메뉴 건너뛰기




Volumn , Issue , 2012, Pages 129-148

Historical perspectives on the discovery and development of drugs to treat neurological disorders

Author keywords

[No Author keywords available]

Indexed keywords


EID: 84865175827     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1017/CBO9780511980053.008     Document Type: Chapter
Times cited : (5)

References (237)
  • 1
    • 0037638809 scopus 로고    scopus 로고
    • Effects of rofecoxib or naproxen vs placebo on alzheimer disease progression: A randomized controlled trial
    • Aisen PS, Schafer KA, Grundman M et al. 2003. Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial. J Am Med Assoc 289:2819–2828.
    • (2003) J am Med Assoc , vol.289 , pp. 2819-2828
    • Aisen, P.S.1    Schafer, K.A.2    Grundman, M.3
  • 2
    • 55949117032 scopus 로고    scopus 로고
    • Frequent amyloid deposition without significant cognitive impairment among the elderly
    • Aizenstein HJ, Nebes RD, Saxton, JA et al. 2008. Frequent amyloid deposition without significant cognitive impairment among the elderly. Arch Neurol 65:1509–1517.
    • (2008) Arch Neurol , vol.65 , pp. 1509-1517
    • Aizenstein, H.J.1    Nebes, R.D.2    Saxton, J.A.3
  • 4
    • 73149116008 scopus 로고    scopus 로고
    • T-cell microglia dialogue in parkinson’s disease and amyotrophic lateral sclerosis: Are we listening?
    • Appel SH, Beers DR, Henkel JS. 2009. T-cell microglia dialogue in Parkinson’s disease and amyotrophic lateral sclerosis: are we listening? Trends Immunol 31:7–17.
    • (2009) Trends Immunol , vol.31 , pp. 7-17
    • Appel, S.H.1    Beers, D.R.2    Henkel, J.S.3
  • 5
    • 79951562474 scopus 로고    scopus 로고
    • Stress as a risk factor for multiple sclerosis onset or relapse: A systematic review
    • Artemiadis AK, Anagnostouli MC, Alexopoulos EC. 2011. Stress as a risk factor for multiple sclerosis onset or relapse: a systematic review. Neuroepidemiology 36:109–120.
    • (2011) Neuroepidemiology , vol.36 , pp. 109-120
    • Artemiadis, A.K.1    Anagnostouli, M.C.2    Alexopoulos, E.C.3
  • 6
    • 34447508481 scopus 로고    scopus 로고
    • Environmental risk factors for multiple sclerosis. Part ii: Noninfectious factors
    • Ascherio A, Munger KL. 2007. Environmental risk factors for multiple sclerosis. Part II: Noninfectious factors. Ann Neurol 61:504–513.
    • (2007) Ann Neurol , vol.61 , pp. 504-513
    • Ascherio, A.1    Munger, K.L.2
  • 8
    • 79957452852 scopus 로고    scopus 로고
    • A therapeutic antibody targeting bace1 inhibits amyloid-beta production in vivo
    • Atwal JK, Chen Y, Chiu C et al. 2011. A therapeutic antibody targeting BACE1 inhibits amyloid-beta production in vivo. Sci Transl Med 3:84r43.
    • (2011) Sci Transl Med 3:84R43
    • Atwal, J.K.1    Chen, Y.2    Chiu, C.3
  • 9
    • 78651274000 scopus 로고    scopus 로고
    • Insulin resistance and alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes
    • Baker LD, Cross DJ, Minoshima S et al. 2011. Insulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes. Arch Neurol 68:51–57.
    • (2011) Arch Neurol , vol.68 , pp. 51-57
    • Baker, L.D.1    Cross, D.J.2    Minoshima, S.3
  • 10
    • 0034125843 scopus 로고    scopus 로고
    • On neurodegenerative diseases, models and treatment strategies: Lessons learned and lessons forgotten a generation following the cholinergic hypothesis
    • Bartus RT. 2000. On neurodegenerative diseases, models and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis. Exp Neurol 163:495–529.
    • (2000) Exp Neurol , vol.163 , pp. 495-529
    • Bartus, R.T.1
  • 11
    • 25444474703 scopus 로고    scopus 로고
    • Mitochondria take center stage in aging and neurodegeneration
    • Beal MF. 2005. Mitochondria take center stage in aging and neurodegeneration. Ann Neurol 58:495–505.
    • (2005) Ann Neurol , vol.58 , pp. 495-505
    • Beal, M.F.1
  • 13
    • 33646375711 scopus 로고    scopus 로고
    • High levels of mitochondrial dna deletions in substantia nigra neurons in aging and parkinson disease
    • Bender A, Krishnan KJ, Morris CM et al. 2006. High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease. Nat Genet 38:515–517.
    • (2006) Nat Genet , vol.38 , pp. 515-517
    • Bender, A.1    Krishnan, K.J.2    Morris, C.M.3
  • 14
    • 58849122658 scopus 로고    scopus 로고
    • Riluzole treatment, survival and diagnostic criteria in parkinson plus disorders: The nnipps study
    • Bensimon G, Ludoplh A, Agid Y et al. 2009. Riluzole treatment, survival and diagnostic criteria in Parkinson plus disorders: the NNIPPS study. Brain 132:156–171.
    • (2009) Brain , vol.132 , pp. 156-171
    • Bensimon, G.1    Ludoplh, A.2    Agid, Y.3
  • 15
    • 33845892752 scopus 로고    scopus 로고
    • Systematic meta-analyses of alzheimer disease genetic association studies: The alzgene database
    • Bertram L, McQueen MB, Mullin K, Blacker D, Tanzi RE. 2007. Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat Genet 39:17–23.
    • (2007) Nat Genet , vol.39 , pp. 17-23
    • Bertram, L.1    McQueen, M.B.2    Mullin, K.3    Blacker, D.4    Tanzi, R.E.5
  • 16
    • 79959344616 scopus 로고    scopus 로고
    • Pten-inducible kinase 1 (Pink1)/park6 is indispensable for normal heart function
    • Billia F, Hauck L, Konecny F et al. 2011. PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function. Proc Natl Acad Sci USA 108:9572–9577.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 9572-9577
    • Billia, F.1    Hauck, L.2    Konecny, F.3
  • 18
    • 78751663378 scopus 로고    scopus 로고
    • Sirt1 modulation as a novel approach to the treatment of diseases of aging
    • Blum CA, Ellis JL, Loh C et al. 2011. SIRT1 modulation as a novel approach to the treatment of diseases of aging. J Med Chem 54:417–432.
    • (2011) J Med Chem , vol.54 , pp. 417-432
    • Blum, C.A.1    Ellis, J.L.2    Loh, C.3
  • 19
    • 80052340822 scopus 로고    scopus 로고
    • Impact of omega-3-fatty acids in parkinson’s disease
    • Bousquet M, Calon F, Cicchetti F. 2011. Impact of omega-3-fatty acids in Parkinson’s disease. Ageing Res Rev 10:453–463.
    • (2011) Ageing Res Rev , vol.10 , pp. 453-463
    • Bousquet, M.1    Calon, F.2    Cicchetti, F.3
  • 20
    • 79955754364 scopus 로고    scopus 로고
    • Common alzheimer’s disease risk variant within the clu gene affects white matter microstructure in young adults
    • Braskie MN, Jahnshad N, Stein JL et al. 2011. Common Alzheimer’s disease risk variant within the CLU gene affects white matter microstructure in young adults. J Neurosci 31: 6764–6770.
    • (2011) J Neurosci , vol.31 , pp. 6764-6770
    • Braskie, M.N.1    Jahnshad, N.2    Stein, J.L.3
  • 21
    • 78049480679 scopus 로고    scopus 로고
    • Fingolimod (Fty720): Discovery and development of an oral drug to treat multiple sclerosis
    • Brinkmann V, Billich A, Baumruker T et al. 2010. Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis. Nat Rev Drug Discov 9:883–897.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 883-897
    • Brinkmann, V.1    Billich, A.2    Baumruker, T.3
  • 22
    • 70349638299 scopus 로고    scopus 로고
    • Advances in taufocused drug discovery for alzheimer’s disease and related tauopathies
    • Brunden KR, Trojanowski JQ, Lee VMY. 2009. Advances in taufocused drug discovery for Alzheimer’s disease and related tauopathies. Nat Rev Drug Discov 8:783–793.
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 783-793
    • Brunden, K.R.1    Trojanowski, J.Q.2    Lee, V.3
  • 23
    • 67649756320 scopus 로고    scopus 로고
    • Impaired mitochondrial dynamics and function in the pathogenesis of parkinson’s disease
    • Bueler H. 2009. Impaired mitochondrial dynamics and function in the pathogenesis of Parkinson’s disease. Exp Neurol 218:235–246.
    • (2009) Exp Neurol , vol.218 , pp. 235-246
    • Bueler, H.1
  • 24
    • 33646855957 scopus 로고    scopus 로고
    • Neuropathology of alzheimer disease: Pathognomonic but not pathogenic
    • Castellani RJ, Lee H-G, Zhu X et al. 2006. Neuropathology of Alzheimer disease: pathognomonic but not pathogenic. Acta Neuropathol 111:503–509.
    • (2006) Acta Neuropathol , vol.111 , pp. 503-509
    • Castellani, R.J.1    Lee, H.-G.2    Zhu, X.3
  • 26
    • 79959772357 scopus 로고    scopus 로고
    • Human apoe isoforms differentially regulate brain amyloid-beta peptide clearance
    • Castellano JM, Kim J, Stewart FR et al. 2011. Human apoE isoforms differentially regulate brain amyloid-beta peptide clearance. Sci Translat Med 3:89ra57.
    • (2011) Sci Translat Med 3:89Ra57
    • Castellano, J.M.1    Kim, J.2    Stewart, F.R.3
  • 27
    • 51549098145 scopus 로고    scopus 로고
    • Dietary oxyresveratrol prevents parkinsonian mimetic 6-hydroxydopamine neurotoxicity
    • Chao J, Yu MS, Ho YS, Wang M, Chang RCC. 2008. Dietary oxyresveratrol prevents parkinsonian mimetic 6-hydroxydopamine neurotoxicity. Free Radical Biol Med 45:1019–1026.
    • (2008) Free Radical Biol Med , vol.45 , pp. 1019-1026
    • Chao, J.1    Yu, M.S.2    Ho, Y.S.3    Wang, M.4    Chang, R.5
  • 28
    • 0141987860 scopus 로고    scopus 로고
    • The ubiquitin-proteasome system in neurodegenerative disorders: Sometimes the chicken, sometimes the egg
    • Chechanover A, Brundin P. 2003. The ubiquitin-proteasome system in neurodegenerative disorders: sometimes the chicken, sometimes the egg. Neuron 40:427–446.
    • (2003) Neuron , vol.40 , pp. 427-446
    • Chechanover, A.1    Brundin, P.2
  • 29
    • 77957600542 scopus 로고    scopus 로고
    • Impacts of methylxanthines and adenosine receptors on neurodegeneration: Human and experimental studies
    • Chen J-F, Chern Y. 2011. Impacts of methylxanthines and adenosine receptors on neurodegeneration: human and experimental studies. Handb Exp Pharmacol 200:267–310.
    • (2011) Handb Exp Pharmacol , vol.200 , pp. 267-310
    • Chen, J.-F.1    Chern, Y.2
  • 30
    • 79952368703 scopus 로고    scopus 로고
    • Loss of mitochondrial complex i activity potentiates dopamine neuron death induced by microtubule dysfunction in a parkinson’s disease model
    • Choi WS, Palmiter RD, Xia Z. 2011. Loss of mitochondrial complex I activity potentiates dopamine neuron death induced by microtubule dysfunction in a Parkinson’s disease model. J Cell Biol 192:873–882.
