메뉴 건너뛰기




Volumn , Issue , 2010, Pages 585-624

Anticipating and minimizing drug interactions in a drug discovery and development setting: An industrial perspective

Author keywords

[No Author keywords available]

Indexed keywords


EID: 84865180954     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4419-0840-7_23     Document Type: Chapter
Times cited : (3)

References (154)
  • 2
    • 48749108122 scopus 로고    scopus 로고
    • Role of transport proteins in drug discovery and development: A pharmaceutical perspective
    • Ayrton A and Morgan P (2008) Role of transport proteins in drug discovery and development: a pharmaceutical perspective. Xenobiotica 38:676-708
    • (2008) Xenobiotica , vol.38 , pp. 676-708
    • Ayrton, A.1    Morgan, P.2
  • 3
    • 33644861762 scopus 로고    scopus 로고
    • Inhibition constants, inhibitor concentrations and the prediction of inhibitory drug drug interactions: Pitfalls, progress and promise
    • Bachmann KA (2006) Inhibition constants, inhibitor concentrations and the prediction of inhibitory drug drug interactions: pitfalls, progress and promise. Curr Drug Metab 7:1-14
    • (2006) Curr Drug Metab , vol.7 , pp. 1-14
    • Bachmann, K.A.1
  • 4
    • 23444452547 scopus 로고    scopus 로고
    • Rifampin markedly decreases and gemfibrozil increases the plasma concentrations of atorvastatin and its metabolites
    • Backman JT, Luurila H, Neuvonen M and Neuvonen PJ (2005) Rifampin markedly decreases and gemfibrozil increases the plasma concentrations of atorvastatin and its metabolites. Clin Pharmacol Ther 78:154-167
    • (2005) Clin Pharmacol Ther , vol.78 , pp. 154-167
    • Backman, J.T.1    Luurila, H.2    Neuvonen, M.3    Neuvonen, P.J.4
  • 5
    • 33646640645 scopus 로고    scopus 로고
    • Current industrial practices of assessing permeability and P-glycoprotein interaction
    • Balimane PV, Han YH and Chong S (2006) Current industrial practices of assessing permeability and P-glycoprotein interaction. Aaps J 8:E1-E13
    • (2006) Aaps J , vol.8
    • Balimane, P.V.1    Han, Y.H.2    Chong, S.3
  • 7
    • 0142106303 scopus 로고    scopus 로고
    • Transporter-enzyme interactions: Implications for predicting drug-drug interactions from in vitro data
    • Benet LZ, Cummins CL and Wu CY (2003) Transporter-enzyme interactions: implications for predicting drug-drug interactions from in vitro data. Curr Drug Metab 4:393-398
    • (2003) Curr Drug Metab , vol.4 , pp. 393-398
    • Benet, L.Z.1    Cummins, C.L.2    Wu, C.Y.3
  • 8
    • 33747841593 scopus 로고    scopus 로고
    • Use of cryopreserved human hepatocytes in sandwich culture to measure hepatobiliary transport
    • Bi YA, Kazolias D and Duignan DB (2006) Use of cryopreserved human hepatocytes in sandwich culture to measure hepatobiliary transport. Drug Metab Dispos 34:1658-1665
    • (2006) Drug Metab Dispos , vol.34 , pp. 1658-1665
    • Bi, Y.A.1    Kazolias, D.2    Duignan, D.B.3
  • 10
    • 33748946044 scopus 로고    scopus 로고
    • Prediction of in vivo drug-drug interactions from in vitro data: Factors affecting prototypic drug-drug interactions involving CYP2C9, CYP2D6 and CYP3A4
    • Brown HS, Galetin A, Hallifax D and Houston JB (2006) Prediction of in vivo drug-drug interactions from in vitro data: factors affecting prototypic drug-drug interactions involving CYP2C9, CYP2D6 and CYP3A4. Clin Pharmacokinet 45:1035-1050
    • (2006) Clin Pharmacokinet , vol.45 , pp. 1035-1050
    • Brown, H.S.1    Galetin, A.2    Hallifax, D.3    Houston, J.B.4
  • 11
    • 27444445468 scopus 로고    scopus 로고
    • Prediction of in vivo drug-drug interactions from in vitro data: Impact of incorporating parallel pathways of drug elimination and inhibitor absorption rate constant
    • Brown HS, Ito K, Galetin A and Houston JB (2005) Prediction of in vivo drug-drug interactions from in vitro data: impact of incorporating parallel pathways of drug elimination and inhibitor absorption rate constant. Br J Clin Pharmacol 60:508-518
    • (2005) Br J Clin Pharmacol , vol.60 , pp. 508-518
    • Brown, H.S.1    Ito, K.2    Galetin, A.3    Houston, J.B.4
  • 12
    • 0035408523 scopus 로고    scopus 로고
    • Novel strategies for immortalization of human hepatocytes
    • Cascio SM (2001) Novel strategies for immortalization of human hepatocytes. Artif Organs 25:529-538
    • (2001) Artif Organs , vol.25 , pp. 529-538
    • Cascio, S.M.1
  • 13
    • 0033795486 scopus 로고    scopus 로고
    • Potential role of P-glycoprotein in affecting hepatic metabolism of drugs
    • Chiou WL, Chung SM and Wu TC (2000) Potential role of P-glycoprotein in affecting hepatic metabolism of drugs. Pharm Res 17:903-905
    • (2000) Pharm Res , vol.17 , pp. 903-905
    • Chiou, W.L.1    Chung, S.M.2    Wu, T.C.3
  • 14
    • 0032866401 scopus 로고    scopus 로고
    • The use of heterologously expressed drug metabolizing enzymes-state of the art and prospects for the future
    • Crespi CL and Miller VP (1999) The use of heterologously expressed drug metabolizing enzymes-state of the art and prospects for the future. Pharmacol Ther 84:121-131
    • (1999) Pharmacol Ther , vol.84 , pp. 121-131
    • Crespi, C.L.1    Miller, V.P.2
  • 15
    • 0031570357 scopus 로고    scopus 로고
    • Microtiter plate assays for inhibition of human, drug-metabolizing cytochromes P450
    • Crespi CL, Miller VP and Penman BW (1997) Microtiter plate assays for inhibition of human, drug-metabolizing cytochromes P450. Anal Biochem 248:188-190
    • (1997) Anal Biochem , vol.248 , pp. 188-190
    • Crespi, C.L.1    Miller, V.P.2    Penman, B.W.3
  • 16
    • 33845794361 scopus 로고    scopus 로고
    • Regulation and induction of CYP3A11, CYP3A13 and CYP3A25 in C57BL/6 J mouse liver
    • Down MJ, Arkle S and Mills JJ (2007) Regulation and induction of CYP3A11, CYP3A13 and CYP3A25 in C57BL/6 J mouse liver. Arch Biochem Biophys 457:105-110
    • (2007) Arch Biochem Biophys , vol.457 , pp. 105-110
    • Down, M.J.1    Arkle, S.2    Mills, J.J.3
  • 18
    • 0034781795 scopus 로고    scopus 로고
    • Use of a reporter gene assay to predict and rank the potency and efficacy of CYP3A4 inducers
    • El-Sankary W, Gibson GG, Ayrton A and Plant N (2001) Use of a reporter gene assay to predict and rank the potency and efficacy of CYP3A4 inducers. Drug Metab Dispos 29:1499-1504
    • (2001) Drug Metab Dispos , vol.29 , pp. 1499-1504
    • El-Sankary, W.1    Gibson, G.G.2    Ayrton, A.3    Plant, N.4
  • 19
    • 47949115175 scopus 로고    scopus 로고
    • A combined model for predicting CYP3A4 clinical net drug-drug interaction based on CYP3A4 inhibition, inactivation, and induction determined in vitro
    • Fahmi OA, Maurer TS, Kish M, Cardenas E, Boldt S and Nettleton D (2008) A combined model for predicting CYP3A4 clinical net drug-drug interaction based on CYP3A4 inhibition, inactivation, and induction determined in vitro. Drug Metab Dispos 36:1698-1708
