Neuroplastic changes in depression: A role for the immune system

Psychoneuroendocrinology

Volumn 37, Issue 9, 2012, Pages 1397-1416

  Eyre, Harris ^a,b   Baune, Bernhard T ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b JAMES COOK UNIVERSITY   (Australia)

Author keywords

Cellular; Depression; Humoral; Immune system; Neuroplasticity; Recovery; Treatment

Indexed keywords

ANTIDEPRESSANT AGENT; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; NEUROTROPHIN; OMEGA 3 FATTY ACID; PHOSPHATIDYLINOSITOL 3 KINASE; RAS PROTEIN; STAT PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TUMOR NECROSIS FACTOR ALPHA;

ASTROCYTE; CD4+ T LYMPHOCYTE; CELL SURVIVAL; CELLULAR IMMUNITY; DEPRESSION; DRUG EFFECT; HIPPOCAMPUS; HUMAN; HUMORAL IMMUNITY; IMMUNE SYSTEM; LONG TERM POTENTIATION; MACROPHAGE; MICROGLIA; NERVE CELL PLASTICITY; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; PHYSICAL ACTIVITY; PRIORITY JOURNAL; REGULATORY MECHANISM; REGULATORY T LYMPHOCYTE; REVIEW; SYNAPSE; SYSTEMATIC REVIEW;

BRAIN; DEPRESSIVE DISORDER; HUMANS; INTERLEUKIN-1; INTERLEUKIN-6; LYMPHOCYTES; NEURONAL PLASTICITY; NEURONS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84864759986     PISSN: 03064530     EISSN: 18733360     Source Type: Journal    
DOI: 10.1016/j.psyneuen.2012.03.019     Document Type: Review

References (284)

1. Ahdidan J., Hviid L.B., et al. Longitudinal MR study of brain structure and hippocampus volume in major depressive disorder. Acta Psychiatr. Scand. 2011, 123(3):211-219.
2. Alahmed S., Herbert J. Strain differences in proliferation of progenitor cells in the dentate gyrus of the adult rat and the response to fluoxetine are dependent on corticosterone. Neuroscience 2008, 157(3):677-682.
3. Albensi B.C., Mattson M.P. Evidence for the involvement of TNF and NF-kappaB in hippocampal synaptic plasticity. Synapse 2000, 35(2):151-159.
4. Albrecht P.J., Dahl J.P., et al. Ciliary neurotrophic factor activates spinal cord astrocytes, stimulating their production and release of fibroblast growth factor-2, to increase motor neuron survival. Exp. Neurol. 2002, 173(1):46-62.
5. Allan S.M., Rothwell N.J. Inflammation in central nervous system injury. Philos. Trans. R. Soc. Lond. B: Biol. Sci. 2003, 358(1438):1669-1677.
6. Aloe L., Properzi F., et al. Learning abilities, NGF and BDNF brain levels in two lines of TNF-alpha transgenic mice, one characterized by neurological disorders, the other phenotypically normal. Brain Res. 1999, 840(1-2):125-137.
7. Amminger G.P., Schafer M.R., et al. Long-chain omega-3 fatty acids for indicated prevention of psychotic disorders: a randomized, placebo-controlled trial. Arch. Gen. Psychiatry 2010, 67(2):146-154.
8. Anisman H. Cascading effects of stressors and inflammatory immune system activation: implications for major depressive disorder. J. Psychiatry Neurosci. 2009, 34(1):4-20.
9. Arnett H.A., Mason J., et al. TNF alpha promotes proliferation of oligodendrocyte progenitors and remyelination. Nat. Neurosci. 2001, 4(11):1116-1122.
10. Arnone D., McIntosh A.M., et al. Magnetic resonance imaging studies in unipolar depression: systematic review and meta-regression analyses. Eur. Neuropsychopharmacol. 2011.
11. Arunrut T., Alejandre H., et al. Differential behavioral and neurochemical effects of exercise, reboxetine and citalopram with the forced swim test. Life Sci. 2009, 84(17-18):584-589.
12. Autry A.E., Adachi M., et al. Gender-specific impact of brain-derived neurotrophic factor signaling on stress-induced depression-like behavior. Biol. Psychiatry 2009, 66(1):84-90.
13. Avitsur R., Pollak Y., et al. Different receptor mechanisms mediate the effects of endotoxin and interleukin-1 on female sexual behavior. Brain Res. 1997, 773(1-2):149-161.
14. Bachstetter A.D., Morganti J.M., et al. Fractalkine and CX 3 CR1 regulate hippocampal neurogenesis in adult and aged rats. Neurobiol. Aging 2011, 32(11):2030-2044.
15. Balasubramaniam B., Carter D.A., et al. Microglia derived IL-6 suppresses neurosphere generation from adult human retinal cell suspensions. Exp. Eye Res. 2009, 89(5):757-766.
16. Banasr M., Valentine G.W., et al. Chronic unpredictable stress decreases cell proliferation in the cerebral cortex of the adult rat. Biol. Psychiatry 2007, 62(5):496-504.
17. Barkho B.Z., Song H., et al. Identification of astrocyte-expressed factors that modulate neural stem/progenitor cell differentiation. Stem Cells Dev. 2006, 15(3):407-421.
18. Baron R., Nemirovsky A., et al. IFN-gamma enhances neurogenesis in wild-type mice and in a mouse model of Alzheimer's disease. FASEB J. 2008, 22(8):2843-2852.
19. Barrientos R.M., Sprunger D.B., et al. Brain-derived neurotrophic factor mRNA downregulation produced by social isolation is blocked by intrahippocampal interleukin-1 receptor antagonist. Neuroscience 2003, 121(4):847-853.
20. Baud V., Karin M. Signal transduction by tumor necrosis factor and its relatives. Trends Cell Biol. 2001, 11(9):372-377.
21. Bauer S. Cytokine control of adult neural stem cells. Ann. N. Y. Acad. Sci. 2009, 1153:48-56.
22. Bauer S., Patterson P.H. Leukemia inhibitory factor promotes neural stem cell self-renewal in the adult brain. J. Neurosci. 2006, 26(46):12089-12099.
23. Baune B. Conceptual challenges of a tentative model of stress-induced depression. PLoS One 2009, 4(1):e4266.
24. Baune B.T., Dannlowski U., et al. The interleukin 1 beta (IL1B) gene is associated with failure to achieve remission and impaired emotion processing in major depression. Biol. Psychiatry 2010, 67(6):543-549.
25. Baune B.T., Eyre H. Novel perspectives on the role of immune biomarkers in exercise and depression. Brain Behav. Immun. 2012, 26(3):512.
26. Bechmann I., Nitsch R. Astrocytes and microglial cells incorporate degenerating fibers following entorhinal lesion: a light, confocal, and electron microscopical study using a phagocytosis-dependent labeling technique. Glia 1997, 20(2):145-154.
27. Bednarczyk M.R., Aumont A., et al. Prolonged voluntary wheel-running stimulates neural precursors in the hippocampus and forebrain of adult CD1 mice. Hippocampus 2009, 19(10):913-927.
28. Beers D.R., Henkel J.S., et al. CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS. Proc. Natl. Acad. Sci. U. S. A. 2008, 105(40):15558-15563.
