메뉴 건너뛰기




Volumn 43, Issue 2, 2011, Pages 305-311

The role of IκB kinase complex in the neurobiology of Huntington's disease

Author keywords

DNA damage; Htt cleavage; Huntington's disease; IKK ; Neuroinflammation

Indexed keywords

4 (2 AMINOETHYLAMINO) 1,8 DIMETHYLIMIDAZO[1,2 A]QUINOXALINE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; ENZYME INHIBITOR; HUNTINGTIN; I KAPPA B KINASE BETA; I KAPPA B KINASE BETA INHIBITOR; MUTANT PROTEIN; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

EID: 79958191139     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2011.04.015     Document Type: Review
Times cited : (41)

References (56)
  • 3
    • 34447130222 scopus 로고    scopus 로고
    • Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild type and mutant huntingtin toxicity in neurons
    • Anne S.L., Saudou F., Humbert S. Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild type and mutant huntingtin toxicity in neurons. J. Neurosci. 2007, 27:7318-7328.
    • (2007) J. Neurosci. , vol.27 , pp. 7318-7328
    • Anne, S.L.1    Saudou, F.2    Humbert, S.3
  • 4
    • 21544450545 scopus 로고    scopus 로고
    • P53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease
    • Bae B.I., Xu H., Igarashi S., Fujimuro M., Agrawal N., Taya Y., et al. p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease. Neuron 2005, 47:29-41.
    • (2005) Neuron , vol.47 , pp. 29-41
    • Bae, B.I.1    Xu, H.2    Igarashi, S.3    Fujimuro, M.4    Agrawal, N.5    Taya, Y.6
  • 5
    • 49249089029 scopus 로고    scopus 로고
    • A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease
    • Björkqvist M., Wild E.J., Thiele J., Silvestroni A., Andre R., Lahiri N., et al. A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease. J. Exp. Med. 2008, 205:1869-1877.
    • (2008) J. Exp. Med. , vol.205 , pp. 1869-1877
    • Björkqvist, M.1    Wild, E.J.2    Thiele, J.3    Silvestroni, A.4    Andre, R.5    Lahiri, N.6
  • 6
    • 77952584927 scopus 로고    scopus 로고
    • RNAi therapeutics for CNS disorders
    • Boudreau R.L., Davidson B.L. RNAi therapeutics for CNS disorders. Brain Res. 2010, 1338:112-121.
    • (2010) Brain Res. , vol.1338 , pp. 112-121
    • Boudreau, R.L.1    Davidson, B.L.2
  • 8
    • 0032581167 scopus 로고    scopus 로고
    • Trinucleotide (CAG) repeat length is positively correlated with the degree of DNA fragmentation in Huntington's disease striatum
    • Butterworth N.J., Williams L., Bullock J.Y., Love D.R., Faull R.L., Dragunow M. Trinucleotide (CAG) repeat length is positively correlated with the degree of DNA fragmentation in Huntington's disease striatum. Neuroscience 1998, 87:49-53.
    • (1998) Neuroscience , vol.87 , pp. 49-53
    • Butterworth, N.J.1    Williams, L.2    Bullock, J.Y.3    Love, D.R.4    Faull, R.L.5    Dragunow, M.6
  • 9
    • 68749103771 scopus 로고    scopus 로고
    • The NF-kappaB-independent functions of IKK subunits in immunity and cancer
    • Chariot A. The NF-kappaB-independent functions of IKK subunits in immunity and cancer. Trends Cell Biol. 2009, 19:404-413.
    • (2009) Trends Cell Biol. , vol.19 , pp. 404-413
    • Chariot, A.1
  • 10
    • 55749113001 scopus 로고    scopus 로고
    • Role of microglial IKK beta in kainic acid-induced hippocampal neuronal cell death
    • Cho I.H., Hong J., Suh E.C., Kim J.H., Lee H., Lee J.E., et al. Role of microglial IKK beta in kainic acid-induced hippocampal neuronal cell death. Brain 2008, 131:3019-3033.
