메뉴 건너뛰기




Volumn 31, Issue 1, 2010, Pages 7-17

T cell-microglial dialogue in Parkinson's disease and amyotrophic lateral sclerosis: are we listening?

Author keywords

[No Author keywords available]

Indexed keywords

GLATIRAMER; GLUTAMIC ACID; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA; NITRIC OXIDE; SUPEROXIDE; TUMOR NECROSIS FACTOR ALPHA;

EID: 73149116008     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.it.2009.09.003     Document Type: Review
Times cited : (221)

References (94)
  • 1
    • 33748743268 scopus 로고    scopus 로고
    • CNS immune privilege: hiding in plain sight
    • Carson M.J., et al. CNS immune privilege: hiding in plain sight. Immunol. Rev. 213 (2006) 48-65
    • (2006) Immunol. Rev. , vol.213 , pp. 48-65
    • Carson, M.J.1
  • 2
    • 0027401203 scopus 로고
    • Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
    • Rosen D.R., et al. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 362 (1993) 59-62
    • (1993) Nature , vol.362 , pp. 59-62
    • Rosen, D.R.1
  • 3
    • 33749056809 scopus 로고    scopus 로고
    • ALS: a disease of motor neurons and their nonneuronal neighbors
    • Boillée S., et al. ALS: a disease of motor neurons and their nonneuronal neighbors. Neuron 52 (2006) 39-59
    • (2006) Neuron , vol.52 , pp. 39-59
    • Boillée, S.1
  • 4
    • 0032829070 scopus 로고    scopus 로고
    • Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure
    • Langston J.W., et al. Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure. Ann. Neurol. 46 (1999) 598-605
    • (1999) Ann. Neurol. , vol.46 , pp. 598-605
    • Langston, J.W.1
  • 5
    • 0141741347 scopus 로고    scopus 로고
    • Parkinson's disease: Mechanisms and Models
    • Dauer W., and Przedborski S. Parkinson's disease: Mechanisms and Models. Neuron 39 (2003) 889-909
    • (2003) Neuron , vol.39 , pp. 889-909
    • Dauer, W.1    Przedborski, S.2
  • 6
    • 0141642203 scopus 로고    scopus 로고
    • Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice
    • Clement A.M., et al. Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice. Science 302 (2003) 113-117
    • (2003) Science , vol.302 , pp. 113-117
    • Clement, A.M.1
  • 7
    • 0030882856 scopus 로고    scopus 로고
    • Alpha-synuclein in Lewy bodies
    • Spillantini M.G., et al. Alpha-synuclein in Lewy bodies. Nature 388 (1997) 839-840
    • (1997) Nature , vol.388 , pp. 839-840
    • Spillantini, M.G.1
  • 8
    • 67650966680 scopus 로고    scopus 로고
    • Microglial physiology: unique stimuli, specialized responses
    • Ransohoff R.M., and Perry V.H. Microglial physiology: unique stimuli, specialized responses. Annu. Rev. Immunol. 27 (2009) 119-145
    • (2009) Annu. Rev. Immunol. , vol.27 , pp. 119-145
    • Ransohoff, R.M.1    Perry, V.H.2
  • 9
    • 46749135222 scopus 로고    scopus 로고
    • Blood monocytes: distinct subsets, how they relate to dendritic cells, and their possible roles in the regulation of T-cell responses
    • Geissmann F., et al. Blood monocytes: distinct subsets, how they relate to dendritic cells, and their possible roles in the regulation of T-cell responses. Immunol. Cell Biol. 86 (2008) 398-408
    • (2008) Immunol. Cell Biol. , vol.86 , pp. 398-408
    • Geissmann, F.1
  • 10
    • 38449102676 scopus 로고    scopus 로고
    • Macrophage activation and polarization
    • Martinez F.O., et al. Macrophage activation and polarization. Front. Biosci. 13 (2008) 453-461
    • (2008) Front. Biosci. , vol.13 , pp. 453-461
    • Martinez, F.O.1
  • 11
    • 56149103896 scopus 로고    scopus 로고
    • Macrophage polarization in bacterial infections
    • Benoit M., et al. Macrophage polarization in bacterial infections. J. Immunol. 181 (2008) 3733-3739
    • (2008) J. Immunol. , vol.181 , pp. 3733-3739
    • Benoit, M.1
  • 12
    • 67349251479 scopus 로고    scopus 로고
    • Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: Effects of oligomeric and fibrillar amyloid-beta
    • Michelucci A., et al. Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: Effects of oligomeric and fibrillar amyloid-beta. J. Neuroimmunol. 210 (2009) 3-12