29. Bellani M., Dusi N., et al. The effects of antidepressants on human brain as detected by imaging studies. Focus on major depression. Prog. Neuropsychopharmacol. Biol. Psychiatry 2011, 35(7):1544-1552.
30. Ben-Hur T., Ben-Menachem O., et al. Effects of proinflammatory cytokines on the growth, fate, and motility of multipotential neural precursor cells. Mol. Cell. Neurosci. 2003, 24(3):623-631.
31. Ben Menachem-Zidon O., Avital A., et al. Astrocytes support hippocampal-dependent memory and long-term potentiation via interleukin-1 signaling. Brain Behav. Immun. 2011, 25(5):1008-1016.
32. Ben Menachem-Zidon O., Goshen I., et al. Intrahippocampal transplantation of transgenic neural precursor cells overexpressing interleukin-1 receptor antagonist blocks chronic isolation-induced impairment in memory and neurogenesis. Neuropsychopharmacology 2008, 33(9):2251-2262.
33. Bessa J.M., Ferreira D., et al. The mood-improving actions of antidepressants do not depend on neurogenesis but are associated with neuronal remodeling. Mol. Psychiatry 2009, 14(8):764-773. 739.
34. Bettelli E., Carrier Y., et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006, 441(7090):235-238.
35. Bezzi P., Domercq M., et al. CXCR4-activated astrocyte glutamate release via TNFalpha: amplification by microglia triggers neurotoxicity. Nat. Neurosci. 2001, 4(7):702-710.
36. Bloch M.H., Qawasmi A. Omega-3 fatty acid supplementation for the treatment of children with attention-deficit/hyperactivity disorder symptomatology: systematic review and meta-analysis. J. Am. Acad. Child Adolesc. Psychiatry 2011, 50(10):991-1000.
37. Bluthe R.M., Beaudu C., et al. Differential effects of IL-1ra on sickness behavior and weight loss induced by IL-1 in rats. Brain Res. 1995, 677(1):171-176.
38. Bonde S., Ekdahl C.T., et al. Long-term neuronal replacement in adult rat hippocampus after status epilepticus despite chronic inflammation. Eur. J. Neurosci. 2006, 23(4):965-974.
39. Bowen K.K., Dempsey R.J., et al. Adult interleukin-6 knockout mice show compromised neurogenesis. Neuroreport 2011, 22(3):126-130.
40. Bracchi-Ricard V., Brambilla R., et al. Astroglial nuclear factor-kappaB regulates learning and memory and synaptic plasticity in female mice. J. Neurochem. 2008, 104(3):611-623.
41. Brenneman D.E., Schultzberg M., et al. Cytokine regulation of neuronal survival. J. Neurochem. 1992, 58(2):454-460.
42. Brynskikh A., Warren T., et al. Adaptive immunity affects learning behavior in mice. Brain Behav. Immun. 2008, 22(6):861-869.
43. Butler M.P., O'Connor J.J., et al. Dissection of tumor-necrosis factor-alpha inhibition of long-term potentiation (LTP) reveals a p38 mitogen-activated protein kinase-dependent mechanism which maps to early-but not late-phase LTP. Neuroscience 2004, 124(2):319-326.
44. Butovsky O., Ziv Y., et al. Microglia activated by IL-4 or IFN-gamma differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells. Mol. Cell. Neurosci. 2006, 31(1):149-160.
45. Cacci E., Ajmone-Cat M.A., et al. In vitro neuronal and glial differentiation from embryonic or adult neural precursor cells are differently affected by chronic or acute activation of microglia. Glia 2008, 56(4):412-425.
46. Cali C., Bezzi P. CXCR4-mediated glutamate exocytosis from astrocytes. J. Neuroimmunol. 2010, 224(1-2):13-21.
47. Capuron L., Miller A.H. Immune system to brain signaling: neuropsychopharmacological implications. Pharmacol. Ther. 2011, 130(2):226-238.
48. Capuron L., Pagnoni G., et al. Anterior cingulate activation and error processing during interferon-alpha treatment. Biol. Psychiatry 2005, 58(3):190-196.
49. Capuron L., Pagnoni G., et al. Basal ganglia hypermetabolism and symptoms of fatigue during interferon-alpha therapy. Neuropsychopharmacology 2007, 32(11):2384-2392.
50. Cardona A.E., Pioro E.P., et al. Control of microglial neurotoxicity by the fractalkine receptor. Nat. Neurosci. 2006, 9(7):917-924.
51. Cardone J., Le Friec G., et al. Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells. Nat. Immunol. 2010, 11(9):862-871.
52. Caruso C., Candore G., et al. Biological significance of soluble IL-2 receptor. Mediators Inflamm. 1993, 2(1):3-21.
53. Castanon N., Medina C., et al. Chronic administration of tianeptine balances lipopolysaccharide-induced expression of cytokines in the spleen and hypothalamus of rats. Psychoneuroendocrinology 2004, 29(6):778-790.
54. Chen Y., Jiang T., et al. Emerging tendency towards autoimmune process in major depressive patients: a novel insight from Th17 cells. Psychiatry Res. 2011, 188(2):224-230.
55. Chiu I.M., Chen A., et al. T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS. Proc. Natl. Acad. Sci. U. S. A. 2008, 105(46):17913-17918.
56. Choi S.H., Li Y., et al. Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF. Mol. Neurodegener. 2009, 4:52.
57. Choi Y.S., Cho H.Y., et al. IGF-1 receptor-mediated ERK/MAPK signaling couples status epilepticus to progenitor cell proliferation in the subgranular layer of the dentate gyrus. Glia 2008, 56(7):791-800.
58. Chu Y.X., Zhang Y., et al. Involvement of microglial P2X7 receptors and downstream signaling pathways in long-term potentiation of spinal nociceptive responses. Brain Behav. Immun. 2010, 24(7):1176-1189.
59. Clark J., Vagenas P., et al. What does tumour necrosis factor excess do to the immune system long term?. Ann. Rheum. Dis. 2005, 64(Suppl. 4):iv70-iv76.
60. Clark P.J., Brzezinska W.J., et al. Functional analysis of neurovascular adaptations to exercise in the dentate gyrus of young adult mice associated with cognitive gain. Hippocampus 2009, 19(10):937-950.
61. Cohen H., Ziv Y., et al. Maladaptation to mental stress mitigated by the adaptive immune system via depletion of naturally occurring regulatory CD4+CD25+ cells. J. Neurobiol. 2006, 66(6):552-563.
62. Conklin S.M., Gianaros P.J., et al. Long-chain omega-3 fatty acid intake is associated positively with corticolimbic gray matter volume in healthy adults. Neurosci. Lett. 2007, 421(3):209-212.
63. Connor T.J., Harkin A., et al. Olfactory bulbectomy provokes a suppression of interleukin-1beta and tumour necrosis factor-alpha production in response to an in vivo challenge with lipopolysaccharide: effect of chronic desipramine treatment. Neuroimmunomodulation 2000, 7(1):27-35.
