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Volumn 68, Issue 8, 2009, Pages 902-914

Neprilysin and insulin-degrading enzyme levels are increased in Alzheimer disease in relation to disease severity

Author keywords

Alzheimer disease; Amyloid A peptide; Apolipoprotein E; Insulin degrading enzyme; Neprilysin; Neuron specific enolase

Indexed keywords

AMYLOID BETA PROTEIN; INSULIN; MEMBRANE METALLOENDOPEPTIDASE; APOLIPOPROTEIN E4; ENOLASE; INSULINASE;

EID: 69449102820     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/NEN.0b013e3181afe475     Document Type: Article
Times cited : (102)

References (53)
  • 1
    • 0026597063 scopus 로고
    • Alzheimer's disease: The amyloid cascade hypothesis
    • Hardy JA, Higgins GA. Alzheimer's disease: The amyloid cascade hypothesis. Science 1992;256:184-185
    • (1992) Science , vol.256 , pp. 184-185
    • Hardy, J.A.1    Higgins, G.A.2
  • 2
    • 0025753852 scopus 로고
    • The molecular pathology of Alzheimer's disease
    • Selkoe DJ. The molecular pathology of Alzheimer's disease. Neuron 1991;6:487-498
    • (1991) Neuron , vol.6 , pp. 487-498
    • Selkoe, D.J.1
  • 3
    • 41149157623 scopus 로고    scopus 로고
    • Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer's disease
    • Weller RO, Subash M, Preston SD, et al. Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer's disease. Brain Pathol 2008;18:253-266
    • (2008) Brain Pathol , vol.18 , pp. 253-266
    • Weller, R.O.1    Subash, M.2    Preston, S.D.3
  • 4
    • 48949117577 scopus 로고    scopus 로고
    • The role of the cell surface LRP and soluble LRP in blood-brain barrier Abeta clearance in Alzheimer's disease
    • Deane R, Sagare A, Zlokovic BV. The role of the cell surface LRP and soluble LRP in blood-brain barrier Abeta clearance in Alzheimer's disease. Curr Pharm Des 2008;14:1601-1605
    • (2008) Curr Pharm des , vol.14 , pp. 1601-1605
    • Deane, R.1    Sagare, A.2    Zlokovic, B.V.3
  • 5
    • 0036077536 scopus 로고    scopus 로고
    • Beta-amyloid catabolism: Roles for neprilysin (NEP) and other metallopeptidases?
    • Carson JA, Turner AJ. Beta-amyloid catabolism: Roles for neprilysin (NEP) and other metallopeptidases? J Neurochem 2002;81:1-8
    • (2002) J Neurochem , vol.81 , pp. 1-8
    • Carson, J.A.1    Turner, A.J.2
  • 6
    • 14944344493 scopus 로고    scopus 로고
    • Targeting amyloid-degrading enzymes as therapeutic strategies in neurodegeneration
    • Turner AJ, Fisk L, Nalivaeva NN. Targeting amyloid-degrading enzymes as therapeutic strategies in neurodegeneration. Ann N Y Acad Sci 2004;1035:1-20
    • (2004) Ann N y Acad Sci , vol.1035 , pp. 1-20
    • Turner, A.J.1    Fisk, L.2    Nalivaeva, N.N.3
  • 7
    • 0031052381 scopus 로고    scopus 로고
    • Amyloid, the presenilins and Alzheimer's disease
    • Hardy J. Amyloid, the presenilins and Alzheimer's disease. Trends Neurosci 1997;20:154-159
    • (1997) Trends Neurosci , vol.20 , pp. 154-159
    • Hardy, J.1
  • 8
    • 0036434569 scopus 로고    scopus 로고
    • Et al. alpha- and beta-secretase: Profound changes in Alzheimer's disease
    • Tyler SJ, Dawbarn D, Wilcock GK, et al. alpha- and beta-secretase: Profound changes in Alzheimer's disease. Biochem Biophys Res Commun 2002;299:373-376
    • (2002) Biochem Biophys Res Commun , vol.299 , pp. 373-376
    • Tyler, S.J.1    Dawbarn, D.2    Wilcock, G.K.3
  • 9
    • 34147120073 scopus 로고    scopus 로고
    • Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: Implications for Alzheimer's disease pathogenesis
    • Zhao J, Fu Y, Yasvoina M, et al. Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: Implications for Alzheimer's disease pathogenesis. J Neurosci 2007;27:3639-3649