    • (2008) Brain , vol.131 , pp. 3019-3033
    • Cho, I.H.1    Hong, J.2    Suh, E.C.3    Kim, J.H.4    Lee, H.5    Lee, J.E.6
  • 11
    • 36749015082 scopus 로고    scopus 로고
    • Selective inhibition of NF-kappaB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease
    • Ghosh A., Roy A., Liu X., Kordower J.H., Mufson E.J., Hartley D.M., et al. Selective inhibition of NF-kappaB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease. Proc. Natl. Acad. Sci. U. S. A. 2007, 104:18754-18759.
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 18754-18759
    • Ghosh, A.1    Roy, A.2    Liu, X.3    Kordower, J.H.4    Mufson, E.J.5    Hartley, D.M.6
  • 12
    • 77950363010 scopus 로고    scopus 로고
    • Mechanisms underlying inflammation in neurodegeneration
    • Glass C.K., Saijo K., Winner B., Marchetto M.C., Gage F.H. Mechanisms underlying inflammation in neurodegeneration. Cell 2010, 140:918-934.
    • (2010) Cell , vol.140 , pp. 918-934
    • Glass, C.K.1    Saijo, K.2    Winner, B.3    Marchetto, M.C.4    Gage, F.H.5
  • 13
    • 77955436243 scopus 로고    scopus 로고
    • Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis
    • Godin J.D., Colombo K., Molina-Calavita M., Keryer G., Zala D., et al. Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis. Neuron 2010, 67:392-406.
    • (2010) Neuron , vol.67 , pp. 392-406
    • Godin, J.D.1    Colombo, K.2    Molina-Calavita, M.3    Keryer, G.4    Zala, D.5
  • 14
    • 33745003424 scopus 로고    scopus 로고
    • Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin
    • Graham R.K., Deng Y., Slow E.J., Haigh B., Bissada N., Lu G., et al. Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin. Cell 2006, 125:1179-1191.
    • (2006) Cell , vol.125 , pp. 1179-1191
    • Graham, R.K.1    Deng, Y.2    Slow, E.J.3    Haigh, B.4    Bissada, N.5    Lu, G.6
  • 15
    • 52049127039 scopus 로고    scopus 로고
    • From synapse to nucleus: calcium-dependent gene transcription in the control of synapse development and function
    • Greer P.L., Greenberg M.E. From synapse to nucleus: calcium-dependent gene transcription in the control of synapse development and function. Neuron 2008, 59:846-860.
    • (2008) Neuron , vol.59 , pp. 846-860
    • Greer, P.L.1    Greenberg, M.E.2
  • 16
    • 72149107077 scopus 로고    scopus 로고
    • Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice
    • Gu X., Greiner E.R., Mishra R., Kodali R., Osmand A., Finkbeiner S., et al. Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice. Neuron 2009, 64:828-840.
    • (2009) Neuron , vol.64 , pp. 828-840
    • Gu, X.1    Greiner, E.R.2    Mishra, R.3    Kodali, R.4    Osmand, A.5    Finkbeiner, S.6
  • 17
    • 39049183044 scopus 로고    scopus 로고
    • Regulation and function of IKK and IKK-related kinases
    • Hacker H., Karin M. Regulation and function of IKK and IKK-related kinases. Sci. STKE 2006, 357:re13.
    • (2006) Sci. STKE , vol.357
    • Hacker, H.1    Karin, M.2
  • 18
    • 79952615363 scopus 로고    scopus 로고
    • Preferential accumulation of N-terminal mutant huntingtin in the nuclei of striatal neurons is regulated by phosphorylation
    • Havel L.S., Wang C.E., Wade B., Huang B., Li S., Li X.J. Preferential accumulation of N-terminal mutant huntingtin in the nuclei of striatal neurons is regulated by phosphorylation. Hum. Mol. Genet. 2011, 20:1424-1437.
    • (2011) Hum. Mol. Genet. , vol.20 , pp. 1424-1437
    • Havel, L.S.1    Wang, C.E.2    Wade, B.3    Huang, B.4    Li, S.5    Li, X.J.6
  • 20
    • 34047248402 scopus 로고    scopus 로고
    • Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB
    • Huang W.C., Ju T.K., Hung M.C., Chen C.C. Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB. Mol. Cell 2007, 26:75-87.