64. Cope A.P., Londei M., et al. Chronic exposure to tumor necrosis factor (TNF) in vitro impairs the activation of T cells through the T cell receptor/CD3 complex; reversal in vivo by anti-TNF antibodies in patients with rheumatoid arthritis. J. Clin. Invest. 1994, 94(2):749-760.
65. Couillard-Despres S., Wuertinger C., et al. Ageing abolishes the effects of fluoxetine on neurogenesis. Mol. Psychiatry 2009, 14(9):856-864.
66. Covacu R., Arvidsson L., et al. TLR activation induces TNF-alpha production from adult neural stem/progenitor cells. J. Immunol. 2009, 182(11):6889-6895.
67. Cunningham A.J., Murray C.A., et al. Interleukin-1 beta (IL-1 beta) and tumour necrosis factor (TNF) inhibit long-term potentiation in the rat dentate gyrus in vitro. Neurosci. Lett. 1996, 203(1):17-20.
68. D'Mello C., Le T., et al. Cerebral microglia recruit monocytes into the brain in response to tumor necrosis factoralpha signaling during peripheral organ inflammation. J. Neurosci. 2009, 29(7):2089-2102.
69. Dantzer R. Cytokine-induced sickness behavior: mechanisms and implications. Ann. N. Y. Acad. Sci. 2001, 933:222-234.
70. Dantzer R., O'Connor J.C., et al. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat. Rev. Neurosci. 2008, 9(1):46-56.
71. Dantzer R., O'Connor J.C., et al. Inflammation-associated depression: from serotonin to kynurenine. Psychoneuroendocrinology 2011, 36(3):426-436.
72. Davalos D., Grutzendler J., et al. ATP mediates rapid microglial response to local brain injury in vivo. Nat. Neurosci. 2005, 8(6):752-758.
73. Del Rey A., Roggero E., et al. IL-1 resets glucose homeostasis at central levels. Proc. Natl. Acad. Sci. U. S. A. 2006, 103(43):16039-16044.
74. Delgado y Palacios R., Campo A., et al. Magnetic resonance imaging and spectroscopy reveal differential hippocampal changes in anhedonic and resilient subtypes of the chronic mild stress rat model. Biol. Psychiatry 2011, 70(5):449-457.
75. Derecki N.C., Cardani A.N., et al. Regulation of learning and memory by meningeal immunity: a key role for IL-4. J. Exp. Med. 2010, 207(5):1067-1080.
76. Derecki N.C., Quinnies K.M., et al. Alternatively activated myeloid (M2) cells enhance cognitive function in immune compromised mice. Brain Behav. Immun. 2011, 25(3):379-385.
77. Dowlati Y., Herrmann N., et al. A meta-analysis of cytokines in major depression. Biol. Psychiatry 2010, 67(5):446-457.
78. Drevets W.C. Neuroimaging abnormalities in the amygdala in mood disorders. Ann. N.Y. Acad. Sci. 2003, 985:420-444.
79. Drevets W.C. Orbitofrontal cortex function and structure in depression. Ann. N.Y. Acad. Sci. 2007, 1121:499-527.
80. Drevets W.C., Price J.L., et al. Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression. Brain Struct. Funct. 2008, 213(1-2):93-118.
81. Dyall S.C. Amyloid-beta peptide, oxidative stress and inflammation in alzheimer's disease: potential neuroprotective effects of omega-3 polyunsaturated fatty acids. Int. J. Alzheimers Dis. 2010, 2010.
82. Ebert S., Weigelt K., et al. Docosahexaenoic acid attenuates microglial activation and delays early retinal degeneration. J. Neurochem. 2009, 110(6):1863-1875.
83. Ekdahl C.T., Claasen J.H., et al. Inflammation is detrimental for neurogenesis in adult brain. Proc. Natl. Acad. Sci. U. S. A. 2003, 100(23):13632-13637.
84. Ekdahl C.T., Kokaia Z., et al. Brain inflammation and adult neurogenesis: the dual role of microglia. Neuroscience 2009, 158(3):1021-1029.
85. Erickson K.I., Raji C.A., et al. Physical activity predicts gray matter volume in late adulthood: the Cardiovascular Health Study. Neurology 2010, 75(16):1415-1422.
86. Erickson K.I., Voss M.W., et al. Exercise training increases size of hippocampus and improves memory. Proc. Natl. Acad. Sci. U. S. A. 2011, 108(7):3017-3022.
87. Eyre H., Baune B.T. Neuroimmunological effects of physical exercise in depression. Brain Behav. Immun. 2012, 26(2):251-266.
88. Fiore M., Angelucci F., et al. Learning performances, brain NGF distribution and NPY levels in transgenic mice expressing TNF-alpha. Behav. Brain Res. 2000, 112(1-2):165-175.
89. Floel A., Ruscheweyh R., et al. Physical activity and memory functions: are neurotrophins and cerebral gray matter volume the missing link?. Neuroimage 2010, 49(3):2756-2763.
90. Fournier N.M., Duman R.S. Role of vascular endothelial growth factor in adult hippocampal neurogenesis: implications for the pathophysiology and treatment of depression. Behav. Brain Res. 2011, 227(2):440-449.
91. Frodl T., Jager M., et al. Effect of hippocampal and amygdala volumes on clinical outcomes in major depression: a 3-year prospective magnetic resonance imaging study. J. Psychiatry Neurosci. 2008, 33(5):423-430.
92. Frodl T., Meisenzahl E.M., et al. Hippocampal and amygdala changes in patients with major depressive disorder and healthy controls during a 1-year follow-up. J. Clin. Psychiatry 2004, 65(4):492-499.
93. Frodl T., Reinhold E., et al. Childhood stress, serotonin transporter gene and brain structures in major depression. Neuropsychopharmacology 2010, 35(6):1383-1390.
94. Garcia-Bueno B., Caso J.R., et al. Stress as a neuroinflammatory condition in brain: damaging and protective mechanisms. Neurosci. Biobehav. Rev. 2008, 32(6):1136-1151.
95. Garcia C., Chen M.J., et al. The influence of specific noradrenergic and serotonergic lesions on the expression of hippocampal brain-derived neurotrophic factor transcripts following voluntary physical activity. Neuroscience 2003, 119(3):721-732.
96. Gatt J.M., Nemeroff C.B., et al. Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety. Mol. Psychiatry 2009, 14(7):681-695.
97. Goehler L.E., Gaykema R.P., et al. Interleukin-1beta in immune cells of the abdominal vagus nerve: a link between the immune and nervous systems?. J. Neurosci. 1999, 19(7):2799-2806.
98. Golan H., Levav T., et al. Involvement of tumor necrosis factor alpha in hippocampal development and function. Cereb. Cortex 2004, 14(1):97-105.
99. Gomez-Nicola D., Valle-Argos B., et al. Interleukin-15 regulates proliferation and self-renewal of adult neural stem cells. Mol. Biol. Cell 2011, 22(12):1960-1970.
100. Gomez-Pinilla F. The combined effects of exercise and foods in preventing neurological and cognitive disorders. Prev. Med. 2011, 52(Suppl. 1):S75-S80.
101. Gomez-Pinilla F., Ying Z., et al. Voluntary exercise induces a BDNF-mediated mechanism that promotes neuroplasticity. J. Neurophysiol. 2002, 88(5):2187-2195.