    • (2007) J Neurosci , vol.27 , pp. 3639-3649
    • Zhao, J.1    Fu, Y.2    Yasvoina, M.3
  • 11
    • 33750047859 scopus 로고    scopus 로고
    • Regulation of steady-state beta-amyloid levels in the brain by neprilysin and endothelin-converting enzyme but not angiotensin-converting enzyme
    • Eckman EA, Adams SK, Troendle FJ, et al. Regulation of steady-state beta-amyloid levels in the brain by neprilysin and endothelin-converting enzyme but not angiotensin-converting enzyme. J Biol Chem 2006;281: 30471-30478
    • (2006) J Biol Chem , vol.281 , pp. 30471-30478
    • Eckman, E.A.1    Adams, S.K.2    Troendle, F.J.3
  • 12
    • 9144266913 scopus 로고    scopus 로고
    • Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain
    • Iwata N, Mizukami H, Shirotani K, et al. Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain. J Neurosci 2004;24:991-998
    • (2004) J Neurosci , vol.24 , pp. 991-998
    • Iwata, N.1    Mizukami, H.2    Shirotani, K.3
  • 13
    • 0035947207 scopus 로고    scopus 로고
    • Metabolic regulation of brain Abeta by neprilysin
    • Iwata N, Tsubuki S, Takaki Y, et al. Metabolic regulation of brain Abeta by neprilysin. Science 2001;292:1550-1552
    • (2001) Science , vol.292 , pp. 1550-1552
    • Iwata, N.1    Tsubuki, S.2    Takaki, Y.3
  • 14
    • 0037390039 scopus 로고    scopus 로고
    • Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the betaamyloid precursor protein intracellular domain in vivo
    • Farris W, Mansourian S, Chang Y, et al. Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the betaamyloid precursor protein intracellular domain in vivo. Proc Natl Acad Sci U S A 2003;100:4162-4167
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 4162-4167
    • Farris, W.1    Mansourian, S.2    Chang, Y.3
  • 15
    • 0037947406 scopus 로고    scopus 로고
    • Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo
    • Miller BC, Eckman EA, Sambamurti K, et al. Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo. Proc Natl Acad Sci U S A 2003;100:6221-6226
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 6221-6226
    • Miller, B.C.1    Eckman, E.A.2    Sambamurti, K.3
  • 16
    • 0346101885 scopus 로고    scopus 로고
    • Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death
    • Leissring MA, Farris W, Chang AY, et al. Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death. Neuron 2003;40:1087-1093
    • (2003) Neuron , vol.40 , pp. 1087-1093
    • Leissring, M.A.1    Farris, W.2    Chang, A.Y.3
  • 17
    • 0037444432 scopus 로고    scopus 로고
    • Neprilysin gene transfer reduces human amyloid pathology in transgenic mice
    • Marr RA, Rockenstein E, Mukherjee A, et al. Neprilysin gene transfer reduces human amyloid pathology in transgenic mice. J Neurosci 2003; 23:1992-1996
    • (2003) J Neurosci , vol.23 , pp. 1992-1996
    • Marr, R.A.1    Rockenstein, E.2    Mukherjee, A.3
  • 18
    • 34548456959 scopus 로고    scopus 로고
    • Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: A novel therapeutic approach to Alzheimer disease
    • Hemming ML, Patterson M, Reske-Nielsen C, et al. Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: A novel therapeutic approach to Alzheimer disease. PLoS Med 2007;4:e362
    • (2007) PLoS Med , vol.4
    • Hemming, M.L.1    Patterson, M.2    Reske-Nielsen, C.3
  • 19
    • 34249030519 scopus 로고    scopus 로고
    • Neprilysin protects neurons against Abeta peptide toxicity
    • El-Amouri SS, Zhu H, Yu J, et al. Neprilysin protects neurons against Abeta peptide toxicity. Brain Res 2007;1152:191-200
    • (2007) Brain Res , vol.1152 , pp. 191-200
    • El-Amouri, S.S.1    Zhu, H.2    Yu, J.3
  • 20
    • 43449092187 scopus 로고    scopus 로고