    • (2007) Mol. Cell , vol.26 , pp. 75-87
    • Huang, W.C.1    Ju, T.K.2    Hung, M.C.3    Chen, C.C.4
  • 21
    • 33845609294 scopus 로고    scopus 로고
    • Bim and Noxa are candidates to mediate the deleterious effect of the NF-kappa B subunit RelA in cerebral ischemia
    • Inta I., Paxian S., Maegele I., Zhang W., Pizzi M., Spano P., et al. Bim and Noxa are candidates to mediate the deleterious effect of the NF-kappa B subunit RelA in cerebral ischemia. J. Neurosci. 2006, 26:12896-12903.
    • (2006) J. Neurosci. , vol.26 , pp. 12896-12903
    • Inta, I.1    Paxian, S.2    Maegele, I.3    Zhang, W.4    Pizzi, M.5    Spano, P.6
  • 23
    • 45449088310 scopus 로고    scopus 로고
    • DNA strand breaks, neurodegeneration and aging in the brain
    • Katyal S., McKinnon P.J. DNA strand breaks, neurodegeneration and aging in the brain. Mech. Ageing Dev. 2008, 129:483-491.
    • (2008) Mech. Ageing Dev. , vol.129 , pp. 483-491
    • Katyal, S.1    McKinnon, P.J.2
  • 24
    • 84873091910 scopus 로고    scopus 로고
    • in preparation. IKKα regulates MeCP2 activity and the expression of BDNF.
    • Khoshnan, A., Patterson, P.H., in preparation. IKKα regulates MeCP2 activity and the expression of BDNF.
    • Khoshnan, A.1    Patterson, P.H.2
  • 25
    • 0037154165 scopus 로고    scopus 로고
    • Effects of intracellular expression of anti-huntingtin antibodies of various specificities on mutant huntingtin aggregation and toxicity
    • Khoshnan A., Ko J., Patterson P.H. Effects of intracellular expression of anti-huntingtin antibodies of various specificities on mutant huntingtin aggregation and toxicity. Proc. Natl. Acad. Sci. U. S. A. 2002, 99:1002-1007.
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 1002-1007
    • Khoshnan, A.1    Ko, J.2    Patterson, P.H.3
  • 26
    • 4644307407 scopus 로고    scopus 로고
    • Activation of the IkappaB kinase complex and nuclear factor-kappaB contributes to mutant huntingtin neurotoxicity
    • Khoshnan A., Ko J., Watkin E.E., Paige L.A., Reinhart P.H., Patterson P.H. Activation of the IkappaB kinase complex and nuclear factor-kappaB contributes to mutant huntingtin neurotoxicity. J. Neurosci. 2004, 24:7999-8008.
    • (2004) J. Neurosci. , vol.24 , pp. 7999-8008
    • Khoshnan, A.1    Ko, J.2    Watkin, E.E.3    Paige, L.A.4    Reinhart, P.H.5    Patterson, P.H.6
  • 27
    • 66849129318 scopus 로고    scopus 로고
    • IKKα and IKKβ regulation of DNA damage-induced cleavage of huntingtin
    • Khoshnan A., Ko J., Tescu S., Brundin P., Patterson P.H. IKKα and IKKβ regulation of DNA damage-induced cleavage of huntingtin. PLoS One 2009, 4:e5768.
    • (2009) PLoS One , vol.4
    • Khoshnan, A.1    Ko, J.2    Tescu, S.3    Brundin, P.4    Patterson, P.H.5
  • 28
    • 68649128600 scopus 로고    scopus 로고
    • Linking cell cycle reentry and DNA damage in neurodegeneration
    • Kim D., Tsai L.H. Linking cell cycle reentry and DNA damage in neurodegeneration. Ann. N.Y. Acad. Sci. 2009, 1170:674-679.
    • (2009) Ann. N.Y. Acad. Sci. , vol.1170 , pp. 674-679
    • Kim, D.1    Tsai, L.H.2
  • 29
    • 0035940412 scopus 로고    scopus 로고
    • Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis
    • Kim Y.J., Yi Y., Sapp E., Wang Y., Cuiffo B., Kegel K.B., et al. Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:12784-12789.
