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Volumn 175, Issue 4, 2005, Pages 221-230

Dioxin: A review of its environmental effects and its aryl hydrocarbon receptor biology

Author keywords

Aryl hydrocarbon receptor (AhR); CYP1A1; Dioxin; TCDD

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; CARCINOGEN; CYTOCHROME P450 1A1;

EID: 20044386351     PISSN: 01741578     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00360-005-0483-3     Document Type: Review
Times cited : (506)

References (96)
  • 3
    • 0036667364 scopus 로고    scopus 로고
    • Tissue-specific expression of AHR2, ARNT2, and CYP1A in zebrafish embryo and larvae: Effects of developmental stage and 2,3,7,8-tetrachlorodibenzo-p- dioxin exposure
    • Andreasen EA, Spitsbergen JM, Tanguay RL, Stegeman JJ, Heideman W, Peterson RE (2002) Tissue-specific expression of AHR2, ARNT2, and CYP1A in zebrafish embryo and larvae: effects of developmental stage and 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure. Toxicol Sci 68:403-419
    • (2002) Toxicol Sci , vol.68 , pp. 403-419
    • Andreasen, E.A.1    Spitsbergen, J.M.2    Tanguay, R.L.3    Stegeman, J.J.4    Heideman, W.5    Peterson, R.E.6
  • 6
    • 11244252611 scopus 로고    scopus 로고
    • Health risk characterization of dioxins and related compounds
    • Schecter A, Gasiewicz TA (eds) Wiley-Interscience, New York
    • Birnbaum LS, Farland WH (2003) Health risk characterization of dioxins and related compounds. In: Schecter A, Gasiewicz TA (eds) Dioxins and health. Wiley-Interscience, New York, pp 159-189
    • (2003) Dioxins and Health , pp. 159-189
    • Birnbaum, L.S.1    Farland, W.H.2
  • 7
    • 0038746906 scopus 로고    scopus 로고
    • Cancer and developmental exposure to endocrine disruptors
    • Birnbaum LS, Fenton SE (2003) Cancer and developmental exposure to endocrine disruptors. Environ Health Perspect 111:389-394
    • (2003) Environ Health Perspect , vol.111 , pp. 389-394
    • Birnbaum, L.S.1    Fenton, S.E.2
  • 8
    • 0037184815 scopus 로고    scopus 로고
    • Reproductive failure and endocrine disruption by organohalogens in fish-eating birds
    • Bosveld ATC, van den Berg M (2002) Reproductive failure and endocrine disruption by organohalogens in fish-eating birds. Toxicology 181-182:155-159
    • (2002) Toxicology , vol.181-182 , pp. 155-159
    • Bosveld, A.T.C.1    Van Den Berg, M.2
  • 9
    • 0026071422 scopus 로고
    • Purification and N-terminal amino acid sequence of the Ah receptor from the C57BL/ 6J mouse
    • Bradfield CA, Glover E, Poland A (1991) Purification and N-terminal amino acid sequence of the Ah receptor from the C57BL/ 6J mouse. Mol Pharmacol 39:13-19
    • (1991) Mol Pharmacol , vol.39 , pp. 13-19
    • Bradfield, C.A.1    Glover, E.2    Poland, A.3
  • 12
    • 0037145008 scopus 로고    scopus 로고
    • Induction of cellular oxidative stress by aryl hydrocarbon receptor activation
    • Dalton TP, Puga A, Shertzer HG (2002) Induction of cellular oxidative stress by aryl hydrocarbon receptor activation. Chem Biol Interact 141:77-95
    • (2002) Chem Biol Interact , vol.141 , pp. 77-95
    • Dalton, T.P.1    Puga, A.2    Shertzer, H.G.3
  • 13
    • 0036753803 scopus 로고    scopus 로고
    • Estrous cycle-regulated expression of CYP1B1 mRNA in the rat ovary
    • Dasmahapatra AK, Trewin AL, Hutz RJ (2002) Estrous cycle-regulated expression of CYP1B1 mRNA in the rat ovary. Comp Biochem Physiol B 133:127-134
    • (2002) Comp Biochem Physiol B , vol.133 , pp. 127-134
    • Dasmahapatra, A.K.1    Trewin, A.L.2    Hutz, R.J.3
  • 14
    • 0024210678 scopus 로고
    • The DNA recognition site for the dioxin-Ah receptor complex:nucleotide sequence and functional analysis
    • Denison MS, Fisher JM, Whitlock JP (1988) The DNA recognition site for the dioxin-Ah receptor complex:nucleotide sequence and functional analysis. J Biol Chem 263:17221-17224
    • (1988) J Biol Chem , vol.263 , pp. 17221-17224