    • (2008) Drug Metab Dispos , vol.36 , pp. 1698-1708
    • Fahmi, O.A.1    Maurer, T.S.2    Kish, M.3    Cardenas, E.4    Boldt, S.5    Nettleton, D.6
  • 20
    • 0035120332 scopus 로고    scopus 로고
    • Lack of correlation between in vitro inhibition of CYP3A-mediated metabolism by a PPAR-gamma agonist and its effect on the clinical pharmacokinetics of midazolam, an in vivo probe of CYP3A activity
    • Fayer JL, Zannikos PN, Stevens JC, Luo Y, Sidhu R and Kirkesseli S (2001) Lack of correlation between in vitro inhibition of CYP3A-mediated metabolism by a PPAR-gamma agonist and its effect on the clinical pharmacokinetics of midazolam, an in vivo probe of CYP3A activity. J Clin Pharmacol 41:305-316
    • (2001) J Clin Pharmacol , vol.41 , pp. 305-316
    • Fayer, J.L.1    Zannikos, P.N.2    Stevens, J.C.3    Luo, Y.4    Sidhu, R.5    Kirkesseli, S.6
  • 22
    • 24944510505 scopus 로고    scopus 로고
    • Cytochrome p450 enzymes mechanism based inhibitors: Common sub-structures and reactivity
    • Fontana E, Dansette PM and Poli SM (2005) Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. Curr Drug Metab 6:413-454
    • (2005) Curr Drug Metab , vol.6 , pp. 413-454
    • Fontana, E.1    Dansette, P.M.2    Poli, S.M.3
  • 23
    • 29944446485 scopus 로고    scopus 로고
    • Prediction of time-dependent CYP3A4 drugdrug interactions: Impact of enzyme degradation, parallel elimination pathways, and intestinal inhibition
    • Galetin A, Burt H, Gibbons L and Houston JB (2006) Prediction of time-dependent CYP3A4 drugdrug interactions: impact of enzyme degradation, parallel elimination pathways, and intestinal inhibition. Drug Metab Dispos 34:166-175
    • (2006) Drug Metab Dispos , vol.34 , pp. 166-175
    • Galetin, A.1    Burt, H.2    Gibbons, L.3    Houston, J.B.4
  • 24
    • 35348880290 scopus 로고    scopus 로고
    • Maximal inhibition of intestinal first-pass metabolism as a pragmatic indicator of intestinal contribution to the drug-drug interactions for CYP3A4 cleared drugs
    • Galetin A, Hinton LK, Burt H, Obach RS and Houston JB (2007) Maximal inhibition of intestinal first-pass metabolism as a pragmatic indicator of intestinal contribution to the drug-drug interactions for CYP3A4 cleared drugs. Curr Drug Metab 8:685-693
    • (2007) Curr Drug Metab , vol.8 , pp. 685-693
    • Galetin, A.1    Hinton, L.K.2    Burt, H.3    Obach, R.S.4    Houston, J.B.5
  • 25
    • 33144459032 scopus 로고    scopus 로고
    • Cytochrome P450 and xenobiotic receptor humanized mice
    • Gonzalez FJ and Yu AM (2006) Cytochrome P450 and xenobiotic receptor humanized mice. Annu Rev Pharmacol Toxicol 46:41-64
    • (2006) Annu Rev Pharmacol Toxicol , vol.46 , pp. 41-64
    • Gonzalez, F.J.1    Yu, A.M.2
  • 26
    • 0032702726 scopus 로고    scopus 로고
    • The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module
    • Goodwin B, Hodgson E and Liddle C (1999) The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module. Mol Pharmacol 56:1329-1339
    • (1999) Mol Pharmacol , vol.56 , pp. 1329-1339
    • Goodwin, B.1    Hodgson, E.2    Liddle, C.3
  • 28
    • 33645961595 scopus 로고    scopus 로고
    • The impact of in vitro binding on in vitro-in vivo extrapolations, projections of metabolic clearance and clinical drug-drug interactions
    • Grime K and Riley RJ (2006) The impact of in vitro binding on in vitro-in vivo extrapolations, projections of metabolic clearance and clinical drug-drug interactions. Curr Drug Metab 7:251-264
    • (2006) Curr Drug Metab , vol.7 , pp. 251-264
    • Grime, K.1    Riley, R.J.2
  • 30
    • 34247517355 scopus 로고    scopus 로고
    • The human hepatoma HepaRG cells: A highly differentiated model for studies of liver metabolism and toxicity of xenobiotics
    • Guillouzo A, Corlu A, Aninat C, Glaise D, Morel F and Guguen-Guillouzo C (2007) The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics. Chem Biol Interact 168:66-73
    • (2007) Chem Biol Interact , vol.168 , pp. 66-73
    • Guillouzo, A.1    Corlu, A.2    Aninat, C.3    Glaise, D.4    Morel, F.5    Guguen-Guillouzo, C.6
  • 31
    • 0037427972 scopus 로고    scopus 로고
    • The superfamily of organic anion transporting polypeptides
    • Hagenbuch B and Meier PJ (2003) The superfamily of organic anion transporting polypeptides. Biochim Biophys Acta 1609:1-18
    • (2003) Biochim Biophys Acta , vol.1609 , pp. 1-18
    • Hagenbuch, B.1    Meier, P.J.2
  • 32
    • 1242272736 scopus 로고    scopus 로고
    • Organic anion transporting polypeptides of the OATP/SLC21 family: Phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties
    • Hagenbuch B and Meier PJ (2004) Organic anion transporting polypeptides of the OATP/SLC21 family: phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties. Pflugers Arch 447:653-665
    • (2004) Pflugers Arch , vol.447 , pp. 653-665
    • Hagenbuch, B.1    Meier, P.J.2
  • 33
    • 0242694739 scopus 로고    scopus 로고
    • Immortalization and transformation of human cells
    • Hahn WC (2002) Immortalization and transformation of human cells. Mol Cells 13:351-361
    • (2002) Mol Cells , vol.13 , pp. 351-361
    • Hahn, W.C.1
  • 34
    • 0034803066 scopus 로고    scopus 로고
    • Regulation of cell morphology and cytochrome P450 expression in human hepatocytes by extracellular matrix and cell-cell interactions
    • Hamilton GA, Jolley SL, Gilbert D, Coon DJ, Barros S and Le Cluyse EL (2001) Regulation of cell morphology and cytochrome P450 expression in human hepatocytes by extracellular matrix and cell-cell interactions. Cell Tissue Res 306:85-99
    • (2001) Cell Tissue Res , vol.306 , pp. 85-99
    • Hamilton, G.A.1    Jolley, S.L.2    Gilbert, D.3    Coon, D.J.4    Barros, S.5    Le Cluyse, E.L.6
  • 35
    • 34248561199 scopus 로고    scopus 로고
    • The role of nuclear receptors in pharmacokinetic drug-drug interactions in oncology
    • Harmsen S, Meijerman I, Beijnen JH and Schellens JH (2007) The role of nuclear receptors in pharmacokinetic drug-drug interactions in oncology. Cancer Treat Rev 33:369-380
    • (2007) Cancer Treat Rev , vol.33 , pp. 369-380
    • Harmsen, S.1    Meijerman, I.2    Beijnen, J.H.3    Schellens, J.H.4
  • 36
    • 40849083767 scopus 로고    scopus 로고
    • A human immunodeficiency virus protease inhibitor is a novel functional inhibitor of human pregnane X receptor
    • Healan-Greenberg C, Waring JF, Kempf DJ, Blomme EA, Tirona RG and Kim RB (2008) A human immunodeficiency virus protease inhibitor is a novel functional inhibitor of human pregnane X receptor. Drug Metab Dispos 36:500-507
    • (2008) Drug Metab Dispos , vol.36 , pp. 500-507
    • Healan-Greenberg, C.1    Waring, J.F.2    Kempf, D.J.3    Blomme, E.A.4    Tirona, R.G.5    Kim, R.B.6
  • 37
    • 34247505094 scopus 로고    scopus 로고
    • Induction of drug metabolizing enzymes: A survey of in vitro methodologies and interpretations used in the pharmaceutical industry-do they comply with FDA recommendations?