102. Gong X., He X., et al. Stromal cell derived factor-1 acutely promotes neural progenitor cell proliferation in vitro by a mechanism involving the ERK1/2 and PI-3K signal pathways. Cell Biol. Int. 2006, 30(5):466-471.
103. Gonzalez-Perez O., Quinones-Hinojosa A., et al. Immunological control of adult neural stem cells. J. Stem Cells 2010, 5(1):23-31.
104. Goshen I., Kreisel T., et al. Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression. Mol. Psychiatry 2008, 13(7):717-728.
105. Goshen I., Yirmiya R. Interleukin-1 (IL-1): a central regulator of stress responses. Front. Neuroendocrinol. 2009, 30(1):30-45.
106. Greco S.J., Rameshwar P. Enhancing effect of IL-1alpha on neurogenesis from adult human mesenchymal stem cells: implication for inflammatory mediators in regenerative medicine. J. Immunol. 2007, 179(5):3342-3350.
107. Gronli J., Bramham C., et al. Chronic mild stress inhibits BDNF protein expression and CREB activation in the dentate gyrus but not in the hippocampus proper. Pharmacol. Biochem. Behav. 2006, 85(4):842-849.
108. Halassa M.M., Haydon P.G. Integrated brain circuits: astrocytic networks modulate neuronal activity and behavior. Annu. Rev. Physiol. 2010, 72:335-355.
109. Hanisch U.K., Kettenmann H. Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat. Neurosci. 2007, 10(11):1387-1394.
110. Hannestad J., Dellagioia N., et al. The effect of antidepressant medication treatment on serum levels of inflammatory cytokines: a meta-analysis. Neuropsychopharmacology 2011, 36(12):2452-2459.
111. Hannestad J., DellaGioia N., et al. Citalopram reduces endotoxin-induced fatigue. Brain Behav. Immun. 2011, 25(2):256-259.
112. Hanson N.D., Owens M.J., et al. Depression, antidepressants, and neurogenesis: a critical reappraisal. Neuropsychopharmacology 2011, 36(13):2589-2602.
113. Haroon E., Raison C.L., et al. Psychoneuroimmunology meets neuropsychopharmacology: translational implications of the impact of inflammation on behavior. Neuropsychopharmacology 2011, 37(1):137-162.
114. Harrison N.A., Brydon L., et al. Inflammation causes mood changes through alterations in subgenual cingulate activity and mesolimbic connectivity. Biol. Psychiatry 2009, 66(5):407-414.
115. Hart B.L. Biological basis of the behavior of sick animals. Neurosci. Biobehav. Rev. 1988, 12(2):123-137.
116. Heldmann U., Thored P., et al. TNF-alpha antibody infusion impairs survival of stroke-generated neuroblasts in adult rat brain. Exp. Neurol. 2005, 196(1):204-208.
117. Henneberger C., Papouin T., et al. Long-term potentiation depends on release of d-serine from astrocytes. Nature 2010, 463(7278):232-236.
118. Himmerich H., Milenovic S., et al. Regulatory T cells increased while IL-1beta decreased during antidepressant therapy. J. Psychiatr. Res. 2010, 44(15):1052-1057.
119. Hirano T., Nakajima K., et al. Signaling mechanisms through gp130: a model of the cytokine system. Cytokine Growth Factor Rev. 1997, 8(4):241-252.
120. Ho A., Blum M. Regulation of astroglial-derived dopaminergic neurotrophic factors by interleukin-1 beta in the striatum of young and middle-aged mice. Exp. Neurol. 1997, 148(1):348-359.
121. Hoek R.M., Ruuls S.R., et al. Down-regulation of the macrophage lineage through interaction with OX2 (CD200). Science 2000, 290(5497):1768-1771.
122. Hsieh M.H., McQuoid D.R., et al. Hippocampal volume and antidepressant response in geriatric depression. Int. J. Geriatr. Psychiatry 2002, 17(6):519-525.
123. Huang G.J., Smith A.L., et al. A genetic and functional relationship between T cells and cellular proliferation in the adult hippocampus. PLoS Biol. 2010, 8(12):e1000561.
124. Hunsberger J., Austin D.R., et al. The neurotrophic and neuroprotective effects of psychotropic agents. Dialogues Clin. Neurosci. 2009, 11(3):333-348.
125. Ibarguen-Vargas Y., Surget A., et al. Deficit in BDNF does not increase vulnerability to stress but dampens antidepressant-like effects in the unpredictable chronic mild stress. Behav. Brain Res. 2009, 202(2):245-251.
126. Iosif R.E., Ekdahl C.T., et al. Tumor necrosis factor receptor 1 is a negative regulator of progenitor proliferation in adult hippocampal neurogenesis. J. Neurosci. 2006, 26(38):9703-9712.
127. Ishibashi S., Maric D., et al. Mucosal tolerance to E-selectin promotes the survival of newly generated neuroblasts via regulatory T-cell induction after stroke in spontaneously hypertensive rats. J. Cereb. Blood Flow Metab. 2009, 29(3):606-620.
128. Islam O., Gong X., et al. Interleukin-6 and neural stem cells: more than gliogenesis. Mol. Biol. Cell 2009, 20(1):188-199.
129. Ivanov I.I., McKenzie B.S., et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 2006, 126(6):1121-1133.
130. Janssen D.G., Caniato R.N., et al. A psychoneuroimmunological review on cytokines involved in antidepressant treatment response. Hum. Psychopharmacol. 2010, 25(3):201-215.
131. Jayatissa M.N., Bisgaard C.F., et al. The number of granule cells in rat hippocampus is reduced after chronic mild stress and re-established after chronic escitalopram treatment. Neuropharmacology 2008, 54(3):530-541.
132. Johansson S., Price J., et al. Effect of inflammatory cytokines on major histocompatibility complex expression and differentiation of human neural stem/progenitor cells. Stem Cells 2008, 26(9):2444-2454.
133. Jurgens H.A., Johnson R.W. Dysregulated neuronal-microglial cross-talk during aging, stress and inflammation. Exp. Neurol. 2010.
134. Kahn M.A., De Vellis J. Regulation of an oligodendrocyte progenitor cell line by the interleukin-6 family of cytokines. Glia 1994, 12(2):87-98.
135. Kang M.K., Kang S.K. Interleukin-6 induces proliferation in adult spinal cord-derived neural progenitors via the JAK2/STAT3 pathway with EGF-induced MAPK phosphorylation. Cell Prolif. 2008, 41(3):377-392.
136. Kebir H., Kreymborg K., et al. Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. Nat. Med. 2007, 13(10):1173-1175.
137. Kempermann G. Why new neurons? Possible functions for adult hippocampal neurogenesis. J. Neurosci. 2002, 22(3):635-638.
138. Kent S., Bluthe R.M., et al. Sickness behavior as a new target for drug development. Trends Pharmacol. Sci. 1992, 13(1):24-28.
139. Khairova R.A., Machado-Vieira R., et al. A potential role for pro-inflammatory cytokines in regulating synaptic plasticity in major depressive disorder. Int. J. Neuropsychopharmacol. 2009, 12(4):561-578.
