The inflammatory & neurodegenerative (I&ND) hypothesis of depression: Leads for future research and new drug developments in depression

Metabolic Brain Disease

Volumn 24, Issue 1, 2009, Pages 27-53

  Maes, Michael ^a   Yirmyia, Raz ^b   Noraberg, Jens ^c   Brene, Stefan ^d   Hibbeln, Joe ^e   Perini, Giulia ^f   Kubera, Marta ^g   Bob, Petr ^h   Lerer, Bernard ⁱ   Maj, Mario ^j  

^a Clinical Research Center for Mental Health of Antwerp   (Belgium)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^c UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^d KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^e NATIONAL INSTITUTES OF HEALTH   (United States)

^f UNIVERSITY OF PADOVA   (Italy)

^g INSTITUTE OF PHARMACOLOGY   (Poland)

^h CHARLES UNIVERSITY   (Czech Republic)

ⁱ HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^j SECOND UNIVERSITY OF NAPLES   (Italy)

more..

Author keywords

Cytokines; Depression; IDO.; Inflammation; Neurodegeneration; Nitrosative stress; Oxidative stress; Serotonin; Tryptophan

Indexed keywords

ANTIDEPRESSANT AGENT; BIOLOGICAL MARKER; CELECOXIB; CURCUMIN; CYCLOOXYGENASE 2 INHIBITOR; CYTOKINE; DIPEPTIDYL PEPTIDASE IV; FLUOXETINE; GLUCOCORTICOID RECEPTOR; HYDROCORTISONE; INTERLEUKIN 1BETA; INTERLEUKIN 6; KYNURENINE; LITHIUM; MALONALDEHYDE; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE; MOCLOBEMIDE; OMEGA 3 FATTY ACID; OXYGEN RADICAL; PAROXETINE; QUINOLINIC ACID; REBOXETINE; SEROTONIN; SEROTONIN UPTAKE INHIBITOR; TIANEPTINE; TRICYCLIC ANTIDEPRESSANT AGENT; TRYPTOPHAN; TRYPTOPHAN CATABOLITES ALONG THE IDO PATHWAY; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; BRAIN SLICE; CYTOKINE PRODUCTION; DEGENERATIVE DISEASE; DEPRESSION; DNA MICROARRAY; DRUG EFFICACY; ELECTROPORATION; EX VIVO STUDY; GENOTYPE; HIGH THROUGHPUT SCREENING; HUMAN; IN VITRO STUDY; INFLAMMATION; MEDICAL RESEARCH; MENTAL STRESS; MOUSE; NERVE DEGENERATION; NONHUMAN; PATHOPHYSIOLOGY; PHENOTYPE; REVIEW; SEROTONIN RELEASE; TRANSGENIC MOUSE;

ANIMALS; BIOLOGICAL MARKERS; CAUSALITY; CYTOKINES; DEPRESSIVE DISORDER; DISEASE MODELS, ANIMAL; ENCEPHALITIS; HUMANS; NERVE DEGENERATION; OXIDATIVE STRESS; STRESS, PSYCHOLOGICAL; TRYPTOPHAN;

ANIMALIA; MUS MUSCULUS;

EID: 57749179191     PISSN: 08857490     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11011-008-9118-1     Document Type: Review

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