    • Neprilysin: An enzyme candidate to slow the progression of Alzheimer's disease
    • El-Amouri SS, Zhu H, Yu J, et al. Neprilysin: An enzyme candidate to slow the progression of Alzheimer's disease. Am J Pathol 2008;172: 1342-1354
    • (2008) Am J Pathol , vol.172 , pp. 1342-1354
    • El-Amouri, S.S.1    Zhu, H.2    Yu, J.3
  • 21
    • 33750841488 scopus 로고    scopus 로고
    • Neuronal neprilysin overexpression is associated with attenuation of A -related spatial memory deficit
    • Poirier R, Wolfer DP, Welzl H, et al. Neuronal neprilysin overexpression is associated with attenuation of A(-related spatial memory deficit. Neurobiol Dis 2006;24:475-83
    • (2006) Neurobiol Dis , vol.24 , pp. 475-83
    • Poirier, R.1    Wolfer, D.P.2    Welzl, H.3
  • 22
    • 0036794008 scopus 로고    scopus 로고
    • Declining expression of neprilysin in Alzheimer disease vasculature: Possible involvement in cerebral amyloid angiopathy
    • Carpentier M, Robitaille Y, DesGroseillers L, et al. Declining expression of neprilysin in Alzheimer disease vasculature: Possible involvement in cerebral amyloid angiopathy. J Neuropathol Exp Neurol 2002;61:849-856
    • (2002) J Neuropathol Exp Neurol , vol.61 , pp. 849-856
    • Carpentier, M.1    Robitaille, Y.2    Desgroseillers, L.3
  • 23
    • 33749475139 scopus 로고    scopus 로고
    • Decreased expression and activity of neprilysin in Alzheimer disease are associated with cerebral amyloid angiopathy
    • Miners JS, Van Helmond Z, Chalmers K, et al. Decreased expression and activity of neprilysin in Alzheimer disease are associated with cerebral amyloid angiopathy. J Neuropathol Exp Neurol 2006;65: 1012-1021
    • (2006) J Neuropathol Exp Neurol , vol.65 , pp. 1012-1021
    • Miners, J.S.1    Van Helmond, Z.2    Chalmers, K.3
  • 24
    • 41149149615 scopus 로고    scopus 로고
    • Abeta-degrading enzymes in Alzheimer's disease
    • Miners JS, Baig S, Palmer J, et al. Abeta-degrading enzymes in Alzheimer's disease. Brain Pathol 2008;18:240-252
    • (2008) Brain Pathol , vol.18 , pp. 240-252
    • Miners, J.S.1    Baig, S.2    Palmer, J.3
  • 25
    • 0034038036 scopus 로고    scopus 로고
    • Degradation of soluble amyloid beta-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains
    • Perez A, Morelli L, Cresto JC, et al. Degradation of soluble amyloid beta-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains. Neurochem Res 2000;25:247-255
    • (2000) Neurochem Res , vol.25 , pp. 247-255
    • Perez, A.1    Morelli, L.2    Cresto, J.C.3
  • 26
    • 34247100646 scopus 로고    scopus 로고
    • Insulin degrading enzyme activity selectively decreases in the hippocampal formation of cases at high risk to develop Alzheimer's disease
    • Zhao Z, Xiang Z, Haroutunian V, et al. Insulin degrading enzyme activity selectively decreases in the hippocampal formation of cases at high risk to develop Alzheimer's disease. Neurobiol Aging 2007;28: 824-830
    • (2007) Neurobiol Aging , vol.28 , pp. 824-830
    • Zhao, Z.1    Xiang, Z.2    Haroutunian, V.3
  • 27
    • 37549012213 scopus 로고    scopus 로고
    • Age-dependent decline of neprilysin in Alzheimer's disease and normal brain: Inverse correlation with Abeta levels
    • Hellstrom-Lindahl E, Ravid R, Nordberg A. Age-dependent decline of neprilysin in Alzheimer's disease and normal brain: Inverse correlation with Abeta levels. Neurobiol Aging 2008;29:210-221
    • (2008) Neurobiol Aging , vol.29 , pp. 210-221
    • Hellstrom-Lindahl, E.1    Ravid, R.2    Nordberg, A.3
  • 28
    • 13644266898 scopus 로고    scopus 로고
    • Age- and region-dependent alterations in Abeta-degrading enzymes: Implications for Abeta-induced disorders
