메뉴 건너뛰기




Volumn 205, Issue , 2005, Pages 244-256

The immune system, amyloid-β peptide, and Alzheimer's disease

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN ANTIBODY; AMYLOID BETA PROTEIN[1-42]; ANTIBODY; IMMUNOGLOBULIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY M266; UNCLASSIFIED DRUG;

EID: 20344384992     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0105-2896.2005.00264.x     Document Type: Review
Times cited : (62)

References (78)
  • 2
    • 0002038785 scopus 로고    scopus 로고
    • "Variolation" and vaccination in late imperial China, ca 1570-1911
    • Plotkin SA, Fantini B, eds. Paris: Elsevier
    • Leung AKC. "Variolation" and vaccination in late imperial China, ca 1570-1911. In: Plotkin SA, Fantini B, eds. Vaccinia, Vaccination, Vaccinology. Paris: Elsevier, 1996:65.
    • (1996) Vaccinia, Vaccination, Vaccinology , pp. 65
    • Leung, A.K.C.1
  • 3
    • 20344389080 scopus 로고    scopus 로고
    • Edward Jenner's role in the introduction of smallpox vaccine p59
    • Plotkin SA, Fantini B, eds. Paris: Elsevier
    • Baxby D. Edward Jenner's role in the introduction of smallpox vaccine p59. In: Plotkin SA, Fantini B, eds. Vaccinia, Vaccination, Vaccinology. Paris: Elsevier, 1996.
    • (1996) Vaccinia, Vaccination, Vaccinology
    • Baxby, D.1
  • 5
    • 84925840665 scopus 로고
    • Ueber das zustandekommen der diphtherie-immunitat und der tetanus-immunitat bei theiren
    • von Behring EA, Kitasato S. Ueber das Zustandekommen der Diphtherie-Immunitat und der Tetanus-Immunitat bei Theiren. Deutsche Med Wochenschr 1890;16:1113-1114.
    • (1890) Deutsche Med Wochenschr , vol.16 , pp. 1113-1114
    • Von Behring, E.A.1    Kitasato, S.2
  • 6
    • 0035818044 scopus 로고    scopus 로고
    • Immunomodulation of autoimmune and inflammatory diseases with intravenous immune globulin
    • Kazatchkine MD, Kaveri SV. Immunomodulation of autoimmune and inflammatory diseases with intravenous immune globulin. N Engl J Med 2001;345:747-755.
    • (2001) N Engl J Med , vol.345 , pp. 747-755
    • Kazatchkine, M.D.1    Kaveri, S.V.2
  • 7
    • 0014404849 scopus 로고
    • Reciprocal change with age in antibody to extrinsic and intrinsic antigens
    • Rowley MJ, Buchanan H, Mackay IR. Reciprocal change with age in antibody to extrinsic and intrinsic antigens. Lancet 1968;2:24-26.
    • (1968) Lancet , vol.2 , pp. 24-26
    • Rowley, M.J.1    Buchanan, H.2    Mackay, I.R.3
  • 8
    • 0025810756 scopus 로고
    • "Cross-wiring" of the immune response in old mice: Increased autoantibody response despite reduced antibody response to nominal antigen
    • Bovbjerg DH, Kim YT, Schwab R, Schmitt K, DeBlasio T, Weksler ME. "Cross-wiring" of the immune response in old mice: increased autoantibody response despite reduced antibody response to nominal antigen. Cell Immunol 1991;135:519-525.
    • (1991) Cell Immunol , vol.135 , pp. 519-525
    • Bovbjerg, D.H.1    Kim, Y.T.2    Schwab, R.3    Schmitt, K.4    DeBlasio, T.5    Weksler, M.E.6
  • 10
    • 0003430697 scopus 로고
    • Autoantibodies and the physiological role of immunoglobulins
    • Grabar P. Autoantibodies and the physiological role of immunoglobulins. Immunol Today 1983;4:337-340.
    • (1983) Immunol Today , vol.4 , pp. 337-340
    • Grabar, P.1
  • 12
    • 0027394331 scopus 로고
    • Lower antibody response to tetanus toxoid associated with higher auto-antiidiotypic antibody in old compared with young humans
    • Areaza EE, Gibbons JJ, Siskind GW, Weksler ME. Lower antibody response to tetanus toxoid associated with higher auto-antiidiotypic antibody in old compared with young humans. Clin Exp Immunol 1993;92:169-173.