140. Kim T.S., Misumi S., et al. Increase in dopaminergic neurons from mouse embryonic stem cell-derived neural progenitor/stem cells is mediated by hypoxia inducible factor-1alpha. J. Neurosci. Res. 2008, 86(11):2353-2362.
141. Kipnis J., Avidan H., et al. Dual effect of CD4+CD25+ regulatory T cells in neurodegeneration: a dialogue with microglia. Proc. Natl. Acad. Sci. U. S. A. 2004, 101(Suppl. 2):14663-14669.
142. Kipnis J., Mizrahi T., et al. Neuroprotective autoimmunity: naturally occurring CD4+CD25+ regulatory T cells suppress the ability to withstand injury to the central nervous system. Proc. Natl. Acad. Sci. U. S. A. 2002, 99(24):15620-15625.
143. Koo J.W., Duman R.S. IL-1beta is an essential mediator of the antineurogenic and anhedonic effects of stress. Proc. Natl. Acad. Sci. U. S. A. 2008, 105(2):751-756.
144. Koo J.W., Russo S.J., et al. Nuclear factor-kappaB is a critical mediator of stress-impaired neurogenesis and depressive behavior. Proc. Natl. Acad. Sci. U. S. A. 2010, 107(6):2669-2674.
145. Kronenberg G., Bick-Sander A., et al. Physical exercise prevents age-related decline in precursor cell activity in the mouse dentate gyrus. Neurobiol. Aging 2006, 27(10):1505-1513.
146. Kronmuller K.T., Pantel J., et al. Hippocampal volume and 2-year outcome in depression. Br. J. Psychiatry 2008, 192(6):472-473.
147. Kubera M., Maes M., et al. Prolonged desipramine treatment increases the production of interleukin-10, an anti-inflammatory cytokine, in C57BL/6 mice subjected to the chronic mild stress model of depression. J. Affect. Disord. 2001, 63(1-3):171-178.
148. Kubera M., Obuchowicz E., et al. In animal models, psychosocial stress-induced (neuro)inflammation, apoptosis and reduced neurogenesis are associated to the onset of depression. Prog. Neuropsychopharmacol. Biol. Psychiatry 2010, 35(3):744-759.
149. Kubera M., Obuchowicz E., et al. In animal models, psychosocial stress-induced (neuro)inflammation, apoptosis and reduced neurogenesis are associated to the onset of depression. Prog. Neuropsychopharmacol. Biol. Psychiatry 2011, 35(3):744-759.
150. Kubera M., Symbirtsev A., et al. Effect of chronic treatment with imipramine on interleukin 1 and interleukin 2 production by splenocytes obtained from rats subjected to a chronic mild stress model of depression. Pol. J. Pharmacol. 1996, 48(5):503-506.
151. Kuhn H.G., Dickinson-Anson H., et al. Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation. J. Neurosci. 1996, 16(6):2027-2033.
152. Larsen M.H., Mikkelsen J.D., et al. Regulation of brain-derived neurotrophic factor (BDNF) in the chronic unpredictable stress rat model and the effects of chronic antidepressant treatment. J. Psychiatr. Res. 2010, 44(13):808-816.
153. Lee K.J., Kim S.J., et al. Chronic mild stress decreases survival, but not proliferation, of new-born cells in adult rat hippocampus. Exp. Mol. Med. 2006, 38(1):44-54.
154. Lee L.F., Lih C.J., et al. Genomic expression profiling of TNF-alpha-treated BDC2.5 diabetogenic CD4+ T cells. Proc. Natl. Acad. Sci. U. S. A. 2008, 105(29):10107-10112.
155. Lee S.C., Liu W., et al. Cytokine production by human fetal microglia and astrocytes. Differential induction by lipopolysaccharide and IL-1 beta. J. Immunol. 1993, 150(7):2659-2667.
156. Lepine J.P., Briley M. The increasing burden of depression. Neuropsychiatr. Dis. Treat. 2011, 7(Suppl. 1):3-7.
157. Lewitus G.M., Wilf-Yarkoni A., et al. Vaccination as a novel approach for treating depressive behavior. Biol. Psychiatry 2009, 65(4):283-288.
158. Li A.J., Katafuchi T., et al. Interleukin-6 inhibits long-term potentiation in rat hippocampal slices. Brain Res. 1997, 748(1-2):30-38.
159. Li S., Wang C., et al. Chronic mild stress impairs cognition in mice: from brain homeostasis to behavior. Life Sci. 2008, 82(17-18):934-942.
160. Licht T., Goshen I., et al. Reversible modulations of neuronal plasticity by VEGF. Proc. Natl. Acad. Sci. U. S. A. 2011, 108(12):5081-5086.
161. Liu J., Gong N., et al. Neuromodulatory activities of CD4+CD25+ regulatory T cells in a murine model of HIV-1-associated neurodegeneration. J. Immunol. 2009, 182(6):3855-3865.
162. Liu X.S., Zhang Z.G., et al. Chemokine ligand 2 (CCL2) induces migration and differentiation of subventricular zone cells after stroke. J. Neurosci. Res. 2007, 85(10):2120-2125.
163. Llorens-Martin M., Torres-Aleman I., et al. Exercise modulates insulin-like growth factor 1-dependent and -independent effects on adult hippocampal neurogenesis and behaviour. Mol. Cell. Neurosci. 2010, 44(2):109-117.
164. London A., Itskovich E., et al. Neuroprotection and progenitor cell renewal in the injured adult murine retina requires healing monocyte-derived macrophages. J. Exp. Med. 2011, 208(1):23-39.
165. Loscher C.E., Mills K.H., et al. Interleukin-1 receptor antagonist exerts agonist activity in the hippocampus independent of the interleukin-1 type I receptor. J. Neuroimmunol. 2003, 137(1-2):117-124.
166. Lu D.Y., Tsao Y.Y., et al. Docosahexaenoic acid suppresses neuroinflammatory responses and induces heme oxygenase-1 expression in BV-2 microglia: implications of antidepressant effects for omega-3 fatty acids. Neuropsychopharmacology 2010, 35(11):2238-2248.
167. MacEwan D.J. TNF ligands and receptors - a matter of life and death. Br. J. Pharmacol. 2002, 135(4):855-875.
168. MacQueen G., Frodl T. The hippocampus in major depression: evidence for the convergence of the bench and bedside in psychiatric research?. Mol. Psychiatry 2011, 16(3):252-264.
169. MacQueen G.M., Yucel K., et al. Posterior hippocampal volumes are associated with remission rates in patients with major depressive disorder. Biol. Psychiatry 2008, 64(10):880-883.
170. Maes M. Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression. Prog. Neuropsychopharmacol. Biol. Psychiatry 2010, 35(3):676-692.
171. Maes M., Galecki P., et al. A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness. Prog. Neuropsychopharmacol. Biol. Psychiatry 2010.
172. Maes M., Meltzer H.Y., et al. Increased plasma concentrations of interleukin-6, soluble interleukin-6, soluble interleukin-2 and transferrin receptor in major depression. J. Affect. Disord. 1995, 34(4):301-309.
173. Maes M., Yirmyia R., et al. The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression. Metab. Brain Dis. 2009, 24(1):27-53.
