Clinical trials of disease-modifying therapies for neurodegenerative diseases: The challenges and the future

Nature Medicine

Volumn 16, Issue 11, 2010, Pages 1223-1226

  Lang, Anthony E ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER;

ALZHEIMER DISEASE; CLINICAL TRIAL; DEGENERATIVE DISEASE; DEMENTIA; DISEASE COURSE; DISEASE MODIFYING THERAPY; HEALTH CARE SYSTEM; HUMAN; MOLECULARLY TARGETED THERAPY; NERVE DEGENERATION; NONHUMAN; NOTE; PARKINSON DISEASE; PHARMACEUTICAL CARE; PHARMACOGENOMICS; PRIORITY JOURNAL; STUDY DESIGN; TREATMENT PLANNING;

ANIMALS; CLINICAL TRIALS AS TOPIC; HUMANS; NEURODEGENERATIVE DISEASES; TERMINOLOGY AS TOPIC;

EID: 78149299057     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.2220     Document Type: Note

References (54)

1. The Lewin Group. Saving lives, saving money: dividends for Americans investing in Alzheimer's Research. (Falls Church, Virginia, USA, 2004).
2. Alzheimer's Association. http://www.alz.org/documents-custom/trajectory. pdf (2010).
3. Alzheimer's Disease International. http://www.alz. co.uk/research/files/ WorldAlzheimerReport.pdf (2009).
4. Dorsey, E.R. et al. Neurology 68, 384-386 (2007).
5. DeKosky, S.T. & Marek, K. Science 302, 830-834 (2003).
6. Brookmeyer, R., Gray, S. & Kawas, C. Am. J. Public Health 88, 1337-1342 (1998).
7. Olanow, C.W., Kieburtz, K. & Schapira, A.H. Ann. Neurol. 64 Suppl 2, S101-S110 (2008).
8. Francis, P.T., Norberg, A. & Arnold, S.E. Trends Pharmacol. Sci. 26, 104-111 (2005).
9. Brooks, D.J. Ann. Neurol. 44, S10-S18 (1998).
10. Broussolle, E. et al. Neurology 55, 877-879 (2000).
11. Levy, G. Arch. Neurol. 64, 1242-1246 (2007).
12. Levy, G. et al. Arch. Neurol. 62, 467-472 (2005).
13. Aarsland, D. et al. J. Neurol. 254, 38-45 (2007).
14. Jenner, P. Ann. Neurol. 64, S16-S29 (2008).
15. Dawson, T.M., Ko, H.S. & Dawson, V.L. Neuron 66, 646-661 (2010).
16. Ashe, K.H. & Zahs, K.R. Neuron 66, 631-645 (2010).
17. Epis, R. et al. Eur. J. Pharmacol. 626, 57-63 (2010).
18. Kokjohn, T.A. & Roher, A.E. Alzheimers Dement. 5, 340-347 (2009).
19. Philipson, O. et al. FEBS J. 277, 1389-1409 (2010)
20. Lang, A.E. Lancet Neurol. 5, 990-991 (2006).
21. Jucker, M. Nat. Med. published online, doi:10.1038/nm.2224 (21 September 2010)
22. Hirsch, E.C. & Hunot, S. Lancet Neurol. 8, 382-397 (2009).
23. Aisen, P.S. et al. Alzheimers Dement. 6, 239-246 (2010).
24. Trojanowski, J.Q. et al. Alzheimers Dement. 6, 230-238 (2010).
25. Weiner, M.W. et al. Alzheimers Dement. 6, 202-211 (2010).
26. Ravina, B. et al. Mov. Disord. 24, 2081-2090 (2009).
27. Scherzer, C.R. Neurobiol. Dis. 35, 148-156 (2009).
28. Hampel, H. et al. Nat. Rev. Drug Discov. 9, 560-574 (2010).
29. Blennow, K. Nat. Med. published online, doi:10.1038/nm.2221 (21 September 2010).
30. Blennow, K., Hampel, H., Weiner, M. & Zetterberg, H. Nat. Rev. Neurol. 6, 131-144 (2010).
31. Fahn, S. et al. N. Engl. J. Med. 351, 2498-2508 (2004).
32. Dubois, B. et al. Lancet Neurol. 6, 734-746 (2007).
33. Siderowf, A. & Stern, M.B. Ann. Neurol. 64, S139-S147 (2008).
34. Ponsen, M.M., Stoffers, D., Twisk, J.W.R., Wolters, E.C. & Berendse, H.W. Mov. Disord. 24, 1060-1065 (2009).
35. Haehner, A. et al. Mov. Disord. 22, 839-842 (2007).
36. Kieburtz, K. Neurology 66, S50-S57 (2006).
37. Parkinson Study Group. N. Engl. J. Med. 321, 1364-1371 (1989).
38. Parkinson Study Group PRECEPT Investigators et al. Neurology 69, 1480-1490 (2007)
39. Olanow, C.W. et al. Lancet Neurol. 5, 1013-1020 (2006).
40. Leber, P. Alzheimer Dis. Assoc. Disord. 11 Suppl 5, S10-S21 (1997).
41. Olanow, C.W. et al. Mov. Disord. 23, 2194-2201 (2008).
42. Clarke, C.E. Mov. Disord. 23, 784-789 (2008)
43. D'Agostino, R.B. Sr. N. Engl. J. Med. 361, 1304-1306 (2009).
44. Ploeger, B.A. & Holford, N.H. Pharm. Stat. 8, 225-238 (2009).
45. Parkinson Study Group et al. J. Am. Med. Assoc. 287, 1653-1661 (2002).
46. Whone, A.L. et al. Ann. Neurol. 54, 93-101 (2003).
47. Freed, C.R. et al. N. Engl. J. Med. 344, 710-719 (2001).
48. Olanow, C.W. et al. Ann. Neurol. 54, 403-414 (2003).
49. Tang, C.C., Poston, K.L., Dhawan, V. & Eidelberg, D. J. Neurosci. 30, 1049-1056 (2010).
50. Eckert, T., Tong, C. & Eidelberg, D. Lancet Neurol. 6, 926-932 (2007).
51. Lim, S.Y., Fox, S.H. & Lang, A.E. Arch. Neurol. 66, 167-172 (2009).
52. Huang, P. et al. Mov. Disord 24, 1732-1739 (2009).
53. NINDS NET-PD Investigators et al. Neurology 68, 20-28 (2007).
54. Salloway, S. et al. Neurology 73, 2061-2070 (2009).