    • (2009) J. Neuroimmunol. , vol.210 , pp. 3-12
    • Michelucci, A.1
  • 13
    • 64049116317 scopus 로고    scopus 로고
    • Distribution of the immune inhibitory molecules CD200 and CD200R in the normal central nervous system and multiple sclerosis lesions suggests neuron-glia and glia-glia interactions
    • Koning N., et al. Distribution of the immune inhibitory molecules CD200 and CD200R in the normal central nervous system and multiple sclerosis lesions suggests neuron-glia and glia-glia interactions. J. Neuropathol. Exp. Neurol. 68 (2009) 159-167
    • (2009) J. Neuropathol. Exp. Neurol. , vol.68 , pp. 159-167
    • Koning, N.1
  • 14
    • 0023782375 scopus 로고
    • Expression of the histocompatibility glycoprotein HLA-DR in neurological disease
    • McGeer P.L., et al. Expression of the histocompatibility glycoprotein HLA-DR in neurological disease. Acta Neuropathol. 76 (1988) 550-555
    • (1988) Acta Neuropathol. , vol.76 , pp. 550-555
    • McGeer, P.L.1
  • 15
    • 0033121299 scopus 로고    scopus 로고
    • FcepsilonRII/CD23 is expressed in Parkinson's disease and induces, in vitro, production of nitric oxide and tumor necrosis factor-alpha in glial cells
    • Hunot S., et al. FcepsilonRII/CD23 is expressed in Parkinson's disease and induces, in vitro, production of nitric oxide and tumor necrosis factor-alpha in glial cells. J. Neurosci. 19 (1999) 3440-3447
    • (1999) J. Neurosci. , vol.19 , pp. 3440-3447
    • Hunot, S.1
  • 16
    • 18144406539 scopus 로고    scopus 로고
    • Oxidative stress and inflammation in Parkinson's disease: is there a causal link?
    • Hald A., and Lotharius J. Oxidative stress and inflammation in Parkinson's disease: is there a causal link?. Exp. Neurol. 193 (2005) 279-290
    • (2005) Exp. Neurol. , vol.193 , pp. 279-290
    • Hald, A.1    Lotharius, J.2
  • 17
    • 34547681540 scopus 로고    scopus 로고
    • CD200-CD200R regulation of microglia activation in the pathogenesis of Parkinson's disease
    • Wang X.-J., et al. CD200-CD200R regulation of microglia activation in the pathogenesis of Parkinson's disease. J. Neuroimmune Pharmacol. 2 (2007) 259-264
    • (2007) J. Neuroimmune Pharmacol. , vol.2 , pp. 259-264
    • Wang, X.-J.1
  • 18
    • 0032710609 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease
    • Liberatore G.T., et al. Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease. Nat. Med. 5 (1999) 1403-1409
    • (1999) Nat. Med. , vol.5 , pp. 1403-1409
    • Liberatore, G.T.1
  • 19
    • 0037947448 scopus 로고    scopus 로고
    • NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease
    • Wu D.C., et al. NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 145-150
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 145-150
    • Wu, D.C.1
  • 20
    • 0035503074 scopus 로고    scopus 로고
    • Microglial activation and dopaminergic cell injury: an in vitro model relevant to Parkinson's disease
    • Le W., et al. Microglial activation and dopaminergic cell injury: an in vitro model relevant to Parkinson's disease. J. Neurosci. 21 (2001) 8447-8455
    • (2001) J. Neurosci. , vol.21 , pp. 8447-8455
    • Le, W.1
  • 21
    • 3142729054 scopus 로고    scopus 로고
    • Chemokines and glial cells: a complex network in the central nervous system
    • Ambrosini E., and Aloisi F. Chemokines and glial cells: a complex network in the central nervous system. Neurochem. Res. 29 (2004) 1017-1038
    • (2004) Neurochem. Res. , vol.29 , pp. 1017-1038
    • Ambrosini, E.1    Aloisi, F.2
  • 22
    • 33845980539 scopus 로고    scopus 로고
    • Chemokines in the MPTP model of Parkinson's disease: Absence of CCL2 and its receptor CCR2 does not protect against striatal neurodegeneration
    • Kalkonde Y.V., et al. Chemokines in the MPTP model of Parkinson's disease: Absence of CCL2 and its receptor CCR2 does not protect against striatal neurodegeneration. Brain Res. 1128 (2007) 1-11
    • (2007) Brain Res. , vol.1128 , pp. 1-11
    • Kalkonde, Y.V.1
  • 23
    • 0023093745 scopus 로고
    • + and mitochondrial function
    • + and mitochondrial function. Life Sci 40 (1987) 721-729
