A genetic and functional relationship between T cells and cellular proliferation in the adult hippocampus

PLoS Biology

Volumn 8, Issue 12, 2010, Pages

  Huang, Guo Jen ^a   Smith, Adrian L ^b   Gray, Daniel H D ^c   Cosgrove, Cormac ^d   Singer, Benjamin H ^e   Edwards, Andrew ^a   Sim, Stuart ^d   Parent, Jack M ^e   Johnsen, Alyssa ^c   Mott, Richard ^a   Mathis, Diane ^c   Klenerman, Paul ^d   Benoist, Christophe ^c   Flint, Jonathan ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR ALPHA CHAIN; KI 67 ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR;

ADULTHOOD; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL PROLIFERATION; CONTROLLED STUDY; GENE LOCUS; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; GENETIC VARIABILITY; HIPPOCAMPUS; MOUSE; NONHUMAN; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; ANIMAL; CD4 CD8 RATIO; CYTOLOGY; GENETICS; IMMUNOLOGY; MOUSE STRAIN; MUTATION; NERVOUS SYSTEM DEVELOPMENT; OUTBRED STRAIN; QUANTITATIVE TRAIT LOCUS;

MUS;

ANIMALS; ANIMALS, OUTBRED STRAINS; CD4-CD8 RATIO; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; GENETIC VARIATION; HIPPOCAMPUS; KI-67 ANTIGEN; MICE; MICE, INBRED STRAINS; MUTATION; NEUROGENESIS; QUANTITATIVE TRAIT LOCI; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA;

EID: 78650469845     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.1000561     Document Type: Article

References (48)

