Synthesis and biophysical characterization of R-6′-Me-α-l-LNA modified oligonucleotides

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 4, 2011, Pages 1122-1125

  Seth, Punit P ^a   Yu, Jinghua ^a   Allerson, Charles R ^a,b   Berdeja, Andres ^a   Swayze, Eric E ^a  

^a ISIS PHARMACEUTICALS   (United States)

^b REGULUS THERAPEUTICS   (United States)

Author keywords

l LNA; Oligonucleotides; R 6 Me l LNA; Thermal stability

Indexed keywords

6' METHYL ALPHA LEVO LOCKED NUCLEIC ACID; OLIGONUCLEOTIDE; SUGAR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CHROMATOGRAPHY; DRUG STRUCTURE; DRUG SYNTHESIS; HYBRIDIZATION; RNA SEQUENCE; SUBSTITUTION REACTION; THERMOSTABILITY;

BASE SEQUENCE; BICYCLO COMPOUNDS, HETEROCYCLIC; NUCLEIC ACID CONFORMATION; OLIGONUCLEOTIDES; STEREOISOMERISM; TRANSITION TEMPERATURE;

EID: 79851510892     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.12.119     Document Type: Article

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