scopus 로고    scopus 로고
    • Paracrine Hedgehog signaling in cancer
    • Theunissen JW, de Sauvage FJ. Paracrine Hedgehog signaling in cancer. Cancer Res 2009; 69: 6007-6010.
    • (2009) Cancer Res , vol.69 , pp. 6007-6010
    • Theunissen, J.W.1    de Sauvage, F.J.2
  • 19
    • 0036648241 scopus 로고    scopus 로고
    • Mutations in SUFU predispose to medulloblastoma
    • Taylor MD, Liu L, Raffel C, et al. Mutations in SUFU predispose to medulloblastoma. Nat Genet 2002; 31: 306-310.
    • (2002) Nat Genet , vol.31 , pp. 306-310
    • Taylor, M.D.1    Liu, L.2    Raffel, C.3
  • 20
    • 44349145643 scopus 로고    scopus 로고
    • The EWS/FLI1 oncogenic transcription factor deregulates GLI1
    • Zwerner JP, Joo J, Warner KL, et al. The EWS/FLI1 oncogenic transcription factor deregulates GLI1. Oncogene 2008; 27: 3282-3291.
    • (2008) Oncogene , vol.27 , pp. 3282-3291
    • Zwerner, J.P.1    Joo, J.2    Warner, K.L.3
  • 21
    • 0030860745 scopus 로고    scopus 로고
    • Undifferentiated sarcomas of children: Pathology and clinical behavior-An Intergroup Rhabdomyosarcoma study
    • Pawel BR, Hamoudi AB, Asmar L, et al. Undifferentiated sarcomas of children: Pathology and clinical behavior-An Intergroup Rhabdomyosarcoma study. Med Pediatr Oncol 1997; 29: 170-180.
    • (1997) Med Pediatr Oncol , vol.29 , pp. 170-180
    • Pawel, B.R.1    Hamoudi, A.B.2    Asmar, L.3
  • 22
    • 0035876634 scopus 로고    scopus 로고
    • Intergroup rhabdomyosarcoma study-IV: Results for patients with nonmetastatic disease
    • Crist WM, Anderson JR, Meza JL, et al. Intergroup rhabdomyosarcoma study-IV: Results for patients with nonmetastatic disease. J Clin Oncol 2001; 19: 3091-3102.
    • (2001) J Clin Oncol , vol.19 , pp. 3091-3102
    • Crist, W.M.1    Anderson, J.R.2    Meza, J.L.3
  • 23
    • 77953679047 scopus 로고    scopus 로고
    • GDC-0449-Targeting the hedgehog signaling pathway
    • Dierks C. GDC-0449-Targeting the hedgehog signaling pathway. Recent Results Cancer Res 184: 235-238.
    • Recent Results Cancer Res , vol.184 , pp. 235-238
    • Dierks, C.1
  • 24
    • 70349244812 scopus 로고    scopus 로고
    • Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449
    • Rudin CM, Hann CL, Laterra J, et al. Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449. N Engl J Med 2009; 361: 1173-1178.
    • (2009) N Engl J Med , vol.361 , pp. 1173-1178
    • Rudin, C.M.1    Hann, C.L.2    Laterra, J.3
  • 25
    • 70349238733 scopus 로고    scopus 로고
    • Inhibition of the hedgehog pathway in advanced basal-cell carcinoma
    • Von Hoff DD, LoRusso PM, Rudin CM, et al. Inhibition of the hedgehog pathway in advanced basal-cell carcinoma. N Engl J Med 2009; 361: 1164-1172.
    • (2009) N Engl J Med , vol.361 , pp. 1164-1172
    • Von Hoff, D.D.1    LoRusso, P.M.2    Rudin, C.M.3
  • 26
    • 70350496540 scopus 로고    scopus 로고
    • Smoothened mutation confers resistance to a hedgehog pathway inhibitor in medulloblastoma
    • Yauch RL, Dijkgraaf GJ, Alicke B, et al. Smoothened mutation confers resistance to a hedgehog pathway inhibitor in medulloblastoma. Science 2009; 326: 572-574.
    • (2009) Science , vol.326 , pp. 572-574
    • Yauch, R.L.1    Dijkgraaf, G.J.2    Alicke, B.3
  • 27
    • 34249867843 scopus 로고    scopus 로고
    • Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists
    • Lauth M, Bergstrom A, Shimokawa T, et al. Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc Natl Acad Sci USA 2007; 104: 8455-8460.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 8455-8460
    • Lauth, M.1    Bergstrom, A.2    Shimokawa, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.