    • Denison, M.S.1    Fisher, J.M.2    Whitlock, J.P.3
  • 15
    • 0034046390 scopus 로고    scopus 로고
    • Animal studies addressing the carcinogenicity of TCDD (or related compounds) with an emphasis on tumour promotion
    • Dragan YP, Chrenk D (2000) Animal studies addressing the carcinogenicity of TCDD (or related compounds) with an emphasis on tumour promotion. Food Addit Contam 17:289-302
    • (2000) Food Addit Contam , vol.17 , pp. 289-302
    • Dragan, Y.P.1    Chrenk, D.2
  • 16
    • 0037139361 scopus 로고    scopus 로고
    • Effects of src-deficiency on the expression of in vivo toxicity of TCDD in a strain of c-Src knockout mice procured through six generations of backcrossings to C57BL/6 mice
    • Dunlap DY, Ikeda I, Nagashima H, Vogel CF, Matsumura F (2002) Effects of src-deficiency on the expression of in vivo toxicity of TCDD in a strain of c-Src knockout mice procured through six generations of backcrossings to C57BL/6 mice. Toxicology 172:125-141
    • (2002) Toxicology , vol.172 , pp. 125-141
    • Dunlap, D.Y.1    Ikeda, I.2    Nagashima, H.3    Vogel, C.F.4    Matsumura, F.5
  • 17
    • 0028034621 scopus 로고
    • Dioxin binding activities of polymorphic forms of mouse and human arylhydrocarbon receptors
    • Ema M, Ohe N, Suzuki M, Mimura J, Sogawa K, Ikawa Y, Fujii-Kuriyama Y (1994) Dioxin binding activities of polymorphic forms of mouse and human arylhydrocarbon receptors. J Biol Chem 269:27337-27343
    • (1994) J Biol Chem , vol.269 , pp. 27337-27343
    • Ema, M.1    Ohe, N.2    Suzuki, M.3    Mimura, J.4    Sogawa, K.5    Ikawa, Y.6    Fujii-Kuriyama, Y.7
  • 18
  • 19
  • 20
    • 0033539378 scopus 로고    scopus 로고
    • Olestra increases faecal excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin
    • Geusau A, Tschachler E, Meixner M (1999) Olestra increases faecal excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Lancet 354:1266-1267
    • (1999) Lancet , vol.354 , pp. 1266-1267
    • Geusau, A.1    Tschachler, E.2    Meixner, M.3
  • 21
    • 0026771141 scopus 로고
    • Hepatotoxicity and carcinogenicity in female Sprague-Dawley rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): A pathology working group reevaluation
    • Goodman DG, Sauer RM (1992) Hepatotoxicity and carcinogenicity in female Sprague-Dawley rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): a pathology working group reevaluation. Regul Toxicol Pharmacol 15:245-252
    • (1992) Regul Toxicol Pharmacol , vol.15 , pp. 245-252
    • Goodman, D.G.1    Sauer, R.M.2
  • 23
    • 9444265876 scopus 로고    scopus 로고
    • Latent effects of pesticides and toxic substances on sexual differentiation of rodents
    • Gray LE Jr, Kelce WR (1996) Latent effects of pesticides and toxic substances on sexual differentiation of rodents. Toxicol Ind Health 12:515-531
    • (1996) Toxicol Ind Health , vol.12 , pp. 515-531
    • Gray Jr., L.E.1    Kelce, W.R.2
  • 24
    • 0030771038 scopus 로고    scopus 로고
    • In utero exposure to low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin alters reproductive development of female Long Evans hooded rat offspring
    • Gray LE Jr, Wolf C, Mann P, Ostby JS (1997) In utero exposure to low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin alters reproductive development of female Long Evans hooded rat offspring. Toxicol Appl Pharmacol 146:237-244
    • (1997) Toxicol Appl Pharmacol , vol.146 , pp. 237-244
    • Gray Jr., L.E.1    Wolf, C.2    Mann, P.3    Ostby, J.S.4
  • 25
    • 0004052360 scopus 로고    scopus 로고
    • Xenoendocrine disrupters: Laboratory studies on male reproductive effects
    • Gray LE Jr (1998) Xenoendocrine disrupters: laboratory studies on male reproductive effects. Toxicol Lett 102-103:331-335
    • (1998) Toxicol Lett , vol.102-103 , pp. 331-335
    • Gray Jr., L.E.1
  • 26
    • 0031459411 scopus 로고    scopus 로고
    • Molecular evolution of two vertebrate aryl hydrocarbon (dioxin) receptors (AHR1 and AHR2) and the PAS family