    • Hewitt NJ, De Kanter R and Le Cluyse E (2007a) Induction of drug metabolizing enzymes: a survey of in vitro methodologies and interpretations used in the pharmaceutical industry-do they comply with FDA recommendations?. Chem Biol Interact 168:51-65
    • (2007) Chem Biol Interact , vol.168 , pp. 51-65
    • Hewitt, N.J.1    De Kanter, R.2    Le Cluyse, E.3
  • 38
    • 1842627852 scopus 로고    scopus 로고
    • Phase I and II enzyme characterization of two sources of HepG2 cell lines
    • Hewitt NJ and Hewitt P (2004) Phase I and II enzyme characterization of two sources of HepG2 cell lines. Xenobiotica 34:243-256
    • (2004) Xenobiotica , vol.34 , pp. 243-256
    • Hewitt, N.J.1    Hewitt, P.2
  • 40
    • 0035524138 scopus 로고    scopus 로고
    • Assessing the absorption of new pharmaceuticals
    • Hidalgo I (2001) Assessing the absorption of new pharmaceuticals. Curr Topics Med Chem 1:385-401
    • (2001) Curr Topics Med Chem , vol.1 , pp. 385-401
    • Hidalgo, I.1
  • 41
    • 42049097101 scopus 로고    scopus 로고
    • Multiple inhibition mechanisms and prediction of drug-drug interactions: Status of metabolism and transporter models as exemplified by gemfibrozil-drug interactions
    • Hinton LK, Galetin A and Houston JB (2008) Multiple inhibition mechanisms and prediction of drug-drug interactions: status of metabolism and transporter models as exemplified by gemfibrozil-drug interactions. Pharm Res 25:1063-1074
    • (2008) Pharm Res , vol.25 , pp. 1063-1074
    • Hinton, L.K.1    Galetin, A.2    Houston, J.B.3
  • 42
    • 4644364576 scopus 로고    scopus 로고
    • Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans
    • Hirano M, Maeda K, Shitara Y and Sugiyama Y (2004) Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans. J Pharmacol Exp Ther 311:139-146
    • (2004) J Pharmacol Exp Ther , vol.311 , pp. 139-146
    • Hirano, M.1    Maeda, K.2    Shitara, Y.3    Sugiyama, Y.4
  • 43
    • 0038798874 scopus 로고    scopus 로고
    • Drug-activated nuclear receptors CAR and PXR
    • Honkakoski P, Sueyoshi T and Negishi M (2003) Drug-activated nuclear receptors CAR and PXR. Ann Med 35:172-182
    • (2003) Ann Med , vol.35 , pp. 172-182
    • Honkakoski, P.1    Sueyoshi, T.2    Negishi, M.3
  • 44
    • 84900647345 scopus 로고    scopus 로고
    • In vitro to in vivo prediction of p-glycoprotein based drug interactions at the human and rodent blood-brain barrier
    • Hsiao P, Bui T, Ho RJ and Unadkat JD (2007) In vitro to in vivo prediction of p-glycoprotein based drug interactions at the human and rodent blood-brain barrier. Drug Metab Dispos 34:786-792.
    • (2007) Drug Metab Dispos , vol.34 , pp. 786-792
    • Hsiao, P.1    Bui, T.2    Ho, R.J.3    Unadkat, J.D.4
  • 46
    • 43349093221 scopus 로고    scopus 로고
    • Projection of exposure and efficacious dose prior to first-in-human studies: How successful have we been?
    • Huang C, Zheng M, Yang Z, Rodrigues AD and Marathe P (2008) Projection of exposure and efficacious dose prior to first-in-human studies: how successful have we been?. Pharm Res 25:713-726
    • (2008) Pharm Res , vol.25 , pp. 713-726
    • Huang, C.1    Zheng, M.2    Yang, Z.3    Rodrigues, A.D.4    Marathe, P.5
  • 47
    • 0033306846 scopus 로고    scopus 로고
    • Assessment of the quality and quantity of drugdrug interaction studies in recent NDA submissions: Study design and data analysis issues
    • Huang SM, Lesko LJ and Williams RL (1999) Assessment of the quality and quantity of drugdrug interaction studies in recent NDA submissions: study design and data analysis issues. J Clin Pharmacol 39:1006-1014
    • (1999) J Clin Pharmacol , vol.39 , pp. 1006-1014
    • Huang, S.M.1    Lesko, L.J.2    Williams, R.L.3
  • 48
    • 1942455361 scopus 로고    scopus 로고
    • Database analyses for the prediction of in vivo drug-drug interactions from in vitro data
    • Ito K, Brown HS and Houston JB (2004) Database analyses for the prediction of in vivo drug-drug interactions from in vitro data. Br J Clin Pharmacol 57:473-486
    • (2004) Br J Clin Pharmacol , vol.57 , pp. 473-486
    • Ito, K.1    Brown, H.S.2    Houston, J.B.3
  • 49
    • 0031723235 scopus 로고    scopus 로고
    • Prediction of pharmacokinetic alterations caused by drug-drug interactions: Metabolic interaction in the liver
    • Ito K, Iwatsubo T, Kanamitsu S, Ueda K, Suzuki H and Sugiyama Y (1998) Prediction of pharmacokinetic alterations caused by drug-drug interactions: metabolic interaction in the liver. Pharmacol Rev 50:387-412
    • (1998) Pharmacol Rev , vol.50 , pp. 387-412
    • Ito, K.1    Iwatsubo, T.2    Kanamitsu, S.3    Ueda, K.4    Suzuki, H.5    Sugiyama, Y.6
  • 50
    • 33745727121 scopus 로고    scopus 로고
    • Montelukast and zafirlukast do not affect the pharmacokinetics of the CYP2C8 substrate pioglitazone
    • Jaakkola T, Backman JT, Neuvonen M, Niemi M and Neuvonen PJ (2006) Montelukast and zafirlukast do not affect the pharmacokinetics of the CYP2C8 substrate pioglitazone. Eur J Clin Pharmacol 62:503-509
    • (2006) Eur J Clin Pharmacol , vol.62 , pp. 503-509
    • Jaakkola, T.1    Backman, J.T.2    Neuvonen, M.3    Niemi, M.4    Neuvonen, P.J.5
  • 51
    • 33748304477 scopus 로고    scopus 로고
    • The effects of the oral, pan-VEGF-R kinase inhibitor CEP-7055 and chemotherapy in orthotopic models of glioblastoma and colon carcinoma in mice
    • Jones-Bolin S, Zhao H, Hunter K, Klein-Szanto A and Ruggeri B (2006) The effects of the oral, pan-VEGF-R kinase inhibitor CEP-7055 and chemotherapy in orthotopic models of glioblastoma and colon carcinoma in mice. Mol Cancer Ther 5:1744-1753
    • (2006) Mol Cancer Ther , vol.5 , pp. 1744-1753
    • Jones-Bolin, S.1    Zhao, H.2    Hunter, K.3    Klein-Szanto, A.4    Ruggeri, B.5
  • 53
    • 33644817278 scopus 로고    scopus 로고
    • Pioglitazone, an in vitro inhibitor of CYP2C8 and CYP3A4, does not increase the plasma concentrations of the CYP2C8 and CYP3A4 substrate repaglinide
    • Kajosaari LI, Jaakkola T, Neuvonen PJ and Backman JT (2006) Pioglitazone, an in vitro inhibitor of CYP2C8 and CYP3A4, does not increase the plasma concentrations of the CYP2C8 and CYP3A4 substrate repaglinide. Eur J Clin Pharmacol 62:217-223
    • (2006) Eur J Clin Pharmacol , vol.62 , pp. 217-223
    • Kajosaari, L.I.1    Jaakkola, T.2    Neuvonen, P.J.3    Backman, J.T.4
  • 54
    • 0033994866 scopus 로고    scopus 로고
    • Quantitative prediction of in vivo drug-drug interactions from in vitro data based on physiological pharmacokinetics: Use of maximum unbound concentration of inhibitor at the inlet to the liver