    • (1993) Clin Exp Immunol , vol.92 , pp. 169-173
    • Areaza, E.E.1    Gibbons, J.J.2    Siskind, G.W.3    Weksler, M.E.4
  • 13
    • 4444277259 scopus 로고    scopus 로고
    • Neuroimmunology of the paraneoplastic neurological degenerations
    • Roberts WK, Darnell RB. Neuroimmunology of the paraneoplastic neurological degenerations. Curr Opin Immunol 2004;16:616-622.
    • (2004) Curr Opin Immunol , vol.16 , pp. 616-622
    • Roberts, W.K.1    Darnell, R.B.2
  • 15
    • 0036085702 scopus 로고    scopus 로고
    • Patients with Alzheimer disease have lower levels of serum anti-amyloid peptide antibodies than healthy elderly individuals
    • Weksler ME, Relkin N, Turkenich R, LaRusse S, Zhou L, Szabo P. Patients with Alzheimer disease have lower levels of serum anti-amyloid peptide antibodies than healthy elderly individuals. Exp Gerontol 2002;37:943-948.
    • (2002) Exp Gerontol , vol.37 , pp. 943-948
    • Weksler, M.E.1    Relkin, N.2    Turkenich, R.3    LaRusse, S.4    Zhou, L.5    Szabo, P.6
  • 16
    • 0029742199 scopus 로고    scopus 로고
    • Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice
    • Hsiao K, et al. Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 1996;274:99-102.
    • (1996) Science , vol.274 , pp. 99-102
    • Hsiao, K.1
  • 17
    • 0021207461 scopus 로고
    • Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein
    • Glenner GG, Wong CW. Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein. Biochem Biophys Res Commun 1994;122:1131-1135.
    • (1994) Biochem Biophys Res Commun , vol.122 , pp. 1131-1135
    • Glenner, G.G.1    Wong, C.W.2
  • 18
    • 0023105114 scopus 로고
    • The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
    • Kang J, et al. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 1987;325:733-736.
    • (1987) Nature , vol.325 , pp. 733-736
    • Kang, J.1
  • 19
    • 1542299128 scopus 로고    scopus 로고
    • Toward Alzheimer therapies based on genetic knowledge
    • Hardy J. Toward Alzheimer therapies based on genetic knowledge. Annu Rev Med 2004;55:15-25.
    • (2004) Annu Rev Med , vol.55 , pp. 15-25
    • Hardy, J.1
  • 20
    • 0028985574 scopus 로고
    • Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein
    • Games D, et al. Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein. Nature 1995;373:523-527.
    • (1995) Nature , vol.373 , pp. 523-527
    • Games, D.1
  • 21
    • 13044287361 scopus 로고    scopus 로고
    • Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models
    • Hsia AY, et al. Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models. Proc Natl Acad Sci USA 1999;96:3228-3233.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 3228-3233
    • Hsia, A.Y.1
  • 22
    • 0032590054 scopus 로고    scopus 로고
    • Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease
    • McLean CA, et al. Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease. Ann Neurol 1999;46:860-866.
    • (1999) Ann Neurol , vol.46 , pp. 860-866
    • McLean, C.A.1
  • 23
    • 0038117796 scopus 로고    scopus 로고
    • Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline
    • Naslund J, et al. Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline. J Am Med Assoc 2000;283:1571-1577.
    • (2000) J Am Med Assoc , vol.283 , pp. 1571-1577
    • Naslund, J.1
  • 25
    • 0035159785 scopus 로고    scopus 로고
    • Intracellular mechanisms of amyloid accumulation and pathogenesis in Alzheimer's disease
    • Glabe C. Intracellular mechanisms of amyloid accumulation and pathogenesis in Alzheimer's disease. J Mol Neurosci 2001;17:37-45.
    • (2001) J Mol Neurosci , vol.17 , pp. 37-45
    • Glabe, C.1
  • 26
    • 0033622324 scopus 로고    scopus 로고
    • Intraneuronal Abeta42 accumulation in human brain
    • Gouras GK, et al. Intraneuronal Abeta42 accumulation in human brain. Am J Pathol 2000;156:15-20.
