Autoimmunity on alert: Naturally occurring regulatory CD4+CD25+ T cells as part of the evolutionary compromise between a 'need' and a 'risk'

Trends in Immunology

Volumn 23, Issue 11, 2002, Pages 530-534

  Schwartz, Michal ^a   Kipnis, Jonathan ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM DISEASE; DOWN REGULATION; EFFECTOR CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOCOMPETENT CELL; IMMUNOREGULATION; LYMPHOCYTE CLONE; MOLECULAR EVOLUTION; MYELINATED NERVE; NERVE DEGENERATION; NONHUMAN; T LYMPHOCYTE; THYMUS;

EID: 0036839021     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4906(02)02322-0     Document Type: Review

References (51)

1. Moalem G., et al. Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy. Nat. Med. 5:1999;49-55.
2. + regulatory T cells and worsened by neonatal tolerance to myelin proteins. Proc. Natl. Acad. Sci. U. S. A. (in press)
3. Moalem G., et al. Differential T cell response in central and peripheral nerve injury: connection with immune privilege. FASEB J. 13:1999;1207-1217.
4. Faden A.I. Experimental neurobiology of central nervous system trauma. Crit. Rev. Neurobiol. 7:1993;175-186.
5. Liu D., et al. Hydroxyl radicals generated in vivo kill neurons in the rat spinal cord: electrophysiological, histological, and neurochemical results. J. Neurochem. 62:1994;37-44.
6. Yoles E., Schwartz M. Degeneration of spared axons following partial white matter lesion: implications for optic nerve neuropathies. Exp. Neurol. 153:1998;1-7.
7. Moalem G., et al. Autoimmune T cells retard the loss of function in injured rat optic nerves. J. Neuroimmunol. 106:2000;189-197.
8. Hauben E., et al. Autoimmune T cells as potential neuroprotective therapy for spinal cord injury. Lancet. 355:2000;286-287.
9. Fisher J., et al. Vaccination for neuroprotection in the mouse optic nerve: implications for optic neuropathies. J. Neurosci. 21:2001;136-142.
10. Kipnis J., et al. Myelin specific Th1 cells are necessary but not sufficient for post-traumatic protective autoimmunity. J. Neuroimmunol. 130:2002;78-85.
11. Yoles E., et al. Protective autoimmunity is a physiological response to CNS trauma. J. Neurosci. 21:2001;3740-3748.
12. Schwartz M., Kipnis J. Protective autoimmunity: regulation and prospects for vaccination after brain and spinal cord injuries. Trends Mol. Med. 7:2001;252-258.
13. Kipnis J., et al. Neuronal survival after CNS insult is determined by a genetically encoded autoimmune response. J. Neurosci. 21:2001;4564-4571.
14. Schori H., et al. T-cell-based immunity counteracts the potential toxicity of glutamate in the central nervous system. J. Neuroimmunol. 119:2001;199-204.
15. Schori H., et al. Vaccination for protection of retinal ganglion cells against death from glutamate cytotoxicity and ocular hypertension: implications for glaucoma. Proc. Natl. Acad. Sci. U. S. A. 98:2001;3398-3403.
16. Mizrahi, and T. Schwartz, M. Pathogenic self-antigens in autoimmune diseases are potentially protective: a lesson from the visual system. J. Immunol. (in press)
17. Burnet F.M. The Clonal Selection Theory of Acquired Immunity. 1959;Cambridge University Press.
18. Burnet F.M. The concept of immunological surveillance. Prog. Exp. Tumor Res. 13:1970;1-27.
19. Talmage D.W., Hemmingsen H. Cell interaction in antibody synthesis. J. Allergy. 43:1969;323-335.
20. Talmage D.W., et al. Cell interaction in antibody synthesis. Adv. Immunol. 12:1970;271-282.
21. Lafferty K.J., Gill R.G. The maintenance of self-tolerance. Immunol. Cell Biol. 71:1993;209-214.
22. Lafferty K.J., Gazda L.S. Tolerance: a case of self/not-self discrimination maintained by clonal deletion? Hum. Immunol. 52:1997;119-126.
23. Droge W. Hypothesis on the origin of the strong alloreactivity. Immunobiology. 156:1979;2-12.