    • Kanamitsu S, Ito K and Sugiyama Y (2000) Quantitative prediction of in vivo drug-drug interactions from in vitro data based on physiological pharmacokinetics: use of maximum unbound concentration of inhibitor at the inlet to the liver. Pharm Res 17:336-343
    • (2000) Pharm Res , vol.17 , pp. 336-343
    • Kanamitsu, S.1    Ito, K.2    Sugiyama, Y.3
  • 55
    • 3142628354 scopus 로고    scopus 로고
    • Model for the drug-drug interaction responsible for CYP3A enzyme inhibition. I: Evaluation of cynomolgus monkeys as surrogates for humans
    • Kanazu T, Yamaguchi Y, Okamura N, Baba T and Koike M (2004) Model for the drug-drug interaction responsible for CYP3A enzyme inhibition. I: evaluation of cynomolgus monkeys as surrogates for humans. Xenobiotica 34:391-402
    • (2004) Xenobiotica , vol.34 , pp. 391-402
    • Kanazu, T.1    Yamaguchi, Y.2    Okamura, N.3    Baba, T.4    Koike, M.5
  • 56
    • 0035032365 scopus 로고    scopus 로고
    • Development of a miniaturized 384-well high throughput screen for the detection of substrates of cytochrome P450 2D6 and 3A4 metabolism
    • Kariv I, Fereshteh MP and Oldenburg KR (2001) Development of a miniaturized 384-well high throughput screen for the detection of substrates of cytochrome P450 2D6 and 3A4 metabolism. J Biomol Screen 6:91-99
    • (2001) J Biomol Screen , vol.6 , pp. 91-99
    • Kariv, I.1    Fereshteh, M.P.2    Oldenburg, K.R.3
  • 57
    • 33644868785 scopus 로고    scopus 로고
    • Development, validation and utility of an in vitro technique for assessment of potential clinical drug-drug interactions involving P-glycoprotein
    • Keogh JP and Kunta JR (2006) Development, validation and utility of an in vitro technique for assessment of potential clinical drug-drug interactions involving P-glycoprotein. Eur J Pharm Sci 27:543-554
    • (2006) Eur J Pharm Sci , vol.27 , pp. 543-554
    • Keogh, J.P.1    Kunta, J.R.2
  • 58
    • 2642527944 scopus 로고    scopus 로고
    • Combined application of parallel artificial membrane permeability assay and Caco-2 permeability assays in drug discovery
    • Kerns E, Di L, Petusky S, Farris M, Ley R and Jupp P (2004) Combined application of parallel artificial membrane permeability assay and Caco-2 permeability assays in drug discovery. J Pharma Sci 93:1440-1453
    • (2004) J Pharma Sci , vol.93 , pp. 1440-1453
    • Kerns, E.1    Di, L.2    Petusky, S.3    Farris, M.4    Ley, R.5    Jupp, P.6
  • 59
    • 15244342411 scopus 로고    scopus 로고
    • UDP-glucuronosyltransferases and clinical drugdrug interactions
    • Kiang TK, Ensom MH and Chang TK (2005) UDP-glucuronosyltransferases and clinical drugdrug interactions. Pharmacol Ther 106:97-132
    • (2005) Pharmacol Ther , vol.106 , pp. 97-132
    • Kiang, T.K.1    Ensom, M.H.2    Chang, T.K.3
  • 60
    • 33846995662 scopus 로고    scopus 로고
    • Effect of multiple doses of montelukast on the pharmacokinetics of rosiglitazone, a CYP2C8 substrate, in humans
    • Kim KA, Park PW, Kim KR and Park JY (2007) Effect of multiple doses of montelukast on the pharmacokinetics of rosiglitazone, a CYP2C8 substrate, in humans. Br J Clin Pharmacol 63:339-345
    • (2007) Br J Clin Pharmacol , vol.63 , pp. 339-345
    • Kim, K.A.1    Park, P.W.2    Kim, K.R.3    Park, J.Y.4
  • 61
    • 0036799870 scopus 로고    scopus 로고
    • The nuclear pregnane X receptor: A key regulator of xenobiotic metabolism
    • Kliewer SA, Goodwin B and Willson TM (2002) The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism. Endocr Rev 23:687-702
    • (2002) Endocr Rev , vol.23 , pp. 687-702
    • Kliewer, S.A.1    Goodwin, B.2    Willson, T.M.3
  • 63
    • 33746089203 scopus 로고    scopus 로고
    • In vitro and in vivo correlation of hepatic transporter effects on erythromycin metabolism: Characterizing the importance of transporterenzyme interplay
    • Lam JL, Okochi H, Huang Y and Benet LZ (2006) In vitro and in vivo correlation of hepatic transporter effects on erythromycin metabolism: characterizing the importance of transporterenzyme interplay. Drug Metab Dispos 34:1336-1344
    • (2006) Drug Metab Dispos , vol.34 , pp. 1336-1344
    • Lam, J.L.1    Okochi, H.2    Huang, Y.3    Benet, L.Z.4
  • 64
    • 33846571368 scopus 로고    scopus 로고
    • Effect of OATP1B transporter inhibition on the pharmacokinetics of atorvastatin in healthy volunteers
    • Lau YY, Huang Y, Frassetto L and Benet LZ (2007) Effect of OATP1B transporter inhibition on the pharmacokinetics of atorvastatin in healthy volunteers. Clin Pharmacol Ther 81:194-204
    • (2007) Clin Pharmacol Ther , vol.81 , pp. 194-204
    • Lau, Y.Y.1    Huang, Y.2    Frassetto, L.3    Benet, L.Z.4
  • 67
    • 33745050401 scopus 로고    scopus 로고
    • Using positron emission tomography to facilitate CNS drug development
    • Lee CM and Farde L (2006) Using positron emission tomography to facilitate CNS drug development. Trends Pharmacol Sci 27:310-316
    • (2006) Trends Pharmacol Sci , vol.27 , pp. 310-316
    • Lee, C.M.1    Farde, L.2
  • 68
    • 34250782654 scopus 로고    scopus 로고
    • Esterase inhibition attribute of grapefruit juice leading to a new drug interaction
    • Li P, Callery PS, Gan LS and Balani SK (2007) Esterase inhibition attribute of grapefruit juice leading to a new drug interaction. Drug Metab Dispos 35:1023-1031
    • (2007) Drug Metab Dispos , vol.35 , pp. 1023-1031
    • Li, P.1    Callery, P.S.2    Gan, L.S.3    Balani, S.K.4
  • 69
    • 0037229942 scopus 로고    scopus 로고
    • Role of P-glycoprotein in pharmacokinetics
    • Lin J and Yamazaki M (2003) Role of P-glycoprotein in pharmacokinetics. Clin Pharmacokinet 42:59-98
    • (2003) Clin Pharmacokinet , vol.42 , pp. 59-98
    • Lin, J.1    Yamazaki, M.2
  • 70
    • 34250331903 scopus 로고    scopus 로고
    • Transporter-mediated drug interactions: Clinical implications and in vitro assessment
    • Lin JH (2007) Transporter-mediated drug interactions: clinical implications and in vitro assessment. Expert Opin Drug Metab Toxicol 3:81-92
    • (2007) Expert Opin Drug Metab Toxicol , vol.3 , pp. 81-92
    • Lin, J.H.1
  • 71
    • 0031794361 scopus 로고    scopus 로고
    • Inhibition and induction of cytochrome P450 and the clinical implications
    • Lin JH and Lu AY (1998) Inhibition and induction of cytochrome P450 and the clinical implications. Clin Pharmacokinet 35:361-390
    • (1998) Clin Pharmacokinet , vol.35 , pp. 361-390
    • Lin, J.H.1    Lu, A.Y.2
  • 72
    • 0042704609 scopus 로고    scopus 로고
    • Prediction of metabolic drug interactions: Quantitative or qualitative?
    • Rodrigues AD ed, Marcel Dekker, Basel, Switzerland
    • Lin JH and Pearson PG (2002) Prediction of metabolic drug interactions: quantitative or qualitative?, in Drug-Drug Interactions (Rodrigues AD ed) pp 415-438, Marcel Dekker, Basel, Switzerland.