    • (2000) Am J Pathol , vol.156 , pp. 15-20
    • Gouras, G.K.1
  • 27
    • 0042697305 scopus 로고    scopus 로고
    • Triple-transgenic model of Alzheimer's disease with plaques and tangles: Intracellular Abeta and synaptic dysfunction
    • Oddo S, et al. Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron 2003;39:409-421.
    • (2003) Neuron , vol.39 , pp. 409-421
    • Oddo, S.1
  • 28
    • 0034700480 scopus 로고    scopus 로고
    • A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease
    • Chen G, et al. A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease. Nature 2000;408:975-979.
    • (2000) Nature , vol.408 , pp. 975-979
    • Chen, G.1
  • 29
    • 4043167747 scopus 로고    scopus 로고
    • Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome
    • Oddo S, Billings L, Kesslak JP, Cribbs DH, LaFerla FM. Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome. Neuron 2004;43:321-332.
    • (2004) Neuron , vol.43 , pp. 321-332
    • Oddo, S.1    Billings, L.2    Kesslak, J.P.3    Cribbs, D.H.4    LaFerla, F.M.5
  • 30
    • 1542377619 scopus 로고    scopus 로고
    • Toxicity of amyloid beta peptide: Tales of calcium, mitochondria, and oxidative stress
    • Canevari L, Abramov AY, Duchen MR. Toxicity of amyloid beta peptide: tales of calcium, mitochondria, and oxidative stress. Neurochem Res 2004;29:637-650.
    • (2004) Neurochem Res , vol.29 , pp. 637-650
    • Canevari, L.1    Abramov, A.Y.2    Duchen, M.R.3
  • 31
    • 0033590975 scopus 로고    scopus 로고
    • High levels of circulating Abeta42 are sequestered by plasma proteins in Alzheimer's disease
    • Kuo YM, et al. High levels of circulating Abeta42 are sequestered by plasma proteins in Alzheimer's disease. Biochem Biophys Res Commun 1999;257:787-791.
    • (1999) Biochem Biophys Res Commun , vol.257 , pp. 787-791
    • Kuo, Y.M.1
  • 32
    • 12944291025 scopus 로고    scopus 로고
    • Overcoming antigen masking of anti-amyloidbeta antibodies reveals breaking of B cell tolerance by virus-like particles in amyloidbeta immunized amyloid precursor protein transgenic mice
    • Li Q, et al. Overcoming antigen masking of anti-amyloidbeta antibodies reveals breaking of B cell tolerance by virus-like particles in amyloidbeta immunized amyloid precursor protein transgenic mice. BMC Neurosci 2004;5:21-28.
    • (2004) BMC Neurosci , vol.5 , pp. 21-28
    • Li, Q.1
  • 33
    • 3242694207 scopus 로고    scopus 로고
    • An attenuated immune response is sufficient to enhance cognition in an Alzheimer's disease mouse model immunized with amyloid-beta derivatives
    • Sigurdsson EM, et al. An attenuated immune response is sufficient to enhance cognition in an Alzheimer's disease mouse model immunized with amyloid-beta derivatives. J Neurosci 2004;24:6277-6282.
    • (2004) J Neurosci , vol.24 , pp. 6277-6282
    • Sigurdsson, E.M.1
  • 34
    • 85047690140 scopus 로고    scopus 로고
    • A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model
    • Postina R, et al. A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model. J Clin Invest 2004;113:1456-1464.
    • (2004) J Clin Invest , vol.113 , pp. 1456-1464
    • Postina, R.1
  • 35
    • 0031626697 scopus 로고    scopus 로고
    • Abeta42, presenilins, and Alzheimer's disease
    • Iwatsubo T. Abeta42, presenilins, and Alzheimer's disease. Neurobiol Aging 1998;19:S11-S13.
    • (1998) Neurobiol Aging , vol.19
    • Iwatsubo, T.1
  • 37
    • 0031824782 scopus 로고    scopus 로고
    • Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity
    • Geula C, Wu CK, Saroff D, Lorenzo A, Yuan M, Yankner BA. Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity. Nat Med 1998;4:827-831.