    • Caccamo A, Oddo S, Sugarman MC, et al. Age- and region-dependent alterations in Abeta-degrading enzymes: Implications for Abeta-induced disorders. Neurobiol Aging 2005;26:645-654
    • (2005) Neurobiol Aging , vol.26 , pp. 645-654
    • Caccamo, A.1    Oddo, S.2    Sugarman, M.C.3
  • 29
    • 28444463703 scopus 로고    scopus 로고
    • Brain neprilysin activity and susceptibility to transgene-induced Alzheimer amyloidosis
    • Carter TL, Pedrini S, Ghiso J, et al. Brain neprilysin activity and susceptibility to transgene-induced Alzheimer amyloidosis. Neurosci Lett 2006;392:235-239
    • (2006) Neurosci Lett , vol.392 , pp. 235-239
    • Carter, T.L.1    Pedrini, S.2    Ghiso, J.3
  • 30
    • 0037219221 scopus 로고    scopus 로고
    • Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 allele
    • Cook DG, Leverenz JB, McMillan PJ, et al. Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 allele. Am J Pathol 2003; 162:313-319
    • (2003) Am J Pathol , vol.162 , pp. 313-319
    • Cook, D.G.1    Leverenz, J.B.2    McMillan, P.J.3
  • 31
    • 28944439607 scopus 로고    scopus 로고
    • Beta-site APP cleaving enzyme 1 (BACE1) is increased in remaining neurons in Alzheimer's disease brains
    • Harada H, Tamaoka A, Ishii K, et al. Beta-site APP cleaving enzyme 1 (BACE1) is increased in remaining neurons in Alzheimer's disease brains. Neurosci Res 2006;54:24-29
    • (2006) Neurosci Res , vol.54 , pp. 24-29
    • Harada, H.1    Tamaoka, A.2    Ishii, K.3
  • 32
    • 37049011221 scopus 로고    scopus 로고
    • Immunocapture-based fluorometric assay for the measurement of neprilysin-specific enzyme activity in brain tissue homogenates and cerebrospinal fluid
    • Miners JS, Verbeek MM, Rikkert MO, et al. Immunocapture-based fluorometric assay for the measurement of neprilysin-specific enzyme activity in brain tissue homogenates and cerebrospinal fluid. J Neurosci Methods 2008;167:229-236
    • (2008) J Neurosci Methods , vol.167 , pp. 229-236
    • Miners, J.S.1    Verbeek, M.M.2    Rikkert, M.O.3
  • 33
    • 39749194421 scopus 로고    scopus 로고
    • Immunocapture-based fluorometric assay for the measurement of insulin-degrading enzyme activity in brain tissue homogenates
    • Miners JS, Kehoe PG, Love S. Immunocapture-based fluorometric assay for the measurement of insulin-degrading enzyme activity in brain tissue homogenates. J Neurosci Methods 2008;169:177-181
    • (2008) J Neurosci Methods , vol.169 , pp. 177-181
    • Miners, J.S.1    Kehoe, P.G.2    Love, S.3
  • 34
    • 0035369189 scopus 로고    scopus 로고
    • Immunohistochemical localization of neprilysin in the human cerebral cortex: Inverse association with vulnerability to amyloid beta-protein (Abeta) deposition
    • Akiyama H, Kondo H, Ikeda K, et al. Immunohistochemical localization of neprilysin in the human cerebral cortex: Inverse association with vulnerability to amyloid beta-protein (Abeta) deposition. Brain Res 2001;902:277-281
    • (2001) Brain Res , vol.902 , pp. 277-281
    • Akiyama, H.1    Kondo, H.2    Ikeda, K.3
  • 35
    • 0035846826 scopus 로고    scopus 로고
    • Reduced neprilysin in high plaque areas of Alzheimer brain: A possible relationship to deficient degradation of beta-amyloid peptide
    • Yasojima K, Akiyama H, McGeer EG, et al. Reduced neprilysin in high plaque areas of Alzheimer brain: A possible relationship to deficient degradation of beta-amyloid peptide. Neurosci Lett 2001;297:97-100
    • (2001) Neurosci Lett , vol.297 , pp. 97-100
    • Yasojima, K.1    Akiyama, H.2    McGeer, E.G.3
  • 36
    • 20944435413 scopus 로고    scopus 로고
    • Decreased neprilysin immunoreactivity in Alzheimer disease, but not in pathological aging
    • Wang DS, Lipton RB, Katz MJ, et al. Decreased neprilysin immunoreactivity in Alzheimer disease, but not in pathological aging. J Neuropathol Exp Neurol 2005;64:378-385