    • (2002) Drug-Drug Interactions , pp. 415-438
    • Lin, J.H.1    Pearson, P.G.2
  • 74
    • 34249023089 scopus 로고    scopus 로고
    • Effect of DPC 333 [(2R)-2-{(3R)-3-amino-3-[4-(2-methylquinolin-4- ylmethoxy) phenyl]-2-oxopyrr olidin-1-yl}-N-hydroxy-4-methylpentanamide], a human tumor necrosis factor alpha-converting enzyme inhibitor, on the disposition of methotrexate: A transporter-based drug-drug interaction case study
    • Luo G, Garner CE, Xiong H, Hu H, Richards LE, Brouwer KL, Duan J, Decicco CP, Maduskuie T, Shen H, Lee FW and Gan LS (2007) Effect of DPC 333 [(2R)-2-{(3R)-3-amino-3-[4-(2-methylquinolin-4-ylmethoxy) phenyl]-2-oxopyrr olidin-1-yl}-N-hydroxy-4-methylpentanamide], a human tumor necrosis factor alpha-converting enzyme inhibitor, on the disposition of methotrexate: a transporter-based drug-drug interaction case study. Drug Metab Dispos 35:835-840
    • (2007) Drug Metab Dispos , vol.35 , pp. 835-840
    • Luo, G.1    Garner, C.E.2    Xiong, H.3    Hu, H.4    Richards, L.E.5    Brouwer, K.L.6    Duan, J.7    Decicco, C.P.8    Maduskuie, T.9    Shen, H.10    Lee, F.W.11    Gan, L.S.12
  • 77
    • 33846461683 scopus 로고    scopus 로고
    • The PREgnane X receptor gene-humanized mouse: A model for investigating drug-drug interactions mediated by cytochromes P450 3A
    • Ma X, Shah Y, Cheung C, Guo GL, Feigenbaum L, Krausz KW, Idle JR and Gonzalez FJ (2007) The PREgnane X receptor gene-humanized mouse: a model for investigating drug-drug interactions mediated by cytochromes P450 3A. Drug Metab Dispos 35:194-200
    • (2007) Drug Metab Dispos , vol.35 , pp. 194-200
    • Ma, X.1    Shah, Y.2    Cheung, C.3    Guo, G.L.4    Feigenbaum, L.5    Krausz, K.W.6    Idle, J.R.7    Gonzalez, F.J.8
  • 78
    • 0013212389 scopus 로고    scopus 로고
    • In vitro approaches for studying the inhibition of drug-metabolizing enzymes and identifying the drug-metabolizing enzymes responsible for the metabolism of drugs
    • Rodrigues AD ed, Marcel Dekker, Inc, Basel-Switzerland
    • Madan A, Usuki E, Burton LA, Ogilvie BW and Parkinson A (2002) In vitro approaches for studying the inhibition of drug-metabolizing enzymes and identifying the drug-metabolizing enzymes responsible for the metabolism of drugs, in Drug-drug interactions (Rodrigues AD ed) pp 217-294, Marcel Dekker, Inc, Basel-Switzerland.
    • (2002) Drug-drug Interactions , pp. 217-294
    • Madan, A.1    Usuki, E.2    Burton, L.A.3    Ogilvie, B.W.4    Parkinson, A.5
  • 79
    • 20044386351 scopus 로고    scopus 로고
    • Dioxin: A review of its environmental effects and its aryl hydrocarbon receptor biology
    • Mandal PK (2005) Dioxin: a review of its environmental effects and its aryl hydrocarbon receptor biology. J Comp Physiol [B] 175:221-230
    • (2005) J Comp Physiol [B] , vol.175 , pp. 221-230
    • Mandal, P.K.1
  • 80
    • 33749443439 scopus 로고    scopus 로고
    • In vivo animal models for investigating potential CYP3A- and Pgp-mediated drug-drug interactions
    • Marathe PH and Rodrigues AD (2006) In vivo animal models for investigating potential CYP3A- and Pgp-mediated drug-drug interactions. CurrDrug Metab 7:687-704
    • (2006) CurrDrug Metab , vol.7 , pp. 687-704
    • Marathe, P.H.1    Rodrigues, A.D.2
  • 81
    • 37549011739 scopus 로고    scopus 로고
    • Use of sandwich-cultured hepatocytes to evaluate impaired bile acid transport as a mechanism of drug-induced hepatotoxicity
    • Marion TL, Leslie EM and Brouwer KL (2007) Use of sandwich-cultured hepatocytes to evaluate impaired bile acid transport as a mechanism of drug-induced hepatotoxicity. Mol Pharm 4:911-918
    • (2007) Mol Pharm , vol.4 , pp. 911-918
    • Marion, T.L.1    Leslie, E.M.2    Brouwer, K.L.3
  • 82
    • 0034964222 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic implications of P-gp modulation
    • Matheny C, Lamb M, Brouwer K and Pollak G (2001) Pharmacokinetic and pharmacodynamic implications of P-gp modulation. Pharmacotherapy 21:778-796
    • (2001) Pharmacotherapy , vol.21 , pp. 778-796
    • Matheny, C.1    Lamb, M.2    Brouwer, K.3    Pollak, G.4
  • 84
    • 15744384408 scopus 로고    scopus 로고
    • Transcriptional induction of CYP3A4 by o, p'-DDT in HepG2 cells
    • Medina-Diaz IM and Elizondo G (2005) Transcriptional induction of CYP3A4 by o, p'-DDT in HepG2 cells. Toxicol Lett 157:41-47
    • (2005) Toxicol Lett , vol.157 , pp. 41-47
    • Medina-Diaz, I.M.1    Elizondo, G.2
  • 87
    • 1642273510 scopus 로고    scopus 로고
    • Induction of drug metabolism enzymes and MDR1 using a novel human hepatocyte cell line
    • Mills JB, Rose KA, Sadagopan N, Sahi J and De Morais SM (2004) Induction of drug metabolism enzymes and MDR1 using a novel human hepatocyte cell line. J Pharmacol Exp Ther 309:303-309
    • (2004) J Pharmacol Exp Ther , vol.309 , pp. 303-309
    • Mills, J.B.1    Rose, K.A.2    Sadagopan, N.3    Sahi, J.4    De Morais, S.M.5
  • 88
    • 0344610168 scopus 로고    scopus 로고
    • Predicting human drug glucuronidation parameters: Application of in vitro and in silico modeling approaches
    • Miners JO, Smith PA, Sorich MJ, McKinnon RA and Mackenzie PI (2004) Predicting human drug glucuronidation parameters: application of in vitro and in silico modeling approaches. Annu Rev Pharmacol Toxicol 44:1-25
    • (2004) Annu Rev Pharmacol Toxicol , vol.44 , pp. 1-25
    • Miners, J.O.1    Smith, P.A.2    Sorich, M.J.3    McKinnon, R.A.4    Mackenzie, P.I.5
  • 89
    • 7444242763 scopus 로고    scopus 로고
    • Utility of microtiter plate assays for human cytochrome P450 inhibition studies in drug discovery: Application of simple method for detecting quasi-irreversible and irreversible inhibitors
    • Naritomi Y, Teramura Y, Terashita S and Kagayama A (2004) Utility of microtiter plate assays for human cytochrome P450 inhibition studies in drug discovery: application of simple method for detecting quasi-irreversible and irreversible inhibitors. Drug Metab Pharmacokinet 19:55-61
    • (2004) Drug Metab Pharmacokinet , vol.19 , pp. 55-61
    • Naritomi, Y.1    Teramura, Y.2    Terashita, S.3    Kagayama, A.4
  • 90
    • 34548103493 scopus 로고    scopus 로고
    • Role of OATP transporters in the disposition of drugs
    • Niemi M (2007) Role of OATP transporters in the disposition of drugs. Pharmacogenomics 8:787-802
    • (2007) Pharmacogenomics , vol.8 , pp. 787-802
    • Niemi, M.1
  • 92
    • 34548532926 scopus 로고    scopus 로고
    • Comparison of inducibility of CYP1A and CYP3A mRNAs by prototypical inducers in primary cultures of human, cynomolgus monkey, and rat hepatocytes
    • Nishimura M, Koeda A, Suganuma Y, Suzuki E, Shimizu T, Nakayama M, Satoh T, Narimatsu S and Naito S (2007) Comparison of inducibility of CYP1A and CYP3A mRNAs by prototypical inducers in primary cultures of human, cynomolgus monkey, and rat hepatocytes. Drug Metab Pharmacokinet 22:178-186
    • (2007) Drug Metab Pharmacokinet , vol.22 , pp. 178-186
    • Nishimura, M.1    Koeda, A.2    Suganuma, Y.3    Suzuki, E.4    Shimizu, T.5    Nakayama, M.6    Satoh, T.7    Narimatsu, S.8    Naito, S.9
  • 93
    • 0035147471 scopus 로고    scopus 로고
    • The prediction of human clearance from hepatic microsomal metabolism data
    • Obach RS (2001) The prediction of human clearance from hepatic microsomal metabolism data. Curr Opin Drug Discovery Dev 4:36-44