    • (1987) Life Sci , vol.40 , pp. 721-729
    • Nicklas, W.J.1
  • 24
    • 0033557640 scopus 로고    scopus 로고
    • Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons
    • Lotharius J., et al. Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons. J. Neurosci. 19 (1999) 1284-1293
    • (1999) J. Neurosci. , vol.19 , pp. 1284-1293
    • Lotharius, J.1
  • 25
    • 0035067196 scopus 로고    scopus 로고
    • Glutamatergic influences on the basal ganglia
    • Greenamyre J.T. Glutamatergic influences on the basal ganglia. Clin. Neuropharmacol. 24 (2001) 65-70
    • (2001) Clin. Neuropharmacol. , vol.24 , pp. 65-70
    • Greenamyre, J.T.1
  • 26
    • 0030744876 scopus 로고    scopus 로고
    • Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
    • Polymeropoulos M.H., et al. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 276 (1997) 2045-2047
    • (1997) Science , vol.276 , pp. 2045-2047
    • Polymeropoulos, M.H.1
  • 27
    • 10744227740 scopus 로고    scopus 로고
    • Comparison of kindreds with parkinsonism and α-synuclein genomic multiplications
    • Farrer M. Comparison of kindreds with parkinsonism and α-synuclein genomic multiplications. Ann. Neurol. 55 (2004) 174-179
    • (2004) Ann. Neurol. , vol.55 , pp. 174-179
    • Farrer, M.1
  • 28
    • 38849174979 scopus 로고    scopus 로고
    • Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy
    • Martinez-Vicente M., et al. Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy. J. Clin. Invest. 118 (2008) 777-788
    • (2008) J. Clin. Invest. , vol.118 , pp. 777-788
    • Martinez-Vicente, M.1
  • 29
    • 61549111872 scopus 로고    scopus 로고
    • alpha-Synuclein and neuronal cell death
    • Cookson M.R. alpha-Synuclein and neuronal cell death. Mol. Neurodegener. 4 (2009) 9
    • (2009) Mol. Neurodegener. , vol.4 , pp. 9
    • Cookson, M.R.1
  • 30
    • 21344456506 scopus 로고    scopus 로고
    • Intravesicular localization and exocytosis of alpha-synuclein and its aggregates
    • Lee H.J., et al. Intravesicular localization and exocytosis of alpha-synuclein and its aggregates. J. Neurosci. 25 (2005) 6016-6024
    • (2005) J. Neurosci. , vol.25 , pp. 6016-6024
    • Lee, H.J.1
  • 31
    • 20144389524 scopus 로고    scopus 로고
    • Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease
    • Zhang W., et al. Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease. FASEB J. 19 (2005) 533-542
    • (2005) FASEB J. , vol.19 , pp. 533-542
    • Zhang, W.1
  • 32
    • 50549085408 scopus 로고    scopus 로고
    • Neuroinflammation and oxidation/nitration of alpha-synuclein linked to dopaminergic neurodegeneration
    • Gao H.M., et al. Neuroinflammation and oxidation/nitration of alpha-synuclein linked to dopaminergic neurodegeneration. J. Neurosci. 28 (2008) 7687-7698
    • (2008) J. Neurosci. , vol.28 , pp. 7687-7698
    • Gao, H.M.1
  • 33
    • 58849107919 scopus 로고    scopus 로고
    • + lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease
    • + lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease. J. Clin. Invest. 119 (2009) 182-192
    • (2009) J. Clin. Invest. , vol.119 , pp. 182-192
    • Brochard, V.1
  • 34
    • 38949151035 scopus 로고    scopus 로고
    • Nitrated alpha-synuclein immunity accelerates degeneration of nigral dopaminergic neurons
    • Benner E.J., et al. Nitrated alpha-synuclein immunity accelerates degeneration of nigral dopaminergic neurons. PLoS One. 3 (2008) e1376
    • (2008) PLoS One. , vol.3
    • Benner, E.J.1
  • 35
    • 12144288237 scopus 로고    scopus 로고
    • Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco) bacteria
    • Verreck F.A., et al. Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco) bacteria. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 4560-4565
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 4560-4565
    • Verreck, F.A.1
  • 36
    • 33947515418 scopus 로고    scopus 로고
    • Involvement of interferon-gamma in microglial-mediated loss of dopaminergic neurons
    • Mount M.P. Involvement of interferon-gamma in microglial-mediated loss of dopaminergic neurons. J. Neurosci. 27 (2007) 3328-3337
