메뉴 건너뛰기




Volumn 15, Issue 7, 2010, Pages 756-766

Examination of the current top candidate genes for AD in a genome-wide association study

Author keywords

AlzGene; Alzheimer disease; candidate genes; genetics; genome wide association study

Indexed keywords

APOLIPOPROTEIN E;

EID: 77953912200     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/mp.2008.141     Document Type: Article
Times cited : (109)

References (52)
  • 2
    • 0029166112 scopus 로고
    • Apolipoprotein e genotypes and age of onset in early-onset familial Alzheimer's disease
    • Levy-Lahad E, Lahad A, Wijsman EM, Bird TD, Schellenberg GD. Apolipoprotein E genotypes and age of onset in early-onset familial Alzheimer's disease. Ann Neurol 1995; 38: 678-680.
    • (1995) Ann Neurol , vol.38 , pp. 678-680
    • Levy-Lahad, E.1    Lahad, A.2    Wijsman, E.M.3    Bird, T.D.4    Schellenberg, G.D.5
  • 3
    • 0029004341 scopus 로고
    • Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
    • Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 1995; 375: 754-760.
    • (1995) Nature , vol.375 , pp. 754-760
    • Sherrington, R.1    Rogaev, E.I.2    Liang, Y.3    Rogaeva, E.A.4    Levesque, G.5    Ikeda, M.6
  • 4
    • 0034839595 scopus 로고    scopus 로고
    • Gene identification in Alzheimer's disease
    • Saunders AM. Gene identification in Alzheimer's disease. Phar-macogenomics 2001; 2: 239-249.
    • (2001) Phar-macogenomics , vol.2 , pp. 239-249
    • Saunders, A.M.1
  • 5
    • 43549116348 scopus 로고    scopus 로고
    • APOE epsilon4 lowers age at onset and is a high risk factor for Alzheimer's disease; A case control study from central Norway
    • Sando SB, Melquist S, Cannon A, Hutton ML, Sletvold O, Saltvedt I et al. APOE epsilon4 lowers age at onset and is a high risk factor for Alzheimer's disease; a case control study from central Norway. BMC Neurol 2008; 8: 9.
    • (2008) BMC Neurol , vol.8 , pp. 9
    • Sando, S.B.1    Melquist, S.2    Cannon, A.3    Hutton, M.L.4    Sletvold, O.5    Saltvedt, I.6
  • 6
    • 0027194791 scopus 로고
    • Gene dose of apolipoprotein e type 4 allele and the risk of Alzheimer's disease in late onset families
    • Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 1993; 261: 921-923.
    • (1993) Science , vol.261 , pp. 921-923
    • Corder, E.H.1    Saunders, A.M.2    Strittmatter, W.J.3    Schmechel, D.E.4    Gaskell, P.C.5    Small, G.W.6
  • 8
    • 12044254746 scopus 로고
    • Binding of human apolipoprotein e to synthetic amyloid beta peptide: Isoform-specific effects and implications for late-onset Alzheimer disease
    • Strittmatter WJ, Weisgraber KH, Huang DY, Dong LM, Salvesen GS, Pericak-Vance M et al. Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease. Proc Natl Acad Sci USA 1993; 90: 8098-8102.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 8098-8102
    • Strittmatter, W.J.1    Weisgraber, K.H.2    Huang, D.Y.3    Dong, L.M.4    Salvesen, G.S.5    Pericak-Vance, M.6
  • 9
    • 0034951751 scopus 로고    scopus 로고
    • Alzheimer's disease: Insights from epidemiology
    • McDowell I. Alzheimer's disease: insights from epidemiology. Aging (Milano) 2001; 13: 143-162.
    • (2001) Aging (Milano) , vol.13 , pp. 143-162
    • McDowell, I.1
  • 11
    • 0034704198 scopus 로고    scopus 로고
    • Evidence for genetic linkage of Alzheimer's disease to chromosome 10q
    • Bertram L, Blacker D, Mullin K, Keeney D, Jones J, Basu S et al. Evidence for genetic linkage of Alzheimer's disease to chromosome 10q. Science 2000; 290: 2302-2303.