24. Iwatani Y., et al. Peripheral self-tolerance and autoimmunity: the protective role of expression of class II major histocompatibility antigens on non-lymphoid cells. Biomed. Pharmacother. 43:1989;593-605.
25. Bretscher P., Cohn M. A theory of self-nonself discrimination. Science. 169:1970;1042-1049.
26. Janeway C.A. Jr. The immune system evolved to discriminate infectious nonself from noninfectious self. Immunol. Today. 13:1992;11-16.
27. Cohen I.R. The cognitive paradigm and the immunological homunculus. Immunol. Today. 13:1992;490-494.
28. Matzinger P. Tolerance, danger, and the extended family. Annu. Rev. Immunol. 12:1994;991-1045.
29. Matzinger P. The danger model: a renewed sense of self. Science. 296:2002;301-305.
30. Coutinho A., et al. Some reasons why deletion and anergy do not satisfactorily account for natural tolerance. Res. Immunol. 143:1992;345-354.
31. Coutinho A., et al. The role of thymic epithelium in the establishment of transplantation tolerance. Immunol. Rev. 133:1993;225-240.
32. von Boehmer H. Positive and negative selection of the α β T-cell repertoire in vivo. Curr. Opin. Immunol. 3:1991;210-215.
33. Modigliani Y., et al. A model for developmentally acquired thymus-dependent tolerance to central and peripheral antigens. Immunol. Rev. 149:1996;155-220.
34. Lafaille J.J., et al. High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T-cell receptor transgenic mice. Cell. 78:1994;399-408.
35. Sakaguchi S., et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155:1995;1151-1164.
36. + immunoregulatory T cells suppress polyclonal T-cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188:1998;287-296.
37. Seddon B., Mason D. The third function of the thymus. Immunol. Today. 21:2000;95-99.
38. Shevach E.M. Regulatory T cells in autoimmunity*. Annu. Rev. Immunol. 18:2000;423-449.
39. Kawahata K., et al. Generation of CD4(+)CD25(+) regulatory T cells from autoreactive T cells simultaneously with their negative selection in the thymus and from nonautoreactive T cells by endogenous TCR expression. J. Immunol. 168:2002;4399-4405.
40. Romagnoli P., et al. Preferential recognition of self antigens despite normal thymic deletion of CD4(+)CD25(+) regulatory T cells. J. Immunol. 168:2002;1644-1648.
41. + T cells. J. Immunol. 168:2002;613-620.
42. + regulatory T cells from human peripheral blood. J. Immunol. 166:2001;7282-7289.
43. Pontoux C., et al. Natural CD4 CD25(+) regulatory T cells control the burst of superantigen-induced cytokine production: the role of IL-10. Int. Immunol. 14:2002;233-239.
44. Kingsley C.I., et al. CD25+CD4+ regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponses. J. Immunol. 168:2002;1080-1086.
45. Piccirillo C.A., et al. CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor β1 production and responsiveness. J. Exp. Med. 196:2002;237-246.
46. Nakamura K., et al. Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor β J. Exp. Med. 194:2001;629-644.
47. Jones T.B., et al. Pathological CNS autoimmune disease triggered by traumatic spinal cord injury: implications for autoimmune vaccine therapy. J. Neurosci. 22:2002;2690-2700.
48. Butovsky O., et al. Morphological aspects of spinal cord autoimmune neuroprotection: colocalization of T cells with B7-2 (CD86) and prevention of cyst formation. FASEB J. 15:2001;1065-1067.
49. Schwartz M., Kipnis J. Multiple sclerosis as a by-product of the failure to sustain protective autoimmunity: a paradigm shift. Neuroscientist. 8:2002;405-413.
50. Nakajima K., et al. Ability of rat microglia to uptake extracellular glutamate. Neurosci. Lett. 307:2001;171-174.
51. van Landeghem F.K., et al. Early expression of glutamate transporter proteins in ramified microglia after controlled cortical impact injury in the rat. Glia. 35:2001;167-179.