Transporter-enzyme interactions: Implications for predicting drug-drug interactions from in vitro data

Current Drug Metabolism

Volumn 4, Issue 5, 2003, Pages 393-398

  Benet, L Z ^a   Cummins, C L ^a   Wu, C Y ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

CYP3A; Drug drug interactions; Metabolic enzymes; P glycoprotein; Transporters

Indexed keywords

CARRIER PROTEIN; CYCLOSPORIN; CYSTEINE PROTEINASE; CYTOCHROME P450 3A4; CYTOCHROME P450 INHIBITOR; DIGOXIGENIN BISDIGITOXOSIDE; DIGOXIN; DRUG METABOLITE; DRUG METABOLIZING ENZYME; ELACRIDAR; FELODIPINE; GLYCOPROTEIN P; MIDAZOLAM; PROTEIN INHIBITOR; PROTEINASE INHIBITOR; QUINIDINE; RAPAMYCIN; RIFAMPICIN; TACROLIMUS; TRAMAZOLINE; TROLEANDOMYCIN;

CELL LEVEL; CELL STRAIN CACO 2; COST BENEFIT ANALYSIS; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG INTERACTION; DRUG METABOLISM; DRUG TRANSPORT; ENZYME LOCALIZATION; ENZYME SUBSTRATE; GENETIC TRANSFECTION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INTESTINE ABSORPTION; INTESTINE MUCOSA; INTESTINE PERFUSION; LIVER PERFUSION; NONHUMAN; PREDICTION; PROTEIN PROTEIN INTERACTION; REVIEW;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CARRIER PROTEINS; CYTOCHROME P-450 CYP3A; DRUG INTERACTIONS; ENZYMES; HUMANS; INTESTINES; LIVER; OXIDOREDUCTASES, N-DEMETHYLATING; P-GLYCOPROTEIN; PREDICTIVE VALUE OF TESTS;

EID: 0142106303     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/1389200033489389     Document Type: Review

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