Chronic interpersonal stress predicts activation of pro- and anti-inflammatory signaling pathways 6 months later

Psychosomatic Medicine

Volumn 71, Issue 1, 2009, Pages 57-62

  Miller, Gregory E ^a   Rohleder, Nicolas ^a   Cole, Steve W ^b,c  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cytokines; Glucocorticoid receptor; Inflammation; Social conflict; Social support; Stress

Indexed keywords

BIOLOGICAL MARKER; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; C REACTIVE PROTEIN; GLUCOCORTICOID RECEPTOR; I KAPPA B; IL6 PROTEIN, HUMAN;

ADOLESCENT; ADULT; ARTICLE; CYTOPLASM; DEPRESSION; EX VIVO STUDY; FEMALE; HUMAN; INTERPERSONAL STRESS; INTERVIEW; LEUKOCYTE; LIFESTYLE; MENTAL STRESS; PRIORITY JOURNAL; BIOSYNTHESIS; CHRONIC DISEASE; CONFLICT; DRUG EFFECT; FAMILY CONFLICT; FOLLOW UP; FRIEND; GENETICS; HUMAN RELATION; INFLAMMATION; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; PROSPECTIVE STUDY; SEXUALITY; SIGNAL TRANSDUCTION;

ADOLESCENT; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CHRONIC DISEASE; CONFLICT (PSYCHOLOGY); FAMILY CONFLICT; FEMALE; FOLLOW-UP STUDIES; FRIENDS; HUMANS; I-KAPPA B PROTEINS; INFLAMMATION; INTERLEUKIN-6; INTERPERSONAL RELATIONS; LEUKOCYTES; LIFE STYLE; LIPOPOLYSACCHARIDES; NF-KAPPA B; PROSPECTIVE STUDIES; RECEPTORS, GLUCOCORTICOID; RNA, MESSENGER; SEXUAL PARTNERS; SIGNAL TRANSDUCTION; STRESS, PSYCHOLOGICAL; YOUNG ADULT;

EID: 65549099293     PISSN: 00333174     EISSN: 15347796     Source Type: Journal    
DOI: 10.1097/PSY.0b013e318190d7de     Document Type: Article

References (38)

