An exocyclic methylene group acts as a bioisostere of the 2′-oxygen atom in lna

Journal of the American Chemical Society

Volumn 132, Issue 42, 2010, Pages 14942-14950

  Seth, Punit P ^a   Allerson, Charles R ^a   Berdeja, Andres ^a   Siwkowski, Andrew ^a   Pallan, Pradeep S ^b   Gaus, Hans ^a   Prakash, Thazha P ^a   Watt, Andrew T ^a   Egli, Martin ^b   Swayze, Eric E ^a  

^a ISIS PHARMACEUTICALS   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENTS; ANTISENSE OLIGONUCLEOTIDES; BINDING AFFINITIES; BIOLOGICAL ACTIVITIES; DIAGNOSTIC APPLICATIONS; EXOCYCLIC METHYLENE GROUP; IN-VIVO; INTRAMOLECULAR CYCLIZATIONS; LOCKED NUCLEIC ACID; METHYLENE GROUPS; MINOR GROOVES; MODIFIED OLIGONUCLEOTIDES; NEGATIVE POLARIZATION; NUCLEIC ACID STRUCTURE; OXYGEN ATOM; REDUCED TOXICITY; THERMAL STABILITY;

BINDING ENERGY; BIOMOLECULES; HYDROGEN; HYDROGEN BONDS; NUCLEIC ACIDS; OLIGONUCLEOTIDES; OXYGEN; SYNTHESIS (CHEMICAL); THERMODYNAMIC STABILITY;

CYCLIZATION;

ANTISENSE OLIGONUCLEOTIDE; CARBENE; COMPLEMENTARY DNA; DEOXYRIBOSE; LOCKED NUCLEIC ACID; NUCLEOSIDE; OLIGONUCLEOTIDE; OXYGEN;

ARTICLE; BINDING AFFINITY; CHEMICAL MODIFICATION; CRYSTAL STRUCTURE; CYCLIZATION; HYBRIDIZATION; HYDROGEN BOND; HYDROPHILICITY; NUCLEIC ACID STRUCTURE; REACTION ANALYSIS; SYNTHESIS; THERMOSTABILITY;

ALKENES; ANIMALS; CRYSTALLOGRAPHY, X-RAY; MICE; MODELS, MOLECULAR; NUCLEIC ACID HYBRIDIZATION; NUCLEIC ACIDS; OXYGEN; PTEN PHOSPHOHYDROLASE; RNA, MESSENGER; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77958461485     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja105875e     Document Type: Article

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