174. Martin D.S., Lonergan P.E., et al. Apoptotic changes in the aged brain are triggered by interleukin-1beta-induced activation of p38 and reversed by treatment with eicosapentaenoic acid. J. Biol. Chem. 2002, 277(37):34239-34246.
175. Mayberg H.S. Modulating dysfunctional limbic-cortical circuits in depression: towards development of brain-based algorithms for diagnosis and optimised treatment. Br. Med. Bull. 2003, 65:193-207.
176. McAfoose J., Baune B.T. Evidence for a cytokine model of cognitive function. Neurosci. Biobehav. Rev. 2009, 33(3):355-366.
177. McKinnon M.C., Yucel K., et al. A meta-analysis examining clinical predictors of hippocampal volume in patients with major depressive disorder. J. Psychiatry Neurosci. 2009, 34(1):41-54.
178. McNamara R.K. DHA deficiency and prefrontal cortex neuropathology in recurrent affective disorders. J. Nutr. 2010, 140(4):864-868.
179. McNay E.C., Fries T.M., et al. Decreases in rat extracellular hippocampal glucose concentration associated with cognitive demand during a spatial task. Proc. Natl. Acad. Sci. U. S. A. 2000, 97(6):2881-2885.
180. Mellor A.L., Munn D., et al. Tryptophan catabolism and T cell responses. Adv. Exp. Med. Biol. 2003, 527:27-35.
181. Miller A.H. Depression and immunity: a role for T cells?. Brain Behav. Immun. 2010, 24(1):1-8.
182. Miller A.H., Maletic V., et al. Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol. Psychiatry 2009, 65(9):732-741.
183. Miller G.E., Rohleder N., et al. Chronic interpersonal stress predicts activation of pro- and anti-inflammatory signaling pathways 6 months later. Psychosom. Med. 2009, 71(1):57-62.
184. Mineur Y.S., Belzung C., et al. Functional implications of decreases in neurogenesis following chronic mild stress in mice. Neuroscience 2007, 150(2):251-259.
185. Moalem G., Leibowitz-Amit R., et al. Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy. Nat. Med. 1999, 5(1):49-55.
186. Molina-Holgado E., Molina-Holgado F. Mending the broken brain: neuroimmune interactions in neurogenesis. J. Neurochem. 2010, 114(5):1277-1290.
187. Molyneaux K.A., Zinszner H., et al. The chemokine SDF1/CXCL12 and its receptor CXCR4 regulate mouse germ cell migration and survival. Development 2003, 130(18):4279-4286.
188. Monje M.L., Toda H., et al. Inflammatory blockade restores adult hippocampal neurogenesis. Science 2003, 302(5651):1760-1765.
189. Moser K.V., Reindl M., et al. Brain capillary endothelial cells proliferate in response to NGF, express NGF receptors and secrete NGF after inflammation. Brain Res. 2004, 1017(1-2):53-60.
190. Mossner R., Mikova O., et al. Consensus paper of the WFSBP Task Force on Biological Markers: biological markers in depression. World J. Biol. Psychiatry 2007, 8(3):141-174.
191. Mullen A., Loscher C.E., et al. Anti-inflammatory effects of EPA and DHA are dependent upon time and dose-response elements associated with LPS stimulation in THP-1-derived macrophages. J. Nutr. Biochem. 2010, 21(5):444-450.
192. Murphy M., Dutton R., et al. Cytokines which signal through the LIF receptor and their actions in the nervous system. Prog. Neurobiol. 1997, 52(5):355-378.
193. Myint A.M., O'Mahony S., et al. Role of paroxetine in interferon-alpha-induced immune and behavioural changes in male Wistar rats. J. Psychopharmacol. 2007, 21(8):843-850.
194. Napoli I., Neumann H. Microglial clearance function in health and disease. Neuroscience 2009, 158(3):1030-1038.
195. Nimmerjahn A., Kirchhoff F., et al. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 2005, 308(5726):1314-1318.
196. O'Connor J.C., McCusker R.H., et al. Regulation of IGF-I function by proinflammatory cytokines: at the interface of immunology and endocrinology. Cell. Immunol. 2008, 252(1-2):91-110.
197. O'Connor M.F., Irwin M.R., et al. When grief heats up: pro-inflammatory cytokines predict regional brain activation. Neuroimage 2009, 47(3):891-896.
198. O'Sullivan J.B., Ryan K.M., et al. Noradrenaline reuptake inhibitors inhibit expression of chemokines IP-10 and RANTES and cell adhesion molecules VCAM-1 and ICAM-1 in the CNS following a systemic inflammatory challenge. J. Neuroimmunol. 2010, 220(1-2):34-42.
199. Oh J., McCloskey M.A., et al. Astrocyte-derived interleukin-6 promotes specific neuronal differentiation of neural progenitor cells from adult hippocampus. J. Neurosci. Res. 2010, 88(13):2798-2809.
200. Ohbayashi N., Ikeda O., et al. LIF- and IL-6-induced acetylation of STAT3 at Lys-685 through PI3K/Akt activation. Biol. Pharm. Bull. 2007, 30(10):1860-1864.
201. Oshima K., Teo D.T., et al. LIF promotes neurogenesis and maintains neural precursors in cell populations derived from spiral ganglion stem cells. BMC Dev. Biol. 2007, 7:112.
202. Paizanis E., Hamon M., et al. Hippocampal neurogenesis, depressive disorders, and antidepressant therapy. Neural Plast. 2007, 2007:73754.
203. Park K.M., Bowers W.J. Tumor necrosis factor-alpha mediated signaling in neuronal homeostasis and dysfunction. Cell. Signal. 2010, 22(7):977-983.
204. Penet M.F., Laigle C., et al. In vivo characterization of brain morphometric and metabolic endophenotypes in three inbred strains of mice using magnetic resonance techniques. Behav. Genet. 2006, 36(5):732-744.
205. Peng H., Huang Y., et al. Stromal cell-derived factor 1-mediated CXCR4 signaling in rat and human cortical neural progenitor cells. J. Neurosci. Res. 2004, 76(1):35-50.
206. Petrik D., Lagace D.C., et al. The neurogenesis hypothesis of affective and anxiety disorders: are we mistaking the scaffolding for the building?. Neuropharmacology 2011, 62(1):21-34.
207. Pickering M., O'Connor J.J. Pro-inflammatory cytokines and their effects in the dentate gyrus. Prog. Brain Res. 2007, 163:339-354.
208. Piser T.M. Linking the cytokine and neurocircuitry hypotheses of depression: a translational framework for discovery and development of novel anti-depressants. Brain Behav. Immun. 2010, 24(4):515-524.
209. Plotkin S.R., Banks W.A., et al. Comparison of saturable transport and extracellular pathways in the passage of interleukin-1 alpha across the blood-brain barrier. J. Neuroimmunol. 1996, 67(1):41-47.
210. Polazzi E., Monti B. Microglia and neuroprotection: from in vitro studies to therapeutic applications. Prog. Neurobiol. 2010, 92(3):293-315.
