Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 10, 2004, Pages 3498-3503

  Wexler, Nancy S ^a   Lorimer, Judith ^a   Porter, Julie ^a   Gomez, Fidela ^a   Moskowitz, Carol ^a   Shackell, Edith ^a   Marder, Karen ^a   Penchaszadeh, Graciela ^a   Roberts, Simone A ^a   Gayán, Javier ^b   Brocklebank, Denise ^b   Cherny, Stacey S ^b   Cardon, Lon R ^b   Gray, Jacqueline ^c   Dlouhy, Stephen R ^c   Wiktorski, Sandra ^c   Hodes, Marion E ^c   Conneally, P Michael ^c   Penney, Jack B ^d   Gusella, James ^d   Cha, Jang Ho ^d   Irizarry, Michael ^d   Rosas, Diana ^d   Hersch, Steven ^d   Hollingsworth, Zane ^d   MacDonald, Marcy ^d   Young, Anne B ^d   Andresen, J Michael ^e   Housman, David E ^e   Mieja De Young, Margot ^f   Bonilla, Ernesto ^f   Stillings, Theresa ^f   Negrette, Americo ^f   Snodgrass, S Robert ^g   Martinez Jaurrieta, Maria Dolores ^h   Ramos Arroyo, Maria A ^h   Bickham, Jacqueline ⁱ   Ramos, Juan Sanchez ^j   Marshall, Frederick ^k   Shoulson, Ira ^k   Rey, Gustavo J ^l   Feigin, Andrew ^m   Arnheim, Norman ⁿ   Acevedo Cruz, Amarilis ^o   Acosta, Leticia ^p   Alvir, Jose ^q   Fischbeck, Kenneth ^r   Thompson, Leslie M ^s   Young, Angela ^t   Dure, Leon ^t   O'Brien, Christopher J ^u   Paulsen, Jane ^v   Brickman, Adam ^w   Krch, Denise ^w   Peery, Shelley ^w   Hogarth, Penelope ^x   Higgins Jr , Donald S ^y   Landwehrmeyeri, Bernhard ^z   more..

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c INDIANA UNIVERSITY   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^f UNIVERSIDAD DEL ZULIA   (Venezuela)

^g MATTEL CHILDREN S HOSPITAL   (United States)

^h Universidad Pública de Navarra   (Spain)

ⁱ UNIVERSITY OF TEXAS   (United States)

^j UNIVERSITY OF SOUTH FLORIDA   (United States)

^k UNIVERSITY OF ROCHESTER   (United States)

^l MIAMI CHILDREN'S HOSPITAL   (United States)

^m NORTH SHORE UNIVERSITY HOSPITAL   (United States)

ⁿ UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^o MOUNT SINAI MEDICAL CENTER   (United States)

^p UNIVERSITY OF CALIFORNIA COOPERATIVE EXTENSION   (United States)

^q NEW YORK UNIVERSITY   (United States)

^r NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^s UNIVERSITY OF CALIFORNIA   (United States)

^t UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^u THOMAS JEFFERSON UNIVERSITY   (United States)

^v UNIVERSITY OF IOWA   (United States)

^w CITY UNIVERSITY OF NEW YORK   (United States)

^x OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^y ALBANY MEDICAL COLLEGE   (United States)

^z UNIVERSITY OF ULM   (Germany)

more..

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

ALLELE; ARTICLE; AUTOSOMAL DOMINANT DISORDER; CELL IMMORTALIZATION; DEGENERATIVE DISEASE; DNA FINGERPRINTING; ENVIRONMENTAL FACTOR; FAMILIAL DISEASE; FEMALE; GENE MUTATION; GENETIC RISK; GENETIC VARIABILITY; HEREDITY; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; HUNTINGTON CHOREA; LYMPHOCYTE; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PHENOTYPE; PRIORITY JOURNAL; SIBLING; VENEZUELA;

EID: 12144288251     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0308679101     Document Type: Article

References (32)