    • Hahn ME, Karchner SI, Shapiro MA, Perera SA (1997) Molecular evolution of two vertebrate aryl hydrocarbon (dioxin) receptors (AHR1 and AHR2) and the PAS family. Proc Natl Acad Sci USA 94:13743-13748
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 13743-13748
    • Hahn, M.E.1    Karchner, S.I.2    Shapiro, M.A.3    Perera, S.A.4
  • 28
    • 0027948272 scopus 로고
    • The role of the aryl hydrocarbon receptor nuclear translocator protein in aryl hydrocarbon receptor action
    • Hankinson O (1994) The role of the aryl hydrocarbon receptor nuclear translocator protein in aryl hydrocarbon receptor action. Trends Endocrinol Metab 5:240-244
    • (1994) Trends Endocrinol Metab , vol.5 , pp. 240-244
    • Hankinson, O.1
  • 29
    • 0028987872 scopus 로고
    • The aryl hydrocarbon receptor complex
    • Hankinson O (1995) The aryl hydrocarbon receptor complex. Annu Rev Pharmacol Toxicol 35:307-340
    • (1995) Annu Rev Pharmacol Toxicol , vol.35 , pp. 307-340
    • Hankinson, O.1
  • 32
    • 0034418176 scopus 로고    scopus 로고
    • Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the expression of cytochrome P4501A1, the aryl hydrocarbon receptor, and the aryl hydrocarbon receptor nuclear translocator, in rat brain and pituitary
    • Huang P, Rannug A, Ahlbom E, Hakansson H, Ceccatelli S (2000) Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the expression of cytochrome P4501A1, the aryl hydrocarbon receptor, and the aryl hydrocarbon receptor nuclear translocator, in rat brain and pituitary. Toxicol Appl Pharmacol 169:159-167
    • (2000) Toxicol Appl Pharmacol , vol.169 , pp. 159-167
    • Huang, P.1    Rannug, A.2    Ahlbom, E.3    Hakansson, H.4    Ceccatelli, S.5
  • 33
    • 0031768876 scopus 로고    scopus 로고
    • Characterization of 2,3,7,8-tetrachlorodibenzofuran-dependent suppression and AH receptor pathway gene expression in the developing mouse mammary gland
    • Hushka LJ, Williams JS, Greenlee WF (1998) Characterization of 2,3,7,8-tetrachlorodibenzofuran-dependent suppression and AH receptor pathway gene expression in the developing mouse mammary gland. Toxicol Appl Pharmacol 152:200-210
    • (1998) Toxicol Appl Pharmacol , vol.152 , pp. 200-210
    • Hushka, L.J.1    Williams, J.S.2    Greenlee, W.F.3
  • 34
    • 20044393712 scopus 로고    scopus 로고
    • Polychlorinated dibenzo-para-dioxins and polychlorinated dibenzofurans
    • IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Lyon, France
    • IARC Monographs on the Evaluation of Carcinogenic Risks to Humans (1997) Polychlorinated dibenzo-para-dioxins and polychlorinated dibenzofurans. IARC Scientific Publ. No. 69, Lyon, France
    • (1997) IARC Scientific Publ. No. 69
  • 35
    • 0024445437 scopus 로고
    • Human CYP1A2: Sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression
    • Ikeya K, Jaiswal AK, Owens RA, Jones JE, Nebert DW, Kimura S (1989) Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression. Mol Endocrinol 3:1399-1408
    • (1989) Mol Endocrinol , vol.3 , pp. 1399-1408
    • Ikeya, K.1    Jaiswal, A.K.2    Owens, R.A.3    Jones, J.E.4    Nebert, D.W.5    Kimura, S.6
  • 36
    • 0030596466 scopus 로고    scopus 로고
    • Evidence that mammalian sex ratio at birth are partially controlled by parental hormone levels at the time of conception
    • James WH (1996) Evidence that mammalian sex ratio at birth are partially controlled by parental hormone levels at the time of conception. J Theor Biol 180:271-286
    • (1996) J Theor Biol , vol.180 , pp. 271-286
    • James, W.H.1
  • 37
    • 0042170246 scopus 로고    scopus 로고
    • Developmental neurotoxicity of dioxin and its related compounds
    • Kakeyama M, Tohyama C (2003) Developmental neurotoxicity of dioxin and its related compounds. Ind Health 41:215-230
    • (2003) Ind Health , vol.41 , pp. 215-230
    • Kakeyama, M.1    Tohyama, C.2
  • 38
    • 0036510573 scopus 로고    scopus 로고