    • (2011) J Cell Biol , vol.192 , pp. 873-882
    • Choi, W.S.1    Palmiter, R.D.2    Xia, Z.3
  • 31
    • 79551473183 scopus 로고    scopus 로고
    • 5-lipoxygenase as an endogenous modulator of amyloid b formation in vivo
    • Chu J, Pratico D. 2011. 5-Lipoxygenase as an endogenous modulator of amyloid b formation in vivo. Ann Neurol 69:34–46.
    • (2011) Ann Neurol , vol.69 , pp. 34-46
    • Chu, J.1    Pratico, D.2
  • 34
    • 77954552201 scopus 로고    scopus 로고
    • Evidence linking genetics, environment, and epigenetics to impaired dna repair in alzheimer’s disease
    • Coppede F, Migliore L. 2010. Evidence linking genetics, environment, and epigenetics to impaired DNA repair in Alzheimer’s disease. J Alzheimer’s Dis 20:953–966.
    • (2010) J Alzheimer’s Dis , vol.20 , pp. 953-966
    • Coppede, F.1    Migliore, L.2
  • 35
    • 79952449386 scopus 로고    scopus 로고
    • Insulin-resistant brain state: The culprit in sporadic alzheimer’s disease?
    • Correia SC, Santos RX, Perry G et al. 2011. Insulin-resistant brain state: the culprit in sporadic Alzheimer’s disease? Ageing Res Rev 10:264–273.
    • (2011) Ageing Res Rev , vol.10 , pp. 264-273
    • Correia, S.C.1    Santos, R.X.2    Perry, G.3
  • 37
    • 78049423315 scopus 로고    scopus 로고
    • What can be inferred from the interruption of the semagacestat trial for treatment of alzheimer’s disease?
    • Cummings J. 2010. What can be inferred from the interruption of the semagacestat trial for treatment of Alzheimer’s disease? Biol Psychiatry 68:876–878.
    • (2010) Biol Psychiatry , vol.68 , pp. 876-878
    • Cummings, J.1
  • 38
    • 44849140748 scopus 로고    scopus 로고
    • No effect of one-year treatment with indomethacin on alzheimer’s disease progression: A randomized controlled trial
    • e1475
    • de Jong D, Jansen R, Hoefnagels W et al. 2008. No effect of one-year treatment with indomethacin on Alzheimer’s disease progression: a randomized controlled trial. PLoS ONE 3:e1475.
    • (2008) Plos ONE , vol.3
    • De Jong, D.1    Jansen, R.2    Hoefnagels, W.3
  • 39
    • 79955670031 scopus 로고    scopus 로고
    • Revision of the criteria for alzheimer’s disease: A symposium
    • DeKosky ST, Carrillo MC, Phelps C et al. 2011. Revision of the criteria for Alzheimer’s disease: a symposium. Alzheimer’s Dement 7:e1–e12.
    • (2011) Alzheimer’s Dement , vol.7 , pp. ee1-e12
    • DeKosky, S.T.1    Carrillo, M.C.2    Phelps, C.3
  • 40
    • 33748755428 scopus 로고    scopus 로고
    • Therapeutic rescue of neurodegeneration in experimental type 3 diabetes: Relevance to alzheimer’s disease
    • de la Monte SM, Tong M, Lester-Coll N, Plater M Jr, Wands JR. 2006. Therapeutic rescue of neurodegeneration in experimental type 3 diabetes: relevance to Alzheimer’s disease. J Alzheimer’s Dis 10:89–109.
    • (2006) J Alzheimer’s Dis , vol.10 , pp. 89-109
    • De La Monte, S.M.1    Tong, M.2    Lester-Coll, N.3    Plater, M.4    Wands, J.R.5
  • 42
    • 73649112749 scopus 로고    scopus 로고
    • Dysregulation of insulin signaling, glucose transporters, o-glcnacylation and phosphorylation of tau and neurofilaments: Relevance to alzheimer’s disease
    • Deng T, Li B, Liu Y et al. 2009. Dysregulation of insulin signaling, glucose transporters, O-GlcNAcylation and phosphorylation of tau and neurofilaments: relevance to Alzheimer’s disease. Am J Pathol 175:2089–2098.
    • (2009) Am J Pathol , vol.175 , pp. 2089-2098
    • Deng, T.1    Li, B.2    Liu, Y.3
  • 43
    • 79952918505 scopus 로고    scopus 로고
    • Characterization of a selective inhibitor of the parkinson’s disease kinase lrrk2
    • Deng X, Dzamk N, Prescott A et al. 2011. Characterization of a selective inhibitor of the Parkinson’s disease kinase LRRK2. Nat Chem Biol 7:203–205.
    • (2011) Nat Chem Biol , vol.7 , pp. 203-205
    • Deng, X.1    Dzamk, N.2    Prescott, A.3
  • 44
    • 79951931880 scopus 로고    scopus 로고
    • Transcranial laser therapy attenuates amyloid-beta peptide neuropathology in amyloidbeta protein precursor transgenic mice
    • DeTaboada L, Yu J, El-Amouri S et al. 2011. Transcranial laser therapy attenuates amyloid-beta peptide neuropathology in amyloidbeta protein precursor transgenic mice. J Alzheimer’s Dis 23:521–535.
    • (2011) J Alzheimer’s Dis , vol.23 , pp. 521-535
    • DeTaboada, L.1    Yu, J.2    El-Amouri, S.3
  • 45
    • 46749142660 scopus 로고    scopus 로고
    • Do csf total tau, phosphorylated tau, and b-amyloid 42 help to predict progression of mild cognitive impairment to alzheimer’s disease? A systematic review and meta-analysis of the literature
    • Diniz BS, Pinto JA Jr, Forlenz OV. 2008. Do CSF total tau, phosphorylated tau, and b-amyloid 42 help to predict progression of mild cognitive impairment to Alzheimer’s disease? A systematic review and meta-analysis of the literature. World J Biol Psychiatry 9:172–182.
    • (2008) World J Biol Psychiatry , vol.9 , pp. 172-182
    • Diniz, B.S.1    Pinto, J.A.2    Forlenz, O.V.3
  • 46
    • 77955046461 scopus 로고    scopus 로고
    • Sirt1 suppresses b-amyloid production by activating the a-secretase gene adam10
    • Donmez G, Wang D, Cohen DE, Guarente L. 2010. SIRT1 suppresses b-amyloid production by activating the a-secretase gene ADAM10. Cell 142:320–332.
    • (2010) Cell , vol.142 , pp. 320-332
    • Donmez, G.1    Wang, D.2    Cohen, D.E.3    Guarente, L.4
  • 47
    • 79952728896 scopus 로고    scopus 로고
    • Global issues in drug development for alzheimer’s disease
    • Doody RS, Coleb PE, Millerc DS et al. 2011. Global issues in drug development for Alzheimer’s disease. Alzheimer’s Dement 7:197–207.
    • (2011) Alzheimer’s Dement , vol.7 , pp. 197-207
    • Doody, R.S.1    Coleb, P.E.2    Millerc, D.S.3
  • 48
    • 47149108940 scopus 로고    scopus 로고
    • Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-tomoderate alzheimer’s disease: A randomised, double-blind, placebocontrolled study
    • Doody RS, Gavrilova SI, Sano M et al. 2008. Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-tomoderate Alzheimer’s disease: a randomised, double-blind, placebocontrolled study. Lancet 372:207–215.
    • (2008) Lancet , vol.372 , pp. 207-215
    • Doody, R.S.1    Gavrilova, S.I.2    Sano, M.3
  • 50
    • 77957951112 scopus 로고    scopus 로고
    • Revising the definition of alzheimer’s disease: A new lexicon
    • Dubois B, Feldman HH, Jacova J et al. 2010. Revising the definition of Alzheimer’s disease: a new lexicon. Lancet Neurol 9:1118–1124.
    • (2010) Lancet Neurol , vol.9 , pp. 1118-1124
    • Dubois, B.1    Feldman, H.H.2    Jacova, J.3
  • 51
    • 79959197550 scopus 로고    scopus 로고
    • Ecnp summit on the future of cns drug research in europe 2011: Report prepared for ecnp by david nutt and guy goodwin
    • ECNP Summit Report 2011. ECNP Summit on the future of CNS drug research in Europe 2011: report prepared for ECNP by David Nutt and Guy Goodwin. Eur Neuropsychopharmacol 21:495–499.
    • (2011) Eur Neuropsychopharmacol , vol.21 , pp. 495-499
    • Summit Report, E.1
  • 52
    • 79955389000 scopus 로고    scopus 로고
    • Independent and joint effects of the mapt and snca genes in parkinson disease
    • Elbaz A, Ross OA, Ioannidis JPA et al. 2011. Independent and joint effects of the MAPT and SNCA genes in Parkinson disease. Ann Neurol 69:778–792.
    • (2011) Ann Neurol , vol.69 , pp. 778-792
    • Elbaz, A.1    Ross, O.A.2    Ioannidis, J.3
  • 53
    • 77957361080 scopus 로고    scopus 로고
    • Alzheimer’s failure raises questions about diseasemodifying strategies
    • Extance A. 2010. Alzheimer’s failure raises questions about diseasemodifying strategies. Nat Rev Drug Discov 9:749–751.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 749-751
    • Extance, A.1
  • 54
    • 77949425172 scopus 로고    scopus 로고
    • Cerebrospinal fluid tau and ptau181 increase with cortical amyloid deposition in cognitively normal individuals: Implications for future clinical trials of alzheimer’s disease
    • Fagan AM, Mintun MA, Shah AR, Alde P, Roe CM. 2009. Cerebrospinal fluid tau and ptau181 increase with cortical amyloid deposition in cognitively normal individuals: implications for future clinical trials of Alzheimer’s disease. EMBO Mol Med 1:371–380.
    • (2009) EMBO Mol Med , vol.1 , pp. 371-380
    • Fagan, A.M.1    Mintun, M.A.2    Shah, A.R.3    Alde, P.4    Roe, C.M.5
  • 55
    • 77952029838 scopus 로고    scopus 로고
    • New approaches to the pathology and genetics of neurodegeneration
    • Feany MB. 2010. New approaches to the pathology and genetics of neurodegeneration. Am J Pathol 176:2058–2066.
    • (2010) Am J Pathol , vol.176 , pp. 2058-2066
    • Feany, M.B.1
  • 56
    • 74149087857 scopus 로고    scopus 로고
    • Zweig rm et al. For the 6002-us-051 study group 2010. Istradefylline as monotherapy for parkinson disease: Results of the 6002-us 051 trial
    • Fernandez HH, Greeley DR, Zweig RM et al. for the 6002-US-051 Study Group 2010. Istradefylline as monotherapy for Parkinson disease: results of the 6002-US 051 trial. Parkinsonism Relat Disord 16:16–20.
    • Parkinsonism Relat Disord , vol.16 , pp. 16-20
    • Fernandez, H.H.1    Greeley, D.R.2
  • 57
    • 77953912200 scopus 로고    scopus 로고
    • Examination of the current top candidate genes for ad in a genome-wide association study
    • Feulner TM, Laes SM, Friedrich P et al. 2010. Examination of the current top candidate genes for AD in a genome-wide association study. Mol Psychiatry 15:756–766.
    • (2010) Mol Psychiatry , vol.15 , pp. 756-766
    • Feulner, T.M.1    Laes, S.M.2    Friedrich, P.3
  • 58
    • 78149324557 scopus 로고    scopus 로고
    • Bridging the valley of death of therapeutics for neurodegeneration
    • Finkbeiner S. 2010. Bridging the valley of death of therapeutics for neurodegeneration. Nat Med 16:1227–1232.