1. Bates, G., Harper, P. & Jones, L. (2002) Huntington's Disease (Oxford Univ. Press, efford), 3rd Ed.
2. Gisella, J. F., Wexler, N. S., Conneally, P. M., Naylor, S. L., Anderson, M. A., Tanzi, R. E., Watkins, P. C., Ottina, K., Wallace, M. R., Sakaguchi, A. Y., et al. (1983) Nature 306, 234-238.
3. The Huntington's Disease Collaborative Research Group (1993) Cell 72, 971-983.
4. Feigin, A. & Zgaljardic, D. (2002) Curr. Opin. Neurol. 15, 483-489.
5. Ross, C. A. (2002) Neuron 35, 819-822.
6. Tobin, A. J. & Signer, E. R. (2000) Trends Cell. Biol. 10, 531-536.
7. Snell, R. G., MacMillan, J. C., Cheadle, J. P., Fenton, I., Lazarou, L. P., Davies, P., MacDonald, M. E., Gusella, J. F., Harper, P. S. & Shaw, D. J. (1993) Nat. Genet. 4, 393-397.
8. Andrew, S. E., Goldberg, Y. P., Kremer, B., Telenius, H., Theilmann, J., Adam, S., Starr, E., Squitieri, F., Lin, B., Kalchman, M. A., et al. (1993) Nat. Genet. 4, 398-403.
9. Dayao, M., Ambrose, C., Myers, R., Novelletto, A., Persichetti, F.,Frontali, M., Folstein, S. Ross, C., Franz, M., Abbott, M., et al. (1993) Nat. Genet. 4, 387-392.
10. Squitieri, F., Sabbadini, G., Mandich, P., Gellera, C., Di Maria, E., Bellone, E., Castellotti, B., Nargi, E., de Grazia, U., Frontali, M., et al. (2000) Am. J. Med. Genet. 95, 376-373.
11. Li, J. L., Hayden, M. R., Almqvist, E. W., Brinkman, R. R., Durr, A., Dode, C., Morrison, P. J., Suchowersky, O., Ross, C. A., Margolis, et al. (2003) Am. J. Hum. Genet. 73, 682-687.
12. Negrette, A. (1955) Corea de Huntington: Estudio de Una Sola Familia a Traves de Varias Genereaciones (Universidad de Zulia, Maracaibo, Venezuela).
13. Young, A. B., Shoulson, I., Penney, J. B., Starosta-Rubinstein, S., Gomez, F., Travers, H, Ramos-Arroyo, M. A., Snodgrass, S. R., Bonilla, E., Moreno, H., et al. (1986) Neurology 36, 244-249.
14. Penney, J. B., Jr., Young, A. B., Shoulson, I., Starosta-Rubenstein, S., Snodgrass, S. R., Sanchez-Ramos, J., Ramos-Arroyo, M., Gomez, F., Penchaszadeh, G., Alvir, J., et al. (1990) Movement Disorders 5, 93-99.
15. Bond, C. E. & Hodes, M. E. (1996) Clin. Chem. 42, 773-774.
16. SAS Institute (2000) SAS (SAS Institute, Cary, NC), Version 8.
17. Statistical Solutions (2002) SAGE, Statistical Analysis for Genetic Epidemiology (Statistical Solutions, Cork, Ireland).
18. Neale, M. C., Boker, S. M., Xie, G., Maes, H. H. (2002) MX: Statistical Modeling (Virginia Commonwealth Univ., Richmond, VA).
19. Abecasis, G. R., Cookson, W. O. & Cardon, L. R. (2000) Eur. J. Hum. Genet. 8, 545-551.
20. Abecasis, G. R., Cardon, L. R. & Cookson, W. O. (2000) Am. J. Hum. Genet. 66, 279-292.
21. Harper, P. (1991) Huntington's Disease (Saunders, London).
22. Falconer, D. (1989) Introduction to Quantitative Genetics (Wiley, New York).
23. Neale, M. & Cardon, L. (1992) Methodology for Genetic Studies of Twins and Families (Kluwer Academic, Boston).
24. Yoon, S. R., Dubeau, L., de Young, M., Wexler, N. S. & Arnheim, N. (2003) Proc. Natl. Acad. Sci. USA 100, 8834-8838.
25. Nenguke, T., Aladjem, M. I., Gusella, J. F., Wexler, N. S. & Arnheim, N. (2003) Hum. Mol. Genet. 12, 1021-1028.
26. Leeflang, E. P., Tavare, S., Marjoram, P., Neal, C. O., Srinidhi, J., MacFarlane, H., MacDonald, M. E., Gusella, J. F., de Young, M., Wexler, N. S., et al. (1999) Hum. Mol. Genet. 8, 173-183.
27. Leeflang, E. P., Zhang, L., Tavare, S., Hubert, R., Srinidhi, J., MacDonald, M. E., Myers, R. H., de Young, M., Wexler, N. S., Gusella, J. F., et al. (1995) Hum. Mol. Genet. 4, 1519-1526.
28. Rosenblatt, A., Brinkman, R. R., Liang, K. Y., Almqvist, E. W., Margolis, R. L., Huang, C. Y., Sherr, M., Franz, M. L., Abbott, M. H., Hayden, M. R., et al. (2001) Am. J. Med. Genet. 105, 399-403.
29. Chattopadhyay, B., Ghosh, S., Gangopadhyay, P. K., Das, S. K., Roy, T., Sinha, K. K., Jha, D. K., Mukherjee, S. C., Chakraborty, A., Singhal, B. S., et al. (2003) Neurosci. Lett. 345, 93-96.
30. Squitieri, F., Cannella, M., Giallonardo, P., Maglione, V., Mariotti, C. & Hayden, M. R. (2001) Brain Res. Bull. 56, 233-238.
31. Naze, P., Vuillaume, I., Destee, A., Pasquier, F. & Sablonniere, B. (2002) Neurosci. Lett. 328, 1-4.
32. Djousse, L., Knowlton, B., Hayden, M., Almqvist, E. W., Brinkman, R., Ross, C., Margolis, R., Rosenblatt, A., Durr, A., Dode, C., et al. (2003) Am. J. Med. Genet. 119A, 279-282.