Reduced hippocampal neurogenesis in adult transgenic mice with chronic astrocytic production of interleukin-6

Journal of Neuroscience

Volumn 22, Issue 2, 2002, Pages 486-492

  Valliéres, Luc ^a   Campbell, Iain L ^b   Gage, Fred H ^a   Sawchenko, Paul E ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Chronic inflammation; Fluoro jade; Hippocampus; Interleukin 6; Neural progenitor cells; Postnatal neurogenesis; Proinflammatory cytokine; Transgenic mice

Indexed keywords

CYTOKINE; INTERLEUKIN 6;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; CELL COUNT; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DEGENERATIVE DISEASE; GLIA CELL; HIPPOCAMPUS; LONG TERM EXPOSURE; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; STEM CELL; TRANSGENIC MOUSE;

EID: 0037079993     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-02-00486.2002     Document Type: Article

References (55)

1. Estimation of nuclear population from microtome sections
2. Transcriptional analysis of multiple sclerosis brain lesions reveals a complex pattern of cytokine expression
3. Apoptosis and proliferation of dentate gyrus neurons after single and intermittent limbic seizures
4. Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway
5. Neuronal activity and transcription of proinflammatory cytokines, IkappaBalpha, and iNOS in the mouse brain during acute endotoxemia and chronic infection with Trypanosoma brucei brucei
6. Adult neurogenesis is regulated by adrenal steroids in the dentate gyrus
7. Differentiation of newly born neurons and glia in the dentate gyrus of the adult rat
8. Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6
9. Reactive gliosis as a consequence of interleukin-6 expression in the brain: Studies in transgenic mice
10. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
11. Hematopoietic cells differentiate into both microglia and macroglia in the brains of adult mice
12. Opiates inhibit neurogenesis in the adult rat hippocampus
13. Interleukin 6 promotes vasculogenesis of murine brain microvessel endothelial cells
14. Survival and differentiation of adult neuronal progenitor cells transplanted to the adult brain
15. Regulation of neuronal differentiation in human CNS stem cell progeny by leukemia inhibitory factor
16. Lesion-induced proliferation of neuronal progenitors in the dentate gyrus of the adult rat
17. Adrenal hormones suppress cell division in the adult rat dentate gyrus
18. Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and NMDA receptor activation
19. Learning enhances adult neurogenesis in the hippocampal formation
20. Kainic acid increases the proliferation of granule cell progenitors in the dentate gyrus of the adult rat
21. Neurogenesis in the adult brain: Death of a dogma
22. Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain
23. Microglia-specific localisation of a novel calcium binding protein, Iba1
24. Distribution of glial fibrillary acidic protein (GFAP)-immunoreactive astrocytes in the rat brain. I. Forebrain
25. Mitotic neuroblasts in the 9-day-old and 11-month-old rodent hippocampus
26. Neurogenesis in the adult rat: Electron microscopic analysis of light radioautographs
27. More hippocampal neurons in adult mice living in an enriched environment
28. Experience-induced neurogenesis in the senescent dentate gyrus
29. Neural precursor differentiation into astrocytes requires signaling through the leukemia inhibitory factor receptor
30. Neurogenesis in the dentate gyrus of the adult rat: Age-related decrease of neuronal progenitor proliferation
31. Cerebrospinal fluid interleukin-6 activity in HIV infection and inflammatory and noninflammatory diseases of the nervous system
32. Prenatal stress produces learning deficits associated with an inhibition of neurogenesis in the hippocampus
33. Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbils
34. Adult-generated neurons in the dentate gyrus send axonal projections to field CA3 and are surrounded by synaptic vesicles
35. Increased cerebrospinal fluid fas (Apo-1) levels in Alzheimer's disease: Relationship with IL-6 concentrations
36. The role of tumour necrosis factor, interleukin 6, interferon-gamma and inducible nitric oxide synthase in the development and pathology of the nervous system
37. Enhancement of progenitor cell division in the dentate gyrus triggered by initial limbic seizures in rat models of epilepsy
38. Enriched environment increases neurogenesis in the adult rat dentate gyrus and improves spatial memory
39. 3H-thymidine incorporation and neurogenesis
40. Vascular niche for adult hippocampal neurogenesis
41. Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus
42. Interleukin-6 and soluble interleukin-6 receptor: Direct stimulation of gp130 and hematopoiesis
43. Modulation of hypothalamic-pituitary-adrenal function by transgenic expression of interleukin-6 in the CNS of mice
44. Interleukin-6 (Il-6), Il-6 receptor expression in the rat hippocampus in response to status epilepticus: Time-course, distribution, correlation with neuronal degeneration
45. Marrow-mindedness: A perspective on neuropoiesis
46. Fluoro-Jade: A novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration
47. Kindling-induced neurogenesis in the dentate gyrus of the rat
48. Identification of the neural stem cells in the adult hippocampus
49. The ciliary neurotrophic factor/leukemia inhibitory factor/gp130 receptor complex operates in the maintenance of mammalian forebrain neural stem cells
50. Neurogenesis in the adult is involved in the formation of trace memories
51. Evidence that granule cells generated in the dentate gyrus of adult rats extend axonal projections
52. Regulation of the hypothalamic-pituitary-adrenal axis by cytokines: Actions and mechanisms of action
53. Seizures produced by pilocarpine in mice: A behavioral, electroencephalographic and morphological analysis
54. Regulation of the genes encoding interleukin-6, its receptor, and gp130 in the rat brain in response to the immune activator lipopolysaccharide and the proinflammatory cytokine interleukin-1beta
55. Interleukin-6 is a needed proinflammatory cytokine in the prolonged neural activity and transcriptional activation of corticotropin-releasing factor during endotoxemia