    • (2010) Nat Med , vol.16 , pp. 1227-1232
    • Finkbeiner, S.1
  • 59
    • 79955438992 scopus 로고    scopus 로고
    • Developing predictive csf biomarkers – a challenge critical to success in alzheimer’s disease and neuropsychiatric translational medicine
    • Flood DG, Marek GJ, Williams M. 2011. Developing predictive CSF biomarkers – a challenge critical to success in Alzheimer’s disease and neuropsychiatric translational medicine. Biochem Pharmacol 81:1422–1434.
    • (2011) Biochem Pharmacol , vol.81 , pp. 1422-1434
    • Flood, D.G.1    Marek, G.J.2    Williams, M.3
  • 60
    • 79953839752 scopus 로고    scopus 로고
    • Gene– environment interactions: Key to unraveling the mystery of parkinson’s disease
    • Gao HM, Hong JS. 2011. Gene– environment interactions: key to unraveling the mystery of Parkinson’s disease. Prog Neurobiol 94:1–19.
    • (2011) Prog Neurobiol , vol.94 , pp. 1-19
    • Gao, H.M.1    Hong, J.S.2
  • 61
    • 79952941281 scopus 로고    scopus 로고
    • Use of ibuprofen and risk of parkinson’s disease
    • Gao X, Chen H, Schwarzschild M, Ascherio A. 2011. Use of ibuprofen and risk of Parkinson’s disease. Neurology 76:863–869.
    • (2011) Neurology , vol.76 , pp. 863-869
    • Gao, X.1    Chen, H.2    Schwarzschild, M.3    Ascherio, A.4
  • 62
    • 77955346228 scopus 로고    scopus 로고
    • Identifying pd-causing genes and genetic susceptibility factors: Current approaches and future prospects
    • Gasser T. 2010. Identifying PD-causing genes and genetic susceptibility factors: current approaches and future prospects. Prog Brain Res 183:2–20.
    • (2010) Prog Brain Res , vol.183 , pp. 2-20
    • Gasser, T.1
  • 63
    • 77949897022 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis and frontotemporal lobar degeneration: A spectrum of tdp-43 proteinopathies
    • Geser F, Lee VM, Trojanowski JQ. 2010. Amyotrophic lateral sclerosis and frontotemporal lobar degeneration: a spectrum of TDP-43 proteinopathies. Neuropathology 30:103–112.
    • (2010) Neuropathology , vol.30 , pp. 103-112
    • Geser, F.1    Lee, V.M.2    Trojanowski, J.Q.3
  • 64
    • 68349125007 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis, frontotemporal dementia and beyond: The tdp-43 diseases
    • Geser F, Martinez-Lage M, Trojanowski JQ et al. 2009. Amyotrophic lateral sclerosis, frontotemporal dementia and beyond: the TDP-43 diseases. J Neurol 256:1205–1214.
    • (2009) J Neurol , vol.256 , pp. 1205-1214
    • Geser, F.1    Martinez-Lage, M.2    Trojanowski, J.Q.3
  • 65
  • 66
    • 72549105935 scopus 로고    scopus 로고
    • Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild alzheimer disease
    • Green RC, Schneider LS, Amato DA et al. 2009. Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease. J Am Med Assoc 302:2557–2564.
    • (2009) J am Med Assoc , vol.302 , pp. 2557-2564
    • Green, R.C.1    Schneider, L.S.2    Amato, D.A.3
  • 67
    • 0141860155 scopus 로고    scopus 로고
    • Excess incidence of als in young gulf war veterans
    • Haley RW. 2003. Excess incidence of ALS in young Gulf War veterans. Neurology 61:750–756.
    • (2003) Neurology , vol.61 , pp. 750-756
    • Haley, R.W.1
  • 70
    • 79951720949 scopus 로고    scopus 로고
    • Preladenant in patients with parkinson’s disease and motor fluctuations: A phase 2, doubleblind, randomised trial
    • Hauser RA, Cantillon M, Pourcher E et al. 2011. Preladenant in patients with Parkinson’s disease and motor fluctuations: a phase 2, doubleblind, randomised trial. Lancet Neurol 10:221–229.
    • (2011) Lancet Neurol , vol.10 , pp. 221-229
    • Hauser, R.A.1    Cantillon, M.2    Pourcher, E.3
  • 71
    • 62549133546 scopus 로고    scopus 로고
    • Neuroinflammation in parkinson’s disease: A target for neuroprotection?
    • Hirsch EC, Hunot S. 2009. Neuroinflammation in Parkinson’s disease: a target for neuroprotection? Lancet Neurol 8:382–397.
    • (2009) Lancet Neurol , vol.8 , pp. 382-397
    • Hirsch, E.C.1    Hunot, S.2
  • 72
    • 79955484414 scopus 로고    scopus 로고
    • Common variants at abca7, ms4a6a/ms4a4e, epha1, cd33 and cd2ap are associated with alzheimer’s disease
    • Hollingworth P, Harold D, Sims R et al. 2011. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer’s disease. Nat Genet 43:429–435.
    • (2011) Nat Genet , vol.43 , pp. 429-435
    • Hollingworth, P.1    Harold, D.2    Sims, R.3
  • 73
    • 47149112621 scopus 로고    scopus 로고
    • Long-term effects of ab immunisation in alzheimer’s disease: Follow-up of a randomised, placebo-controlled phase i trial
    • Holmes C, Boche D, Wilkinson D et al. 2008. Long-term effects of Ab immunisation in Alzheimer’s disease: follow-up of a randomised, placebo-controlled phase I trial. Lancet 372:216–223.
    • (2008) Lancet , vol.372 , pp. 216-223
    • Holmes, C.1    Boche, D.2    Wilkinson, D.3
  • 75
    • 1842785179 scopus 로고    scopus 로고
    • Glucose metabolism and insulin receptor signal transduction in alzheimer disease
    • Hoyer S. 2004. Glucose metabolism and insulin receptor signal transduction in Alzheimer disease. Eur J Pharmacol 490:115–125.
    • (2004) Eur J Pharmacol , vol.490 , pp. 115-125
    • Hoyer, S.1
  • 76
    • 78650034178 scopus 로고    scopus 로고
    • Ubiquitin/proteasome pathway impairment in neurodegeneration: Therapeutic implications
    • Huang Q, Figueiredo-Pereira ME. 2009. Ubiquitin/proteasome pathway impairment in neurodegeneration: therapeutic implications. Apoptosis 15:1292–1311.
    • (2009) Apoptosis , vol.15 , pp. 1292-1311
    • Huang, Q.1    Figueiredo-Pereira, M.E.2
  • 77
    • 62149120882 scopus 로고    scopus 로고
    • Cell biology, regulation and inhibition of beta-secretase (Bace-1)
    • Hunt CE, Turner AJ. 2009. Cell biology, regulation and inhibition of beta-secretase (BACE-1). FEBS J 276:1854–1859.
    • (2009) FEBS J , vol.276 , pp. 1854-1859
    • Hunt, C.E.1    Turner, A.J.2
  • 78
    • 0027480960 scopus 로고
    • A novel gene containing a trinucleotide repeat that is expanded and unstable on huntington’s disease chromosomes
    • Huntington’s Disease Collaborative Research Group 1993. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington’s disease chromosomes. Cell 72:971–983.
    • (1993) Cell , vol.72 , pp. 971-983
  • 79
    • 3042693940 scopus 로고    scopus 로고
    • Glutamate-mediated excitotoxicity and neurodegeneration in alzheimer’s disease
    • Hynd MR, Scott HL, Dodd PR. 2004. Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer’s disease. Neurochem Int 45:583–595.
    • (2004) Neurochem Int , vol.45 , pp. 583-595
    • Hynd, M.R.1    Scott, H.L.2    Dodd, P.R.3
  • 80
    • 2342614850 scopus 로고    scopus 로고
    • Neurovascular regulation in the normal brain and alzheimer’s disease
    • Iadecola C. 2004. Neurovascular regulation in the normal brain and Alzheimer’s disease. Nat Rev Neurosci 5:347–360.
    • (2004) Nat Rev Neurosci , vol.5 , pp. 347-360
    • Iadecola, C.1
  • 81
    • 79958204001 scopus 로고    scopus 로고
    • The l-type channel antagonist isradipine is neuroprotective in a mouse model of parkinson’s disease
    • Ilijic E, Guzman JN, Surmeier DJ. 2011. The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson’s disease. Neurobiol Dis 43:364–371.
    • (2011) Neurobiol Dis , vol.43 , pp. 364-371
    • Ilijic, E.1    Guzman, J.N.2    Surmeier, D.J.3
  • 82
    • 79959944588 scopus 로고    scopus 로고
    • G- secretase inhibitors and modulators for the treatment of alzheimer’s disease: Disappointments and hopes
    • Imbimbo BP, Giardina GA. 2011. g- Secretase inhibitors and modulators for the treatment of Alzheimer’s disease: disappointments and hopes. Curr Top Med Chem 11:1555–1570.
    • (2011) Curr Top Med Chem , vol.11 , pp. 1555-1570
    • Imbimbo, B.P.1    Giardina, G.A.2
  • 83
    • 79957789708 scopus 로고    scopus 로고
    • Comparison of effect sizes associated with biomarkers reported in highly cited individual articles and in subsequent meta-analyses
    • Ioannidis JPA, Panagiotou OA. 2011. Comparison of effect sizes associated with biomarkers reported in highly cited individual articles and in subsequent meta-analyses. J Am Med Assoc 305:2200–2210.
    • (2011) J am Med Assoc , vol.305 , pp. 2200-2210
    • Ioannidis, J.1    Panagiotou, O.A.2
  • 84
    • 78751644048 scopus 로고    scopus 로고
    • Amyloid-b and tau – a toxic pas de deux in alzheimer’s disease
    • Ittner LM, Gotz J. 2011. Amyloid-b and tau – a toxic pas de deux in Alzheimer’s disease. Nat Rev Neurosci 12:65–72.
    • (2011) Nat Rev Neurosci , vol.12 , pp. 65-72
    • Ittner, L.M.1    Gotz, J.2
  • 85
    • 79956076567 scopus 로고    scopus 로고
    • Introduction to the recommendations from the national institute on aging– alzheimer’s association workgroups on diagnostic guidelines for alzheimer’s disease
    • Jack CR Jr, Albert MS, Knopman DS et al. 2011. Introduction to the recommendations from the National Institute on Aging– Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimer’s Dement 7:257–262.
    • (2011) Alzheimer’s Dement , vol.7 , pp. 257-262
    • Jack, C.R.1    Albert, M.S.2    Knopman, D.S.3
  • 86
    • 78049477126 scopus 로고    scopus 로고
    • Brain beta-amyloid measures and magnetic resonance imaging atrophy both predict time-toprogression from mild cognitive impairment to alzheimer’s disease
    • Jack CR Jr, Wiste HJ, Vemuri P et al. 2010. Brain beta-amyloid measures and magnetic resonance imaging atrophy both predict time-toprogression from mild cognitive impairment to Alzheimer’s disease. Brain 133:3336–3348.
    • (2010) Brain , vol.133 , pp. 3336-3348
    • Jack, C.R.1    Wiste, H.J.2    Vemuri, P.3
  • 87
    • 41849115606 scopus 로고    scopus 로고
    • Are adenosine antagonists, such as istradefylline, caffeine, and chocolate, useful in the treatment of parkinson’s disease?
    • Jankovic J. 2008. Are adenosine antagonists, such as istradefylline, caffeine, and chocolate, useful in the treatment of Parkinson’s disease? Ann Neurol 63:267–269.
    • (2008) Ann Neurol , vol.63 , pp. 267-269
    • Jankovic, J.1
  • 88
    • 76949085430 scopus 로고    scopus 로고
    • Dopamine gene therapy for parkinson’s disease in a nonhuman primate without associated dyskinesia
    • Jarraya B, Boulet S, Ralph SG et al. 2009. Dopamine gene therapy for Parkinson’s disease in a nonhuman primate without associated dyskinesia. Sci Transl Med 1:2ra4.