    • (2005) J Neuropathol Exp Neurol , vol.64 , pp. 378-385
    • Wang, D.S.1    Lipton, R.B.2    Katz, M.J.3
  • 37
    • 27544432457 scopus 로고    scopus 로고
    • Neprylisin decreases uniformly in Alzheimer's disease and in normal aging
    • Russo R, Borghi R, Markesbery W, et al. Neprylisin decreases uniformly in Alzheimer's disease and in normal aging. FEBS Lett 2005;579: 6027-6030
    • (2005) FEBS Lett , vol.579 , pp. 6027-6030
    • Russo, R.1    Borghi, R.2    Markesbery, W.3
  • 38
    • 20444426464 scopus 로고    scopus 로고
    • Cerebrospinal fluid neprilysin is reduced in prodromal Alzheimer's disease
    • Maruyama M, Higuchi M, Takaki Y, et al. Cerebrospinal fluid neprilysin is reduced in prodromal Alzheimer's disease. Ann Neurol 2005;57: 832-842
    • (2005) Ann Neurol , vol.57 , pp. 832-842
    • Maruyama, M.1    Higuchi, M.2    Takaki, Y.3
  • 39
    • 0037468588 scopus 로고    scopus 로고
    • Aging-related down-regulation of neprilysin, a putative beta-amyloid-degrading enzyme, in transgenic Tg2576 Alzheimer-like mouse brain is accompanied by an astroglial upregulation in the vicinity of beta-amyloid plaques
    • Apelt J, Ach K, Schliebs R. Aging-related down-regulation of neprilysin, a putative beta-amyloid-degrading enzyme, in transgenic Tg2576 Alzheimer-like mouse brain is accompanied by an astroglial upregulation in the vicinity of beta-amyloid plaques. Neurosci Lett 2003;339: 183-186
    • (2003) Neurosci Lett , vol.339 , pp. 183-186
    • Apelt, J.1    Ach, K.2    Schliebs, R.3
  • 40
    • 33749495463 scopus 로고    scopus 로고
    • Plaque-associated over-expression of insulin-degrading enzyme in the cerebral cortex of aged transgenic tg2576 mice with Alzheimer pathology
    • Leal MC, Dorfman VB, Gamba AF, et al. Plaque-associated over-expression of insulin-degrading enzyme in the cerebral cortex of aged transgenic tg2576 mice with Alzheimer pathology. J Neuropathol Exp Neurol 2006;65:976-987
    • (2006) J Neuropathol Exp Neurol , vol.65 , pp. 976-987
    • Leal, M.C.1    Dorfman, V.B.2    Gamba, A.F.3
  • 42
    • 0032900361 scopus 로고    scopus 로고
    • Activated isoforms of MMP-2 are induced in U87 human glioma cells in response to beta-amyloid peptide
    • Deb S, Zhang JW, Gottschall PE. Activated isoforms of MMP-2 are induced in U87 human glioma cells in response to beta-amyloid peptide. J Neurosci Res 1999;55:44-53
    • (1999) J Neurosci Res , vol.55 , pp. 44-53
    • Deb, S.1    Zhang, J.W.2    Gottschall, P.E.3
  • 43
    • 0038241040 scopus 로고    scopus 로고
    • Pathogenic A beta induces the expression and activation of matrix metalloproteinase-2 in human cerebrovascular smooth muscle cells
    • Jung SS, Zhang W, Van Nostrand WE. Pathogenic A beta induces the expression and activation of matrix metalloproteinase-2 in human cerebrovascular smooth muscle cells. J Neurochem 2003;85:1208-1215
    • (2003) J Neurochem , vol.85 , pp. 1208-1215
    • Jung, S.S.1    Zhang, W.2    Van Nostrand, W.E.3
  • 44
    • 0041835847 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 and spontaneous hemorrhage in an animal model of cerebral amyloid angiopathy
    • Lee JM, Yin KJ, Hsin I, et al. Matrix metalloproteinase-9 and spontaneous hemorrhage in an animal model of cerebral amyloid angiopathy. Ann Neurol 2003;54:379-382
    • (2003) Ann Neurol , vol.54 , pp. 379-382
    • Lee, J.M.1    Yin, K.J.2    Hsin, I.3
  • 45
    • 0033788789 scopus 로고    scopus 로고
    • Tissue plasminogen activator requires plasminogen to modulate amyloid-beta neurotoxicity and deposition
