Ciliary neurotrophic factor activates spinal cord astrocytes, stimulating their production and release of fibroblast growth factor-2, to increase motor neuron survival

Experimental Neurology

Volumn 173, Issue 1, 2002, Pages 46-62

  Albrecht, Phillip J ^a   Dahl, John P ^b   Stoltzfus, Olivia K ^a   Levenson, Robert ^b   Levison, Steven W ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

Author keywords

CNS injury; CNTF; Cytokines; FGF 2; Gliosis; Growth factors; IL 1 ; Regeneration

Indexed keywords

CILIARY NEUROTROPHIC FACTOR; CYTOKINE; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 2; GLIAL FIBRILLARY ACIDIC PROTEIN; GROWTH FACTOR; INTERLEUKIN 1BETA; LEUKEMIA INHIBITORY FACTOR; MESSENGER RNA; NERVE GROWTH FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ASTROCYTE; AUTOCRINE EFFECT; BRAIN INJURY; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA REPAIR; DNA SYNTHESIS; IMMUNOMODULATION; IMMUNOSTIMULATION; MALE; MOLECULAR MODEL; MOTONEURON; NERVE CELL; NERVE GROWTH; NEURITE; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPINAL CORD INJURY; VENTRAL ROOT;

EID: 0036144963     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.2001.7834     Document Type: Article

References (104)