    • (2000) Science , vol.290 , pp. 2302-2303
    • Bertram, L.1    Blacker, D.2    Mullin, K.3    Keeney, D.4    Jones, J.5    Basu, S.6
  • 12
    • 0034704197 scopus 로고    scopus 로고
    • Susceptibility locus for Alzheimer's disease on chromosome 10
    • Myers A, Holmans P, Marshall H, Kwon J, Meyer D, Ramic D et al. Susceptibility locus for Alzheimer's disease on chromosome 10. Science 2000; 290: 2304-2305.
    • (2000) Science , vol.290 , pp. 2304-2305
    • Myers, A.1    Holmans, P.2    Marshall, H.3    Kwon, J.4    Meyer, D.5    Ramic, D.6
  • 15
    • 0034703979 scopus 로고    scopus 로고
    • Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees
    • Ertekin-Taner N, Graff-Radford N, Younkin LH, Eckman C, Baker M, Adamson J et al. Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. Science 2000; 290: 2303-2304.
    • (2000) Science , vol.290 , pp. 2303-2304
    • Ertekin-Taner, N.1    Graff-Radford, N.2    Younkin, L.H.3    Eckman, C.4    Baker, M.5    Adamson, J.6
  • 16
    • 0030823158 scopus 로고    scopus 로고
    • Effects of age, sex, and ethnicity on the association between apolipoprotein e genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium
    • Farrer LA, Cupples LA, Haines JL, Hyman B, Kukull WA, Mayeux R et al. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. JAMA 1997; 278: 1349-1356.
    • (1997) JAMA , vol.278 , pp. 1349-1356
    • Farrer, L.A.1    Cupples, L.A.2    Haines, J.L.3    Hyman, B.4    Kukull, W.A.5    Mayeux, R.6
  • 17
    • 33845892752 scopus 로고    scopus 로고
    • Systematic meta-analyses of Alzheimer disease genetic association studies: The AlzGene database
    • Bertram L, McQueen MB, Mullin K, Blacker D, Tanzi RE. Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat Genet 2007; 39: 17-23.
    • (2007) Nat Genet , vol.39 , pp. 17-23
    • Bertram, L.1    McQueen, M.B.2    Mullin, K.3    Blacker, D.4    Tanzi, R.E.5
  • 18
    • 0033863391 scopus 로고    scopus 로고
    • SNPing away at complex diseases: Analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease
    • Martin ER, Lai EH, Gilbert JR, Rogala AR, Afshari AJ, Riley J et al. SNPing away at complex diseases: analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease. Am J Hum Genet 2000; 67: 383-394.
    • (2000) Am J Hum Genet , vol.67 , pp. 383-394
    • Martin, E.R.1    Lai, E.H.2    Gilbert, J.R.3    Rogala, A.R.4    Afshari, A.J.5    Riley, J.6
  • 19
    • 34248142174 scopus 로고    scopus 로고
    • Comprehensive analysis of APOE and selected proximate markers for late-onset Alzheimer's disease: Patterns of linkage disequilibrium and disease/marker association
    • Yu CE, Seltman H, Peskind ER, Galloway N, Zhou PX, Rosenthal E et al. Comprehensive analysis of APOE and selected proximate markers for late-onset Alzheimer's disease: patterns of linkage disequilibrium and disease/marker association. Genomics 2007; 89: 655-665.
    • (2007) Genomics , vol.89 , pp. 655-665
    • Yu, C.E.1    Seltman, H.2    Peskind, E.R.3    Galloway, N.4    Zhou, P.X.5    Rosenthal, E.6
  • 20
    • 38349038412 scopus 로고    scopus 로고
    • Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease
    • Li H, Wetten S, Li L, St Jean PL, Upmanyu R, Surh L et al. Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease. Arch Neurol 2008; 65: 45-53.
    • (2008) Arch Neurol , vol.65 , pp. 45-53
    • Li, H.1    Wetten, S.2    Li, L.3    St Jean, P.L.4    Upmanyu, R.5    Surh, L.6
  • 22
    • 34447559923 scopus 로고    scopus 로고
    • Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants
    • Grupe A, Abraham R, Li Y, Rowland C, Hollingworth P, Morgan A et al. Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants. Hum Mol Genet 2007; 16: 865-873.