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 12784-12789
    • Kim, Y.J.1    Yi, Y.2    Sapp, E.3    Wang, Y.4    Cuiffo, B.5    Kegel, K.B.6
  • 31
    • 77950584656 scopus 로고    scopus 로고
    • Proteolysis of mutant huntingtin produces an exon 1 fragment that accumulates as an aggregated protein in neuronal nuclei in Huntington disease
    • Landles C., Sathasivam K., Weiss A., Woodman B., Moffitt H., Finkbeiner S., et al. Proteolysis of mutant huntingtin produces an exon 1 fragment that accumulates as an aggregated protein in neuronal nuclei in Huntington disease. J. Biol. Chem. 2010, 285:8808-8823.
    • (2010) J. Biol. Chem. , vol.285 , pp. 8808-8823
    • Landles, C.1    Sathasivam, K.2    Weiss, A.3    Woodman, B.4    Moffitt, H.5    Finkbeiner, S.6
  • 32
    • 53249129484 scopus 로고    scopus 로고
    • Advances in targeting IKK and IKK-related kinases for cancer therapy
    • Lee D.F., Hung M.C. Advances in targeting IKK and IKK-related kinases for cancer therapy. Clin. Cancer Res. 2008, 14:5656-5662.
    • (2008) Clin. Cancer Res. , vol.14 , pp. 5656-5662
    • Lee, D.F.1    Hung, M.C.2
  • 34
    • 34548585044 scopus 로고    scopus 로고
    • The IkappaB kinase regulates chromatin structure during reconsolidation of conditioned fear memories
    • Lubin F.D., Sweatt J.D. The IkappaB kinase regulates chromatin structure during reconsolidation of conditioned fear memories. Neuron 2007, 55:942-957.
    • (2007) Neuron , vol.55 , pp. 942-957
    • Lubin, F.D.1    Sweatt, J.D.2
  • 35
    • 67650382096 scopus 로고    scopus 로고
    • Inhibiting proinflammatory NF-kappaB signaling using cell penetrating NEMO binding domain peptides
    • Madge L.A., May M.J. Inhibiting proinflammatory NF-kappaB signaling using cell penetrating NEMO binding domain peptides. Methods Mol. Biol. 2009, 512:209-232.
    • (2009) Methods Mol. Biol. , vol.512 , pp. 209-232
    • Madge, L.A.1    May, M.J.2
  • 36
    • 77952419246 scopus 로고    scopus 로고
    • Mutations of optineurin in amyotrophic lateral sclerosis
    • Maruyama H., Morino H., Ito H., Izumi Y., Kato H., Watanabe Y., et al. Mutations of optineurin in amyotrophic lateral sclerosis. Nature 2010, 465:223-226.
    • (2010) Nature , vol.465 , pp. 223-226
    • Maruyama, H.1    Morino, H.2    Ito, H.3    Izumi, Y.4    Kato, H.5    Watanabe, Y.6
  • 37
    • 33646010041 scopus 로고    scopus 로고
    • Roles for NF-kappaB in nerve cell survival, plasticity, and disease
    • Mattson M.P., Meffert M.K. Roles for NF-kappaB in nerve cell survival, plasticity, and disease. Cell Death Differ. 2006, 13:852-860.
    • (2006) Cell Death Differ. , vol.13 , pp. 852-860
    • Mattson, M.P.1    Meffert, M.K.2
  • 38
    • 0033587128 scopus 로고    scopus 로고
    • Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease
    • Ona V.O., Li M., Vonsattel J.P., Andrews L.J., Khan S.Q., Chung W.M., et al. Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease. Nature 1999, 399:263-267.
    • (1999) Nature , vol.399 , pp. 263-267
    • Ona, V.O.1    Li, M.2    Vonsattel, J.P.3    Andrews, L.J.4    Khan, S.Q.5    Chung, W.M.6
  • 39
    • 79953672493 scopus 로고    scopus 로고
    • I{kappa}B kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-{kappa}B in the central nervous system
    • Raasch J., Zeller N., van Loo G., Merkler D., Mildner A., Erny D., Knobeloch K.P., et al. I{kappa}B kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-{kappa}B in the central nervous system. Brain 2011, 134:1184-1198.