1. House JS, Landis KS, Umberson D. Social relationships and health. Science 1988;241:540-5.
2. Cohen S. Social relationships and health. Am Psychol 2004;59:676-84.
3. Kiecolt-Glaser JK, Newton TL. Marriage and health: his and hers. Psychol Bull 2001;127:472-503.
4. Repetti RL, Taylor SE, Seeman TE. Risky families: family social environments and the mental and physical health of offspring. Psychol Bull 2002;128:330-66.
5. Cohen S, Janicki-Deverts DL, Miller GE. Psychological stress and disease. JAMA 2007;298:1685-7.
6. Butzlaff RL, Hooley JM. Expressed emotion and psychiatric relapse: a meta-analysis. Arch Gen Psychiatry 1998;55:547-52.
7. Cohen S, Frank E, Doyle WJ, Skoner DP, Rabin BS, Gwaltney JM Jr. Types of stressors that increase susceptibility to the common cold in healthy adults. Health Psychol 1998;17:214-23.
8. Kiecolt-Glaser JK, Loving TJ, Stowell JR, Malarkey WB, Lemeshow S, Dickinson SL, Glaser R. Hostile marital interactions, proinflammatory cytokine production, and wound healing. Arch Gen Psychiatry 2005;62: 1377-84.
9. Troxel WM, Matthews KA, Gallo LC, Kuller LH. Marital quality and occurrence of the metabolic syndrome in women. Arch Intern Med 2005;165:1022-7.
10. Orth-Gomer K, Wamala SP, Horsten M, Schenck-Gustafsson K, Schneiderman N, Mittleman MA. Marital stress worsens prognosis in women with coronary heart disease. JAMA 2000;284:3008-14.
11. Coyne JC, Rohrbaugh MJ, Shoham V, Sonnega JS, Nicklas JM, Cranford JA. Prognostic importance of marital quality for survival of congestive heart failure. Am J Cardiol 2001;88:526-9.
12. Sloan EK, Capitanio JP, Tarara RP, Mendoza SP, Mason WA, Cole SW. Social stress enhances sympathetic innervation of primate lymph nodes: mechanisms and implications for viral pathogenesis. J Neurosci 2007;27: 8857-65.
13. Quan N, Avitsur R, Stark JL, He L, Shah M, Caligiuri M, Padgett DA, Marucha PT, Sheridan JF. Social stress increases the susceptibility to endotoxic shock. J Neuroimmunol 2001;115:36-45.
14. Sheridan JF, Stark JL, Avitsur R, Padgett DA. Social disruption, immunity, and susceptibility to viral infection: role of glucocorticoid insensitivity and NGF. Ann N Y Acad Sci 2000;917:894-905.
15. Libby P, Theroux P. Pathophysiology of coronary artery disease. Circulation 2005;111:3481-8.
16. Dandona P, Aljada A, Chaudhuri A, Mohanty P, Garg R. Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation. Circulation 2005;111:1448-54.
17. Kronfol Z, Remick DG. Cytokines and the brain: implications for clinical psychiatry. Am J Psychiatry 2000;157:683-94.
18. Sternberg EM. Neural regulation of innate immunity: a coordinated nonspecific host response to pathogens. Nat Rev Immunol 2006;6: 318-28.
19. Webster JI, Tonelli L, Sternberg EM. Neuroendocrine regulation of immunity. Annu Rev Immunol 2002;20:125-63.
20. Dantzer R, O'Connor JC, Freund GG, Johnson RW, Kelley KW. From inflammation to sickness and depression: When the immune system subjugates the brain. Nat Rev Neurosci 2008;9:46-56.
21. Alloy LB, Abramson LY, Whitehouse WG, Hogan ME, Panzarella C, Rose DT. Prospective incidence of first onsets and recurrences of depression in individuals at high and low cognitive risk for depression. J Abnorm Psychol 2006;115:145-56.
22. Hammen C. Generation of stress in the course of unipolar depression. J Abnorm Psychol 1991;100:555-61.
23. Miller GE, Chen E. Life stress and diminished expression of genes encoding glucocorticoid receptor and beta2-adrenergic receptor in children with asthma. Proc Natl Acad Sci U S A 2006;103:5496-501.
24. Goodman E, Adler NE, Kawachi I, Frazier AL, Huang B, Colditz GA. Adolescents' perceptions of social status: development and evaluation of a new indicator. Pediatrics Pediatr 2001;108:e31.
25. Paffenbarger RS, Blair SN, Lee I, Hyde RT. Measurement of physical activity to assess health effects in a free-living population. Med Sci Sport Exer 1993;25:60-70.
26. Monroe SM, Hadjiyannakis K. The social environment and depression: Focusing on severe life stress. In: Gotlib IH, Hammen C, editors. Handbook of Depression. London: Guildford Press; 2002.
27. Capuron L, Miller AH, Irwin MR. Psychoneuroimmunology of depressive disorder: Mechanisms and clinical implications. In: Ader R, editor. Psychoneuroimmunology. 4th Ed. Boston: Elsevier; 2007.
28. Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuring depression. Arch Gen Psychiatry 1961;5:462-7.
29. Raison CL, Capuron L, Miller AH. Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends Immunol 2006;27:24-31.
30. Kiecolt-Glaser JK, Glaser R, Cacioppo JT, MacCallum RC, Snydersmith M, Kim C, Malarkey WB. Marital conflict in older adults: endocrinological and immunological correlates. Psychosom Med 1997;59: 339-49.
31. Bierhaus A, Wolf J, Andrassy M, Rohleder N, Humpert PM, Petrov D, Ferstl R, von EM, Wendt T, Rudofsky G, Joswig M, Morcos M, Schwaninger M, McEwen B, Kirschbaum C, Nawroth PP. A mechanism converting psychosocial stress into mononuclear cell activation. Proc Natl Acad Sci U S A 2003;100:1920-5.
32. Stetler C, Dickerson SS, Miller GE. Uncoupling of social zeitgebers and diurnal cortisol secretion in clinical depression. Psychoneuroendocrinology 2004;29:1250-9.
33. Stetler CA, Miller GE. Blunted cortisol response to awakening in mild to moderate depression: regulatory influences of sleep patterns and social contacts. J Abnorm Psychol 2005;114:697-705.
34. Miller GE, Chen E, Sze J, Marin T, Arevalo JMG, Doll R, Ma R, Cole SW. A genomic fingerprint of chronic stress in humans: blunted glucocorticoid and increased NF-κB signaling. Biol Psychiatry 2008;64: 266-72.
35. Stark JL, Avitsur R, Padgett DA, Campbell KA, Beck FM, Sheridan JF. Social stress induces glucocorticoid resistance in macrophages. Am J Physiol 2001;280:1799-1805.
36. Cole SW, Hawkley LC, Arevalo JM, Sung CS, Rose RM, Cacioppo JT. Social regulation of gene expression: inflammation and the human transcriptional response to loneliness. Genome Biol 2007;8:r89.
37. Hofer MA. Relationships as regulators: a psychobiologic perspective on bereavement. Psychosom Med 1984;46:183-97.
38. Weiner H. Perturbing the Organism: The Biology of Stressful Experience. Chicago: University of Chicago Press; 1992.