211. Quan N., Banks W.A. Brain-immune communication pathways. Brain Behav. Immun. 2007, 21(6):727-735.
212. Raison C.L., Borisov A.S., et al. Interferon-alpha effects on diurnal hypothalamic-pituitary-adrenal axis activity: relationship with proinflammatory cytokines and behavior. Mol. Psychiatry 2010, 15(5):535-547.
213. Raison C.L., Capuron L., et al. Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends Immunol. 2006, 27(1):24-31.
214. Raison C.L., Dantzer R., et al. CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha: relationship to CNS immune responses and depression. Mol. Psychiatry 2010, 15(4):393-403.
215. Reynolds A.D., Banerjee R., et al. Neuroprotective activities of CD4+CD25+ regulatory T cells in an animal model of Parkinson's disease. J. Leukoc. Biol. 2007, 82(5):1083-1094.
216. Rowland L.M. Who is resilient to depression? Multimodal imaging of the hippocampus in preclinical chronic mild stress model may provide clues. Biol. Psychiatry 2011, 70(5):406-407.
217. Roybal K.T., Wulfing C. Inhibiting the inhibitor of the inhibitor: blocking PKC-theta to enhance regulatory T cell function. Sci. Signal. 2010, 3(132):pe24.
218. Rubio-Araiz A., Arevalo-Martin A., et al. The endocannabinoid system modulates a transient TNF pathway that induces neural stem cell proliferation. Mol. Cell. Neurosci. 2008, 38(3):374-380.
219. Russo-Neustadt A., Ha T., et al. Physical activity-antidepressant treatment combination: impact on brain-derived neurotrophic factor and behavior in an animal model. Behav. Brain Res. 2001, 120(1):87-95.
220. Russo-Neustadt A.A., Alejandre H., et al. Hippocampal brain-derived neurotrophic factor expression following treatment with reboxetine, citalopram, and physical exercise. Neuropsychopharmacology 2004, 29(12):2189-2199.
221. Russo-Neustadt A.A., Beard R.C., et al. Physical activity and antidepressant treatment potentiate the expression of specific brain-derived neurotrophic factor transcripts in the rat hippocampus. Neuroscience 2000, 101(2):305-312.
222. Santarelli L., Saxe M., et al. Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 2003, 301(5634):805-809.
223. Schmid A.W., Lynch M.A., et al. The effects of IL-1 receptor antagonist on beta amyloid mediated depression of LTP in the rat CA1 in vivo. Hippocampus 2009, 19(7):670-676.
224. Schmidt H.D., Shelton R.C., et al. Functional biomarkers of depression: diagnosis, treatment, and pathophysiology. Neuropsychopharmacology 2011, 36(12):2375-2394.
225. Schneider H., Pitossi F., et al. A neuromodulatory role of interleukin-1beta in the hippocampus. Proc. Natl. Acad. Sci. U. S. A. 1998, 95(13):7778-7783.
226. Schumann J., Fuhrmann H. Impairment of NFkappaB activity by unsaturated fatty acids. Int. Immunopharmacol. 2010, 10(8):978-984.
227. Schwamborn J., Lindecke A., et al. Microarray analysis of tumor necrosis factor alpha induced gene expression in U373 human glioblastoma cells. BMC Genomics 2003, 4(1):46.
228. Schwartz M., Kipnis J. Autoimmunity on alert: naturally occurring regulatory CD4(+)CD25(+) T cells as part of the evolutionary compromise between a 'need' and a 'risk'. Trends Immunol. 2002, 23(11):530-534.
229. Schwartz M., Shechter R. Protective autoimmunity functions by intracranial immunosurveillance to support the mind: the missing link between health and disease. Mol. Psychiatry 2010, 15(4):342-354.
230. Schwartz M., Shechter R. Systemic inflammatory cells fight off neurodegenerative disease. Nat. Rev. Neurol. 2010, 6(7):405-410.
231. Shen Y., Connor T.J., et al. Differential effect of chronic antidepressant treatments on lipopolysaccharide-induced depressive-like behavioural symptoms in the rat. Life Sci. 1999, 65(17):1773-1786.
232. Shie F.S., Chen Y.H., et al. Neuroimmune pharmacology of neurodegenerative and mental diseases. J. Neuroimmune Pharmacol. 2011, 6(1):28-40.
233. Shimazaki T., Shingo T., et al. The ciliary neurotrophic factor/leukemia inhibitory factor/gp130 receptor complex operates in the maintenance of mammalian forebrain neural stem cells. J. Neurosci. 2001, 21(19):7642-7653.
234. Shrikant P., Weber E., et al. Intercellular adhesion molecule-1 gene expression by glial cells. Differential mechanisms of inhibition by IL-10 and IL-6. J. Immunol. 1995, 155(3):1489-1501.
235. Simen B.B., Duman C.H., et al. TNFalpha signaling in depression and anxiety: behavioral consequences of individual receptor targeting. Biol. Psychiatry 2006, 59(9):775-785.
236. Song C., Manku M.S., et al. Long-chain polyunsaturated fatty acids modulate interleukin-1beta-induced changes in behavior, monoaminergic neurotransmitters, and brain inflammation in rats. J. Nutr. 2008, 138(5):954-963.
237. Song C., Wang H. Cytokines mediated inflammation and decreased neurogenesis in animal models of depression. Prog. Neuropsychopharmacol. Biol. Psychiatry 2011, 35(3):760-768.
238. Song C., Zhang X.Y., et al. Increased phospholipase A2 activity and inflammatory response but decreased nerve growth factor expression in the olfactory bulbectomized rat model of depression: effects of chronic ethyl-eicosapentaenoate treatment. J. Neurosci. 2009, 29(1):14-22.
239. Spranger M., Lindholm D., et al. Regulation of nerve growth factor (NGF) synthesis in the rat central nervous system: comparison between the effects of interleukin-1 and various growth factors in astrocyte cultures and in vivo. Eur. J. Neurosci. 1990, 2(1):69-76.
240. Stellwagen D., Malenka R.C. Synaptic scaling mediated by glial TNF-alpha. Nature 2006, 440(7087):1054-1059.
241. Stockinger B., Veldhoen M., et al. Th17 T cells: linking innate and adaptive immunity. Semin. Immunol. 2007, 19(6):353-361.
242. Stockmeier C.A., Mahajan G.J., et al. Cellular changes in the postmortem hippocampus in major depression. Biol. Psychiatry 2004, 56(9):640-650.
243. Stromnes I.M., Cerretti L.M., et al. Differential regulation of central nervous system autoimmunity by T(H)1 and T(H)17 cells. Nat. Med. 2008, 14(3):337-342.
244. Surget A., Saxe M., et al. Drug-dependent requirement of hippocampal neurogenesis in a model of depression and of antidepressant reversal. Biol. Psychiatry 2008, 64(4):293-301.
245. Surget A., Tanti A., et al. Antidepressants recruit new neurons to improve stress response regulation. Mol. Psychiatry 2011, 16(12):1177-1188.
246. Tancredi V., D'Antuono M., et al. The inhibitory effects of interleukin-6 on synaptic plasticity in the rat hippocampus are associated with an inhibition of mitogen-activated protein kinase ERK. J. Neurochem. 2000, 75(2):634-643.
247. Tancredi V., D'Arcangelo G., et al. Tumor necrosis factor alters synaptic transmission in rat hippocampal slices. Neurosci. Lett. 1992, 146(2):176-178.
