Voluntary exercise induces a BDNF-mediated mechanism that promotes neuroplasticity

Journal of Neurophysiology

Volumn 88, Issue 5, 2002, Pages 2187-2195

  Gómez Pinilla, Fernando ^a,c   Ying, Zhe ^b   Roy, Roland R ^c   Molteni, Raffaella ^c   Reggie Edgerton, V ^b,c  

^a Department of Physiological Science ^*  (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BOTULINUM TOXIN A; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; MESSENGER RNA; NEUROMODULIN; NEUROTROPHIN; SYNAPSIN I;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXERCISE; LUMBAR SPINAL CORD; MOTOR ACTIVITY; NERVE CELL PLASTICITY; NEUROMODULATION; NEUROMUSCULAR SYSTEM; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; RAT; SITTING; SOLEUS MUSCLE;

EID: 0036850342     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.00152.2002     Document Type: Article

References (30)

1. Barbacid M. The Trk family of neurotrophin receptors. J Neurobiol 25: 1386-1403, 1994.
2. Bregman BS, McAtee M, Dai HN, and Kuhn PL. Neurotrophic factors increase axonal growth after spinal cord injury and transplantation in the adult rat. Exp Neurol 148: 475-494, 1997.
3. Brock TO and O'Callaghan JP. Quantitative changes in the synaptic vesicle proteins synapsin I and p38 and the astrocyte-specific protein glial fibrillary acidic protein are associated with chemical-induced injury to the rat central nervous system. J Neurosci 7: 931-942, 1987.
4. Causing CG, Gloster A, Aloyz R, Bamji SX, Chang E, Fawcett J, Kuchel G, and Miller FD. Synaptic innervation density is regulated by neuron-derived BDNF. Neuron 18: 257-267, 1997.
5. De Leon RD, Hodgson JA, Roy RR, and Edgerton VR. Locomotor capacity attributable to step training versus spontaneous recovery following spinalization in adult cats. J Neurophysiol 79: 1329-1340, 1998.
6. Finkbeiner S. Calcium regulation of the brain-derived neurotrophic factor gene. Cell Mol Life Sci 57: 394-401, 2000.
7. Finkbeiner S, Tavazoie SF, Maloratsky A, Jacobs KM, Harris KM, and Greenberg ME. CREB: A major mediator of neuronal neurotrophin responses. Neuron 19: 1031-1047, 1997.
8. Gomez-Pinilla F, Ying Z, Opazo P, Roy RR, and Edgerton VR. Differential regulation by exercise of BDNF and NT-3 in rat spinal cord and skeletal muscle. Eur J Neurosci 13: 1078-1084, 2001.
9. Irintchev A and Wernig A. Muscle damage and repair in voluntarily running mice: Strain and muscle differences. Cell Tissue Res 249: 509-521, 1987.
10. Ishihara A, Roy RR, Ohira Y, Ibata Y, and Edgerton VR. Hypertrophy of rat plantaris muscle fibers after voluntary running with increased loads. J Appl Physiol 84: 2183-2189, 1998.
11. Jakeman LB, Wei P, Guan Z, and Stokes BT. Brain-derived neurotrophic factor stimulates hindlimb stepping and sprouting of cholinergic fibers after spinal cord injury. Exp Neurol 154: 170-184, 1998.
12. Jones TA, Chu CJ, Grande LA, and Gregory AD. Motor skills training enhances lesion-induced structural plasticity in the motor cortex of adult rats. J Neurosci 19: 10153-10163, 1999.
13. Jovanovic JN, Benfenati F, Siow YL, Sihra TS, Sanghera JS, Pelech SL, Greengard P, and Czernik AJ. Neurotrophins stimulate phosphorylation of synapsin I by MAP kinase and regulate synapsin I-actin interactions. Proc Natl Acad Sci USA 93: 3679-3683, 1996.
14. Jovanovic JN, Czernik AJ, Fienberg AA, Greengard P, and Sihra TS. Synapsins as mediators of BDNF-enhanced neurotransmitter release. Nat Neurosci 3: 323-329, 2000.
15. Kafitz KW, Rose CR, Thoenen H, and Konnerth A. Neurotrophin-evoked rapid excitation through trkB receptors. Nature 401: 918-921, 1999.
16. Kempermann G, Van Praag H, and Gage FH. Activity-dependent regulation of neuronal plasticity and self repair. Prog Brain Res 127: 35-48, 2000.
17. Kleiman RJ, Tian N, Krizaj D, Hwang TN, Copenhagen DR, and Reichardt LF. BDNF-induced potentiation of spontaneous twitching in innervated myocytes requires calcium release from intracellular stores. J Neurophysiol 84: 472-483, 2000.
18. Koliatsos VE, Clatterbuck RE, Winslow JW, Cayouette MH, and Price DL. Evidence that brain-derived neurotrophic factor is atrophic factor for motor neurons in vivo. Neuron 10: 359-367, 1993.
19. Kramer AF, Hahn S, Cohen NJ, Banich MT, McAuley E, Harrison CR, Chason J, Vakil E, Bardell L, Boileau RA, and Colcombe A. Ageing, fitness, and neurocognitive function. Nature 400: 418-419, 1999.
20. Lu B and Figurov A. Role of neurotrophins in synapse development and plasticity. Rev Neurosci 8: 1-12, 1997.
21. Neeper SA, Gómez-Pinilla F, Choi J, and Cotman C. Exercise and brain neurotrophins. Nature 373: 109, 1995.
22. Nelson SG and Mendell LM. Projection of single knee flexor Ia fibers to homonymous and heteronymous motoneurons. J Neurophysiol 41: 778-87, 1978.
23. Oestreicher AB, De Graan PN, Gispen WH, Verhaagen J, and Schrama LH. B-50, the growth associated protein-43: Modulation of cell morphology and communication in the nervous system. Prog Neurobiol 53: 627-686, 1997.
24. Routtenberg A, Cantallops I, Zaffuto S, Serrano P, and Namgung U. Enhanced learning after genetic overexpression of a brain growth protein. Proc Natl Acad Sci USA 97: 7657-7662, 2000.
25. Roy RR, Hutchison DL, Pierotti DJ, Hodgson JA, and Edgerton VR. EMG patterns of rat ankle extensors and flexors during treadmill locomotion and swimming. J Appl Physiol 70: 2522-2529, 1991.
26. Sagot Y, Rosse T, Vejsada R, Perrelet D, and Kato AC. Differential effects of neurotrophic factors on motoneuron retrograde labeling in a murine model of motoneuron disease. J Neurosci 18: 1132-1141, 1998.
27. Silva AJ, Kogan JH, Frankland PW, and Kida S. CREB and memory. Annu Rev Neurosci 21: 127-148, 1998.
28. Walton M, Connor B, Lawlor P, Young D, Sirimanne E, Gluckman P, Cole G, and Dragunow M. Neuronal death and survival in two models of hypoxic-ischemic brain damage. Brain Res Brain Res Rev 29: 137-168, 1999.
29. Wang T, Xie K, and Lu B. Neurotrophins promote maturation of developing neuromuscular synapses. J Neurosci 15: 4796-4805, 1995.
30. Wernig A, Salvini TF, and Irintchev A. Axonal sprouting and changes in fibre types after running-induced muscle damage. J Neurocytol 20: 903-913, 1991.