    • (2009) Sci Transl Med 1:2Ra4
    • Jarraya, B.1    Boulet, S.2    Ralph, S.G.3
  • 89
    • 79952408978 scopus 로고    scopus 로고
    • Hugging tight in huntington’s
    • Johri A, Chaturvedi, RK, Beal MF. 2011. Hugging tight in Huntington’s. Nat Med 17:245–246.
    • (2011) Nat Med , vol.17 , pp. 245-246
    • Johri, A.1    Chaturvedi, R.K.2    Beal, M.F.3
  • 90
    • 78149320656 scopus 로고    scopus 로고
    • The benefits and limitations of animal models for translational research in neurodegenerative diseases
    • Jucker M. 2010. The benefits and limitations of animal models for translational research in neurodegenerative diseases. Nat Med 16:1210–1214.
    • (2010) Nat Med , vol.16 , pp. 1210-1214
    • Jucker, M.1
  • 91
    • 21544467552 scopus 로고    scopus 로고
    • Cholinesterase inhibitors for patients with alzheimer’s disease: Systematic review of randomised clinical trials
    • Kaduszkiewicz H, Zimmermann T, Beck-Bornholdt H-P, van den Bussche H. 2005. Cholinesterase inhibitors for patients with Alzheimer’s disease: systematic review of randomised clinical trials. Br Med J 331:321.
    • (2005) Br Med J , vol.331 , pp. 321
    • Kaduszkiewicz, H.1    Zimmermann, T.2    Beck-Bornholdt, H.-P.3    Van Den Bussche, H.4
  • 93
    • 79958191139 scopus 로고    scopus 로고
    • The role of ikb kinase complex in the neurobiology of huntington’s disease
    • Khoshnan A, Patterson PH. 2011. The role of IkB kinase complex in the neurobiology of Huntington’s disease. Neurobiol Dis 43:305–311.
    • (2011) Neurobiol Dis , vol.43 , pp. 305-311
    • Khoshnan, A.1    Patterson, P.H.2
  • 94
    • 79952486262 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis
    • Kiernan, MC, Vucic S, Cheah BC et al. 2011. Amyotrophic lateral sclerosis. Lancet 377:942–955.
    • (2011) Lancet , vol.377 , pp. 942-955
    • Kiernan, M.C.1    Vucic, S.2    Cheah, B.C.3
  • 95
    • 77956808539 scopus 로고    scopus 로고
    • Post-stroke inhibition of induced nadph oxidase type 4 prevents oxidative stress and neurodegeneration
    • e1000479
    • Kleinschnitz C, Grund H, Wingler K et al. 2010. Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration. PLoS Biol 8: e1000479.
    • (2010) Plos Biol , vol.8
    • Kleinschnitz, C.1    Grund, H.2    Wingler, K.3
  • 97
    • 79958721731 scopus 로고    scopus 로고
    • New York Times, August 28, 2010, Accessed August 5, 2011
    • Kolata G. 2010. Years later, no magic bullet against Alzheimer’s disease. New York Times, August 28, 2010. Available at: http://www. nytimes.com/2010/08/29/health/research/29prevent.html. Accessed August 5, 2011.
    • (2010) Years Later, No Magic Bullet against Alzheimer’s Disease
    • Kolata, G.1
  • 98
    • 0020042999 scopus 로고
    • Multiple sclerosis in iceland: I. Evidence of a postwar epidemic
    • Kurtzke JF, Gudmundsson KR, Bergmann S. 1982. Multiple sclerosis in Iceland: I. Evidence of a postwar epidemic. Neurology 32:143–150.
    • (1982) Neurology , vol.32 , pp. 143-150
    • Kurtzke, J.F.1    Gudmundsson, K.R.2    Bergmann, S.3
  • 99
    • 79955662958 scopus 로고    scopus 로고
    • Amyloid clearance as a treatment target against alzheimer’s disease
    • Kurz A, Perneczky R. 2011. Amyloid clearance as a treatment target against Alzheimer’s disease. J Alzheimer’s Dis 24(Suppl. 2): 61–73.
    • (2011) J Alzheimer’s Dis , vol.24 , Issue.2 , pp. 61-73
    • Kurz, A.1    Perneczky, R.2
  • 100
  • 101
    • 78149299057 scopus 로고    scopus 로고
    • Clinical trials of disease-modifying therapies for neurodegenerative diseases: The challenges and the future
    • Lang AE. 2010. Clinical trials of disease-modifying therapies for neurodegenerative diseases: the challenges and the future. Nat Med 16:1223–1226.
    • (2010) Nat Med , vol.16 , pp. 1223-1226
    • Lang, A.E.1
  • 102
    • 34248560960 scopus 로고    scopus 로고
    • Amyloid-b in alzheimer disease: The null versus the alternate hypotheses
    • Lee H-G, Zhu X, Castellani RJ et al. 2007. Amyloid-b in Alzheimer disease: the null versus the alternate hypotheses. J Pharmacol Exp Ther 321:823–829.
    • (2007) J Pharmacol Exp Ther , vol.321 , pp. 823-829
    • Lee, H.-G.1    Zhu, X.2    Castellani, R.J.3
  • 103
    • 76849091134 scopus 로고    scopus 로고
    • Can alzheimer disease be prevented by amyloid-b immunotherapy?
    • Lemere CA, Masliah E. 2010. Can Alzheimer disease be prevented by amyloid-b immunotherapy? Nat Rev Neurol 6:108–119.
    • (2010) Nat Rev Neurol , vol.6 , pp. 108-119
    • Lemere, C.A.1    Masliah, E.2
  • 104
    • 63149090431 scopus 로고    scopus 로고
    • Parkinson’s disease: From monogenic forms to genetic susceptibility factors
    • Lesage S, Brice A. 2009. Parkinson’s disease: from monogenic forms to genetic susceptibility factors. Hum Mol Genet 18:R48–R59.
    • (2009) Hum Mol Genet , vol.18 , pp. R48-R59
    • Lesage, S.1    Brice, A.2
  • 105
    • 79952740079 scopus 로고    scopus 로고
    • Aav2-gad gene therapy for advanced parkinson’s disease: A double-blind, sham-surgery controlled, randomised trial
    • LeWitt PA, Rezai AR, Leehey MA et al. 2011. AAV2-GAD gene therapy for advanced Parkinson’s disease: a double-blind, sham-surgery controlled, randomised trial. Lancet Neurol 10:309–319.
    • (2011) Lancet Neurol , vol.10 , pp. 309-319
    • LeWitt, P.A.1    Rezai, A.R.2    Leehey, M.A.3
  • 107
    • 33750347347 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
    • Lin MT, Beal MF. 2006. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443:787–795.
    • (2006) Nature , vol.443 , pp. 787-795
    • Lin, M.T.1    Beal, M.F.2
  • 109
    • 84864278260 scopus 로고    scopus 로고
    • Pink1 defect causes mitochondrial dysfunction, proteasomal deficit and a-synuclein aggregation in cell culture models of parkinson’s disease
    • e4597
    • Liu W, Vives-Bauza C, Acýn-Perez R et al. 2009. PINK1 defect causes mitochondrial dysfunction, proteasomal deficit and a-synuclein aggregation in cell culture models of Parkinson’s disease. PLoS ONE 4: e4597.
    • (2009) Plos ONE , vol.4
    • Liu, W.1    Vives-Bauza, C.2    Acýn-Perez, R.3
  • 110
    • 78649982418 scopus 로고    scopus 로고
    • Searching for biomarkers in neurodegeneration
    • Lovestone S. 2010. Searching for biomarkers in neurodegeneration. Nat Med 16:1371–1372.
    • (2010) Nat Med , vol.16 , pp. 1371-1372
    • Lovestone, S.1
  • 112
    • 66249126971 scopus 로고    scopus 로고
    • Metabolic links between diabetes and alzheimer’s disease
    • Maher PA, Schubert DR. 2009. Metabolic links between diabetes and Alzheimer’s disease. Expert Rev Neurother 9:617–630.
    • (2009) Expert Rev Neurother , vol.9 , pp. 617-630
    • Maher, P.A.1    Schubert, D.R.2
  • 113
    • 80052315458 scopus 로고    scopus 로고
    • The role of b-amyloid peptide in neurodegenerative diseases
    • Maltsev AV, Bystryak S, Galzitskaya OV. 2011. The role of b-amyloid peptide in neurodegenerative diseases. Ageing Res Rev. 10:440–452.
    • (2011) Ageing Res Rev , vol.10 , pp. 440-452
    • Maltsev, A.V.1    Bystryak, S.2    Galzitskaya, O.V.3
  • 115
    • 78649672510 scopus 로고    scopus 로고
    • New treatments in amyotrophic lateral sclerosis
    • Maragakis N, Rothstein JD. 2011. New treatments in amyotrophic lateral sclerosis. Neuropsychopharmacology 36:370–372.
    • (2011) Neuropsychopharmacology , vol.36 , pp. 370-372
    • Maragakis, N.1    Rothstein, J.D.2
  • 116
    • 78349247631 scopus 로고    scopus 로고
    • Gene delivery of aav2- neurturin for parkinson’s disease: A double blind, randomised, controlled trial
    • Marks WJ, Bartus RT, Siffert J et al. 2010. Gene delivery of AAV2- neurturin for Parkinson’s disease: a double blind, randomised, controlled trial. Lancet Neurol 9:1164–1172.
    • (2010) Lancet Neurol , vol.9 , pp. 1164-1172
    • Marks, W.J.1    Bartus, R.T.2    Siffert, J.3
  • 117
    • 41949110690 scopus 로고    scopus 로고
    • Safety and tolerability of intraputaminal delivery of cere- 120 (Adeno-associated virus serotype 2pneurturin) to patients with idiopathic parkinson’s disease: An open-label, phase i trial
    • Marks WJ, Ostrem JL, Verhagen L et al. 2008. Safety and tolerability of intraputaminal delivery of CERE- 120 (adeno-associated virus serotype 2pneurturin) to patients with idiopathic Parkinson’s disease: an open-label, phase I trial. Lancet Neurol 7:400–408.
    • (2008) Lancet Neurol , vol.7 , pp. 400-408
    • Marks, W.J.1    Ostrem, J.L.2    Verhagen, L.3
  • 118
    • 8844239964 scopus 로고    scopus 로고
    • Environmental risk factors in multiple sclerosis aetiology
    • Marrie RA. 2004. Environmental risk factors in multiple sclerosis aetiology. Lancet Neurol 3:709–718.
    • (2004) Lancet Neurol , vol.3 , pp. 709-718
    • Marrie, R.A.1
  • 119
    • 67651204382 scopus 로고    scopus 로고
    • Csf biomarkers and incipient alzheimer disease in patients with mild cognitive impairment
    • Mattsson N, Zetterberg H, Hansson O et al. 2009. CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment. J Am Med Assoc 302:385–393.
    • (2009) J am Med Assoc , vol.302 , pp. 385-393
    • Mattsson, N.1    Zetterberg, H.2    Hansson, O.3
  • 121
    • 62249094525 scopus 로고    scopus 로고
    • Inhibition of soluble tnf signaling in a mouse model of alzheimer’s disease prevents preplaque amyloid-associated neuropathology
    • McAlpine FE, Lee JK, Harms AS et al. 2009. Inhibition of soluble TNF signaling in a mouse model of Alzheimer’s disease prevents preplaque amyloid-associated neuropathology. Neurobiol Dis 34:163–177.