248. Tanti A., Belzung C. Open questions in current models of antidepressant action. Br. J. Pharmacol. 2010, 159(6):1187-1200.
249. Udagawa J., Nimura M., et al. Leptin affects oligodendroglial development in the mouse embryonic cerebral cortex. Neuro Endocrinol. Lett. 2006, 27(1-2):177-182.
250. Vakili K., Pillay S.S., et al. Hippocampal volume in primary unipolar major depression: a magnetic resonance imaging study. Biol. Psychiatry 2000, 47(12):1087-1090.
251. Vallieres L., Campbell I.L., et al. Reduced hippocampal neurogenesis in adult transgenic mice with chronic astrocytic production of interleukin-6. J. Neurosci. 2002, 22(2):486-492.
252. Van der Borght K., Kobor-Nyakas D.E., et al. Physical exercise leads to rapid adaptations in hippocampal vasculature: temporal dynamics and relationship to cell proliferation and neurogenesis. Hippocampus 2009, 19(10):928-936.
253. + pump activity as a potential target via distinct signaling mechanisms. Glia 2002, 39(1):10-18.
254. Vela J.M., Molina-Holgado E., et al. Interleukin-1 regulates proliferation and differentiation of oligodendrocyte progenitor cells. Mol. Cell. Neurosci. 2002, 20(3):489-502.
255. Vesce S., Rossi D., et al. Glutamate release from astrocytes in physiological conditions and in neurodegenerative disorders characterized by neuroinflammation. Int. Rev. Neurobiol. 2007, 82:57-71.
256. Vitkovic L., Konsman J.P., et al. Cytokine signals propagate through the brain. Mol. Psychiatry 2000, 5(6):604-615.
257. Viviani B., Gardoni F., et al. Cytokines and neuronal ion channels in health and disease. Int. Rev. Neurobiol. 2007, 82:247-263.
258. Volterra A., Meldolesi J. Astrocytes, from brain glue to communication elements: the revolution continues. Nat. Rev. Neurosci. 2005, 6(8):626-640.
259. Wager-Smith K., Markou A. Depression: a repair response to stress-induced neuronal microdamage that can grade into a chronic neuroinflammatory condition?. Neurosci. Biobehav. Rev. 2011, 35(3):742-764.
260. Wang X., Fu S., et al. Interleukin-1beta mediates proliferation and differentiation of multipotent neural precursor cells through the activation of SAPK/JNK pathway. Mol. Cell. Neurosci. 2007, 36(3):343-354.
261. Ward L.D., Howlett G.J., et al. High affinity interleukin-6 receptor is a hexameric complex consisting of two molecules each of interleukin-6, interleukin-6 receptor, and gp-130. J. Biol. Chem. 1994, 269(37):23286-23289.
262. Watkins L.R., Goehler L.E., et al. Blockade of interleukin-1 induced hyperthermia by subdiaphragmatic vagotomy: evidence for vagal mediation of immune-brain communication. Neurosci. Lett. 1995, 183(1-2):27-31.
263. Wei H., Zou H., et al. IL-6 is increased in the cerebellum of autistic brain and alters neural cell adhesion, migration and synaptic formation. J. Neuroinflammation 2011, 8:52.
264. Whitney N.P., Eidem T.M., et al. Inflammation mediates varying effects in neurogenesis: relevance to the pathogenesis of brain injury and neurodegenerative disorders. J. Neurochem. 2009, 108(6):1343-1359.
265. WHO The Global Burden of Disease: 2004 Update 2008, Geneva, WHO.
266. Widera D., Holtkamp W., et al. MCP-1 induces migration of adult neural stem cells. Eur. J. Cell Biol. 2004, 83(8):381-387.
267. Widera D., Mikenberg I., et al. Tumor necrosis factor alpha triggers proliferation of adult neural stem cells via IKK/NF-kappaB signaling. BMC Neurosci. 2006, 7:64.
268. Willner P. Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. Neuropsychobiology 2005, 52(2):90-110.
269. Wolf S.A., Steiner B., et al. CD4-positive T lymphocytes provide a neuroimmunological link in the control of adult hippocampal neurogenesis. J. Immunol. 2009, 182(7):3979-3984.
270. Wong G., Goldshmit Y., et al. Interferon-gamma but not TNF alpha promotes neuronal differentiation and neurite outgrowth of murine adult neural stem cells. Exp. Neurol. 2004, 187(1):171-177.
271. Wu A., Ying Z., et al. Dietary omega-3 fatty acids normalize BDNF levels, reduce oxidative damage, and counteract learning disability after traumatic brain injury in rats. J. Neurotrauma 2004, 21(10):1457-1467.
272. Wu C.W., Chang Y.T., et al. Exercise enhances the proliferation of neural stem cells and neurite growth and survival of neuronal progenitor cells in dentate gyrus of middle-aged mice. J. Appl. Physiol. 2008, 105(5):1585-1594.
273. Wu M.D., Hein A.M., et al. Adult murine hippocampal neurogenesis is inhibited by sustained IL-1beta and not rescued by voluntary running. Brain Behav. Immun. 2011, 26(2):292-300.
274. Yau S.Y., Lau B.W., et al. Adult hippocampal neurogenesis: a possible way how physical exercise counteracts stress. Cell Transplant. 2011, 20(1):99-111.
275. Yirmiya R., Goshen I. Immune modulation of learning, memory, neural plasticity and neurogenesis. Brain Behav. Immun. 2011, 25(2):181-213.
276. Yirmiya R., Pollak Y., et al. Effects of antidepressant drugs on the behavioral and physiological responses to lipopolysaccharide (LPS) in rodents. Neuropsychopharmacology 2001, 24(5):531-544.
277. Yong V.W., Power C., et al. Metalloproteinases in biology and pathology of the nervous system. Nat. Rev. Neurosci. 2001, 2(7):502-511.
278. Young S.N. Biologic effects of mindfulness meditation: growing insights into neurobiologic aspects of the prevention of depression. J. Psychiatry Neurosci. 2011, 36(2):75-77.
279. Zanin-Zhorov A., Ding Y., et al. Protein kinase C-theta mediates negative feedback on regulatory T cell function. Science 2010, 328(5976):372-376.
280. Zhang W., Li P., et al. Omega-3 polyunsaturated fatty acids in the brain: metabolism and neuroprotection. Front. Biosci. 2011, 17:2653-2670.
281. Zhong Y., Zhou L.J., et al. The direction of synaptic plasticity mediated by C-fibers in spinal dorsal horn is decided by Src-family kinases in microglia: the role of tumor necrosis factor-alpha. Brain Behav. Immun. 2010, 24(6):874-880.
282. Ziv Y., Finkelstein A., et al. A novel immune-based therapy for stroke induces neuroprotection and supports neurogenesis. Stroke 2007, 38(2 Suppl.):774-782.
283. Ziv Y., Ron N., et al. Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood. Nat. Neurosci. 2006, 9(2):268-275.
284. Ziv Y., Schwartz M. Immune-based regulation of adult neurogenesis: implications for learning and memory. Brain Behav. Immun. 2008, 22(2):167-176.