    • (1998) Nat Med , vol.4 , pp. 827-831
    • Geula, C.1    Wu, C.K.2    Saroff, D.3    Lorenzo, A.4    Yuan, M.5    Yankner, B.A.6
  • 38
    • 11544279355 scopus 로고    scopus 로고
    • Diffusible, nonfibrillar ligands derived from Abeta 1-42 are potent central nervous system neurotoxins
    • Lambert MP, et al. Diffusible, nonfibrillar ligands derived from Abeta 1-42 are potent central nervous system neurotoxins. Proc Natl Acad Sci USA 1998;95:6448-6453.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 6448-6453
    • Lambert, M.P.1
  • 39
    • 0037041426 scopus 로고    scopus 로고
    • Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
    • Walsh DM, et al. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 2002;416:535-539.
    • (2002) Nature , vol.416 , pp. 535-539
    • Walsh, D.M.1
  • 40
    • 0037454478 scopus 로고    scopus 로고
    • Abeta levels in serum, CSF and brain, and cognitive deficits in APP + PS1 transgenic mice
    • Liu L, Tapiola T, Herukka SK, Heikkila M, Tanila H. Abeta levels in serum, CSF and brain, and cognitive deficits in APP + PS1 transgenic mice. Neuroreport 2003;14:163-166.
    • (2003) Neuroreport , vol.14 , pp. 163-166
    • Liu, L.1    Tapiola, T.2    Herukka, S.K.3    Heikkila, M.4    Tanila, H.5
  • 41
    • 0141529993 scopus 로고    scopus 로고
    • In vivo assessment of brain interstitial fluid with microdialysis reveals plaque-associated changes in amyloid-beta metabolism and half-life
    • Cirrito JR, et al. In vivo assessment of brain interstitial fluid with microdialysis reveals plaque-associated changes in amyloid-beta metabolism and half-life. J Neurosci 2003;23:8844-8853.
    • (2003) J Neurosci , vol.23 , pp. 8844-8853
    • Cirrito, J.R.1
  • 42
    • 18844472315 scopus 로고
    • Cerebrospinal fluid levels of amyloid beta-protein in Alzheimer's disease: Inverse correlation with severity of dementia and effect of apolipoprotein E genotype
    • Nitsch RM, et al. Cerebrospinal fluid levels of amyloid beta-protein in Alzheimer's disease: inverse correlation with severity of dementia and effect of apolipoprotein E genotype. Ann Neurol 1995;37:512-518.
    • (1995) Ann Neurol , vol.37 , pp. 512-518
    • Nitsch, R.M.1
  • 43
    • 0034027642 scopus 로고    scopus 로고
    • Age-dependent change in the level of Aβ40 and Aβ42 in cerebrospinal fluid from control subjects, and a decrease in the ratio of Aβ42 to Aβ40 level in cerebrospinal fluid from Alzheimer's disease patients
    • Fukuyama R, Mizuno T, Mori S, Nakajima K, Fushiki S, Yanagisawa K. Age-dependent change in the level of Aβ40 and Aβ42 in cerebrospinal fluid from control subjects, and a decrease in the ratio of Aβ42 to Aβ40 level in cerebrospinal fluid from Alzheimer's disease patients. Eur Neurol 2000;43:155-160.
    • (2000) Eur Neurol , vol.43 , pp. 155-160
    • Fukuyama, R.1    Mizuno, T.2    Mori, S.3    Nakajima, K.4    Fushiki, S.5    Yanagisawa, K.6
  • 44
    • 0030059065 scopus 로고    scopus 로고
    • Cerebrospinal fluid concentrations of soluble amyloid beta-protein and apolipoprotein E in patients with Alzheimer's disease: Correlations with amyloid load in the brain
    • Pirttila T, et al. Cerebrospinal fluid concentrations of soluble amyloid beta-protein and apolipoprotein E in patients with Alzheimer's disease: correlations with amyloid load in the brain. Arch Neurol 1996;53:189-193.
    • (1996) Arch Neurol , vol.53 , pp. 189-193
    • Pirttila, T.1
  • 45
    • 0242412140 scopus 로고    scopus 로고
    • Plasma A (beta) 40 and A (beta) 42 and Alzheimer's disease: Relation to age, mortality, and risk
    • Mayeux R, et al. Plasma A (beta) 40 and A (beta) 42 and Alzheimer's disease: relation to age, mortality, and risk. Neurology 2003;61:1185-1190.