    • Tucker HM, Kihiko-Ehmann M, Wright S, et al. Tissue plasminogen activator requires plasminogen to modulate amyloid-beta neurotoxicity and deposition. J Neurochem 2000;75:2172-2177
    • (2000) J Neurochem , vol.75 , pp. 2172-2177
    • Tucker, H.M.1    Kihiko-Ehmann, M.2    Wright, S.3
  • 46
    • 49649123892 scopus 로고    scopus 로고
    • Overexpression of neprilysin reduces Alzheimer amyloid-beta42 (Abeta42)Yinduced neuron loss and intraneuronal Abeta42 deposits but causes a reduction in cAMP-responsive element-binding proteinYmediated transcription, agedependent axon pathology, and premature death in Drosophila
    • Iijima-Ando K, Hearn SA, Granger L, et al. Overexpression of neprilysin reduces Alzheimer amyloid-beta42 (Abeta42)Yinduced neuron loss and intraneuronal Abeta42 deposits but causes a reduction in cAMP-responsive element-binding proteinYmediated transcription, agedependent axon pathology, and premature death in Drosophila. J Biol Chem 2008;283:19066-19076
    • (2008) J Biol Chem , vol.283 , pp. 19066-19076
    • Iijima-Ando, K.1    Hearn, S.A.2    Granger, L.3
  • 47
    • 20444398562 scopus 로고    scopus 로고
    • Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP
    • Pardossi-Piquard R, Petit A, Kawarai T, et al. Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP. Neuron 2005;46:541-554
    • (2005) Neuron , vol.46 , pp. 541-554
    • Pardossi-Piquard, R.1    Petit, A.2    Kawarai, T.3
  • 48
    • 70349121955 scopus 로고    scopus 로고
    • Response to: Pardossi-Piquard et al. BPresenilin- Dependent Transcriptional Control of the Abeta-Degrading Enzyme Neprilysin by Intracellular Domains of betaAPP and APLP.
    • Chen AC, Selkoe DJ. Response to: Pardossi-Piquard et al. BPresenilin- Dependent Transcriptional Control of the Abeta-Degrading Enzyme Neprilysin by Intracellular Domains of betaAPP and APLP.[ Neuron 46, 541-554
    • Neuron , vol.46 , pp. 541-554
    • Chen, A.C.1    Selkoe, D.J.2
  • 49
    • 33846807664 scopus 로고    scopus 로고
    • Neuron 2007;53:479-83
    • (2007) Neuron , vol.53 , pp. 479-83
  • 50
    • 0029908495 scopus 로고    scopus 로고
    • CD10/neutral endopeptidase 24.11 is phosphorylated by casein kinase II and coassociates with other phosphoproteins including the lyn srcYrelated kinase
    • Ganju RK, Shpektor RG, Brenner DG, et al. CD10/neutral endopeptidase 24.11 is phosphorylated by casein kinase II and coassociates with other phosphoproteins including the lyn srcYrelated kinase. Blood 1996; 88:4159-4165
    • (1996) Blood , vol.88 , pp. 4159-4165
    • Ganju, R.K.1    Shpektor, R.G.2    Brenner, D.G.3
  • 51
    • 39849110726 scopus 로고    scopus 로고
    • The GSK3 hypothesis of Alzheimer's disease
    • Hooper C, Killick R, Lovestone S. The GSK3 hypothesis of Alzheimer's disease. J Neurochem 2008;104:1433-1439
    • (2008) J Neurochem , vol.104 , pp. 1433-1439
    • Hooper, C.1    Killick, R.2    Lovestone, S.3
  • 52
    • 17644425569 scopus 로고    scopus 로고
    • Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation
    • Saito T, Iwata N, Tsubuki S, et al. Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation. Nat Med 2005;11:434-439
    • (2005) Nat Med , vol.11 , pp. 434-439
    • Saito, T.1    Iwata, N.2    Tsubuki, S.3
  • 53
    • 0032500857 scopus 로고    scopus 로고
    • Loss of somatostatinlike immunoreactivity in the frontal cortex of Alzheimer patients carrying the apolipoprotein epsilon 4 allele
    • Grouselle D, Winsky-Sommerer R, David JP, et al. Loss of somatostatinlike immunoreactivity in the frontal cortex of Alzheimer patients carrying the apolipoprotein epsilon 4 allele. Neurosci Lett 1998;255: 21-24
    • (1998) Neurosci Lett , vol.255 , pp. 21-24
    • Grouselle, D.1    Winsky-Sommerer, R.2    David, J.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.