    • Regulatory interactions among three members of the vertebrate aryl hydrocarbon receptor family: AHR repressor, AHR1, and AHR2
    • Karchner SI, Franks DG, Powell WH, Hahn ME (2002) Regulatory interactions among three members of the vertebrate aryl hydrocarbon receptor family: AHR repressor, AHR1, and AHR2. J Biol Chem 277:6949-6959
    • (2002) J Biol Chem , vol.277 , pp. 6949-6959
    • Karchner, S.I.1    Franks, D.G.2    Powell, W.H.3    Hahn, M.E.4
  • 39
    • 0029549649 scopus 로고
    • Immunological effects of chlorinated dibenzo-p-dioxins
    • Kerkvliet NI (1995) Immunological effects of chlorinated dibenzo-p-dioxins. Environ Health Perspect 103:47-53
    • (1995) Environ Health Perspect , vol.103 , pp. 47-53
    • Kerkvliet, N.I.1
  • 42
    • 0036203882 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor (AhR) and its nuclear translocator (Arnt) are dispensable for normal mammary gland development but are required for fertility
    • Le Provost F, Riedlinger G, Yim SH, Benedict J, Gonzalez FJ, Flaws J, Henninghausen L (2002) The aryl hydrocarbon receptor (AhR) and its nuclear translocator (Arnt) are dispensable for normal mammary gland development but are required for fertility. Genesis 32:231-239
    • (2002) Genesis , vol.32 , pp. 231-239
    • Le Provost, F.1    Riedlinger, G.2    Yim, S.H.3    Benedict, J.4    Gonzalez, F.J.5    Flaws, J.6    Henninghausen, L.7
  • 43
    • 0035883851 scopus 로고    scopus 로고
    • 7,12-Dimethylbenz[a]anthracene inhibition of steroid production in MA-10 mouse Leydig tumor cells is not directly linked to induction of CYP1B1
    • Mandal PK, McDaniel LR, Prough RA, Clark BJ (2001) 7,12-Dimethylbenz[a] anthracene inhibition of steroid production in MA-10 mouse Leydig tumor cells is not directly linked to induction of CYP1B1. Toxicol Appl Pharmacol 175:200-208
    • (2001) Toxicol Appl Pharmacol , vol.175 , pp. 200-208
    • Mandal, P.K.1    McDaniel, L.R.2    Prough, R.A.3    Clark, B.J.4
  • 44
    • 0142102655 scopus 로고    scopus 로고
    • On the significance of the role of cellular stress response reactions in the toxic actions of dioxin
    • Matsumura F (2003) On the significance of the role of cellular stress response reactions in the toxic actions of dioxin. Biochem Pharmacol 66:527-540
    • (2003) Biochem Pharmacol , vol.66 , pp. 527-540
    • Matsumura, F.1
  • 45
    • 0032899367 scopus 로고    scopus 로고
    • Identification of a novel mechanism of regulation of Ah (dioxin) receptor function
    • Mimura J, Ema M, Sogawa K, Fujii-Kuriyama Y (1999) Identification of a novel mechanism of regulation of Ah (dioxin) receptor function. Genes Dev 13:20-25
    • (1999) Genes Dev , vol.13 , pp. 20-25
    • Mimura, J.1    Ema, M.2    Sogawa, K.3    Fujii-Kuriyama, Y.4
  • 46
    • 0037450429 scopus 로고    scopus 로고
    • Functional role of AhR in the expression of toxic effects by TCDD
    • Mimura J, Fujii-Kuriyama Y (2003) Functional role of AhR in the expression of toxic effects by TCDD. Biochim Biophys Acta 1619:263-268
    • (2003) Biochim Biophys Acta , vol.1619 , pp. 263-268
    • Mimura, J.1    Fujii-Kuriyama, Y.2
  • 48
    • 0027922810 scopus 로고
    • Role of the Ah receptor and the dioxin-inducible [Ah] gene battery in toxicity, cancer, and signal transduction
    • Nebert DW, Puga A, Vasiliou V (1993) Role of the Ah receptor and the dioxin-inducible [Ah] gene battery in toxicity, cancer, and signal transduction. Ann N Y Acad Sci 685:624-640
    • (1993) Ann N Y Acad Sci , vol.685 , pp. 624-640
    • Nebert, D.W.1    Puga, A.2    Vasiliou, V.3
  • 49
    • 0033990325 scopus 로고    scopus 로고
    • Role of the aromatic hydrocarbon receptor and [Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis
    • Nebert DW, Roe AL, Dieter MZ, Solis WA, Yang Y, Dalton TP (2000) Role of the aromatic hydrocarbon receptor and [Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis. Biochem Pharmacol 59:65-85