    • (2009) Neurobiol Dis , vol.34 , pp. 163-177
    • McAlpine, F.E.1    Lee, J.K.2    Harms, A.S.3
  • 123
    • 33847339301 scopus 로고    scopus 로고
    • Nsaids and alzheimer disease: Epidemiological, animal model and clinical studies
    • McGeer PL, McGeer EG. 2006. NSAIDs and Alzheimer disease: epidemiological, animal model and clinical studies. Neurobiol Aging 28:639–647.
    • (2006) Neurobiol Aging , vol.28 , pp. 639-647
    • McGeer, P.L.1    McGeer, E.G.2
  • 124
    • 84880185810 scopus 로고    scopus 로고
    • Inflammation, antiinflammatory agents and alzheimer disease: The last 12 years
    • McGeer PL, Rogers J, McGeer EG. 2006. Inflammation, antiinflammatory agents and Alzheimer disease: The last 12 years. J Alzheimer’s Dis 9(Suppl. 3): 271–276.
    • (2006) J Alzheimer’s Dis , vol.9 , Issue.3 , pp. 271-276
    • McGeer, P.L.1    Rogers, J.2    McGeer, E.G.3
  • 125
    • 79959535096 scopus 로고    scopus 로고
    • The als/pdc syndrome of guam: Potential biomarkers for an enigmatic disorder
    • McGeer PL, Steele JC. 2011. The ALS/PDC syndrome of Guam: potential biomarkers for an enigmatic disorder. Prog Neurobiol 95:663–669.
    • (2011) Prog Neurobiol , vol.95 , pp. 663-669
    • McGeer, P.L.1    Steele, J.C.2
  • 126
    • 0021271971 scopus 로고
    • Clinical diagnosis of alzheimer’s disease: Report of the nincds-adrda work group under the auspices of department of health and human services task force on alzheimer’s disease
    • McKhann GM, Drachman D, Folstein M et al. 1984. Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology 34:939–944.
    • (1984) Neurology , vol.34 , pp. 939-944
    • McKhann, G.M.1    Drachman, D.2    Folstein, M.3
  • 127
    • 79956142378 scopus 로고    scopus 로고
    • The diagnosis of dementia due to alzheimer’s disease: Recommendations from the national institute on aging and the alzheimer’s association workgroup
    • McKhann GM, Knopman DS, Chertkow H et al. 2011. The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging and the Alzheimer’s Association workgroup. Alzheimer’s Dement 7:263–269.
    • (2011) Alzheimer’s Dement , vol.7 , pp. 263-269
    • McKhann, G.M.1    Knopman, D.S.2    Chertkow, H.3
  • 129
  • 130
    • 59049099828 scopus 로고    scopus 로고
    • A cannabinoid agonist interferes with the progression of a chronic model of multiple sclerosis by downregulating adhesion molecules
    • Mestre L, Docagne F, Correa F et al. 2009. A cannabinoid agonist interferes with the progression of a chronic model of multiple sclerosis by downregulating adhesion molecules. Mol Cell Neurosci 40:258–266.
    • (2009) Mol Cell Neurosci , vol.40 , pp. 258-266
    • Mestre, L.1    Docagne, F.2    Correa, F.3
  • 131
    • 67649185049 scopus 로고    scopus 로고
    • Genetics, environmental factors and the emerging role of epigenetics in neurodegenerative diseases
    • Migliore L, Coppede F. 2009. Genetics, environmental factors and the emerging role of epigenetics in neurodegenerative diseases. Mutat Res/Fund Mol Mechanisms Mutagenesis 667:82–97.
    • (2009) Mutat Res/Fund Mol Mechanisms Mutagenesis , vol.667 , pp. 82-97
    • Migliore, L.1    Coppede, F.2
  • 132
    • 77954559377 scopus 로고    scopus 로고
    • Translational research in genomics of alzheimer’s disease: A review of current practice and future perspectives
    • Mihaescu R, Detmar SB, Cornel MC et al. 2010. Translational research in genomics of Alzheimer’s disease: a review of current practice and future perspectives. J Alzheimer’s Dis 20:967–980.
    • (2010) J Alzheimer’s Dis , vol.20 , pp. 967-980
    • Mihaescu, R.1    Detmar, S.B.2    Cornel, M.C.3
  • 133
    • 70350100277 scopus 로고    scopus 로고
    • Alzheimer’s biomarker initiative hits its stride
    • Miller G. 2009. Alzheimer’s biomarker initiative hits its stride. Science 326:386–389.
    • (2009) Science , vol.326 , pp. 386-389
    • Miller, G.1
  • 134
    • 69449102820 scopus 로고    scopus 로고
    • Neprilysin and insulin-degrading enzyme levels are increased in alzheimer disease in relation to disease severity
    • Miners JS, Baig S, Tayler H, Kehoe PG, Love S. 2009. Neprilysin and insulin-degrading enzyme levels are increased in Alzheimer disease in relation to disease severity. J Neuropathol Exp Neurol 68:902–914.
    • (2009) J Neuropathol Exp Neurol , vol.68 , pp. 902-914
    • Miners, J.S.1    Baig, S.2    Tayler, H.3    Kehoe, P.G.4    Love, S.5
  • 135
    • 58149352987 scopus 로고    scopus 로고
    • A meta-analysis of the accuracy of the mini-mental state examination in the detection of dementia and mild cognitive impairment
    • Mitchell AJ. 2009. A meta-analysis of the accuracy of the mini-mental state examination in the detection of dementia and mild cognitive impairment. J Psychiatr Res 43:411–431.
    • (2009) J Psychiatr Res , vol.43 , pp. 411-431
    • Mitchell, A.J.1
  • 137
    • 52449088325 scopus 로고    scopus 로고
    • Mitochondrial nutrition as a strategy for neuroprotection in parkinson’s disease – research focus in the department of alternative medicine and experimental therapeutics at hokuriku university
    • Mitsumoto Y. 2007. Mitochondrial nutrition as a strategy for neuroprotection in Parkinson’s disease – research focus in the Department of Alternative Medicine and Experimental Therapeutics at Hokuriku University. Evid Based Complement AlternatMed 4:263–265.
    • (2007) Evid Based Complement Alternatmed , vol.4 , pp. 263-265
    • Mitsumoto, Y.1
  • 138
    • 34249821079 scopus 로고    scopus 로고
    • Brain mitochondrial dysfunction as a link between alzheimer’s disease and diabetes
    • Moreira PI, Santos MS, Seica R, Oliveria CR. 2007. Brain mitochondrial dysfunction as a link between Alzheimer’s disease and diabetes. J Neurol Sci 257:206–214.
    • (2007) J Neurol Sci , vol.257 , pp. 206-214
    • Moreira, P.I.1    Santos, M.S.2    Seica, R.3    Oliveria, C.R.4
  • 139
    • 78650210590 scopus 로고    scopus 로고
    • Immunotherapy for alzheimer’s disease
    • Morgan D. 2011. Immunotherapy for Alzheimer’s disease. J Intern Med 269:54–63.
    • (2011) J Intern Med , vol.269 , pp. 54-63
    • Morgan, D.1
  • 140
    • 0035168927 scopus 로고    scopus 로고
    • Pathologic correlates of non demented aging, mild cognitive impairment, and early-stage alzheimer’s disease
    • Morris JC, Price JL. 2001. Pathologic correlates of non demented aging, mild cognitive impairment, and early-stage Alzheimer’s disease. J Mol Neurosci 17:101–118.
    • (2001) J Mol Neurosci , vol.17 , pp. 101-118
    • Morris, J.C.1    Price, J.L.2
  • 142
    • 79952164540 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in parkinson’s disease: Pathogenesis and neuroprotection
    • Mounsey RB, Teismann P. 2011. Mitochondrial dysfunction in Parkinson’s disease: pathogenesis and neuroprotection. Parkinson’s Dis doi:10.4061/2011/617472.
    • (2011) Parkinson’s Dis
    • Mounsey, R.B.1    Teismann, P.2
  • 144
    • 79955464911 scopus 로고    scopus 로고
    • Common variants at ms4a4/ms4a6e, cd2ap, cd33 and epha1 are associated with lateonset alzheimer’s disease
    • Naj AC, Jun G, Beecham GW et al. 2011. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with lateonset Alzheimer’s disease. Nat Genet 43:436–441.
    • (2011) Nat Genet , vol.43 , pp. 436-441
    • Naj, A.C.1    Jun, G.2    Beecham, G.W.3
  • 145
    • 77957273984 scopus 로고    scopus 로고
    • Animal models of neuropsychiatric disorders
    • Nestler EJ, Hyman SE. 2010. Animal models of neuropsychiatric disorders. Nat Neurosci 13:1161– 1169.
    • (2010) Nat Neurosci , vol.13
    • Nestler, E.J.1    Hyman, S.E.2
  • 146
    • 77953229747 scopus 로고    scopus 로고
    • Missing pieces in the parkinson’s disease puzzle
    • Obeso JA, Rodriguez-Oroz MC, Goetz CG et al. 2010. Missing pieces in the Parkinson’s disease puzzle. Nat Med 16: 653–661.
    • (2010) Nat Med , vol.16 , pp. 653-661
    • Obeso, J.A.1    Rodriguez-Oroz, M.C.2    Goetz, C.G.3
  • 147
    • 0036368298 scopus 로고    scopus 로고
    • Neuroprotective effect of riluzole in a primatemodel of parkinson’s disease: Behavioral and histological evidence
    • Obinu MC, Reibaud M, Blanchard V, Moussaoui S, Imperato A. 2002. Neuroprotective effect of riluzole in a primatemodel of Parkinson’s disease: behavioral and histological evidence. Mov Disord 17:3–19.
    • (2002) Mov Disord , vol.17 , pp. 3-19
    • Obinu, M.C.1    Reibaud, M.2    Blanchard, V.3    Moussaoui, S.4    Imperato, A.5
  • 148
    • 79851473226 scopus 로고    scopus 로고
    • Gamma-secretase modulators as potential disease modifying anti- alzheimer’s drugs
    • Oehlrich D, Berthelot DJ, Gijsen HJ. 2011. Gamma-secretase modulators as potential disease modifying anti- Alzheimer’s drugs. J Med Chem 54:669–698.
    • (2011) J Med Chem , vol.54 , pp. 669-698
    • Oehlrich, D.1    Berthelot, D.J.2    Gijsen, H.J.3
  • 149
    • 69149088365 scopus 로고    scopus 로고
    • Is parkinson’s disease a prion disorder?
    • Olanow CW, Pruisner SB. 2009. Is Parkinson’s disease a prion disorder? Proc Natl Acad Sci USA 106:12571–12572.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 12571-12572
    • Olanow, C.W.1    Pruisner, S.B.2
  • 150
    • 33750719088 scopus 로고    scopus 로고
    • Tch346 as a neuroprotective drug in parkinson’s disease: A doubleblind, randomised, controlled trial
    • Olanow CW, Schapira AHV, LeWitt PA et al. 2006. TCH346 as a neuroprotective drug in Parkinson’s disease: a doubleblind, randomised, controlled trial. Lancet Neurol 5:1013–1020.
    • (2006) Lancet Neurol , vol.5 , pp. 1013-1020
    • Olanow, C.W.1    Schapira, A.2    LeWitt, P.A.3
  • 151
    • 66949117423 scopus 로고    scopus 로고
    • The scientific and clinical basis for the treatment of parkinson disease
    • Olanow CW, Stern MB, Sethi K. 2009. The scientific and clinical basis for the treatment of Parkinson disease. Neurology 72:S1–S132.
    • (2009) Neurology , vol.72 , pp. SS1-S132
    • Olanow, C.W.1    Stern, M.B.2    Sethi, K.3
  • 152
    • 71849101413 scopus 로고    scopus 로고
    • Growth factors and cytokines/chemokines as surrogate biomarkers in cerebrospinal fluid and blood for diagnosing alzheimer’s disease and mild cognitive impairment
    • Olson L, Humpel C. 2010. Growth factors and cytokines/chemokines as surrogate biomarkers in cerebrospinal fluid and blood for diagnosing Alzheimer’s disease and mild cognitive impairment. Exp Gerentol 45:41–46.