    • (2007) J. Neurosci. , vol.27 , pp. 3328-3337
    • Mount, M.P.1
  • 37
    • 34948909646 scopus 로고    scopus 로고
    • Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation
    • Kebir H., et al. Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. Nat. Med. 13 (2007) 1173-1175
    • (2007) Nat. Med. , vol.13 , pp. 1173-1175
    • Kebir, H.1
  • 38
    • 0037530542 scopus 로고    scopus 로고
    • Vulnerability of human neurons to T cell-mediated cytotoxicity
    • Giuliani F., et al. Vulnerability of human neurons to T cell-mediated cytotoxicity. J. Immunol. 171 (2003) 368-379
    • (2003) J. Immunol. , vol.171 , pp. 368-379
    • Giuliani, F.1
  • 39
    • 0037180556 scopus 로고    scopus 로고
    • + regulatory T cells suppress the ability to withstand injury to the central nervous system
    • + regulatory T cells suppress the ability to withstand injury to the central nervous system. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 15620-15625
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 15620-15625
    • Kipnis, J.J.1
  • 40
    • 20444422539 scopus 로고    scopus 로고
    • Protective autoimmunity and neuroprotection in inflammatory and noninflammatory neurodegenerative diseases
    • Schwartz M., and Kipnis J.J. Protective autoimmunity and neuroprotection in inflammatory and noninflammatory neurodegenerative diseases. J. Neurol. Sci. 233 (2005) 163-166
    • (2005) J. Neurol. Sci. , vol.233 , pp. 163-166
    • Schwartz, M.1    Kipnis, J.J.2
  • 41
    • 3042592589 scopus 로고    scopus 로고
    • Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease
    • Benner E.J., et al. Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 9435-9440
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 9435-9440
    • Benner, E.J.1
  • 42
    • 0034041863 scopus 로고    scopus 로고
    • Glatiramer acetate (Copaxone) induces degenerate, Th2-polarized immune responses in patients with multiple sclerosis
    • Duda P.W. Glatiramer acetate (Copaxone) induces degenerate, Th2-polarized immune responses in patients with multiple sclerosis. J. Clin. Invest 105 (2000) 967-976
    • (2000) J. Clin. Invest , vol.105 , pp. 967-976
    • Duda, P.W.1
  • 43
    • 33750442559 scopus 로고    scopus 로고
    • Protective effects of an anti-inflammatory cytokine, interleukin-4, on motoneuron toxicity induced by activated microglia
    • Zhao W., et al. Protective effects of an anti-inflammatory cytokine, interleukin-4, on motoneuron toxicity induced by activated microglia. J. Neurochem. 99 (2006) 1176-1187
    • (2006) J. Neurochem. , vol.99 , pp. 1176-1187
    • Zhao, W.1
  • 44
    • 68949144931 scopus 로고    scopus 로고
    • Regulatory properties of copolymer I in Th17 differentiation by altering STAT3 phosphorylation
    • Chen C., et al. Regulatory properties of copolymer I in Th17 differentiation by altering STAT3 phosphorylation. J. Immunol. 183 (2009) 246-253
    • (2009) J. Immunol. , vol.183 , pp. 246-253
    • Chen, C.1
  • 45
    • 63149114677 scopus 로고    scopus 로고
    • Glatiramer acetate increases IL-1 receptor antagonist but decreases T cell-induced IL-1β in human monocytes and multiple sclerosis
    • Burger D., et al. Glatiramer acetate increases IL-1 receptor antagonist but decreases T cell-induced IL-1β in human monocytes and multiple sclerosis. Proc. Natl. Acad. Sci. U. S. A. 106 (2009) 4355-4359
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 4355-4359
    • Burger, D.1
  • 46
    • 36249032567 scopus 로고    scopus 로고
    • + regulatory T cells in an animal model of Parkinson's disease
    • + regulatory T cells in an animal model of Parkinson's disease. J. Leukoc. Biol. 82 (2007) 1083-1094
    • (2007) J. Leukoc. Biol. , vol.82 , pp. 1083-1094
    • Reynolds, A.D.1
  • 47
    • 64249169415 scopus 로고    scopus 로고
    • + T cell subsets
    • + T cell subsets. J. Immunol. 182 (2009) 4137-4149
    • (2009) J. Immunol. , vol.182 , pp. 4137-4149
    • Reynolds, A.D.1
  • 48
    • 0029037348 scopus 로고
    • Natural history of amyotrophic lateral sclerosis in a database population. Validation of a scoring system and a model for survival prediction