    • (2000) Biochem Pharmacol , vol.59 , pp. 65-85
    • Nebert, D.W.1    Roe, A.L.2    Dieter, M.Z.3    Solis, W.A.4    Yang, Y.5    Dalton, T.P.6
  • 51
    • 0036780960 scopus 로고    scopus 로고
    • The U.S. EPA Science Advisory Board Evaluation (2001) of the EPA dioxin reassessment
    • Paustenbach DJ (2002) The U.S. EPA Science Advisory Board Evaluation (2001) of the EPA dioxin reassessment. Regul Toxicol Pharmacol 36:211-219
    • (2002) Regul Toxicol Pharmacol , vol.36 , pp. 211-219
    • Paustenbach, D.J.1
  • 52
    • 0023742858 scopus 로고
    • Association of the Ah receptor with 90-kDa heat shock protein
    • Perdew GH (1988) Association of the Ah receptor with 90-kDa heat shock protein. J Biol Chem 263:13802-13805
    • (1988) J Biol Chem , vol.263 , pp. 13802-13805
    • Perdew, G.H.1
  • 53
    • 0035857291 scopus 로고    scopus 로고
    • A review of mechanisms controlling ovulation with implications for the anovulatory effects of polychlorinated dibenzo-p-dioxins
    • Petroff BK, Roby KF, Gao X, Son D, Williams S, Johnson D, Rozman KK, Terranova PF (2001) A review of mechanisms controlling ovulation with implications for the anovulatory effects of polychlorinated dibenzo-p-dioxins. Toxicology 158:91-107
    • (2001) Toxicology , vol.158 , pp. 91-107
    • Petroff, B.K.1    Roby, K.F.2    Gao, X.3    Son, D.4    Williams, S.5    Johnson, D.6    Rozman, K.K.7    Terranova, P.F.8
  • 54
    • 0034532301 scopus 로고    scopus 로고
    • Subcellular localization of the aryl hydrocarbon receptor ismodulated by the immunophilin homolog hepatitis B virus X-associated protein 2
    • Petrulis JR, Hord NG, Perdew GH (2000) Subcellular localization of the aryl hydrocarbon receptor ismodulated by the immunophilin homolog hepatitis B virus X-associated protein 2. J Biol Chem 275:37448-37453
    • (2000) J Biol Chem , vol.275 , pp. 37448-37453
    • Petrulis, J.R.1    Hord, N.G.2    Perdew, G.H.3
  • 55
    • 0034087885 scopus 로고    scopus 로고
    • Mechanistic aspects - The dioxin (aryl hydrocarbon) receptor
    • Poellinger L (2000) Mechanistic aspects - the dioxin (aryl hydrocarbon) receptor. Food Addit Contam 17:261-266
    • (2000) Food Addit Contam , vol.17 , pp. 261-266
    • Poellinger, L.1
  • 56
    • 0031845222 scopus 로고    scopus 로고
    • Point mutation in intron sequence causes altered carboxyl-terminal structure in the aryl hydrocarbon receptor of the most 2,3,7,8- tetrachlorodibenzo-p-dioxin-resistant rat strain
    • Pohjanvirta R, Wong JM, Li W, Harper PA, Tuomisto J, Okey AB (1998) Point mutation in intron sequence causes altered carboxyl-terminal structure in the aryl hydrocarbon receptor of the most 2,3,7,8-tetrachlorodibenzo-p-dioxin- resistant rat strain. Mol Pharmacol 54:86-93
    • (1998) Mol Pharmacol , vol.54 , pp. 86-93
    • Pohjanvirta, R.1    Wong, J.M.2    Li, W.3    Harper, P.A.4    Tuomisto, J.5    Okey, A.B.6
  • 58
    • 0017145975 scopus 로고
    • Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p- dioxin by hepatic cytosol: Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase
    • Poland A, Glover E, Kende AS (1976) Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol: evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase. J Biol Chem 251:4936-4946
    • (1976) J Biol Chem , vol.251 , pp. 4936-4946
    • Poland, A.1    Glover, E.2    Kende, A.S.3
  • 59
    • 0020010617 scopus 로고
    • 2,3,7,8-Tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons. Examinations of the mechanism of toxicity
    • Poland A, Knutson JC (1982) 2,3,7,8-Tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons. Examinations of the mechanism of toxicity. Annu Rev Pharmacol Toxicol 22:517-554
    • (1982) Annu Rev Pharmacol Toxicol , vol.22 , pp. 517-554
    • Poland, A.1    Knutson, J.C.2
  • 60
    • 0027944549 scopus 로고
    • Analysis of the four alleles of the murine aryl hydrocarbon receptor