    • (2003) Neurology , vol.61 , pp. 1185-1190
    • Mayeux, R.1
  • 46
    • 0034708137 scopus 로고    scopus 로고
    • Amyloid-beta peptides interact with plasma proteins and erythrocytes: Implications for their quantitation in plasma
    • Kuo YM, et al. Amyloid-beta peptides interact with plasma proteins and erythrocytes: implications for their quantitation in plasma. Biochem Biophys Res Commun 2000;268:750-756.
    • (2000) Biochem Biophys Res Commun , vol.268 , pp. 750-756
    • Kuo, Y.M.1
  • 47
    • 0037155581 scopus 로고    scopus 로고
    • Brain to plasma amyloid-beta efflux: A measure of brain amyloid burden in a mouse model of Alzheimer's disease
    • DeMattos RB, Bales KR, Cummins DJ, Paul SM, Holtzman DM. Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease. Science 2002;295:2264-2267.
    • (2002) Science , vol.295 , pp. 2264-2267
    • DeMattos, R.B.1    Bales, K.R.2    Cummins, D.J.3    Paul, S.M.4    Holtzman, D.M.5
  • 48
    • 0030925824 scopus 로고    scopus 로고
    • Increased incidence of anti-beta-amyloid autoantibodies secreted by Epstein - Barr virus transformed B cell lines from patients with Alzheimer's disease
    • Xu S, Gaskin F. Increased incidence of anti-beta-amyloid autoantibodies secreted by Epstein - Barr virus transformed B cell lines from patients with Alzheimer's disease. Mech Ageing Dev 1997;94:213-222.
    • (1997) Mech Ageing Dev , vol.94 , pp. 213-222
    • Xu, S.1    Gaskin, F.2
  • 49
    • 0035964312 scopus 로고    scopus 로고
    • Immune hyporesponsiveness to amyloid beta-peptide in amyloid precursor protein transgenic mice: Implications for the pathogenesis and treatment of Alzheimer's disease
    • Monsonego A, Maron R, Zota V, Selkoe DJ, Weiner HL. Immune hyporesponsiveness to amyloid beta-peptide in amyloid precursor protein transgenic mice: implications for the pathogenesis and treatment of Alzheimer's disease. Proc Natl Acad Sci USA 2001;98:10273-10278.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 10273-10278
    • Monsonego, A.1    Maron, R.2    Zota, V.3    Selkoe, D.J.4    Weiner, H.L.5
  • 50
    • 0001699385 scopus 로고
    • Alzheimer amyloid βA4 protein reactive antibodies in human sera and CSF
    • Iqbal K, et al., eds. Chichester, NY: Wiley
    • Monning U, et al. Alzheimer amyloid βA4 protein reactive antibodies in human sera and CSF. In: Iqbal K, et al., eds. Alzheimer's Disease: Basic Mechanisms, Diagnosis and Therapeutic Strategies. Chichester, NY: Wiley, 1991.
    • (1991) Alzheimer's Disease: Basic Mechanisms, Diagnosis and Therapeutic Strategies
    • Monning, U.1
  • 51
    • 0035845614 scopus 로고    scopus 로고
    • Reduced levels of amyloid beta-peptide antibody in Alzheimer disease
    • Du Y, et al. Reduced levels of amyloid beta-peptide antibody in Alzheimer disease. Neurology 2001;57:801-805.
    • (2001) Neurology , vol.57 , pp. 801-805
    • Du, Y.1
  • 52
    • 0034992393 scopus 로고    scopus 로고
    • Autoantibodies to amyloid-beta and Alzheimer's disease
    • Hyman BT, et al. Autoantibodies to amyloid-beta and Alzheimer's disease. Ann Neurol 2001;49:808-810.
    • (2001) Ann Neurol , vol.49 , pp. 808-810
    • Hyman, B.T.1
  • 53
    • 2942739009 scopus 로고    scopus 로고
    • Autoimmunity in Alzheimer's disease: Increased levels of circulating IgGs binding Abeta and RAGE peptides
    • Mruthinti S, et al. Autoimmunity in Alzheimer's disease: increased levels of circulating IgGs binding Abeta and RAGE peptides. Neurobiol Aging 2004;25:1023-1032.