    • (2010) Exp Gerentol , vol.45 , pp. 41-46
    • Olson, L.1    Humpel, C.2
  • 153
    • 79960956148 scopus 로고    scopus 로고
    • Biomarker-based dissection of neurodegenerative diseases
    • Olsson B, Zetterberg H, Hampel H, Blennow K. 2011. Biomarker-based dissection of neurodegenerative diseases. Prog Neurobiol 95: 520–534.
    • (2011) Prog Neurobiol , vol.95 , pp. 520-534
    • Olsson, B.1    Zetterberg, H.2    Hampel, H.3    Blennow, K.4
  • 154
    • 39549095825 scopus 로고    scopus 로고
    • Nonmotor symptoms as presenting complaints in parkinson’s disease: A clinicopathological study
    • O’Sullivan SS, Williams DR, Gallagher DA et al. 2008. Nonmotor symptoms as presenting complaints in Parkinson’s disease: a clinicopathological study. Mov Disord 23:101–106.
    • (2008) Mov Disord , vol.23 , pp. 101-106
    • O’Sullivan, S.S.1    Williams, D.R.2    Gallagher, D.A.3
  • 155
    • 77954132249 scopus 로고    scopus 로고
    • Amyloidbeta- induced neuronal dysfunction in alzheimer’s disease: From synapses toward neural networks
    • Palop JJ, Mucke L. 2010. Amyloidbeta- induced neuronal dysfunction in Alzheimer’s disease: from synapses toward neural networks. Nat Neurosci 13:812–818.
    • (2010) Nat Neurosci , vol.13 , pp. 812-818
    • Palop, J.J.1    Mucke, L.2
  • 156
    • 78649526412 scopus 로고    scopus 로고
    • Bapineuzumab: Anti-bamyloid monoclonal antibodies for the treatment of alzheimer’s disease
    • Panza F, Frisardi V, Imbimbo BP et al. 2010. Bapineuzumab: anti-bamyloid monoclonal antibodies for the treatment of Alzheimer’s disease. Immunotherapy 2: 767–782.
    • (2010) Immunotherapy , vol.2 , pp. 767-782
    • Panza, F.1    Frisardi, V.2    Imbimbo, B.P.3
  • 157
    • 35148882113 scopus 로고    scopus 로고
    • Mixed lineage kinase inhibitor cep-1347 fails to delay disability in early parkinson disease
    • Parkinson Study Group PRECEPT Investigators 2007. Mixed lineage kinase inhibitor CEP-1347 fails to delay disability in early Parkinson disease. Neurology 69:1480–1490.
    • (2007) Neurology , vol.69 , pp. 1480-1490
  • 158
    • 0036669791 scopus 로고    scopus 로고
    • Cannabinoids and multiple sclerosis
    • Pertwee RG. 2002. Cannabinoids and multiple sclerosis. Pharmacol Ther 95:165–174.
    • (2002) Pharmacol Ther , vol.95 , pp. 165-174
    • Pertwee, R.G.1
  • 159
    • 33847781937 scopus 로고    scopus 로고
    • Inflammation, demyelination, neurodegeneration and neuroprotection in the pathogenesis of multiple sclerosis
    • Peterson LK, Fujinami RS. 2007. Inflammation, demyelination, neurodegeneration and neuroprotection in the pathogenesis of multiple sclerosis. J Neuroimmunol 184:37–44.
    • (2007) J Neuroimmunol , vol.184 , pp. 37-44
    • Peterson, L.K.1    Fujinami, R.S.2
  • 161
    • 39549083677 scopus 로고    scopus 로고
    • Combined effects of smoking, coffee, and nsaids on parkinson’s disease risk
    • Powers KM, Kay DM, Factor SA et al. 2008. Combined effects of smoking, coffee, and NSAIDs on Parkinson’s disease risk. Mov Disord 23:88–95.
    • (2008) Mov Disord , vol.23 , pp. 88-95
    • Powers, K.M.1    Kay, D.M.2    Factor, S.A.3
  • 162
    • 84925593851 scopus 로고    scopus 로고
    • The reluctant social entrepreneur
    • Harvard Business Rev June, 2011
    • Prokesch S. 2011. The reluctant social entrepreneur. Harvard Business Rev June, 2011. [Prod. #:BR1106-MAGENG.]
    • (2011) Prod. #:BR1106-MAGENG
    • Prokesch, S.1
  • 165
    • 29844432266 scopus 로고    scopus 로고
    • Insulin, insulin-degrading enzyme and amyloid-b peptide in alzheimer’s disease: Review and hypothesis
    • Qui WQ, Folstein MF. 2006. Insulin, insulin-degrading enzyme and amyloid-b peptide in Alzheimer’s disease: review and hypothesis. Neurobiol Aging 27:190–198.
    • (2006) Neurobiol Aging , vol.27 , pp. 190-198
    • Qui, W.Q.1    Folstein, M.F.2
  • 166
    • 34247196532 scopus 로고    scopus 로고
    • 11c-pib pet imaging in alzheimer disease and frontotemporal lobar degeneration
    • Rabinovici GD, Furst AJ, Neil JP et al. 2007. 11C-PIB PET imaging in Alzheimer disease and frontotemporal lobar degeneration. Neurology 68:1205–1212.
    • (2007) Neurology , vol.68 , pp. 1205-1212
    • Rabinovici, G.D.1    Furst, A.J.2    Neil, J.P.3
  • 167
    • 77950665407 scopus 로고    scopus 로고
    • Frontotemporal lobar degeneration: Epidemiology, pathophysiology, diagnosis and management
    • Rabinovici G, Miller B. 2010. Frontotemporal lobar degeneration: epidemiology, pathophysiology, diagnosis and management. CNS Drugs 24:375–398.
    • (2010) CNS Drugs , vol.24 , pp. 375-398
    • Rabinovici, G.1    Miller, B.2
  • 168
    • 41049111771 scopus 로고    scopus 로고
    • Effectiveness of cholinesterase inhibitors and memantine for treating dementia: Evidence review for a clinical practice guideline
    • Raina P, Santaguida P, Ismaila A et al. 2008. Effectiveness of cholinesterase inhibitors and memantine for treating dementia: evidence review for a clinical practice guideline. Ann Intern Med 148:379–397.
    • (2008) Ann Intern Med , vol.148 , pp. 379-397
    • Raina, P.1    Santaguida, P.2    Ismaila, A.3
  • 169
    • 0033019985 scopus 로고    scopus 로고
    • Abt-431, a d1 receptor agonist prodrug, has efficacy in parkinson’s disease
    • Rascol O, Blin O, Thalamas C et al. 1999. ABT-431, a D1 receptor agonist prodrug, has efficacy in Parkinson’s disease. Ann Neurol 45:736–741.
    • (1999) Ann Neurol , vol.45 , pp. 736-741
    • Rascol, O.1    Blin, O.2    Thalamas, C.3
  • 170
    • 79954706259 scopus 로고    scopus 로고
    • A double-blind, delayedstart trial of rasagiline in parkinson’s disease (The adagio study): Pre-specified and post-hoc analyses of the need for additional therapies, changes in updrs scores, and non-motor outcomes
    • Rascol O, Fitzer-Attas CJ, Hauser R et al. 2011. A double-blind, delayedstart trial of rasagiline in Parkinson’s disease (the ADAGIO study): pre-specified and post-hoc analyses of the need for additional therapies, changes in UPDRS scores, and non-motor outcomes. Lancet Neurol 10:415–423.
    • (2011) Lancet Neurol , vol.10 , pp. 415-423
    • Rascol, O.1    Fitzer-Attas, C.J.2    Hauser, R.3
  • 171
    • 0034745615 scopus 로고    scopus 로고
    • Induction by dopamine d1 receptor agonist abt-431 of dyskinesia similar to levodopa in patients with parkinson disease
    • Rascol O, Nutt JG, Blin O et al. 2001. Induction by dopamine D1 receptor agonist ABT-431 of dyskinesia similar to levodopa in patients with Parkinson disease. Arch Neurol 58:249–254.
    • (2001) Arch Neurol , vol.58 , pp. 249-254
    • Rascol, O.1    Nutt, J.G.2    Blin, O.3
  • 173
    • 79551468717 scopus 로고    scopus 로고
    • Pain and death: Neurodegenerative disease mechanism in the nociceptor
    • Reichling DB, Levine JD. 2011. Pain and death: neurodegenerative disease mechanism in the nociceptor. Ann Neurol 69:13–21.
    • (2011) Ann Neurol , vol.69 , pp. 13-21
    • Reichling, D.B.1    Levine, J.D.2
  • 174
    • 0345830739 scopus 로고    scopus 로고
    • Rofecoxib: No effect on alzheimer’s disease in a 1-year, randomized, blinded, controlled study
    • Reines SA, Block GA, Morris JC et al. 2004. Rofecoxib: no effect on Alzheimer’s disease in a 1-year, randomized, blinded, controlled study. Neurology 62:66–71.
    • (2004) Neurology , vol.62 , pp. 66-71
    • Reines, S.A.1    Block, G.A.2    Morris, J.C.3
  • 175
    • 0030611334 scopus 로고    scopus 로고
    • Adenosine a2a receptor antagonists as new agents for the treatment of parkinson’s disease
    • Richardson PJ, Kase H, Jenner PG. 1997. Adenosine A2A receptor antagonists as new agents for the treatment of Parkinson’s disease. Trends Pharmacol Sci 18:338–344.
    • (1997) Trends Pharmacol Sci , vol.18 , pp. 338-344
    • Richardson, P.J.1    Kase, H.2    Jenner, P.G.3
  • 177
    • 84861304517 scopus 로고    scopus 로고
    • Oxidative stress and neurodegeneration: An inevitable consequence of aging? implications for therapy
    • Ritsner MS, ed. New York: Springer
    • Rodrigues R, Bonda DJ, Perry G et al. 2010. Oxidative stress and neurodegeneration: an inevitable consequence of aging? Implications for therapy. In Brain Protection in Schizophrenia, Mood and Cognitive Disorders. Ritsner MS, ed. New York: Springer, pp. 305–323.
    • (2010) Brain Protection in Schizophrenia, Mood and Cognitive Disorders , pp. 305-323
    • Rodrigues, R.1    Bonda, D.J.2    Perry, G.3
  • 178
    • 0027268393 scopus 로고
    • Clinical trial of indomethacin in alzheimer’s disease
    • Rogers J, Kirby LC, Hempelman SR et al. 1993. Clinical trial of indomethacin in Alzheimer’s disease. Neurology 43:1609–1611.
    • (1993) Neurology , vol.43 , pp. 1609-1611
    • Rogers, J.1    Kirby, L.C.2    Hempelman, S.R.3
  • 179
    • 77949904936 scopus 로고    scopus 로고
    • The ubiquitin-proteasome system: Contributions to cell death or survival in neurodegeneration
    • Rogers N, Paine S, Bedford L, Layfield R. 2010. The ubiquitin-proteasome system: contributions to cell death or survival in neurodegeneration. Neuropathol Appl Neurobiol 36:113–124.
    • (2010) Neuropathol Appl Neurobiol , vol.36 , pp. 113-124
    • Rogers, N.1    Paine, S.2    Bedford, L.3    Layfield, R.4
  • 180
    • 0034738134 scopus 로고    scopus 로고
    • Association of coffee and caffeine intake with the risk of parkinson disease
    • Ross GW, Abbott RD, Petrovitch H et al. 2000. Association of coffee and caffeine intake with the risk of Parkinson disease. J Am Med Assoc 283:2674–2679.