    • Poland A, Palen D, Glover E (1994) Analysis of the four alleles of the murine aryl hydrocarbon receptor. Mol Pharmacol 46:915-921
    • (1994) Mol Pharmacol , vol.46 , pp. 915-921
    • Poland, A.1    Palen, D.2    Glover, E.3
  • 62
    • 0025279978 scopus 로고
    • Stable expression of mouse CYP1A1 and human CYP1A2 cDNAs transfected into mouse hepatoma cells lacking detectable P450 enzyme activity
    • Puga A, Raychaudhuri B, Salata K, Zhang YH, Nebert DW (1990) Stable expression of mouse CYP1A1 and human CYP1A2 cDNAs transfected into mouse hepatoma cells lacking detectable P450 enzyme activity. DNA Cell Biol 9:425-436
    • (1990) DNA Cell Biol , vol.9 , pp. 425-436
    • Puga, A.1    Raychaudhuri, B.2    Salata, K.3    Zhang, Y.H.4    Nebert, D.W.5
  • 63
    • 0034668144 scopus 로고    scopus 로고
    • The transcriptional signature of dioxin in human hepatoma HepG2 cells
    • Puga A, Maier A, Medvedovic M (2000) The transcriptional signature of dioxin in human hepatoma HepG2 cells. Biochem Pharmacol 60:1129-1142
    • (2000) Biochem Pharmacol , vol.60 , pp. 1129-1142
    • Puga, A.1    Maier, A.2    Medvedovic, M.3
  • 64
    • 0142065652 scopus 로고
    • The human CYP1A2 gene supports Ah-receptor binding and promoter-specific induction
    • Quattrochi LC, Vu T, Tukey RH (1994) The human CYP1A2 gene supports Ah-receptor binding and promoter-specific induction. FASEB J 8:A1250
    • (1994) FASEB J , vol.8
    • Quattrochi, L.C.1    Vu, T.2    Tukey, R.H.3
  • 65
    • 0038042814 scopus 로고    scopus 로고
    • Environmental dioxins and endometriosis
    • Rier S, Foster WG (2003) Environmental dioxins and endometriosis. Semin Reprod Med 21:145-154
    • (2003) Semin Reprod Med , vol.21 , pp. 145-154
    • Rier, S.1    Foster, W.G.2
  • 66
    • 0036156514 scopus 로고    scopus 로고
    • Identification of a novel dioxin-inducible cytochrome P450
    • Rivera SP, Saarikoshi O, Hankinson O (2002) Identification of a novel dioxin-inducible cytochrome P450. Mol Pharmacol 61:255-259
    • (2002) Mol Pharmacol , vol.61 , pp. 255-259
    • Rivera, S.P.1    Saarikoshi, O.2    Hankinson, O.3
  • 67
    • 0036852284 scopus 로고    scopus 로고
    • Sex ratios of children of Russian pesticide producers exposed to dioxin
    • Ryan JJ, Zarema A, Carrier G (2002) Sex ratios of children of Russian pesticide producers exposed to dioxin. Environ Health Perspect 110:699-701
    • (2002) Environ Health Perspect , vol.110 , pp. 699-701
    • Ryan, J.J.1    Zarema, A.2    Carrier, G.3
  • 68
    • 0022555425 scopus 로고
    • Comparative toxicology and mechanism of action of polychlorinated dibenzo-p-dioxins and dibenzofurans
    • Safe SH (1986) Comparative toxicology and mechanism of action of polychlorinated dibenzo-p-dioxins and dibenzofurans. Annu Rev Pharmacol Toxicol 26:371-399
    • (1986) Annu Rev Pharmacol Toxicol , vol.26 , pp. 371-399
    • Safe, S.H.1
  • 69
    • 0029118684 scopus 로고
    • Modulation of gene expression and endocrine response pathways by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds
    • Safe SH (1995) Modulation of gene expression and endocrine response pathways by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds. Pharmacol Ther 67:247-281
    • (1995) Pharmacol Ther , vol.67 , pp. 247-281
    • Safe, S.H.1
  • 70
    • 0035977882 scopus 로고    scopus 로고
    • Molecular biology of the Ah receptor and its role in carcinogenesis
    • Safe S (2001) Molecular biology of the Ah receptor and its role in carcinogenesis. Toxicol Lett 120:1-7
    • (2001) Toxicol Lett , vol.120 , pp. 1-7
    • Safe, S.1
  • 71
    • 0034653806 scopus 로고    scopus 로고
    • Ah receptor ligands and tumor promotions: Survival of neoplastic cells
    • Schwarz M, Buchmann A, Stinchcombe S, Kalkuhl A, Bock K (2000) Ah receptor ligands and tumor promotions: survival of neoplastic cells. Toxicol Lett 112-113:5-14
    • (2000) Toxicol Lett , vol.112-113 , pp. 5-14
    • Schwarz, M.1    Buchmann, A.2    Stinchcombe, S.3    Kalkuhl, A.4    Bock, K.5
