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Volumn 2, Issue 11, 2011, Pages 1110-1119

The R-diastereomer of 6′-O-toluoyl-carba-LNA modification in the core region of siRNA leads to 24-times improved RNA silencing potency against the HIV-1 compared to its S-counterpart

(9) Dutta, Suman a Bhaduri, Nipa a Upadhayaya, Ram Shankar b,c Rastogi, Neha a Chandel, Sunita G a Vandavasi, Jaya Kishore b Plashkevych, Oleksandr d Kardile, Ramakant A b Chattopadhyaya, Jyoti d

a Salt Lake Electronics Complex (India)

b Institute of Molecular Medicine (India)

c Maharashtra Industrial Development Corporation India (India)

d UPPSALA UNIVERSITY (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

[6' O (4 TOLUOYL) 7' METHYL]CARBOCYCLIC LOCKED NUCLEIC ACID MODIFIED SMALL INTERFERING RNA; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ANTISENSE OLIGONUCLEOTIDE; ARGONAUTE PROTEIN; DOUBLE STRANDED RNA; LOCKED NUCLEIC ACID; NUCLEASE; P55GAG PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS RNA;

ARTICLE; BINDING AFFINITY; CHEMICAL MODIFICATION; CHIRALITY; CONTROLLED STUDY; CROSS LINKING; DERIVATIZATION; DIASTEREOISOMER; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG STABILITY; DRUG STRUCTURE; DRUG TARGETING; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROPHOBICITY; IC 50; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RNA CLEAVAGE; SERUM; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; VIRUS GENE; VIRUS INHIBITION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 80455163173 PISSN: 20402503 EISSN: 20402511 Source Type: Journal
DOI: 10.1039/c1md00167a Document Type: Article

Times cited : (5)

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