    • (2000) J am Med Assoc , vol.283 , pp. 2674-2679
    • Ross, G.W.1    Abbott, R.D.2    Petrovitch, H.3
  • 181
    • 77957113132 scopus 로고    scopus 로고
    • Latrepirdine for alzheimer’s disease: Trials and tribulations
    • Sabbagh MN, Berk C. 2010. Latrepirdine for Alzheimer’s disease: trials and tribulations. Fut Neurol 5:645–665.
    • (2010) Fut Neurol , vol.5 , pp. 645-665
    • Sabbagh, M.N.1    Berk, C.2
  • 182
    • 0036988312 scopus 로고    scopus 로고
    • Discovery of cep-1347/kt- 7515, an inhibitor of the jnk/sapk pathway for the treatment of neurodegenerative diseases
    • Saporito MS, Hudkin RL, Maroney A. 2002. Discovery of CEP-1347/KT- 7515, an inhibitor of the JNK/SAPK pathway for the treatment of neurodegenerative diseases. Prog Med Chem 40:23–62.
    • (2002) Prog Med Chem , vol.40 , pp. 23-62
    • Saporito, M.S.1    Hudkin, R.L.2    Maroney, A.3
  • 183
    • 84899501241 scopus 로고    scopus 로고
    • Nsaids: How they work and the prospects as therapeutics in alzheimer’s disease
    • Sastre M, Gentleman SM. 2010. NSAIDs: how they work and the prospects as therapeutics in Alzheimer’s disease. Front Aging Neurosci 2:20.
    • (2010) Front Aging Neurosci , vol.2 , pp. 20
    • Sastre, M.1    Gentleman, S.M.2
  • 184
    • 70549084415 scopus 로고    scopus 로고
    • Genome-wide association study identifies common variants at four loci as genetic risk factors for parkinson’s disease
    • Satake W, Nakabayashi Y, Mizuta I et al. 2009. Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson’s disease. Nat Genet 41:1303–1307.
    • (2009) Nat Genet , vol.41 , pp. 1303-1307
    • Satake, W.1    Nakabayashi, Y.2    Mizuta, I.3
  • 185
    • 34250716407 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in parkinson’s disease
    • Schapira AHV. 2007. Mitochondrial dysfunction in Parkinson’s disease. Cell Death Differ 14:1261–1266.
    • (2007) Cell Death Differ , vol.14 , pp. 1261-1266
    • Schapira, A.1
  • 186
    • 84925652854 scopus 로고    scopus 로고
    • Neuroprotection in parkinson’s disease
    • Schapira AHV. 2010. Neuroprotection in Parkinson’s disease. Blue Books Neurol 34:301–320.
    • (2010) Blue Books Neurol , vol.34 , pp. 301-320
    • Schapira, A.1
  • 188
    • 67651156095 scopus 로고    scopus 로고
    • Complicated recessive dystonia parkinsonism syndromes
    • Schneider SA, Bhatia KP, Hardy J. 2009. Complicated recessive dystonia parkinsonism syndromes. Mov Disord 24:490–499.
    • (2009) Mov Disord , vol.24 , pp. 490-499
    • Schneider, S.A.1    Bhatia, K.P.2    Hardy, J.3
  • 190
    • 79952529991 scopus 로고    scopus 로고
    • What the halted phase iii g-secretase inhibitor trial may (Or may not) be telling us
    • Schor NF. 2011. What the halted phase III g-secretase inhibitor trial may (or may not) be telling us. Ann Neurol 69:237–239.
    • (2011) Ann Neurol , vol.69 , pp. 237-239
    • Schor, N.F.1
  • 191
    • 0036771852 scopus 로고    scopus 로고
    • Effects of coenzyme q10 in early parkinson disease: Evidence of slowing of the functional decline
    • Shults CW, Oakes D, Kieburtz K et al. 2002. Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. Arch Neurol 59:1541–1550.
    • (2002) Arch Neurol , vol.59 , pp. 1541-1550
    • Shults, C.W.1    Oakes, D.2    Kieburtz, K.3
  • 194
    • 77954725231 scopus 로고    scopus 로고
    • Epstein-barr virus latent infection and baff expression in b cells in the multiple sclerosis brain: Implications for viral persistence and intrathecal b-cell activation
    • Serafini B, Severa M, Columba- Cabezas S et al. 2010. Epstein-Barr virus latent infection and BAFF expression in B cells in the multiple sclerosis brain: implications for viral persistence and intrathecal B-cell activation. J Neuropathol Exp Neurol 69:677–693.
    • (2010) J Neuropathol Exp Neurol , vol.69 , pp. 677-693
    • Serafini, B.1    Severa, M.2    Columba- Cabezas, S.3
  • 195
    • 65249159879 scopus 로고    scopus 로고
    • Cerebrospinal fluid biomarker signature in alzheimer’s disease neuroimaging initiative studies
    • Shaw LM, Vanderstichele H, Knapik- Czajka M et al. 2009. Cerebrospinal fluid biomarker signature in Alzheimer’s disease neuroimaging initiative studies. Ann Neurol 65:403–413.
    • (2009) Ann Neurol , vol.65 , pp. 403-413
    • Shaw, L.M.1    Vanderstichele, H.2    Knapik- Czajka, M.3
  • 197
    • 78651066204 scopus 로고    scopus 로고
    • Anti-tnf-alpha reduces amyloid plaques and tau phosphorylation and induces cd11c-positive dendritic-like cell in the app/ps1 transgenic mouse brains
    • Shi JQ, Shen W, Chen J et al. 2011a. Anti-TNF-alpha reduces amyloid plaques and tau phosphorylation and induces CD11c-positive dendritic-like cell in the APP/PS1 transgenic mouse brains. Brain Res 1368:239–247.
    • (2011) Brain Res , vol.1368 , pp. 239-247
    • Shi, J.Q.1    Shen, W.2    Chen, J.3
  • 198
    • 79953283868 scopus 로고    scopus 로고
    • Cerebrospinal fluid biomarkers for parkinson disease diagnosis and progression
    • Shi M, Bradner J, Hancock AM et al. 2011b. Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression. Ann Neurol 69:570–580.
    • (2011) Ann Neurol , vol.69 , pp. 570-580
    • Shi, M.1    Bradner, J.2    Hancock, A.M.3
  • 199
    • 70549088602 scopus 로고    scopus 로고
    • Genome-wide association study reveals genetic risk underlying parkinson’s disease
    • Simón-Sánchez J, Schulte C, Bras JM et al. 2009. Genome-wide association study reveals genetic risk underlying Parkinson’s disease. Nat Genet 41: 1308–1312.
    • (2009) Nat Genet , vol.41 , pp. 1308-1312
    • Simón-Sánchez, J.1    Schulte, C.2    Bras, J.M.3
  • 201
    • 77949830350 scopus 로고    scopus 로고
    • The alzheimer’s diseaseassociated amyloid beta-protein is an antimicrobial peptide
    • e9505
    • Soscia SJ, Kirby JE, Washicosky KJ et al. 2010. The Alzheimer’s diseaseassociated amyloid beta-protein is an antimicrobial peptide. PLoS One 3:e9505.
    • (2010) Plos One , vol.3
    • Soscia, S.J.1    Kirby, J.E.2    Washicosky, K.J.3
  • 202
    • 79956098248 scopus 로고    scopus 로고
    • Toward defining the preclinical stages of alzheimer’s disease: Recommendations from the national institute on aging and the alzheimer’s association workgroup
    • Sperling RA, Aisen PS, Beckett LA et al. 2011. Toward defining the preclinical stages of Alzheimer’s disease: recommendations from the National Institute on Aging and the Alzheimer’s Association Workgroup. Alzheimer’s Dement 7:280–292.
    • (2011) Alzheimer’s Dement , vol.7 , pp. 280-292
    • Sperling, R.A.1    Aisen, P.S.2    Beckett, L.A.3
  • 203
    • 44949229417 scopus 로고    scopus 로고
    • A 12-week, placebo-controlled study (6002-us-006) of istradefylline in parkinson disease
    • Stacy M, Silver D, Mendis T et al. 2008. A 12-week, placebo-controlled study (6002-US-006) of istradefylline in Parkinson disease. Neurology 70:2233–2240.
    • (2008) Neurology , vol.70 , pp. 2233-2240
    • Stacy, M.1    Silver, D.2    Mendis, T.3
  • 204
    • 15244351255 scopus 로고    scopus 로고
    • Impaired insulin and insulinlike growth factor expression and signaling mechanisms in alzheimer’s disease – is this type 3 diabetes?
    • Steen E, Terry BM, Rivera EJ et al. 2005. Impaired insulin and insulinlike growth factor expression and signaling mechanisms in Alzheimer’s disease – is this type 3 diabetes? J Alzheimer’s Dis 7:63–80.
    • (2005) J Alzheimer’s Dis , vol.7 , pp. 63-80
    • Steen, E.1    Terry, B.M.2    Rivera, E.J.3
  • 205
    • 78049419440 scopus 로고    scopus 로고
    • A meta-analysis of cytokines in alzheimer’s disease
    • Swardfager W, Lanctot K, Rothenburg L et al. 2010. A meta-analysis of cytokines in Alzheimer’s disease. Biol Psychiatry 68:930–941.
    • (2010) Biol Psychiatry , vol.68 , pp. 930-941
    • Swardfager, W.1    Lanctot, K.2    Rothenburg, L.3
  • 206
    • 77951028451 scopus 로고    scopus 로고
    • Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and ab deposition in an alzheimer mouse model with diabetes
    • Takeda S, Sato N, Uchio-Yamada K et al. 2010. Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Ab deposition in an Alzheimer mouse model with diabetes. Proc Natl Acad Sci USA 107:7036–7041.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 7036-7041
    • Takeda, S.1    Sato, N.2    Uchio-Yamada, K.3
  • 207
    • 33947546011 scopus 로고    scopus 로고
    • Temporal relationship between cigarette smoking and risk of parkinson disease
    • Thacker EL, O’Reilly EJ, Weisskopf MG et al. 2007. Temporal relationship between cigarette smoking and risk of Parkinson disease. Neurology 68:764–768.
    • (2007) Neurology , vol.68 , pp. 764-768
    • Thacker, E.L.1    O’Reilly, E.J.2    Weisskopf, M.G.3
  • 208
    • 79952712678 scopus 로고    scopus 로고
    • Stopping a thief and killer – alzheimer’s disease crisis demands greater commitment to research
    • Thies W. 2011. Stopping a thief and killer – Alzheimer’s disease crisis demands greater commitment to research. Alzheimer’s Dement 7:175–176.
    • (2011) Alzheimer’s Dement , vol.7 , pp. 175-176
    • Thies, W.1
  • 209
    • 79952730699 scopus 로고    scopus 로고
    • Alzheimer’s association report: 2011 alzheimer’s disease facts and figures
    • Thies W, Bleiler L. 2011. Alzheimer’s Association Report: 2011 Alzheimer’s disease facts and figures. Alzheimer’s Dement 7:208–244.
    • (2011) Alzheimer’s Dement , vol.7 , pp. 208-244
    • Thies, W.1    Bleiler, L.2
  • 210
    • 49949104408 scopus 로고    scopus 로고
    • Rapid improvement in verbal fluency and aphasia following perispinal etanercept in alzheimer’s disease
    • Tobinick EL, Gross H. 2008a. Rapid improvement in verbal fluency and aphasia following perispinal etanercept in Alzheimer’s disease. BMC Neurol 8:27.