1. Clelland CD, Choi M, Romberg C, Clemenson GD, Jr., Fragniere A, et al. (2009) A functional role for adult hippocampal neurogenesis in spatial pattern separation. Science 325: 210-213.
2. Deng W, Aimone JB, Gage FH (2010) New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? Nat Rev Neurosci 11: 339-350.
3. Gould E (2007) How widespread is adult neurogenesis in mammals? Nat Rev Neurosci 8: 481-488.
4. Leuner B, Gould E, Shors TJ (2007) Is there a link between adult neurogenesis and learning? Hippocampus 16: 216-224.
5. Jaholkowski P, Kiryk A, Jedynak P, Ben Abdallah NM, Knapska E, et al. (2009) New hippocampal neurons are not obligatory for memory formation; cyclin D2 knockout mice with no adult brain neurogenesis show learning. Learn Mem 16: 439-451.
6. Saxe MD, Battaglia F, Wang JW, Malleret G, David DJ, et al. (2006) Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus. Proc Natl Acad Sci U S A 103: 17501-17506.
7. Dupret D, Revest J-M, Koehl M, Ichas F, De Giorgi F, et al. (2008) Spatial relational memory requires hippocampal adult neurogenesis. PLoS One 3: e1959. doi:10.1371/journal.pone.0001959.
8. Zhang C-L, Zou Y, He W, Gage FH, Evans RM (2008) A role for adult TLXpositive neural stem cells in learning and behvaviour. Nature 451: 1004-1007.
9. Farioli-Vecchioli S, Saraulli D, Costanza M, Pacioni S, Cina I, et al. (2008) The timing of differentiation of adult hippocampal neurons is crucial for spatial memory. PLoS Biology 6: e246. doi:10.1371/journal.pbio.0060246.
10. Imayoshi I, Sakamoto M, Ohtsuka T, Takao K, Miyakawa T, et al. (2008) Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain. Nat Neurosci 11: 1153-1161.
11. Bergami M, Rimondini R, Santi S, Blum R, Götz M, et al. (2008) Deletion of TrkB in adult progenitors alters newborn neuron integration into hippocampal circuits and increases anxiety-like behavior. Proc Natl Acad Sci U S A 105: 15570-15575.
12. Kempermann G, Chesler EJ, Lu L, Williams RW, Gage FH (2006) Natural variation and genetic covariance in adult hippocampal neurogenesis. Proc Natl Acad Sci U S A 103: 780-785.
13. Valdar W, Solberg LC, Gauguier D, Burnett S, Klenerman P, et al. (2006) Genome-wide genetic association of complex traits in heterogeneous stock mice. Nat Genet 38: 879-887.
14. Santarelli L, Saxe M, Gross C, Surget A, Battaglia F, et al. (2003) Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301: 805-809.
15. Chen J, Harrison DE (2002) Quantitative trait loci regulating relative lymphocyte proportions in mouse peripheral blood. Blood 99: 561-566.
16. Valdar W, Holmes CC, Mott R, Flint J (2009) Mapping in structured populations by resample model averaging. Genetics 182: 1263-1277.
17. Yalcin B, Nicod J, Bhomra A, Davidson S, Cleak J, et al. (2010) Commercially available outbred mice for genome-wide association studies. PLoS Genet 6(9): e1001085. doi:10.1371/journal.pgen.1001085.
18. Ferreira MA, Mangino M, Brumme CJ, Zhao ZZ, Medland SE, et al. (2010) Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control. Am J Hum Genet 86: 88-92.
19. Singer BH, Jutkiewicz EM, Fuller CL, Lichtenwalner RJ, Zhang H, et al. (2009) Conditional ablation and recovery of forebrain neurogenesis in the mouse. J Comp Neurol 514: 567-582.
20. Bush TG, Savidge TC, Freeman TC, Cox HJ, Campbell EA, et al. (1998) Fulminant jejuno-ileitis following ablation of enteric glia in adult transgenic mice. Cell 93: 189-201.
21. Garcia AD, Doan NB, Imura T, Bush TG, Sofroniew MV (2004) GFAPexpressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain. Nat Neurosci 7: 1233-1241.
22. Ziv Y, Ron N, Butovsky O, Landa G, Sudai E, et al. (2006) Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood. Nat Neurosci 9: 268-275.
23. Wolf SA, Steiner B, Akpinarli A, Kammertoens T, Nassenstein C, et al. (2009) CD4-positive T lymphocytes provide a neuroimmunological link in the control of adult hippocampal neurogenesis. J Immunol 182: 3979-3984.
24. Kaul M (2009) HIV-1 associated dementia: update on pathological mechanisms and therapeutic approaches. Curr Opin Neurol 22: 315-320.
25. Krathwohl MD, Kaiser JL (2004) HIV-1 promotes quiescence in human neural progenitor cells. J Infect Dis 190: 216-226.
26. Okamoto S, Kang YJ, Brechtel CW, Siviglia E, Russo R, et al. (2007) HIV/ gp120 decreases adult neural progenitor cell proliferation via checkpoint kinasemediated cell-cycle withdrawal and G1 arrest. Cell Stem Cell 1: 230-236.
27. Dembic Z, Ayane M, Klein J, Steinmetz M, Benoist CO, et al. (1985) Inbred and wild mice carry identical deletions in their E alpha MHC genes. EMBO J 4: 127-131.
28. Mathis DJ, Benoist C, Williams VE, 2nd, Kanter M, McDevitt HO (1983) Several mechanisms can account for defective E alpha gene expression in different mouse haplotypes. Proc Natl Acad Sci U S A 80: 273-277.
29. Cosgrove D, Bodmer H, Bogue M, Benoist C, Mathis D (1992) Evaluation of the functional equivalence of major histocompatibility complex class II A and E complexes. J Exp Med 176: 629-634.
30. Littman DR, Rudensky AY Th17 and regulatory T cells in mediating and restraining inflammation. Cell 140: 845-858.
31. Feuerer M, Herrero L, Cipolletta D, Naaz A, Wong J, et al. (2009) Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med 15: 930-939.
32. Goldrath AW, Bevan MJ (1999) Selecting and maintaining a diverse T-cell repertoire. Nature 402: 255-262.
33. Li G, Pleasure SJ (2005) Morphogenesis of the dentate gyrus: what we are learning from mouse mutants. Dev Neurosci 27: 93-99.
34. Inestrosa NC, Arenas E (2010) Emerging roles of Wnts in the adult nervous system. Nat Rev Neurosci 11: 77-86.
35. Zhou CJ, Zhao C, Pleasure SJ (2004) Wnt signaling mutants have decreased dentate granule cell production and radial glial scaffolding abnormalities. J Neurosci 24: 121-126.
36. Wexler EM, Paucer A, Kornblum HI, Palmer TD, Geschwind DH (2009) Endogenous Wnt signaling maintains neural progenitor cell potency. Stem Cells 27: 1130-1141.
37. Kuwabara T, Hsieh J, Muotri A, Yeo G, Warashina M, et al. (2009) Wntmediated activation of NeuroD1 and retro-elements during adult neurogenesis. Nat Neurosci 12: 1097-1105.
38. Gao Z, Ure K, Ables JL, Lagace DC, Nave KA, et al. (2009) Neurod1 is essential for the survival and maturation of adult-born neurons. Nat Neurosci 12: 1090-1092.
39. Mao Y, Ge X, Frank CL, Madison JM, Koehler AN, et al. (2009) Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell 136: 1017-1031.
40. Ageta H, Murayama A, Migishima R, Kida S, Tsuchida K, et al. (2008) Activin in the brain modulates anxiety-related behavior and adult neurogenesis. PLoS One 3: e1869. doi:10.1371/journal.pone.0001869.
41. Lucin KM, Wyss-Coray T (2009) Immune activation in brain aging and neurodegeneration: too much or too little? Neuron 64: 110-122.
42. Shatz CJ (2009) MHC class I: an unexpected role in neuronal plasticity. Neuron 64: 40-45.
43. Yamada S, Nelson WJ (2007) Synapses: sites of cell recognition, adhesion, and functional specification. Annu Rev Biochem 76: 267-294.
44. Chesler EJ, Miller DR, Branstetter LR, Galloway LD, Jackson BL, et al. (2008) The Collaborative Cross at Oak Ridge National Laboratory: developing a powerful resource for systems genetics. Mamm Genome 19: 382-389.
45. Churchill GA, Airey DC, Allayee H, Angel JM, Attie AD, et al. (2004) The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet 36: 1133-1137.
46. Solberg LC, Valdar W, Gauguier D, Nunez G, Taylor A, et al. (2006) A protocol for high-throughput phenotyping, suitable for quantitative trait analysis in mice. Mamm Genome 17: 129-146.
47. Yaworsky PJ, Kappen C (1999) Heterogeneity of neural progenitor cells revealed by enhancers in the nestin gene. Dev Biol 205: 309-321.
48. Deacon RM, Rawlins JN (2005) Hippocampal lesions, species-typical behaviours and anxiety in mice. Behav Brain Res 156: 241-249.