  • 73
    • 0033042644 scopus 로고    scopus 로고
    • Water-soluble 2,3,7,8-tetrachlorodibenzo-p-dioxin complex with human α-fetoprotein: Properties, toxicity in vivo and antitumor activity in vitro
    • Sotnichenko AI, Severin SE, Posypanova GA, Feldman NB, Grigor'ev MI, Severin ES, Petrov RV (1999) Water-soluble 2,3,7,8-tetrachlorodibenzo-p-dioxin complex with human α-fetoprotein: properties, toxicity in vivo and antitumor activity in vitro. FEBS Lett 450:49-51
    • (1999) FEBS Lett , vol.450 , pp. 49-51
    • Sotnichenko, A.I.1    Severin, S.E.2    Posypanova, G.A.3    Feldman, N.B.4    Grigor'Ev, M.I.5    Severin, E.S.6    Petrov, R.V.7
  • 75
    • 0041669509 scopus 로고    scopus 로고
    • Dioxin: Exposure-response analyses and risk assessment
    • Steenland K, Deddens J (2003) Dioxin: exposure-response analyses and risk assessment. Indust Hlth 41:175-180
    • (2003) Indust Hlth , vol.41 , pp. 175-180
    • Steenland, K.1    Deddens, J.2
  • 76
    • 4644362561 scopus 로고    scopus 로고
    • Dioxin revisited: Developments since the 1997 IARC classification of dioxin as a human carcinogen
    • Steenland K, Bertazzi P, Baccarelli A, Kogevinas M (2004) Dioxin revisited: developments since the 1997 IARC classification of dioxin as a human carcinogen. Environ Health Perspect 112:1265-1268
    • (2004) Environ Health Perspect , vol.112 , pp. 1265-1268
    • Steenland, K.1    Bertazzi, P.2    Baccarelli, A.3    Kogevinas, M.4
  • 77
    • 0027458138 scopus 로고
    • The Ah-receptor: Genetics, structure and function
    • Swanson HI, Bradfield CA (1993) The Ah-receptor: genetics, structure and function. Pharmacogenetics 3:213-223
    • (1993) Pharmacogenetics , vol.3 , pp. 213-223
    • Swanson, H.I.1    Bradfield, C.A.2
  • 78
    • 0036711207 scopus 로고    scopus 로고
    • Activation of mitogen-activated protein kinases (MAPKs) by aromatic hydrocarbons: Role in the regulation of aryl hydrocarbon receptor (AHR) function
    • Tan Z, Chang X, Puga A, Xia Y (2002) Activation of mitogen-activated protein kinases (MAPKs) by aromatic hydrocarbons: role in the regulation of aryl hydrocarbon receptor (AHR) function. Biochem Pharmacol 64:771-780
    • (2002) Biochem Pharmacol , vol.64 , pp. 771-780
    • Tan, Z.1    Chang, X.2    Puga, A.3    Xia, Y.4
  • 79
    • 0028333956 scopus 로고
    • Caffeine as a probe for CYP1A2 activity: Potential influence of renal factors on urinary phenotypic trait measurements
    • Tang BK, Zhou Y, Kadar D, Kalow W (1994) Caffeine as a probe for CYP1A2 activity: potential influence of renal factors on urinary phenotypic trait measurements. Pharmacogenetics 4:117-124
    • (1994) Pharmacogenetics , vol.4 , pp. 117-124
    • Tang, B.K.1    Zhou, Y.2    Kadar, D.3    Kalow, W.4
  • 80
    • 0034670093 scopus 로고    scopus 로고
    • Identification and expression of alternatively spliced aryl hydrocarbon nuclear translocator 2 (ARNT) cDNA from zebrafish with distinct functions
    • Tanguay RL, Andreasen E, Heideman W, Peterson RE (2000) Identification and expression of alternatively spliced aryl hydrocarbon nuclear translocator 2 (ARNT) cDNA from zebrafish with distinct functions. Biochem Biophys Acta 1494:117-128
    • (2000) Biochem Biophys Acta , vol.1494 , pp. 117-128
    • Tanguay, R.L.1    Andreasen, E.2    Heideman, W.3    Peterson, R.E.4
  • 81
    • 0033062111 scopus 로고    scopus 로고
    • The AH receptor and a novel gene determine acute toxic responses to TCDD: Segregation of the resistant alleles to different rat lines
    • Tuomisto JT, Viluksela M, Pohjanvirta R, Tuomisto J (1999) The AH receptor and a novel gene determine acute toxic responses to TCDD: segregation of the resistant alleles to different rat lines. Toxicol Appl Pharmacol 155:71-81
    • (1999) Toxicol Appl Pharmacol , vol.155 , pp. 71-81
    • Tuomisto, J.T.1    Viluksela, M.2    Pohjanvirta, R.3    Tuomisto, J.4
  • 82
    • 0004320273 scopus 로고    scopus 로고