    • (2001) Curr Opin Drug Discovery Dev , vol.4 , pp. 36-44
    • Obach, R.S.1
  • 94
    • 33846449874 scopus 로고    scopus 로고
    • Mechanism-based inactivation of human cytochrome p450 enzymes and the prediction of drug-drug interactions
    • Obach RS, Walsky RL and Venkatakrishnan K (2007) Mechanism-based inactivation of human cytochrome p450 enzymes and the prediction of drug-drug interactions. Drug Metab Dispos 35:246-255
    • (2007) Drug Metab Dispos , vol.35 , pp. 246-255
    • Obach, R.S.1    Walsky, R.L.2    Venkatakrishnan, K.3
  • 95
    • 28844476587 scopus 로고    scopus 로고
    • In vitro cytochrome P450 inhibition data and the prediction of drug-drug interactions: Qualitative relationships, quantitative predictions, and the rank-order approach
    • Obach RS, Walsky RL, Venkatakrishnan K, Houston JB and Tremaine LM (2005) In vitro cytochrome P450 inhibition data and the prediction of drug-drug interactions: qualitative relationships, quantitative predictions, and the rank-order approach. Clin Pharmacol Ther 78:582-592
    • (2005) Clin Pharmacol Ther , vol.78 , pp. 582-592
    • Obach, R.S.1    Walsky, R.L.2    Venkatakrishnan, K.3    Houston, J.B.4    Tremaine, L.M.5
  • 96
    • 33847343857 scopus 로고    scopus 로고
    • Effect of oral ketoconazole on intestinal firstpass effect of midazolam and fexofenadine in cynomolgus monkeys
    • Ogasawara A, Kume T and Kazama E (2007) Effect of oral ketoconazole on intestinal firstpass effect of midazolam and fexofenadine in cynomolgus monkeys. Drug Metab Dispos 35:410-418
    • (2007) Drug Metab Dispos , vol.35 , pp. 410-418
    • Ogasawara, A.1    Kume, T.2    Kazama, E.3
  • 97
    • 29944446317 scopus 로고    scopus 로고
    • Glucuronidation converts gemfibrozil to a potent, metabolism-dependent inhibitor of CYP2C8: Implications for drug-drug interactions
    • Ogilvie BW, Zhang D, Li W, Rodrigues AD, Gipson AE, Holsapple J, Toren P and Parkinson A (2006) Glucuronidation converts gemfibrozil to a potent, metabolism-dependent inhibitor of CYP2C8: implications for drug-drug interactions. Drug Metab Dispos 34:191-197
    • (2006) Drug Metab Dispos , vol.34 , pp. 191-197
    • Ogilvie, B.W.1    Zhang, D.2    Li, W.3    Rodrigues, A.D.4    Gipson, A.E.5    Holsapple, J.6    Toren, P.7    Parkinson, A.8
  • 98
    • 34547641389 scopus 로고    scopus 로고
    • General framework for the quantitative prediction of CYP3A4-mediated oral drug interactions based on the AUC increase by coadministration of standard drugs
    • Ohno Y, Hisaka A and Suzuki H (2007) General framework for the quantitative prediction of CYP3A4-mediated oral drug interactions based on the AUC increase by coadministration of standard drugs. Clin Pharmacokinet 46:681-696
    • (2007) Clin Pharmacokinet , vol.46 , pp. 681-696
    • Ohno, Y.1    Hisaka, A.2    Suzuki, H.3
  • 100
    • 33947323721 scopus 로고    scopus 로고
    • New strategies to address drug-drug interactions involving OATPs
    • Poirier A, Funk C, Lave T and Noe J (2007) New strategies to address drug-drug interactions involving OATPs. Curr Opin Drug Discovery Dev 10:74-83
    • (2007) Curr Opin Drug Discovery Dev , vol.10 , pp. 74-83
    • Poirier, A.1    Funk, C.2    Lave, T.3    Noe, J.4
  • 103
    • 0028088621 scopus 로고
    • Inhibition of hepatic P-450 isoenzymes by serotonin selective reuptake inhibitors: In vitro and in vivo findings and their implications for patient care
    • Preskorn SH and Magnus RD (1994) Inhibition of hepatic P-450 isoenzymes by serotonin selective reuptake inhibitors: in vitro and in vivo findings and their implications for patient care. Psychopharmacol Bull 30:251-259
    • (1994) Psychopharmacol Bull , vol.30 , pp. 251-259
    • Preskorn, S.H.1    Magnus, R.D.2
  • 104
    • 33747868126 scopus 로고    scopus 로고
    • In vitro and in vivo CYP3A64 induction and inhibition studies in rhesus monkeys: A preclinical approach for CYP3A-mediated drug interaction studies
    • Prueksaritanont T, Kuo Y, Tang C, Li C, Qiu Y, Lu B, Strong-Basalyga K, Richards K, Carr B and Lin JH (2006) In vitro and in vivo CYP3A64 induction and inhibition studies in rhesus monkeys: a preclinical approach for CYP3A-mediated drug interaction studies. Drug Metab Dispos 34:1546-1555
    • (2006) Drug Metab Dispos , vol.34 , pp. 1546-1555
    • Prueksaritanont, T.1    Kuo, Y.2    Tang, C.3    Li, C.4    Qiu, Y.5    Lu, B.6    Strong-Basalyga, K.7    Richards, K.8    Carr, B.9    Lin, J.H.10
  • 106
    • 15644384598 scopus 로고    scopus 로고
    • AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line
    • Rencurel F, Stenhouse A, Hawley SA, Friedberg T, Hardie DG, Sutherland C and Wolf CR (2005) AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line. J Biol Chem 280:4367-4373
    • (2005) J Biol Chem , vol.280 , pp. 4367-4373
    • Rencurel, F.1    Stenhouse, A.2    Hawley, S.A.3    Friedberg, T.4    Hardie, D.G.5    Sutherland, C.6    Wolf, C.R.7
  • 107
    • 0035154850 scopus 로고    scopus 로고
    • The potential pharmacological and toxicological impact of P450 screening
    • Riley RJ (2001) The potential pharmacological and toxicological impact of P450 screening. Curr Opin Drug Discov Dev 4:45-54
    • (2001) Curr Opin Drug Discov Dev , vol.4 , pp. 45-54
    • Riley, R.J.1
  • 108
    • 33748905486 scopus 로고    scopus 로고
    • Use of immortalized human hepatocytes to predict the magnitude of clinical drug-drug interactions caused by CYP3A4 induction
    • Ripp SL, Mills JB, Fahmi OA, Trevena KA, Liras JL, Maurer TS and De Morais SM (2006) Use of immortalized human hepatocytes to predict the magnitude of clinical drug-drug interactions caused by CYP3A4 induction. Drug Metab Dispos 34:1742-1748
    • (2006) Drug Metab Dispos , vol.34 , pp. 1742-1748
    • Ripp, S.L.1    Mills, J.B.2    Fahmi, O.A.3    Trevena, K.A.4    Liras, J.L.5    Maurer, T.S.6    De Morais, S.M.7
  • 109
    • 40049084668 scopus 로고    scopus 로고
    • Prioritization of clinical drug inteaction studies using in vitro cytochrome P450 data: Proposed refinement and expansion of the "rank order" approach
    • Rodrigues AD (2007) Prioritization of clinical drug inteaction studies using in vitro cytochrome P450 data: proposed refinement and expansion of the "rank order" approach. Drug Metab Lett 1:31-35
    • (2007) Drug Metab Lett , vol.1 , pp. 31-35
    • Rodrigues, A.D.1
  • 110
    • 0035069388 scopus 로고    scopus 로고
    • Use of in vitro drug metabolism data to evaluate metabolic drug-drug interactions in man: The need for quantitative databases
    • Rodrigues AD, Winchell GA and Dobrinska MR (2001) Use of in vitro drug metabolism data to evaluate metabolic drug-drug interactions in man: the need for quantitative databases. J Clin Pharmacol 41:368-373
    • (2001) J Clin Pharmacol , vol.41 , pp. 368-373
    • Rodrigues, A.D.1    Winchell, G.A.2    Dobrinska, M.R.3
  • 111
    • 13244287685 scopus 로고    scopus 로고
    • "In silico" simulations to assess the "in vivo" consequences of "in vitro" metabolic drug-drug interactions
    • Rostami-Hodjegan A and Tucker G (2004) "In silico" simulations to assess the "in vivo" consequences of "in vitro" metabolic drug-drug interactions. Drug Discovery Today 1:441-448
    • (2004) Drug Discovery Today , vol.1 , pp. 441-448
    • Rostami-Hodjegan, A.1    Tucker, G.2
  • 115
    • 0034608788 scopus 로고    scopus 로고
