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Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 1, 2011, Pages 588-591

Replacing the 2′-oxygen with an exocyclic methylene group reverses the stabilization effects of α-l-LNA

(4) Seth, Punit P a Allerson, Charles R a Berdeja, Andres a Swayze, Eric E a

a ISIS PHARMACEUTICALS (United States)

Author keywords

l LNA; cLNA; Methylene cLNA; Oligonucleotides; Thermal stability

Indexed keywords

2' OXYGEN; ALPHA LOCKED NUCLEIC ACID; CARBENE; LOCKED NUCLEIC ACID; OXYGEN DERIVATIVE; UNCLASSIFIED DRUG; OLIGONUCLEOTIDE; OXYGEN;

ARTICLE; CHEMICAL STRUCTURE; NUCLEAR OVERHAUSER EFFECT; NUCLEIC ACID HYBRIDIZATION; SYNTHESIS; CHEMISTRY; CONFORMATION; TRANSITION TEMPERATURE;

NUCLEIC ACID CONFORMATION; OLIGONUCLEOTIDES; OXYGEN; TRANSITION TEMPERATURE;

EID: 78650513817 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2010.10.025 Document Type: Article

Times cited : (10)

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