    • (2007) Hum Mol Genet , vol.16 , pp. 865-873
    • Grupe, A.1    Abraham, R.2    Li, Y.3    Rowland, C.4    Hollingworth, P.5    Morgan, A.6
  • 23
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
    • McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984; 34: 939-944.
    • (1984) Neurology , vol.34 , pp. 939-944
    • McKhann, G.1    Drachman, D.2    Folstein, M.3    Katzman, R.4    Price, D.5    Stadlan, E.M.6
  • 24
    • 0023037928 scopus 로고
    • CAMDEX. A standardised instrument for the diagnosis of mental disorder in the elderly with special reference to the early detection of dementia
    • Roth M, Tym E, Mountjoy CQ, Huppert FA, Hendrie H, Verma S et al. CAMDEX. A standardised instrument for the diagnosis of mental disorder in the elderly with special reference to the early detection of dementia. Br J Psychiatry 1986; 149: 698-709.
    • (1986) Br J Psychiatry , vol.149 , pp. 698-709
    • Roth, M.1    Tym, E.2    Mountjoy, C.Q.3    Huppert, F.A.4    Hendrie, H.5    Verma, S.6
  • 25
    • 0028285127 scopus 로고
    • The consortium to establish a Registry for Alzheimer's Disease (CERAD). Part V. A normative study of the neuropsycho-logical battery
    • Welsh KA, Butters N, Mohs RC, Beekly D, Edland S, Fillenbaum G et al. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part V. A normative study of the neuropsycho-logical battery. Neurology 1994; 44: 609-614.
    • (1994) Neurology , vol.44 , pp. 609-614
    • Welsh, K.A.1    Butters, N.2    Mohs, R.C.3    Beekly, D.4    Edland, S.5    Fillenbaum, G.6
  • 26
    • 0016823810 scopus 로고
    • Mini-mental state. A practical method for grading the cognitive state of patients for the clinician
    • Folstein MF, Folstein SE, McHugh PR. Mini-mental state. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12: 189-198.
    • (1975) J Psychiatr Res , vol.12 , pp. 189-198
    • Folstein, M.F.1    Folstein, S.E.2    McHugh, P.R.3
  • 27
    • 18144425478 scopus 로고    scopus 로고
    • A genome-wide scalable SNP genotyping assay using microarray technology
    • Gunderson KL, Steemers FJ, Lee G, Mendoza LG, Chee MS. A genome-wide scalable SNP genotyping assay using microarray technology. Nat Genet 2005; 37: 549-554.
    • (2005) Nat Genet , vol.37 , pp. 549-554
    • Gunderson, K.L.1    Steemers, F.J.2    Lee, G.3    Mendoza, L.G.4    Chee, M.S.5
  • 29
    • 79959524146 scopus 로고    scopus 로고
    • A haplotype map of the human genome
    • International Hapmap Consortium
    • International HapMap Consortium. A haplotype map of the human genome. Nature 2005; 437: 1299-1320.
    • (2005) Nature , vol.437 , pp. 1299-1320
  • 31
    • 29444450702 scopus 로고    scopus 로고
    • Common deletions and SNPs are in linkage disequilibrium in the human genome
    • Hinds DA, Kloek AP, Jen M, Chen X, Frazer KA. Common deletions and SNPs are in linkage disequilibrium in the human genome. Nat Genet 2006; 38: 82-85.
    • (2006) Nat Genet , vol.38 , pp. 82-85
    • Hinds, D.A.1    Kloek, A.P.2    Jen, M.3    Chen, X.4    Frazer, K.A.5
  • 34
    • 13444269543 scopus 로고    scopus 로고
    • Haploview: Analysis and visualization of LD and haplotype maps
    • Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005; 21: 263-265.
    • (2005) Bioinformatics , vol.21 , pp. 263-265
    • Barrett, J.C.1    Fry, B.2    Maller, J.3    Daly, M.J.4
  • 35
    • 12144291280 scopus 로고    scopus 로고
    • Candidate gene association studies of the alpha 4 (CHRNA4) and beta 2 (CHRNB2) neuronal nicotinic acetylcholine receptor subunit genes in Alzheimer's disease
    • Cook LJ, Ho LW, Taylor AE, Brayne C, Evans JG, Xuereb J et al. Candidate gene association studies of the alpha 4 (CHRNA4) and beta 2 (CHRNB2) neuronal nicotinic acetylcholine receptor subunit genes in Alzheimer's disease. Neurosci Lett 2004; 358: 142-146.