    • Haverkamp L.J., et al. Natural history of amyotrophic lateral sclerosis in a database population. Validation of a scoring system and a model for survival prediction. Brain 118 (1995) 707-719
    • (1995) Brain , vol.118 , pp. 707-719
    • Haverkamp, L.J.1
  • 49
    • 0345742771 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man
    • Fischer L.R., et al. Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man. Exp. Neurol. 185 (2004) 232-240
    • (2004) Exp. Neurol. , vol.185 , pp. 232-240
    • Fischer, L.R.1
  • 50
    • 0024994099 scopus 로고
    • IgG reactivity in the spinal cord and motor cortex in amyotrophic lateral sclerosis
    • Engelhardt J.I., and Appel S.H. IgG reactivity in the spinal cord and motor cortex in amyotrophic lateral sclerosis. Arch. Neurol. 47 (1990) 1210-1216
    • (1990) Arch. Neurol. , vol.47 , pp. 1210-1216
    • Engelhardt, J.I.1    Appel, S.H.2
  • 51
    • 0027473452 scopus 로고
    • Lymphocytic infiltrates in the spinal cord in amyotrophic lateral sclerosis
    • Engelhardt J.I., et al. Lymphocytic infiltrates in the spinal cord in amyotrophic lateral sclerosis. Arch. Neurol. 50 (1993) 30-36
    • (1993) Arch. Neurol. , vol.50 , pp. 30-36
    • Engelhardt, J.I.1
  • 52
    • 10744229158 scopus 로고    scopus 로고
    • Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue
    • Henkel J.S., et al. Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue. Ann. Neurol 55 (2004) 221-235
    • (2004) Ann. Neurol , vol.55 , pp. 221-235
    • Henkel, J.S.1
  • 53
    • 0035911254 scopus 로고    scopus 로고
    • Absence of monocyte chemoattractant protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis
    • Huang D.R., et al. Absence of monocyte chemoattractant protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis. J. Exp. Med. 193 (2001) 713-726
    • (2001) J. Exp. Med. , vol.193 , pp. 713-726
    • Huang, D.R.1
  • 54
    • 59349095043 scopus 로고    scopus 로고
    • Neuro-immune crosstalk in CNS diseases
    • Kerschensteiner M., et al. Neuro-immune crosstalk in CNS diseases. Neuroscience 158 (2009) 1122-1132
    • (2009) Neuroscience , vol.158 , pp. 1122-1132
    • Kerschensteiner, M.1
  • 55
    • 0028284779 scopus 로고
    • Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation
    • Gurney M.E., et al. Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. Science 264 (1994) 1772-1775
    • (1994) Science , vol.264 , pp. 1772-1775
    • Gurney, M.E.1
  • 56
    • 0029053881 scopus 로고
    • An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria
    • Wong P.C., et al. An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron 14 (1995) 1105-1116
    • (1995) Neuron , vol.14 , pp. 1105-1116
    • Wong, P.C.1
  • 57
    • 0037022339 scopus 로고    scopus 로고
    • Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS)
    • Howland D.S., et al. Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS). Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 1604-1609
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 1604-1609
    • Howland, D.S.1
  • 58
    • 0035833937 scopus 로고    scopus 로고
    • Immune reactivity in a mouse model of familial ALS correlates with disease progression
    • Alexianu M.E., et al. Immune reactivity in a mouse model of familial ALS correlates with disease progression. Neurology 57 (2001) 1282-1289
    • (2001) Neurology , vol.57 , pp. 1282-1289
    • Alexianu, M.E.1
  • 59
    • 33644821966 scopus 로고    scopus 로고
    • The chemokine MCP-1 and the dendritic and myeloid cells it attracts are increased in the mSOD1 mouse model of ALS
    • Henkel J.S., et al. The chemokine MCP-1 and the dendritic and myeloid cells it attracts are increased in the mSOD1 mouse model of ALS. Mol. Cell. Neurosci. 31 (2006) 427-437
    • (2006) Mol. Cell. Neurosci. , vol.31 , pp. 427-437
    • Henkel, J.S.1
  • 60
    • 55749110043 scopus 로고    scopus 로고
    • + T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS
    • + T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 15558-15563
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 15558-15563