    • (2008) BMC Neurol , vol.8 , pp. 27
    • Tobinick, E.L.1    Gross, H.2
  • 211
    • 38549178015 scopus 로고    scopus 로고
    • Rapid cognitive improvement in alzheimer’s disease following perispinal etanercept administration
    • Tobinick EL, Gross H. 2008b. Rapid cognitive improvement in Alzheimer’s disease following perispinal etanercept administration. J Neuroinflammation 5:2.
    • (2008) J Neuroinflammation , vol.5 , pp. 2
    • Tobinick, E.L.1    Gross, H.2
  • 212
    • 48349136909 scopus 로고    scopus 로고
    • Progress in parkinson’s disease – where do we stand?
    • Toulouse A, Sullivan AM. 2008. Progress in Parkinson’s disease – where do we stand? Prog Neurobiol 85:376–392.
    • (2008) Prog Neurobiol , vol.85 , pp. 376-392
    • Toulouse, A.1    Sullivan, A.M.2
  • 213
    • 79952445071 scopus 로고    scopus 로고
    • Mitochondrialnuclear epistasis: Implications for human aging and longevity
    • Tranah GJ. 2011. Mitochondrialnuclear epistasis: implications for human aging and longevity. Ageing Res Rev 10:238–252.
    • (2011) Ageing Res Rev , vol.10 , pp. 238-252
    • Tranah, G.J.1
  • 214
    • 80053100399 scopus 로고    scopus 로고
    • Scientific process, pharmacology and drug discovery
    • Trist DG. 2011. Scientific process, pharmacology and drug discovery. Curr Opin Pharmacol. 11: 528–537.
    • (2011) Curr Opin Pharmacol , vol.11 , pp. 528-537
    • Trist, D.G.1
  • 215
    • 12144288251 scopus 로고    scopus 로고
    • Venezuelan kindreds reveal that genetic and environmental factors modulate huntington’s disease age of onset
    • Proc Natl Acad Sci USA
    • U.S.–Venezuela Collaborative Research Project, Wexler NS. 2004. Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington’s disease age of onset. Proc Natl Acad Sci USA 101:3498–3503.
    • (2004) U.S.–.V.Enezuela Collaborative Research , vol.101 , pp. 3498-3503
    • Wexler, N.S.1
  • 216
    • 78149299855 scopus 로고    scopus 로고
    • The future of genetic research on neurodegeneration
    • Van Broeckhoven C. 2010. The future of genetic research on neurodegeneration. Nat Med 16:1215–1217.
    • (2010) Nat Med , vol.16 , pp. 1215-1217
    • Van Broeckhoven, C.1
  • 218
    • 33750207744 scopus 로고    scopus 로고
    • Recent clinical failures in parkinson’s disease with apoptosis inhibitors underline the need for a paradigm shift in drug discovery for neurodegenerative diseases
    • Waldmeier P, Bozyczko-Coyne D, Williams M, Vaught JL. 2006. Recent clinical failures in Parkinson’s disease with apoptosis inhibitors underline the need for a paradigm shift in drug discovery for neurodegenerative diseases. Biochem Pharmacol 72:1197–1206.
    • (2006) Biochem Pharmacol , vol.72 , pp. 1197-1206
    • Waldmeier, P.1    Bozyczko-Coyne, D.2    Williams, M.3    Vaught, J.L.4
  • 219
    • 0033659663 scopus 로고    scopus 로고
    • Cgp 3466 protects dopaminergic neurons in lesion models of parkinson’s disease
    • Waldmeier P, Spooren WP, Hengerer B. 2000. CGP 3466 protects dopaminergic neurons in lesion models of Parkinson’s disease. Naunyn-Schmideber’s Arch Pharmacol 362:526–537.
    • (2000) Naunyn-Schmideber’s Arch Pharmacol , vol.362 , pp. 526-537
    • Waldmeier, P.1    Spooren, W.P.2    Hengerer, B.3
  • 220
    • 20344384992 scopus 로고    scopus 로고
    • The immune system, amyloid-beta peptide, and alzheimer’s disease
    • Weksler ME, Gouras G, Relkin NR, Szabo P. 2005. The immune system, amyloid-beta peptide, and Alzheimer’s disease. Immunol Rev 205:244–256.
    • (2005) Immunol Rev , vol.205 , pp. 244-256
    • Weksler, M.E.1    Gouras, G.2    Relkin, N.R.3    Szabo, P.4
  • 221
    • 58649094617 scopus 로고    scopus 로고
    • The gene coding for pgc-1a modifies age at onset in huntington’s disease
    • Weydt P, Soyal SM, Gellera C et al. 2009. The gene coding for PGC-1a modifies age at onset in Huntington’s Disease. Mol Neurodegener 4:3.
    • (2009) Mol Neurodegener , vol.4 , pp. 3
    • Weydt, P.1    Soyal, S.M.2    Gellera, C.3
  • 223
    • 76249131324 scopus 로고    scopus 로고
    • Bapineuzumab in alzheimer’s disease: Where now?
    • Wilcock GK. 2010. Bapineuzumab in Alzheimer’s disease: where now? Lancet Neurol 9:134–136.
    • (2010) Lancet Neurol , vol.9 , pp. 134-136
    • Wilcock, G.K.1
  • 224
    • 58449125183 scopus 로고    scopus 로고
    • Progress in alzheimer’s disease drug discovery: An update
    • Williams M. 2009. Progress in Alzheimer’s disease drug discovery: an update. Curr Opin Invest Drugs 10:23–34.
    • (2009) Curr Opin Invest Drugs , vol.10 , pp. 23-34
    • Williams, M.1
  • 225
    • 85057775434 scopus 로고    scopus 로고
    • Rationale for tau aggregation inhibitor therapy in alzheimer’s disease and other taopathies
    • Beta-Amyloid, Tau Protein, and Glucose Metabolism. Martinez A, ed. RSC Drug Discovery Series. Cambridge: Royal Chemical Society
    • Wischik CM, Wischik DJ, Storey JMD, Harrington CR. 2010. Rationale for tau aggregation inhibitor therapy in Alzheimer’s disease and other taopathies. In Emerging Drugs and Targets for Alzheimer’s Disease, Vol. 1, Beta-Amyloid, Tau Protein, and Glucose Metabolism. Martinez A, ed. RSC Drug Discovery Series. Cambridge: Royal Chemical Society, pp. 210–232.
    • (2010) Emerging Drugs and Targets for Alzheimer’s Disease , vol.1 , pp. 210-232
    • Wischik, C.M.1    Wischik, D.J.2    Storey, J.3    Harrington, C.R.4
  • 226
    • 77954116814 scopus 로고    scopus 로고
    • Autophagy gone awry in neurodegenerative diseases
    • Wong E, Cuervo AM. 2010. Autophagy gone awry in neurodegenerative diseases. Nat Neurosci 13:805–811.
    • (2010) Nat Neurosci , vol.13 , pp. 805-811
    • Wong, E.1    Cuervo, A.M.2
  • 227
    • 80053569618 scopus 로고    scopus 로고
    • London, UK, Accessed August 5, 2011
    • World Alzheimer Report 2009. London, UK: Alzheimer’s Disease International. Available at: http://www.alz.co.uk/research/files/WorldAlzheimerReport.pdf. Accessed August 5, 2011.
    • (2009) Alzheimer’s Disease International
  • 228
    • 78651315861 scopus 로고    scopus 로고
    • Preclinical biomarkers of parkinson disease
    • Wu Y, Le W, Jankovic J. 2011. Preclinical biomarkers of Parkinson disease. Arch Neurol 68:22–30.
    • (2011) Arch Neurol , vol.68 , pp. 22-30
    • Wu, Y.1    Le, W.2    Jankovic, J.3
  • 229
    • 14544288232 scopus 로고    scopus 로고
    • Therapeutic potential of adenosine a2a receptor antagonists in parkinson’s disease
    • Xu K, Bastia E, Schwarzschild M. 2005. Therapeutic potential of adenosine A2A receptor antagonists in Parkinson’s disease. Pharmacol Ther 105:267–310.
    • (2005) Pharmacol Ther , vol.105 , pp. 267-310
    • Xu, K.1    Bastia, E.2    Schwarzschild, M.3
  • 230
    • 44949213717 scopus 로고    scopus 로고
    • Mitochondrial dna damage and repair in neurodegenerative disorders
    • Yang J-L, Weissman L, Bohr VA, Mattson MP. 2008. Mitochondrial DNA damage and repair in neurodegenerative disorders. DNA Repair 7:1110–1120.
    • (2008) DNA Repair , vol.7 , pp. 1110-1120
    • Yang, J.-L.1    Weissman, L.2    Bohr, V.A.3    Mattson, M.P.4
  • 231
    • 79957439772 scopus 로고    scopus 로고
    • Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target
    • Yu TJ, Zhang Y, Kenricj M et al. 2011. Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target. Sci Transl Med 3:84ra44.
    • (2011) Sci Transl Med 3:84Ra44
    • Yu, T.J.1    Zhang, Y.2    Kenricj, M.3
  • 232
    • 79951751577 scopus 로고    scopus 로고
    • Role of cannabinoids in multiple sclerosis
    • Zajicek JP, Apostu VI. 2011. Role of cannabinoids in multiple sclerosis. CNS Drugs 25:187–201.
    • (2011) CNS Drugs , vol.25 , pp. 187-201
    • Zajicek, J.P.1    Apostu, V.I.2
  • 233
    • 78649721324 scopus 로고    scopus 로고
    • Use of theragnostic markers to select drugs for phase ii/iii trials for alzheimer disease
    • Zetterberg Z, Mattsson N, Blennow K, Olsson B. 2010. Use of theragnostic markers to select drugs for phase II/III trials for Alzheimer disease. Alzheimer’s Res Ther 2:32.
    • (2010) Alzheimer’s Res Ther , vol.2 , pp. 32
    • Zetterberg, Z.1    Mattsson, N.2    Blennow, K.3    Olsson, B.4
  • 234
    • 10944228564 scopus 로고    scopus 로고
    • Insulin-degrading enzyme as a downstreamtarget of insulin receptor signaling cascade: Implications for alzheimer’s disease intervention
    • Zhao L, Teter B, Morihara T. 2004. Insulin-degrading enzyme as a downstreamtarget of insulin receptor signaling cascade: implications for Alzheimer’s disease intervention. J Neurosci 24:11120–11126.
    • (2004) J Neurosci , vol.24 , pp. 11120-11126
    • Zhao, L.1    Teter, B.2    Morihara, T.3
  • 235
    • 77958072667 scopus 로고    scopus 로고
    • Pgc-1alpha, a potential therapeutic target for early intervention in parkinson’s disease
    • Zheng B, Liao Z, Locascio JJ et al. 2010. PGC-1alpha, a potential therapeutic target for early intervention in Parkinson’s disease. Sci Transl Med 2:52ra73.
    • (2010) Sci Transl Med 2:52Ra73
    • Zheng, B.1    Liao, Z.2    Locascio, J.J.3
  • 236
    • 80054788511 scopus 로고    scopus 로고
    • Neuroprotection with a brain-penetrating biologic tumor necrosis factor inhibitor
    • Zhou Q, Sumbria R, Hui EK-A et al. 2011. Neuroprotection with a brain-penetrating biologic tumor necrosis factor inhibitor. J Pharmacol Exp Ther 339: 618–623.
    • (2011) J Pharmacol Exp Ther , vol.339 , pp. 618-623
    • Zhou, Q.1    Sumbria, R.2    Hui, E.-A.3
  • 237
    • 77955643169 scopus 로고    scopus 로고
    • Molecular mechanisms and potential therapeutical targets in huntington’s disease
    • Zuccato C, Valenza M, Cattaneo C. 2010. Molecular mechanisms and potential therapeutical targets in Huntington’s disease. Physiol Rev 90:905–981.
    • (2010) Physiol Rev , vol.90 , pp. 905-981
    • Zuccato, C.1    Valenza, M.2    Cattaneo, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.