    • U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program (2000) 9th report on Carcinogens
    • (2000) 9th Report on Carcinogens
  • 85
    • 2342424360 scopus 로고    scopus 로고
    • A novel effect of dioxin: Exposure during pregnancy severely impairs mammary gland differentiation
    • Vorderstrasse BA, Fenton SE, Bohn AA, Cundiff JA, Lawrence BP (2004) A novel effect of dioxin: exposure during pregnancy severely impairs mammary gland differentiation. Toxicol Sci 78:248-257
    • (2004) Toxicol Sci , vol.78 , pp. 248-257
    • Vorderstrasse, B.A.1    Fenton, S.E.2    Bohn, A.A.3    Cundiff, J.A.4    Lawrence, B.P.5
  • 86
    • 0034048854 scopus 로고    scopus 로고
    • Impact of exposure to maternal PCBs and dioxins on the neonate's thyroid hormone status
    • Vulsma T (2000) Impact of exposure to maternal PCBs and dioxins on the neonate's thyroid hormone status. Epidemiology 11:239-241
    • (2000) Epidemiology , vol.11 , pp. 239-241
    • Vulsma, T.1
  • 87
    • 0001650774 scopus 로고
    • 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) toxicity during early life stage development of lake trout (Salvelinus namaycush)
    • Walker MK, Spitsbergen JM, Olson JR, Peterson RE (1991) 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) toxicity during early life stage development of lake trout (Salvelinus namaycush). Can J Fish Aquat Sci 48:875-883
    • (1991) Can J Fish Aquat Sci , vol.48 , pp. 875-883
    • Walker, M.K.1    Spitsbergen, J.M.2    Olson, J.R.3    Peterson, R.E.4
  • 88
    • 0030893212 scopus 로고    scopus 로고
    • Expression of the aryl hydrocarbon receptor (AhR) and AhR nuclear translocator during chick cardiogenesis is consistent with 2,3,7,8- tetrachlorodibenzo-p-dioxin-induced heart defects
    • Walker MK, Pollenz RS, Smith SM (1997) Expression of the aryl hydrocarbon receptor (AhR) and AhR nuclear translocator during chick cardiogenesis is consistent with 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced heart defects. Toxicol Appl Pharmacol 143:407-419
    • (1997) Toxicol Appl Pharmacol , vol.143 , pp. 407-419
    • Walker, M.K.1    Pollenz, R.S.2    Smith, S.M.3
  • 91
    • 0025307742 scopus 로고
    • Genetic and molecular aspects of 2,3,7,8-tetrachlorodibenzo-p-dioxin action
    • Whilock JPJ (1990) Genetic and molecular aspects of 2,3,7,8- tetrachlorodibenzo-p-dioxin action. Annu Rev Pharmacol Toxicol 30:251-277
    • (1990) Annu Rev Pharmacol Toxicol , vol.30 , pp. 251-277
    • Whilock, J.P.J.1
  • 92
  • 93
    • 0029743980 scopus 로고    scopus 로고
    • 2,3,7,8-Tetrachlorodibenzo-p-dioxin mechanistic data and risk assessment: Gene regulation, cytotoxicity, enhanced cell proliferation, and tumor promotion
    • Whysner J, Williams GM (1996) 2,3,7,8-Tetrachlorodibenzo-p-dioxin mechanistic data and risk assessment: gene regulation, cytotoxicity, enhanced cell proliferation, and tumor promotion. Pharmacol Ther 71:193-223
    • (1996) Pharmacol Ther , vol.71 , pp. 193-223
    • Whysner, J.1    Williams, G.M.2
  • 94
    • 0031710576 scopus 로고    scopus 로고
    • Mechanisms of ligand-induced aryl hydrocarbon receptor-mediated biochemical and toxic responses
    • Wilson CL, Safe S (1998) Mechanisms of ligand-induced aryl hydrocarbon receptor-mediated biochemical and toxic responses. Toxicol Pathol 26:657-671
    • (1998) Toxicol Pathol , vol.26 , pp. 657-671
    • Wilson, C.L.1    Safe, S.2
  • 95
    • 0347416983 scopus 로고    scopus 로고
    • Protein kinase C δ is activated in mouse ovarian surface epithelial cancer cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
    • Williams SR, Son D-S, Terranova PF (2004) Protein kinase C δ is activated in mouse ovarian surface epithelial cancer cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Toxicol 195:1-17
    • (2004) Toxicol , vol.195 , pp. 1-17
    • Williams, S.R.1    Son, D.-S.2    Terranova, P.F.3


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