    • Beers, D.R.1
  • 61
    • 0032125587 scopus 로고    scopus 로고
    • Relationship of microglial and astrocytic activation to disease onset and progression in a transgenic model of familial ALS
    • Hall E.D., et al. Relationship of microglial and astrocytic activation to disease onset and progression in a transgenic model of familial ALS. Glia 23 (1998) 249-256
    • (1998) Glia , vol.23 , pp. 249-256
    • Hall, E.D.1
  • 62
    • 0033018506 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase up-regulation in a transgenic mouse model of familial amyotrophic lateral sclerosis
    • Almer G., et al. Inducible nitric oxide synthase up-regulation in a transgenic mouse model of familial amyotrophic lateral sclerosis. J. Neurochem. 72 (1999) 2415-2425
    • (1999) J. Neurochem. , vol.72 , pp. 2415-2425
    • Almer, G.1
  • 63
    • 0034623301 scopus 로고    scopus 로고
    • iNOS and nitrotyrosine immunoreactivity in amyotrophic lateral sclerosis
    • Sasaki S., et al. iNOS and nitrotyrosine immunoreactivity in amyotrophic lateral sclerosis. Neurosci. Lett. 291 (2000) 44-48
    • (2000) Neurosci. Lett. , vol.291 , pp. 44-48
    • Sasaki, S.1
  • 64
    • 0034765498 scopus 로고    scopus 로고
    • Induction of proinflammatory molecules in mice with amyotrophic lateral sclerosis: no requirement for proapoptotic interleukin-1beta in neurodegeneration
    • Nguyen M.D., et al. Induction of proinflammatory molecules in mice with amyotrophic lateral sclerosis: no requirement for proapoptotic interleukin-1beta in neurodegeneration. Ann. Neurol. 50 (2001) 630-639
    • (2001) Ann. Neurol. , vol.50 , pp. 630-639
    • Nguyen, M.D.1
  • 65
    • 0036062628 scopus 로고    scopus 로고
    • Hensley, K. et al. (2002) Temporal patterns of cytokine and apoptosis-related gene expression in spinal cords of the G93A-SOD1 mouse model of amyotrophic lateral sclerosis. J. Neurochem. 82, 365-374. Erratum in: J. Neurochem. 82, 1570
    • Hensley, K. et al. (2002) Temporal patterns of cytokine and apoptosis-related gene expression in spinal cords of the G93A-SOD1 mouse model of amyotrophic lateral sclerosis. J. Neurochem. 82, 365-374. Erratum in: J. Neurochem. 82, 1570
  • 66
    • 4444348187 scopus 로고    scopus 로고
    • Activated microglia initiate motor neuron injury by a nitric oxide and glutamate-mediated mechanism
    • Zhao W., et al. Activated microglia initiate motor neuron injury by a nitric oxide and glutamate-mediated mechanism. J. Neuropathol. Exp. Neurol. 63 (2004) 964-977
    • (2004) J. Neuropathol. Exp. Neurol. , vol.63 , pp. 964-977
    • Zhao, W.1
  • 67
    • 34548233140 scopus 로고    scopus 로고
    • Mutant SOD1(G93A) microglia are more neurotoxic relative to wild-type microglia
    • Xiao Q., et al. Mutant SOD1(G93A) microglia are more neurotoxic relative to wild-type microglia. J. Neurochem. 102 (2007) 2008-2019
    • (2007) J. Neurochem. , vol.102 , pp. 2008-2019
    • Xiao, Q.1
  • 68
    • 33750478657 scopus 로고    scopus 로고
    • Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis
    • Beers D.R., et al. Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 16021-16026
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 16021-16026
    • Beers, D.R.1
  • 69
    • 33744798774 scopus 로고    scopus 로고
    • Onset and progression in inherited ALS determined by motor neurons and microglia
    • Boillée S., et al. Onset and progression in inherited ALS determined by motor neurons and microglia. Science 312 (2006) 1389-1392
    • (2006) Science , vol.312 , pp. 1389-1392
    • Boillée, S.1
  • 70
    • 29444443348 scopus 로고    scopus 로고
    • Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis
    • Urushitani M., et al. Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis. Nat. Neurosci. 9 (2006) 108-1018
    • (2006) Nat. Neurosci. , vol.9 , pp. 108-1018
    • Urushitani, M.1
  • 71
    • 73149090610 scopus 로고    scopus 로고
    • Extracellular mutant SOD1 induces microglial-mediated motoneuron injury
    • in press
    • Zhao, W. et al. (2009) Extracellular mutant SOD1 induces microglial-mediated motoneuron injury. Glia. (in press)
