Use of sandwich-cultured hepatocytes to evaluate impaired bile acid transport as a mechanism of drug-induced hepatotoxicity

Molecular Pharmaceutics

Volumn 4, Issue 6, 2007, Pages 911-918

  Marion, Tracy L ^a   Leslie, Elaine M ^a,b   Brouwer, Kim L R ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Bile acid transport; BSEP ABCB11; Hepatotoxicity; NTCP SLC10A1; Sandwich cultured hepatocytes; Troglitazone

Indexed keywords

BILE ACID; BUSPIRONE; CYCLOSPORIN; EFAVIRENZ; GLIBENCLAMIDE; NEFAZODONE; RIFAMPICIN; RITONAVIR; SAQUINAVIR; TRAZODONE; TROGLITAZONE; XENOBIOTIC AGENT;

BILIARY EXCRETION; DRUG EFFECT; DRUG INHIBITION; DRUG POTENCY; HUMAN; IC 50; IN VITRO STUDY; LIPID TRANSPORT; LIVER CELL; LIVER CELL CULTURE; LIVER TOXICITY; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ANIMALS; BILE ACIDS AND SALTS; BIOLOGICAL TRANSPORT; CELL CULTURE TECHNIQUES; CELLS, CULTURED; CHROMANS; HEPATITIS, TOXIC; HUMANS; MEMBRANE TRANSPORT PROTEINS; MODELS, BIOLOGICAL; PPAR GAMMA; RATS; TAUROCHOLIC ACID; THIAZOLIDINEDIONES;

EID: 37549011739     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp0700357     Document Type: Review

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