    • (2004) Neurobiol Aging , vol.25 , pp. 1023-1032
    • Mruthinti, S.1
  • 55
    • 20444459853 scopus 로고    scopus 로고
    • Levels of autoantibodies to redox-modified Abeta are attenuated in the plasma of Alzheimer's disease patients
    • in press
    • Moir RD, et al. Levels of autoantibodies to redox-modified Abeta are attenuated in the plasma of Alzheimer's disease patients. J Biol Chem 2005; in press.
    • (2005) J Biol Chem
    • Moir, R.D.1
  • 56
    • 0029830124 scopus 로고    scopus 로고
    • APP peptides stimulate lymphocyte proliferation in normals, but not in patients with Alzheimer's disease
    • Trieb K, Ransmayr G, Sgonc R, Lassmann H, Grubeck-Loebenstein B. APP peptides stimulate lymphocyte proliferation in normals, but not in patients with Alzheimer's disease. Neurobiol Aging 1996;17:541-547.
    • (1996) Neurobiol Aging , vol.17 , pp. 541-547
    • Trieb, K.1    Ransmayr, G.2    Sgonc, R.3    Lassmann, H.4    Grubeck-Loebenstein, B.5
  • 57
    • 0041886776 scopus 로고    scopus 로고
    • Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease
    • Monsonego A, et al. Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease. J Clin Invest 2003;112:415-422.
    • (2003) J Clin Invest , vol.112 , pp. 415-422
    • Monsonego, A.1
  • 58
    • 0030007964 scopus 로고    scopus 로고
    • Sequence of deposition of heterogeneous amyloid beta-peptides and APOE in Down syndrome: Implications for initial events in amyloid plaque formation
    • Lemere CA, Blusztajn JK, Yamaguchi H, Wisniewski T, Saido TC, Selkoe DJ. Sequence of deposition of heterogeneous amyloid beta-peptides and APOE in Down syndrome: implications for initial events in amyloid plaque formation. Neurobiol Dis 1996;3:16-32.
    • (1996) Neurobiol Dis , vol.3 , pp. 16-32
    • Lemere, C.A.1    Blusztajn, J.K.2    Yamaguchi, H.3    Wisniewski, T.4    Saido, T.C.5    Selkoe, D.J.6
  • 59
    • 0034964390 scopus 로고    scopus 로고
    • Treatment with a copper - Zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice
    • Cherny RA, et al. Treatment with a copper - zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron 2001;30:665-676.
    • (2001) Neuron , vol.30 , pp. 665-676
    • Cherny, R.A.1
  • 60
    • 0033536163 scopus 로고    scopus 로고
    • Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
    • Schenk D, et al. Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 1999;400:173-177.
    • (1999) Nature , vol.400 , pp. 173-177
    • Schenk, D.1
  • 61
    • 0034700471 scopus 로고    scopus 로고
    • A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
    • Janus C, et al. A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature 2000;408:979-982.
    • (2000) Nature , vol.408 , pp. 979-982
    • Janus, C.1
  • 62
    • 84984755327 scopus 로고    scopus 로고
    • A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
    • Morgan D, et al. A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature 2000;408:982-985.
    • (2000) Nature , vol.408 , pp. 982-985
    • Morgan, D.1
  • 63
    • 0036780877 scopus 로고    scopus 로고
    • Amyloid-beta immunotherapy for Alzheimer's disease: The end of the beginning
    • Schenk D. Amyloid-beta immunotherapy for Alzheimer's disease: the end of the beginning. Nat Rev Neurosci 2002;3:824-828.
    • (2002) Nat Rev Neurosci , vol.3 , pp. 824-828
    • Schenk, D.1
  • 64
    • 0037112201 scopus 로고    scopus 로고
    • Cerebral hemorrhage after passive anti-Abeta immunotherapy
    • Pfeifer M, et al. Cerebral hemorrhage after passive anti-Abeta immunotherapy. Science 2002;298:1379.
    • (2002) Science , vol.298 , pp. 1379
    • Pfeifer, M.1
  • 65
    • 0036240395 scopus 로고    scopus 로고
    • Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model
    • Dodart JC, et al. Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model. Nat Neurosci 2002;5:452-457.