    • (2009) Glia
    • Zhao, W.1
  • 72
    • 34250177650 scopus 로고    scopus 로고
    • Wild-type superoxide dismutase acquires binding and toxic properties of ALS-linked mutant forms through oxidation
    • Ezzi S.A., et al. Wild-type superoxide dismutase acquires binding and toxic properties of ALS-linked mutant forms through oxidation. J. Neurochem. 102 (2007) 170-178
    • (2007) J. Neurochem. , vol.102 , pp. 170-178
    • Ezzi, S.A.1
  • 73
    • 34547640096 scopus 로고    scopus 로고
    • Common molecular signature in SOD1 for both sporadic and familial amyotrophic lateral sclerosis
    • Gruzman A., et al. Common molecular signature in SOD1 for both sporadic and familial amyotrophic lateral sclerosis. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 12524-12529
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 12524-12529
    • Gruzman, A.1
  • 74
    • 73149088420 scopus 로고    scopus 로고
    • Alternative vs. classically activated microglial phenotypes throughout disease in the ALS mouse model
    • Book 2, p30, 49.16
    • Henkel J.S., et al. Alternative vs. classically activated microglial phenotypes throughout disease in the ALS mouse model. Soc. for Neurosci. Abstr (2009) Book 2, p30, 49.16
    • (2009) Soc. for Neurosci. Abstr
    • Henkel, J.S.1
  • 75
    • 56649100689 scopus 로고    scopus 로고
    • T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS
    • Chiu I.M., et al. T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 17913-17918
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 17913-17918
    • Chiu, I.M.1
  • 76
    • 50549098607 scopus 로고    scopus 로고
    • Adaptive immune neuroprotection in G93A-SOD1 amyotrophic lateral sclerosis mice
    • Banerjee R., et al. Adaptive immune neuroprotection in G93A-SOD1 amyotrophic lateral sclerosis mice. PLoS ONE. 3 (2008) e2740
    • (2008) PLoS ONE. , vol.3
    • Banerjee, R.1
  • 77
    • 37649015079 scopus 로고    scopus 로고
    • + regulatory T cells induce alternative activation of human monocytes/macrophages
    • + regulatory T cells induce alternative activation of human monocytes/macrophages. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 19446-19451
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 19446-19451
    • Tiemessen, M.M.1
  • 78
    • 49649093608 scopus 로고    scopus 로고
    • + regulatory T cells, which suppress via membrane-bound TGFbeta-1
    • + regulatory T cells, which suppress via membrane-bound TGFbeta-1. J. Immunol. 181 (2008) 2220-2226
    • (2008) J. Immunol. , vol.181 , pp. 2220-2226
    • Savage, N.D.1
  • 79
    • 35748964164 scopus 로고    scopus 로고
    • + T cells to be sustained during chronic infection
    • + T cells to be sustained during chronic infection. J. Immunol. 179 (2007) 3926-3936
    • (2007) J. Immunol. , vol.179 , pp. 3926-3936
    • Loke, P.1
  • 80
    • 32044442102 scopus 로고    scopus 로고
    • Microglial phenotype: is the commitment reversible?
    • Schwartz M., et al. Microglial phenotype: is the commitment reversible?. Trends Neurosci. 29 (2006) 68-74
    • (2006) Trends Neurosci. , vol.29 , pp. 68-74
    • Schwartz, M.1
  • 82
    • 27144452325 scopus 로고    scopus 로고
    • + regulatory T-Cells at the crossroads of health and disease
    • + regulatory T-Cells at the crossroads of health and disease. Neuromolecular Med. 7 (2005) 197-206
    • (2005) Neuromolecular Med. , vol.7 , pp. 197-206
    • Kipnis, J.1    Schwartz, M.2
  • 83
    • 33646596928 scopus 로고    scopus 로고
    • Neuron-mediated generation of regulatory T cells from encephalitogenic T cells suppresses EAE
    • Liu Y., et al. Neuron-mediated generation of regulatory T cells from encephalitogenic T cells suppresses EAE. Nat. Med. 12 (2006) 518-525
    • (2006) Nat. Med. , vol.12 , pp. 518-525
    • Liu, Y.1
  • 84
    • 60349100558 scopus 로고    scopus 로고
    • Neuronal regulation of immune responses in the central nervous system
    • Tian L., et al. Neuronal regulation of immune responses in the central nervous system. Trends Immunol. 30 (2009) 91-99
    • (2009) Trends Immunol. , vol.30 , pp. 91-99
    • Tian, L.1