    • (2004) Neurosci Lett , vol.358 , pp. 142-146
    • Cook, L.J.1    Ho, L.W.2    Taylor, A.E.3    Brayne, C.4    Evans, J.G.5    Xuereb, J.6
  • 37
    • 0033733370 scopus 로고    scopus 로고
    • Genetic association of a cystatin C gene polymorphism with late-onset Alzheimer disease
    • Finckh U, von der Kammer H, Velden J, Michel T, Andresen B, Deng A et al. Genetic association of a cystatin C gene polymorphism with late-onset Alzheimer disease. Arch Neurol 2000; 57: 1579-1583.
    • (2000) Arch Neurol , vol.57 , pp. 1579-1583
    • Finckh, U.1    Von Der Kammer, H.2    Velden, J.3    Michel, T.4    Andresen, B.5    Deng, A.6
  • 38
    • 0037176812 scopus 로고    scopus 로고
    • A polymorphism in the cystatin C promoter region is not associated with an increased risk of AD
    • Dodel RC, Du Y, Depboylu C, Kurz A, Eastwood B, Farlow M et al. A polymorphism in the cystatin C promoter region is not associated with an increased risk of AD. Neurology 2002; 58: 664.
    • (2002) Neurology , vol.58 , pp. 664
    • Dodel, R.C.1    Du, Y.2    Depboylu, C.3    Kurz, A.4    Eastwood, B.5    Farlow, M.6
  • 40
    • 35248854062 scopus 로고    scopus 로고
    • Haplotype-based association analysis of the MAPT locus in late onset Alzheimer's disease
    • Mukherjee O, Kauwe JS, Mayo K, Morris JC, Goate AM. Haplotype-based association analysis of the MAPT locus in late onset Alzheimer's disease. BMC Genet 2007; 8: 3.
    • (2007) BMC Genet , vol.8 , pp. 3
    • Mukherjee, O.1    Kauwe, J.S.2    Mayo, K.3    Morris, J.C.4    Goate, A.M.5
  • 41
    • 33847178181 scopus 로고    scopus 로고
    • The MAPT H1c risk haplotype is associated with increased expression of tau and especially of 4 repeat containing transcripts
    • Myers AJ, Pittman AM, Zhao AS, Rohrer K, Kaleem M, Marlowe L et al. The MAPT H1c risk haplotype is associated with increased expression of tau and especially of 4 repeat containing transcripts. Neurobiol Dis 2007; 25: 561-570.
    • (2007) Neurobiol Dis , vol.25 , pp. 561-570
    • Myers, A.J.1    Pittman, A.M.2    Zhao, A.S.3    Rohrer, K.4    Kaleem, M.5    Marlowe, L.6
  • 42
    • 34247496428 scopus 로고    scopus 로고
    • Fine mapping of the MAPT locus using quantitative trait analysis identifies possible causal variants in Alzheimer's disease
    • Laws SM, Friedrich P, Diehl-Schmid J, Muller J, Eisele T, Bauml J et al. Fine mapping of the MAPT locus using quantitative trait analysis identifies possible causal variants in Alzheimer's disease. Mol Psychiatry 2007; 12: 510-517.
    • (2007) Mol Psychiatry , vol.12 , pp. 510-517
    • Laws, S.M.1    Friedrich, P.2    Diehl-Schmid, J.3    Muller, J.4    Eisele, T.5    Bauml, J.6
  • 43
    • 33846613222 scopus 로고    scopus 로고
    • The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease
    • Rogaeva E, Meng Y, Lee JH, Gu Y, Kawarai T, Zou F et al. The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nat Genet 2007; 39: 168-177.
    • (2007) Nat Genet , vol.39 , pp. 168-177
    • Rogaeva, E.1    Meng, Y.2    Lee, J.H.3    Gu, Y.4    Kawarai, T.5    Zou, F.6
  • 44
    • 34247177933 scopus 로고    scopus 로고
    • The association between genetic variants in SORL1 and Alzheimer disease in an urban, multiethnic, community-based cohort
    • Lee JH, Cheng R, Schupf N, Manly J, Lantigua R, Stern Y et al. The association between genetic variants in SORL1 and Alzheimer disease in an urban, multiethnic, community-based cohort. Arch Neurol 2007; 64: 501-506.