    • UDS induction by an array of standard carcinogens in human and rodent hepatocytes: Effect of cryopreservation
    • Schehrer L, Regan JD and Westendorf J (2000) UDS induction by an array of standard carcinogens in human and rodent hepatocytes: effect of cryopreservation. Toxicology 147:177-191
    • (2000) Toxicology , vol.147 , pp. 177-191
    • Schehrer, L.1    Regan, J.D.2    Westendorf, J.3
  • 116
    • 6944232288 scopus 로고    scopus 로고
    • Sulfotransferase 1E1 is a low km isoform mediating the 3-O-sulfation of ethinyl estradiol
    • Schrag ML, Cui D, Rushmore TH, Shou M, Ma B and Rodrigues AD (2004) Sulfotransferase 1E1 is a low km isoform mediating the 3-O-sulfation of ethinyl estradiol. Drug Metab Dispos 32:1299-1303
    • (2004) Drug Metab Dispos , vol.32 , pp. 1299-1303
    • Schrag, M.L.1    Cui, D.2    Rushmore, T.H.3    Shou, M.4    Ma, B.5    Rodrigues, A.D.6
  • 117
    • 0018901053 scopus 로고
    • Transport systems of isolated hepatocytes. Studies on the transport of biliary compounds
    • Schwenk M (1980) Transport systems of isolated hepatocytes. Studies on the transport of biliary compounds. Arch Toxicol 44:113-126
    • (1980) Arch Toxicol , vol.44 , pp. 113-126
    • Schwenk, M.1
  • 118
  • 119
    • 0028930481 scopus 로고
    • Mechanism-based enzyme inactivators
    • Silverman RB (1995) Mechanism-based enzyme inactivators. Methods Enzymol 249:240-283
    • (1995) Methods Enzymol , vol.249 , pp. 240-283
    • Silverman, R.B.1
  • 120
    • 33646517938 scopus 로고    scopus 로고
    • Evaluation of 170 xenobiotics as transactivators of human pregnane X receptor (hPXR) and correlation to known CYP3A4 drug interactions
    • Sinz M, Kim S, Zhu Z, Chen T, Anthony M, Dickinson K and Rodrigues AD (2006) Evaluation of 170 xenobiotics as transactivators of human pregnane X receptor (hPXR) and correlation to known CYP3A4 drug interactions. Curr Drug Metab 7:375-388
    • (2006) Curr Drug Metab , vol.7 , pp. 375-388
    • Sinz, M.1    Kim, S.2    Zhu, Z.3    Chen, T.4    Anthony, M.5    Dickinson, K.6    Rodrigues, A.D.7
  • 121
    • 33645972546 scopus 로고    scopus 로고
    • Stem cells, immortalized cells and primary cells in ADMET assays
    • Sinz MW and Kim S (2006) Stem cells, immortalized cells and primary cells in ADMET assays. Drug Discovery Today 3:79-85
    • (2006) Drug Discovery Today , vol.3 , pp. 79-85
    • Sinz, M.W.1    Kim, S.2
  • 122
    • 33747866680 scopus 로고    scopus 로고
    • Role of the liver-specific transporters OATP1B1 and OATP1B3 in governing drug elimination
    • Smith NF, Figg WD and Sparreboom A (2005) Role of the liver-specific transporters OATP1B1 and OATP1B3 in governing drug elimination. Expert Opin Drug Metab Toxicol 1:429-445
    • (2005) Expert Opin Drug Metab Toxicol , vol.1 , pp. 429-445
    • Smith, N.F.1    Figg, W.D.2    Sparreboom, A.3
  • 124
    • 33746706762 scopus 로고    scopus 로고
    • PXR and CAR: Nuclear receptors which play a pivotal role in drug disposition and chemical toxicity
    • Stanley LA, Horsburgh BC, Ross J, Scheer N and Wolf CR (2006) PXR and CAR: nuclear receptors which play a pivotal role in drug disposition and chemical toxicity. Drug Metab Rev 38:515-597
    • (2006) Drug Metab Rev , vol.38 , pp. 515-597
    • Stanley, L.A.1    Horsburgh, B.C.2    Ross, J.3    Scheer, N.4    Wolf, C.R.5
  • 125
    • 0015528484 scopus 로고
    • Adverse drug interactions
    • Surveillance BCD (1972) Adverse drug interactions. J Am Med Assoc 220:1238-1239
    • (1972) J Am Med Assoc , vol.220 , pp. 1238-1239
    • Surveillance, B.C.D.1
  • 126
    • 0033739725 scopus 로고    scopus 로고
    • Role of metabolic enzymes and efflux transporters in the absorption of drugs from the small intestine
    • Suzuki H and Sugiyama Y (2000) Role of metabolic enzymes and efflux transporters in the absorption of drugs from the small intestine. Eur J Pharm Sci 12:3-12
    • (2000) Eur J Pharm Sci , vol.12 , pp. 3-12
    • Suzuki, H.1    Sugiyama, Y.2
  • 127
    • 0035038919 scopus 로고    scopus 로고
    • The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux
    • Synold TW, Dussault I and Forman BM (2001) The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. Nat Med 7:584-590
    • (2001) Nat Med , vol.7 , pp. 584-590
    • Synold, T.W.1    Dussault, I.2    Forman, B.M.3
  • 129
    • 21344439074 scopus 로고    scopus 로고
    • Nuclear receptors and drug disposition gene regulation
    • Tirona RG and Kim RB (2005) Nuclear receptors and drug disposition gene regulation. J Pharm Sci 94:1169-1186
    • (2005) J Pharm Sci , vol.94 , pp. 1169-1186
    • Tirona, R.G.1    Kim, R.B.2
  • 130
    • 17044381648 scopus 로고    scopus 로고
    • Highly miniaturized formats for in vitro drug metabolism assays using vivid fluorescent substrates and recombinant human cytochrome P450 enzymes
    • Trubetskoy OV, Gibson JR and Marks BD (2005) Highly miniaturized formats for in vitro drug metabolism assays using vivid fluorescent substrates and recombinant human cytochrome P450 enzymes. J Biomol Screen 10:56-66
    • (2005) J Biomol Screen , vol.10 , pp. 56-66
    • Trubetskoy, O.V.1    Gibson, J.R.2    Marks, B.D.3
  • 131
    • 0034883375 scopus 로고    scopus 로고
    • Optimizing drug development: Strategies to assess drug metabolism/transporter interaction potential-toward a consensus
    • Tucker GT, Houston JB and Huang SM (2001) Optimizing drug development: strategies to assess drug metabolism/transporter interaction potential-toward a consensus. Clin Pharmacol Ther 70:103-114
    • (2001) Clin Pharmacol Ther , vol.70 , pp. 103-114
    • Tucker, G.T.1    Houston, J.B.2    Huang, S.M.3
  • 132
    • 35648987166 scopus 로고    scopus 로고
    • Mechanism-based inactivation of human cytochrome P450 enzymes: Strategies for diagnosis and drug-drug interaction risk assessment
    • Venkatakrishnan K, Obach RS and Rostami-Hodjegan A (2007) Mechanism-based inactivation of human cytochrome P450 enzymes: strategies for diagnosis and drug-drug interaction risk assessment. Xenobiotica 37:1225-1256
    • (2007) Xenobiotica , vol.37 , pp. 1225-1256
    • Venkatakrishnan, K.1    Obach, R.S.2    Rostami-Hodjegan, A.3
  • 134
    • 2342619544 scopus 로고    scopus 로고
    • A human and mouse pregnane X receptor reporter gene assay in combination with cytotoxicity measurements as a tool to evaluate species-specific CYP3A induction
    • Vignati LA, Bogni A, Grossi P and Monshouwer M (2004) A human and mouse pregnane X receptor reporter gene assay in combination with cytotoxicity measurements as a tool to evaluate species-specific CYP3A induction. Toxicology 199:23-33
    • (2004) Toxicology , vol.199 , pp. 23-33
    • Vignati, L.A.1    Bogni, A.2    Grossi, P.3    Monshouwer, M.4
  • 138
    • 0842282550 scopus 로고    scopus 로고
    • Prediction of cytochrome P450 3A inhibition by verapamil enantiomers and their metabolites
    • Wang YH, Jones DR and Hall SD (2004) Prediction of cytochrome P450 3A inhibition by verapamil enantiomers and their metabolites. Drug Metab Dispos 32:259-266
    • (2004) Drug Metab Dispos , vol.32 , pp. 259-266
    • Wang, Y.H.1    Jones, D.R.2    Hall, S.D.3
  • 139
    • 0034034259 scopus 로고    scopus 로고
    • High-throughput screening in drug metabolism and pharmacokinetic support of drug discovery