  • 85
    • 0032146068 scopus 로고    scopus 로고
    • Immune surveillance in the injured nervous system: T-lymphocytes invade the axotomized mouse facial motor nucleus and aggregate around sites of neuronal degeneration
    • Raivich G., et al. Immune surveillance in the injured nervous system: T-lymphocytes invade the axotomized mouse facial motor nucleus and aggregate around sites of neuronal degeneration. J. Neurosci. 18 (1998) 5804-5816
    • (1998) J. Neurosci. , vol.18 , pp. 5804-5816
    • Raivich, G.1
  • 86
    • 4243562216 scopus 로고    scopus 로고
    • Exacerbation of facial motoneuron loss after facial nerve transaction in severe combined immunodeficient (scid) mice
    • Serpe, C.J. et al. (1999) Exacerbation of facial motoneuron loss after facial nerve transaction in severe combined immunodeficient (scid) mice. J. Neurosci. 19, RC7:1-5
    • (1999) J. Neurosci , vol.19 , Issue.RC7 , pp. 1-5
    • Serpe, C.J.1
  • 87
    • 33244455004 scopus 로고    scopus 로고
    • Endogenous T lymphocytes and microglial reactivity in the axotomized facial motor nucleus of mice: effect of genetic background and the RAG2 gene
    • Ha G.K., et al. Endogenous T lymphocytes and microglial reactivity in the axotomized facial motor nucleus of mice: effect of genetic background and the RAG2 gene. J. Neuroimmunol. 172 (2006) 1-8
    • (2006) J. Neuroimmunol. , vol.172 , pp. 1-8
    • Ha, G.K.1
  • 88
    • 0041942742 scopus 로고    scopus 로고
    • + or B, lymphocytes mediate facial motoneuron survival after facial nerve transection
    • + or B, lymphocytes mediate facial motoneuron survival after facial nerve transection. Brain Behav. Immun. 17 (2003) 393-402
    • (2003) Brain Behav. Immun. , vol.17 , pp. 393-402
    • Serpe, C.J.1
  • 89
    • 12344300485 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor supports facial motoneuron survival after facial nerve transaction in immunodeficient mice
    • Serpe C.J., et al. Brain-derived neurotrophic factor supports facial motoneuron survival after facial nerve transaction in immunodeficient mice. Brain Behav. Immun. 19 (2005) 173-180
    • (2005) Brain Behav. Immun. , vol.19 , pp. 173-180
    • Serpe, C.J.1
  • 90
    • 37849185653 scopus 로고    scopus 로고
    • T cell-mediated facial motoneuron survival after injury: Distribution pattern of cell death and rescue throughout the extent of the facial motor nucleus
    • Cahn M.Y., et al. T cell-mediated facial motoneuron survival after injury: Distribution pattern of cell death and rescue throughout the extent of the facial motor nucleus. J. Neuroimmunol. 181 (2006) 93-99
    • (2006) J. Neuroimmunol. , vol.181 , pp. 93-99
    • Cahn, M.Y.1
  • 91
    • 33747120224 scopus 로고    scopus 로고
    • +) T cells
    • +) T cells. Exp. Neurol. 201 (2006) 212-224
    • (2006) Exp. Neurol. , vol.201 , pp. 212-224
    • Deboy, C.A.1
  • 92
    • 2342606947 scopus 로고    scopus 로고
    • CD4-positive T cell-mediated neuroprotection requires dual compartment antigen presentation
    • Byram S.C., et al. CD4-positive T cell-mediated neuroprotection requires dual compartment antigen presentation. J. Neurosci. 24 (2004) 4333-4339
    • (2004) J. Neurosci. , vol.24 , pp. 4333-4339
    • Byram, S.C.1
  • 93
    • 0347993168 scopus 로고    scopus 로고
    • Early activation of microglia as antigen-presenting cells correlates with T cell-mediated protection and repair of the injured central nervous system
    • Shaked I., et al. Early activation of microglia as antigen-presenting cells correlates with T cell-mediated protection and repair of the injured central nervous system. J. Neuroimmunol. 146 (2004) 84-93
    • (2004) J. Neuroimmunol. , vol.146 , pp. 84-93
    • Shaked, I.1
  • 94
    • 0035516124 scopus 로고    scopus 로고
    • From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS
    • Cleveland D.W., and Rothstein J.D. From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS. Nat. Rev. Neurosci. 2 (2001) 806-819
    • (2001) Nat. Rev. Neurosci. , vol.2 , pp. 806-819
    • Cleveland, D.W.1    Rothstein, J.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.