    • (2011) Brain , vol.134 , pp. 1184-1198
    • Raasch, J.1    Zeller, N.2    van Loo, G.3    Merkler, D.4    Mildner, A.5    Erny, D.6    Knobeloch, K.P.7
  • 40
    • 67449094981 scopus 로고    scopus 로고
    • Mutant huntingtin N-terminal fragments of specific size mediate aggregation and toxicity in neuronal cells
    • Ratovitski T., Gucek M., Jiang H., Chighladze E., Waldron E., D'Ambola J., et al. Mutant huntingtin N-terminal fragments of specific size mediate aggregation and toxicity in neuronal cells. J. Biol. Chem. 2009, 284:10855-10867.
    • (2009) J. Biol. Chem. , vol.284 , pp. 10855-10867
    • Ratovitski, T.1    Gucek, M.2    Jiang, H.3    Chighladze, E.4    Waldron, E.5    D'Ambola, J.6
  • 41
    • 68249096784 scopus 로고    scopus 로고
    • Persistent DNA damage signaling triggers senescence-associated inflammatory cytokine secretion
    • Rodier F., Coppé J.P., Patil C.K., Hoeijmakers W.A., Muñoz D.P., Raza S.R., et al. Persistent DNA damage signaling triggers senescence-associated inflammatory cytokine secretion. Nat. Cell Biol. 2009, 11:973-979.
    • (2009) Nat. Cell Biol. , vol.11 , pp. 973-979
    • Rodier, F.1    Coppé, J.P.2    Patil, C.K.3    Hoeijmakers, W.A.4    Muñoz, D.P.5    Raza, S.R.6
  • 42
    • 63049083734 scopus 로고    scopus 로고
    • A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death
    • Saijo K., Winner B., Carson C.T., Collier J.G., Boyer L., Rosenfeld M.G., et al. A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death. Cell 2009, 137:47-59.
    • (2009) Cell , vol.137 , pp. 47-59
    • Saijo, K.1    Winner, B.2    Carson, C.T.3    Collier, J.G.4    Boyer, L.5    Rosenfeld, M.G.6
  • 43
    • 68249112361 scopus 로고    scopus 로고
    • Distinct neuroinflammatory profile in post-mortem human Huntington's disease
    • Silvestroni A., Faull R.L., Strand A.D., Möller T. Distinct neuroinflammatory profile in post-mortem human Huntington's disease. Neuroreport 2009, 20:1098-10103.
    • (2009) Neuroreport , vol.20 , pp. 1098-10103
    • Silvestroni, A.1    Faull, R.L.2    Strand, A.D.3    Möller, T.4
  • 44
    • 34447636065 scopus 로고    scopus 로고
    • Microglial activation in presymptomatic Huntington's disease gene carriers
    • Tai Y.F., Pavese N., Gerhard A., Tabrizi S.J., Barker R.A., Brooks D.J., et al. Microglial activation in presymptomatic Huntington's disease gene carriers. Brain 2007, 130:1759-1766.
    • (2007) Brain , vol.130 , pp. 1759-1766
    • Tai, Y.F.1    Pavese, N.2    Gerhard, A.3    Tabrizi, S.J.4    Barker, R.A.5    Brooks, D.J.6
  • 45
    • 0027480960 scopus 로고
    • A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
    • The Huntington's Disease Collaborative Research Group
    • The Huntington's Disease Collaborative Research Group A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 1993, 72:971-983.
    • (1993) Cell , vol.72 , pp. 971-983
  • 46
    • 72149124383 scopus 로고    scopus 로고
    • IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome
    • Thompson L.M., Aiken C.T., Kaltenbach L.S., Agrawal N., Illes K., Khoshnan A., et al. IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome. J. Cell Biol. 2009, 187:1083-1099.