    • White RE (2000) High-throughput screening in drug metabolism and pharmacokinetic support of drug discovery. Annu Rev Pharmacol Toxicol 40:133-157
    • (2000) Annu Rev Pharmacol Toxicol , vol.40 , pp. 133-157
    • White, R.E.1
  • 140
    • 6944221357 scopus 로고    scopus 로고
    • Drug-drug interactions for UDP-glucuronosyltransferase substrates: A pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios
    • Williams JA, Hyland R, Jones BC, Smith DA, Hurst S, Goosen TC, Peterkin V, Koup JR and Ball SE (2004) Drug-drug interactions for UDP- glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios. Drug Metab Dispos 32:1201-1208
    • (2004) Drug Metab Dispos , vol.32 , pp. 1201-1208
    • Williams, J.A.1    Hyland, R.2    Jones, B.C.3    Smith, D.A.4    Hurst, S.5    Goosen, T.C.6    Peterkin, V.7    Koup, J.R.8    Ball, S.E.9
  • 141
    • 17644380257 scopus 로고    scopus 로고
    • Predicting drug disposition via application of BCS: Transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system
    • Wu CY and Benet LZ (2005) Predicting drug disposition via application of BCS: transport/absorption/elimination interplay and development of a biopharmaceutics drug disposition classification system. Pharm Res 22:11-23
    • (2005) Pharm Res , vol.22 , pp. 11-23
    • Wu, C.Y.1    Benet, L.Z.2
  • 142
    • 0036558204 scopus 로고    scopus 로고
    • Pharmaceutical use of mouse models humanized for the xenobiotic receptor
    • Xie W and Evans RM (2002) Pharmaceutical use of mouse models humanized for the xenobiotic receptor. Drug Discovery Today 7:509-515
    • (2002) Drug Discovery Today , vol.7 , pp. 509-515
    • Xie, W.1    Evans, R.M.2
  • 143
    • 0442313590 scopus 로고    scopus 로고
    • High-throughput screening for the assessment of timedependent inhibitions of new drug candidates on recombinant CYP2D6 and CYP3A4 using a single concentration method
    • Yamamoto T, Suzuki A and Kohno Y (2004) High-throughput screening for the assessment of timedependent inhibitions of new drug candidates on recombinant CYP2D6 and CYP3A4 using a single concentration method. Xenobiotica 34:87-101
    • (2004) Xenobiotica , vol.34 , pp. 87-101
    • Yamamoto, T.1    Suzuki, A.2    Kohno, Y.3
  • 144
    • 0036825366 scopus 로고    scopus 로고
    • Rapidly distinguishing reversible and irreversible CYP450 inhibitors by using fluorometric kinetic analyses
    • Yan Z, Rafferty B, Caldwell GW and Masucci JA (2002) Rapidly distinguishing reversible and irreversible CYP450 inhibitors by using fluorometric kinetic analyses. Eur J Drug Metab Pharmacokinet 27:281-287
    • (2002) Eur J Drug Metab Pharmacokinet , vol.27 , pp. 281-287
    • Yan, Z.1    Rafferty, B.2    Caldwell, G.W.3    Masucci, J.A.4
  • 145
    • 0036771085 scopus 로고    scopus 로고
    • Inhibition-based metabolic drug-drug interactions: Predictions from in vitro data
    • Yao C and Levy RH (2002) Inhibition-based metabolic drug-drug interactions: predictions from in vitro data. J Pharm Sci 91:1923-1935
    • (2002) J Pharm Sci , vol.91 , pp. 1923-1935
    • Yao, C.1    Levy, R.H.2
  • 146
    • 49949086869 scopus 로고    scopus 로고
    • An automated, high-throughput, 384 well cytochrome P450 cocktail IC50 assay using a rapid resolution LC-MS/MS end-point
    • Youdim KA, Lyons R, Payne L, Jones BC and Saunders K (2008) An automated, high-throughput, 384 well cytochrome P450 cocktail IC50 assay using a rapid resolution LC-MS/MS end-point. J Pharm Biomed Anal 48:92-99
    • (2008) J Pharm Biomed Anal , vol.48 , pp. 92-99
    • Youdim, K.A.1    Lyons, R.2    Payne, L.3    Jones, B.C.4    Saunders, K.5
  • 147
    • 33846458253 scopus 로고    scopus 로고
    • Induction of cytochrome P450: Assessment in an immortalized human hepatocyte cell line (Fa2N4) using a novel higher throughput cocktail assay
    • Youdim KA, Tyman CA, Jones BC and Hyland R (2007) Induction of cytochrome P450: assessment in an immortalized human hepatocyte cell line (Fa2N4) using a novel higher throughput cocktail assay. Drug Metab Dispos 35:275-282
    • (2007) Drug Metab Dispos , vol.35 , pp. 275-282
    • Youdim, K.A.1    Tyman, C.A.2    Jones, B.C.3    Hyland, R.4
  • 148
    • 0033328139 scopus 로고    scopus 로고
    • The contribution of P-glycoprotein to pharmacokinetic drug-drug interactions
    • Yu DK (1999) The contribution of P-glycoprotein to pharmacokinetic drug-drug interactions. J Clin Pharmacol 39:1203-1211
    • (1999) J Clin Pharmacol , vol.39 , pp. 1203-1211
    • Yu, D.K.1
  • 150
    • 34247391128 scopus 로고    scopus 로고
    • Reduction of site-specific CYP3A-mediated metabolism for dual angiotensin and endothelin receptor antagonists in various in vitro systems and in cynomolgus monkeys
    • Zhang H, Zhang D, Li W, Yao M, D'Arienzo C, Li YX, Ewing WR, Gu Z, Zhu Y, Murugesan N, Shyu WC and Humphreys WG (2007b) Reduction of site-specific CYP3A-mediated metabolism for dual angiotensin and endothelin receptor antagonists in various in vitro systems and in cynomolgus monkeys. Drug Metab Dispos 35:795-805
    • (2007) Drug Metab Dispos , vol.35 , pp. 795-805
    • Zhang, H.1    Zhang, D.2    Li, W.3    Yao, M.4    D'Arienzo, C.5    Li, Y.X.6    Ewing, W.R.7    Gu, Z.8    Zhu, Y.9    Murugesan, N.10    Shyu, W.C.11    Humphreys, W.G.12
  • 151
    • 57749171180 scopus 로고    scopus 로고
    • Elucidating rifampin's inducing and inhibiting effects on glyburide pharmacokinetics and blood glucose in healthy volunteers: Unmasking the differential effects of enzyme induction and transporter inhibition for a drug and its primary metabolite
    • Zheng HX, Huang Y, Frassetto LA and Benet LZ (2009) Elucidating rifampin's inducing and inhibiting effects on glyburide pharmacokinetics and blood glucose in healthy volunteers: unmasking the differential effects of enzyme induction and transporter inhibition for a drug and its primary metabolite. Clin Pharmacol Ther 85:78-85
    • (2009) Clin Pharmacol Ther , vol.85 , pp. 78-85
    • Zheng, H.X.1    Huang, Y.2    Frassetto, L.A.3    Benet, L.Z.4
  • 152
    • 33845904129 scopus 로고    scopus 로고
    • The dietary isothiocyanate sulforaphane is an antagonist of the human steroid and xenobiotic nuclear receptor
    • Zhou C, Poulton EJ, Grun F, Bammler TK, Blumberg B, Thummel KE and Eaton DL (2007) The dietary isothiocyanate sulforaphane is an antagonist of the human steroid and xenobiotic nuclear receptor. Mol Pharmacol 71:220-229
    • (2007) Mol Pharmacol , vol.71 , pp. 220-229
    • Zhou, C.1    Poulton, E.J.2    Grun, F.3    Bammler, T.K.4    Blumberg, B.5    Thummel, K.E.6    Eaton, D.L.7
  • 154
    • 55549132252 scopus 로고    scopus 로고
    • Development of an in vitro drug-drug interaction assay to simultaneously monitor five cytochrome P450 isoforms and performance assessment using drug library compounds
    • Zientek M, Miller H, Smith D, Dunklee MB, Heinle L, Thurston A, Lee C, Hyland R, Fahmi O and Burdette D (2008) Development of an in vitro drug-drug interaction assay to simultaneously monitor five cytochrome P450 isoforms and performance assessment using drug library compounds. J Pharmacol Toxicol Methods 58:206-214
    • (2008) J Pharmacol Toxicol Methods , vol.58 , pp. 206-214
    • Zientek, M.1    Miller, H.2    Smith, D.3    Dunklee, M.B.4    Heinle, L.5    Thurston, A.6    Lee, C.7    Hyland, R.8    Fahmi, O.9    Burdette, D.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.