An automated, high-throughput, 384 well Cytochrome P450 cocktail IC50 assay using a rapid resolution LC-MS/MS end-point

Journal of Pharmaceutical and Biomedical Analysis

Volumn 48, Issue 1, 2008, Pages 92-99

  Youdim, Kuresh A ^a   Lyons, Richard ^a   Payne, Leon ^a   Jones, Barry C ^a   Saunders, Kenneth ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Cytochrome P450; Drug drug interactions; High performance liquid chromatography; Human liver microsomes

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; DEXTROMETHORPHAN; DICLOFENAC; DISULFIRAM; DRUG METABOLITE; FLUCONAZOLE; FLUNITRAZEPAM; FLUVOXAMINE; KETOCONAZOLE; MEPHENYTOIN; MICONAZOLE; MIDAZOLAM; PAROXETINE; SERTRALINE; TACRINE; TICLOPIDINE;

ANALYTIC METHOD; ARTICLE; AUTOMATION; DRUG ABSORPTION; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG METABOLISM; DRUG MONITORING; ENZYME SUBSTRATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN TISSUE; IC 50; IN VITRO STUDY; INTERMETHOD COMPARISON; LIVER MICROSOME; MEDICAL TECHNOLOGY; PRIORITY JOURNAL;

ARYL HYDROCARBON HYDROXYLASES; BIOLOGICAL ASSAY; CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; DEXTROMETHORPHAN; DICLOFENAC; DRUG INTERACTIONS; HUMANS; HYDROGEN-ION CONCENTRATION; INHIBITORY CONCENTRATION 50; KINETICS; MICROSOMES, LIVER; MIDAZOLAM; MINIATURIZATION; OXIDOREDUCTASES, N-DEMETHYLATING; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SUBSTRATE SPECIFICITY; TACRINE; TANDEM MASS SPECTROMETRY; TIME FACTORS;

EID: 49949086869     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2008.05.011     Document Type: Article

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