    • (2002) Nat Neurosci , vol.5 , pp. 452-457
    • Dodart, J.C.1
  • 66
    • 0036703483 scopus 로고    scopus 로고
    • Reversible memory loss in a mouse transgenic model of Alzheimer's disease
    • Kotilinek LA, et al. Reversible memory loss in a mouse transgenic model of Alzheimer's disease. J Neurosci 2002;22:6331-6335.
    • (2002) J Neurosci , vol.22 , pp. 6331-6335
    • Kotilinek, L.A.1
  • 67
    • 10744230547 scopus 로고    scopus 로고
    • Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization
    • Orgogozo JM, et al. Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization. Neurology 2003;61:46-54.
    • (2003) Neurology , vol.61 , pp. 46-54
    • Orgogozo, J.M.1
  • 68
    • 0037393454 scopus 로고    scopus 로고
    • Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: A case report
    • Nicoll JA, Wilkinson D, Holmes C, Steart P, Markham H, Weller RO. Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report. Nat Med 2003;9:448-452.
    • (2003) Nat Med , vol.9 , pp. 448-452
    • Nicoll, J.A.1    Wilkinson, D.2    Holmes, C.3    Steart, P.4    Markham, H.5    Weller, R.O.6
  • 69
    • 0036853548 scopus 로고    scopus 로고
    • Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer disease
    • Hock C, et al. Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer disease. Nat Med 2002;8:1270-1275.
    • (2002) Nat Med , vol.8 , pp. 1270-1275
    • Hock, C.1
  • 70
    • 0038100154 scopus 로고    scopus 로고
    • Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease
    • Hock C, et al. Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease. Neuron 2003;38:547-554.
    • (2003) Neuron , vol.38 , pp. 547-554
    • Hock, C.1
  • 71
    • 0033835996 scopus 로고    scopus 로고
    • Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
    • Bard F, et al. Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat Med 2000;6:916-919.
    • (2000) Nat Med , vol.6 , pp. 916-919
    • Bard, F.1
  • 73
    • 0037107177 scopus 로고    scopus 로고
    • Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy
    • Bacskai BJ, et al. Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy. J Neurosci 2002;22:7873-7878.
    • (2002) J Neurosci , vol.22 , pp. 7873-7878
    • Bacskai, B.J.1
  • 74
    • 0037452779 scopus 로고    scopus 로고
    • Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer's disease-like neuropathology
    • Bard F, et al. Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer's disease-like neuropathology. Proc Natl Acad Sci USA 2003;100:2023-2028.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 2023-2028
    • Bard, F.1
  • 75
    • 0041320819 scopus 로고    scopus 로고
    • Human anti-beta-amyloid antibodies block beta-amyloid fibril formation and prevent beta-amyloid-induced neurotoxicity
    • Du Y, et al. Human anti-beta-amyloid antibodies block beta-amyloid fibril formation and prevent beta-amyloid-induced neurotoxicity. Brain 2003;126:1935-1939.
    • (2003) Brain , vol.126 , pp. 1935-1939
    • Du, Y.1
  • 76
    • 4644275963 scopus 로고    scopus 로고
    • Intravenous immunoglobulins containing antibodies against beta-amyloid for the treatment of Alzheimer's disease
    • Dodel RC, et al. Intravenous immunoglobulins containing antibodies against beta-amyloid for the treatment of Alzheimer's disease. J Neurol Neurosurg Psychiatry 2004;75:1472-1474.
    • (2004) J Neurol Neurosurg Psychiatry , vol.75 , pp. 1472-1474
    • Dodel, R.C.1
  • 78
    • 8044242063 scopus 로고
    • Intravenous immunoglobulins for treatment of antibody deficiencies
    • Good RA, Lindenlaub E, eds. Stuttgart: F.K. Schattauer Verlag
    • Schiff RI. Intravenous immunoglobulins for treatment of antibody deficiencies. In: Good RA, Lindenlaub E, eds. The Nature, Cellular and Biochemical Basis and Management of Immunodeficiencies. Stuttgart: F.K. Schattauer Verlag, 1987:523-541.
    • (1987) The Nature, Cellular and Biochemical Basis and Management of Immunodeficiencies , pp. 523-541
    • Schiff, R.I.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.