Synergism between Wnt3a and heparin enhances osteogenesis via a phosphoinositide 3-kinase/Akt/RUNX2 pathway

Journal of Biological Chemistry

Volumn 285, Issue 34, 2010, Pages 26233-26244

  Ling, Ling ^a   Dombrowski, Christian ^a   Foong, Kin Mun ^a   Haupt, Larisa M ^a   Stein, Gary S ^b   Nurcombe, Victor ^a,c   Van Wijnen, Andre J ^b   Cool, Simon M ^a,c  

^a INSTITUTE OF MEDICAL BIOLOGY   (Singapore)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE ACTIVITY; BONE DEFECT; BONE FORMATION; CATENIN SIGNALING; EFFECTIVE DOSE; FUNCTIONAL INTERACTION; GLYCOSAMINOGLYCANS; GROWTH FACTOR; HEPARAN; HEPARAN SULFATES; MINIMAL EFFECTS; MITOGENIC RESPONSE; NEW STRATEGY; NON-OSSEOUS TISSUES; OSTEOBLAST DIFFERENTIATION; OSTEOGENESIS; OSTEOGENIC; OSTEOGENIC ACTIVITY; PHOSPHOINOSITIDES; PHYSICAL BINDING; PHYSICAL INTERACTIONS; SIGNALING NETWORKS; THERAPEUTIC DOSE;

BONE; CELL PROLIFERATION; PEPTIDES; PHOSPHATASES; SIGNALING; TRANSCRIPTION FACTORS;

POLYSACCHARIDES;

ALKALINE PHOSPHATASE; BETA CATENIN; GLYCOGEN SYNTHASE KINASE; HEPARIN; LYMPHOID ENHANCER FACTOR 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; T CELL FACTOR PROTEIN; TRANSCRIPTION FACTOR RUNX2; WNT3A PROTEIN;

ANIMAL CELL; ARTICLE; BONE DEVELOPMENT; CELL CYCLE PROGRESSION; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG PROTEIN BINDING; ENZYME ACTIVATION; ENZYME ACTIVITY; MESENCHYME CELL; MITOGENESIS; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SULFATION;

1-PHOSPHATIDYLINOSITOL 4-KINASE; ANIMALS; CELL DIFFERENTIATION; CELL LINE; CORE BINDING FACTOR ALPHA 1 SUBUNIT; DRUG SYNERGISM; HEPARIN; HUMANS; MICE; OSTEOBLASTS; OSTEOGENESIS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; WNT PROTEINS;

EID: 77956203924     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.122069     Document Type: Article

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