    • (2009) J. Cell Biol. , vol.187 , pp. 1083-1099
    • Thompson, L.M.1    Aiken, C.T.2    Kaltenbach, L.S.3    Agrawal, N.4    Illes, K.5    Khoshnan, A.6
  • 48
    • 33747609345 scopus 로고    scopus 로고
    • Inhibition of transcription factor NF-kappaB in the central nervous system ameliorates autoimmune encephalomyelitis in mice
    • Van Loo G., De Lorenzi R., Schmidt H., Huth M., Mildner A., Schmidt-Supprian M., et al. Inhibition of transcription factor NF-kappaB in the central nervous system ameliorates autoimmune encephalomyelitis in mice. Nat. Immunol. 2006, 7:954-961.
    • (2006) Nat. Immunol. , vol.7 , pp. 954-961
    • Van Loo, G.1    De Lorenzi, R.2    Schmidt, H.3    Huth, M.4    Mildner, A.5    Schmidt-Supprian, M.6
  • 49
    • 12144288251 scopus 로고    scopus 로고
    • Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset
    • Wexler N.S., Lorimer J., Porter J., Gomez F., Moskowitz C., Shackell E., et al. Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:3498-3503.
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 3498-3503
    • Wexler, N.S.1    Lorimer, J.2    Porter, J.3    Gomez, F.4    Moskowitz, C.5    Shackell, E.6
  • 50
    • 47949129452 scopus 로고    scopus 로고
    • Induction of a pro-apoptotic ATM-NF-kappaB pathway and its repression by ATR in response to replication stress
    • Wu Z.H., Miyamoto S. Induction of a pro-apoptotic ATM-NF-kappaB pathway and its repression by ATR in response to replication stress. EMBO J. 2008, 27:1963-1973.
    • (2008) EMBO J. , vol.27 , pp. 1963-1973
    • Wu, Z.H.1    Miyamoto, S.2
  • 51
    • 33644538632 scopus 로고    scopus 로고
    • Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli
    • Wu Z.H., Shi Y., Tibbetts R.S., Miyamoto S. Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli. Science 2006, 311:1141-1146.
    • (2006) Science , vol.311 , pp. 1141-1146
    • Wu, Z.H.1    Shi, Y.2    Tibbetts, R.S.3    Miyamoto, S.4
  • 53
    • 52949096557 scopus 로고    scopus 로고
    • Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity
    • Zhang X., Zhang G., Zhang H., Karin M., Bai H., Cai D. Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell 2008, 135:61-73.
    • (2008) Cell , vol.135 , pp. 61-73
    • Zhang, X.1    Zhang, G.2    Zhang, H.3    Karin, M.4    Bai, H.5    Cai, D.6
  • 54
    • 77952411101 scopus 로고    scopus 로고
    • Inhibition of IkappaB kinase-beta protects dopamine neurons against lipopolysaccharide-induced neurotoxicity
    • Zhang F., Qian L., Flood P.M., Shi J.S., Hong J.S., Gao H.M. Inhibition of IkappaB kinase-beta protects dopamine neurons against lipopolysaccharide-induced neurotoxicity. J. Pharmacol. Exp. Ther. 2010, 333:822-833.
    • (2010) J. Pharmacol. Exp. Ther. , vol.333 , pp. 822-833
    • Zhang, F.1    Qian, L.2    Flood, P.M.3    Shi, J.S.4    Hong, J.S.5    Gao, H.M.6
  • 55
    • 34547924464 scopus 로고    scopus 로고
    • Optineurin negatively regulates TNFalpha-induced NF-kappaB activation by competing with NEMO for ubiquitinated RIP
    • Zhu G., Wu C.J., Zhao Y., Ashwell J.D. Optineurin negatively regulates TNFalpha-induced NF-kappaB activation by competing with NEMO for ubiquitinated RIP. Curr. Biol. 2007, 17:1438-1443.
    • (2007) Curr. Biol. , vol.17 , pp. 1438-1443
    • Zhu, G.1    Wu, C.J.2    Zhao, Y.3    Ashwell, J.D.4
  • 56
    • 77955643169 scopus 로고    scopus 로고
    • Molecular mechanisms and potential therapeutical targets in Huntington's disease
    • Zuccato C., Cattaneo E. Molecular mechanisms and potential therapeutical targets in Huntington's disease. Physiol. Rev. 2010, 90:905-981.
    • (2010) Physiol. Rev. , vol.90 , pp. 905-981
    • Zuccato, C.1    Cattaneo, E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.