    • (2007) Arch Neurol , vol.64 , pp. 501-506
    • Lee, J.H.1    Cheng, R.2    Schupf, N.3    Manly, J.4    Lantigua, R.5    Stern, Y.6
  • 46
    • 49849086825 scopus 로고    scopus 로고
    • SORL1 is genetically associated with increased risk for late-onset Alzheimer disease in the Belgian population
    • Bettens K, Brouwers N, Engelborghs S, De Deyn PP, Van Broeckhoven C, Sleegers K. SORL1 is genetically associated with increased risk for late-onset Alzheimer disease in the Belgian population. Hum Mutat 2008; 29: 769-770.
    • (2008) Hum Mutat , vol.29 , pp. 769-770
    • Bettens, K.1    Brouwers, N.2    Engelborghs, S.3    De Deyn, P.P.4    Van Broeckhoven, C.5    Sleegers, K.6
  • 47
    • 45249114641 scopus 로고    scopus 로고
    • Influence of SORL1 gene variants: Association with CSF amyloid-beta products in probable Alzheimer's disease
    • Kolsch H, Jessen F, Wiltfang J, Lewczuk P, Dichgans M, Kornhuber J et al. Influence of SORL1 gene variants: association with CSF amyloid-beta products in probable Alzheimer's disease. Neurosci Lett 2008; 440: 68-71.
    • (2008) Neurosci Lett , vol.440 , pp. 68-71
    • Kolsch, H.1    Jessen, F.2    Wiltfang, J.3    Lewczuk, P.4    Dichgans, M.5    Kornhuber, J.6
  • 48
    • 40549105438 scopus 로고    scopus 로고
    • Association between genetic variants in SORL1 and autopsy-confirmed Alzheimer disease
    • Lee JH, Cheng R, Honig LS, Vonsattel JP, Clark L, Mayeux R. Association between genetic variants in SORL1 and autopsy-confirmed Alzheimer disease. Neurology 2008; 70: 887-889.
    • (2008) Neurology , vol.70 , pp. 887-889
    • Lee, J.H.1    Cheng, R.2    Honig, L.S.3    Vonsattel, J.P.4    Clark, L.5    Mayeux, R.6
  • 49
    • 4644224016 scopus 로고    scopus 로고
    • Association analysis of genes involved in cholesterol metabolism located within the linkage region on chromosome 10 and Alzheimer's disease
    • Riemenschneider M, Mahmoodzadeh S, Eisele T, Klopp N, Schwarz S, Wagenpfeil S et al. Association analysis of genes involved in cholesterol metabolism located within the linkage region on chromosome 10 and Alzheimer's disease. Neurobiol Aging 2004; 25: 1305-1308.
    • (2004) Neurobiol Aging , vol.25 , pp. 1305-1308
    • Riemenschneider, M.1    Mahmoodzadeh, S.2    Eisele, T.3    Klopp, N.4    Schwarz, S.5    Wagenpfeil, S.6
  • 50
    • 1442278755 scopus 로고    scopus 로고
    • Promoter polymorphism in PCK1 (phosphoenolpyruvate carboxykinase gene) associated with type 2 diabetes mellitus
    • Cao H, van der Veer E, Ban MR, Hanley AJ, Zinman B, Harris SB et al. Promoter polymorphism in PCK1 (phosphoenolpyruvate carboxykinase gene) associated with type 2 diabetes mellitus. J Clin Endocrinol Metab 2004; 89: 898-903.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 898-903
    • Cao, H.1    Van Der Veer, E.2    Ban, M.R.3    Hanley, A.J.4    Zinman, B.5    Harris, S.B.6
  • 51
    • 33748470258 scopus 로고    scopus 로고
    • Diabetes mellitus, dementia, and cognitive function in older persons
    • Arvanitakis Z, Wilson RS, Bennett DA. Diabetes mellitus, dementia, and cognitive function in older persons. J Nutr Health Aging 2006; 10: 287-291.
    • (2006) J Nutr Health Aging , vol.10 , pp. 287-291
    • Arvanitakis, Z.1    Wilson, R.S.2    Bennett, D.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.