1. A double-blind placebo-controlled clinical trial of subcutaneous recombinant human ciliary neurotrophic factor (rHCNTF) in amyotrophic lateral sclerosis
2. Characterization of receptors for ciliary neurotrophic factor on rat hippocampal astrocytes
3. Ciliary neurotrophic factor protects striatal output neurons in an animal model of Huntington disease
4. Survival effect of ciliary neurotrophic factor (CNTF) on chick embryonic motoneurons in culture: Comparison with other neurotrophic factors and cytokines
5. Basic FGF in astroglial, microglial, and neuronal cultures: Characterization of binding sites and modulation of release by lymphokines and trophic factors
6. Time course of ciliary neurotrophic factor mRNA expression is coincident with the presence of protoplasmic astrocytes in traumatized rat striatum
7. Astrocytic functions and physiological reactions to injury: The potential to induce and/or exacerbate neuronal dysfunction - A forum position paper
8. Increase in glia-derived nerve growth factor following destruction of hippocampal neurons
9. Reactive astrogliosis in the neonatal mouse brain and its modulation by cytokines
10. Effects of basic fibroblast growth factor (bFGF) on choline acetyltransferase activity and astroglial reaction in adult rats after partial fimbria transection
11. Ciliary neurotrophic factor enhances the rate of oligodendrocyte generation
12. Gliosis
13. A glia-derived signal regulating neuronal differentiation
14. Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway
15. CNS glial scar tissue: A source of molecules which inhibit central neurite outgrowth
16. Vasoactive intestinal peptide: A neurotrophic releasing agent and an astroglial mitogen
17. Identity of neurotrophic molecules released from astroglia by vasoactive intestinal peptide
18. Regulation by interleukin-1 of nerve growth factor secretion and nerve growth factor mRNA expression in rat primary astroglial cultures
19. Tumor necrosis factor-alpha production by astrocytes. Induction by lipopolysaccharide, IFN-gamma, and IL-1 beta
20. Ciliary neurotrophic factor prevents retrograde neuronal death in the adult central nervous system
21. Ciliary neurotrophic factor stimulates the expression of glial fibrillary acidic protein by brain astrocytes in vivo
22. Control of astrocytosis by interleukin-1 and transforming growth factor-beta 1 in human brain
23. Participation of Na,K-ATPase in FGF-2 secretion: Rescue of ouabain-inhibitable FGF-2 secretion by ouabain-resistant Na,K-ATPase alpha subunits
24. Inflammatory cytokines interact to modulate extracellular matrix and astrocytic support of neurite outgrowth
25. Expression of neurotrophins in the adult spinal cord in vivo
26. Ciliary neurotrophic factor receptor expression in spinal cord and motor cortex in amyotrophic lateral sclerosis
27. Molecular profile of reactive astrocytes - Implications for their role in neurologic disease
28. Implants of encapsulated human CNTF-producing fibroblasts prevent behavioral deficits and striatal degeneration in a rodent model of Huntington's disease
29. Astrocytic response to injury
30. Astrocytic and neuronal factors affecting axon regeneration in the damaged central nervous system
31. Glial cell extracellular matrix: Boundaries for axon growth in development and regeneration
32. Signal transduction pathways activated by ciliary neurotrophic factor and related cytokines
33. Interleukin-1 beta and tumor necrosis factor-alpha synergistically stimulate nerve growth factor (NGF) release from cultured rat astrocytes
34. Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization
35. Regulation of astrocyte proliferation by FGF-2 and heparan sulfate in vivo
36. Rat hippocampal neurons in low-density culture
37. Transforming growth factor-beta 3, glial cell line-derived neurotrophic factor, and fibroblast growth factor-2, act in different manners to promote motoneuron survival in vitro
38. Ciliary neurotrophic factor prevents degeneration of adult rat substantia nigra dopaminergic neurons in vivo
39. Cyclic AMP elevation is sufficient to promote the survival of spinal motor neurons in vitro
40. Purified embryonic motoneurons
41. Increase of ciliary neurotrophic factor (CNTF) in the ischemic rat brain as determined by a sensitive enzyme-linked immunoassay
42. Expression of fibroblast growth factor-2 in hypoglossal motoneurons is stimulated by peripheral nerve injury
43. Ciliary neurotrophic factor stimulates astroglial hypertrophy in vivo and in vitro
44. Injury-induced regulation of ciliary neurotrophic factor mRNA in the adult rat brain
45. Ciliary neurotrophic factor and its receptor complex
46. Ciliary neurotrophic factor induces expression of the IGF type I receptor and FGF receptor 1 mRNAs in adult rat brain oligodendrocytes
47. Nuclear accumulation of FGF-2 is associated with proliferation of human astrocytes and glioma cells
48. Transforming growth factor alpha (TGF alpha) expression in degenerating motoneurons of the murine mutant wobbler: A neuronal signal for astrogliosis?
49. CNTF induces GFAP in a S-100 alpha brain cell population: The pattern of CNTF-alpha R suggests an indirect mode of action
50. CNTF regulation of astrogliosis and the activation of microglia in the developing rat central nervous system
51. Cytokine-induced selective increase of high-molecular-weight bFGF isoforms and their subcellular kinetics in cultured rat hippocampal astrocytes
52. Lesion-induced changes in the expression of ciliary neurotrophic factor and its receptor in rat optic nerve
53. Impaired neuroglial activation in interleukin-6 deficient mice
54. Altered acidic and basic fibroblast growth factor expression following spinal cord injury
55. Increased ciliary neurotrophic factor expression in reactive astrocytes following spinal cord injury in the rat
56. Acute exposure to CNTF in vivo induces multiple components of reactive gliosis
57. Ciliary neurotrophic factor stimulates nuclear hypertrophy and increases the GFAP content of cultured astrocytes
58. IL-6-type cytokines enhance epidermal growth factor-stimulated astrocyte proliferation
59. Astroglia in culture
60. Differential regulation of ciliary neurotrophic factor (CNTF) and CNTF receptor alpha (CNTFR alpha) expression following focal cerebral ischemia
61. Transforming growth factor-beta 1 in the rat brain: Increase after injury and inhibition of astrocyte proliferation
62. Neurotrophic growth factors and neurodegenerative diseases: Therapeutic potential of the neurotrophins and ciliary neurotrophic factor
63. Phenotypic alteration of astrocytes induced by ciliary neurotrophic factor in the intact adult brain, as revealed by adenovirus-mediated gene transfer
64. Protection of rat hippocampus against ischemic neuronal damage by pretreatment with sublethal ischemia
65. Ciliary neurotrophic factor promotes the survival of spinal sensory neurons following axotomy but not during the period of programmed cell death
66. Immunohistochemical localization of ciliary neurotrophic factor receptor alpha expression in the rat nervous system
67. Permissive and non-permissive reactive astrocytes: Immunofluorescence study with antibodies to the glial hyaluronate-binding protein
68. Reduction of neurite outgrowth in a model of glial scarring following CNS injury is correlated with the expression of inhibitory molecules on reactive astrocytes
69. Fibroblast growth factor 2 (FGF2) and FGF receptor expression in an experimental demyelinating disease with extensive remyelination
70. Transcriptional regulation of fibroblast growth factor-2 expression in human astro-cytes: Implications for cell plasticity
71. Cytokines which signal through the LIF receptor and their actions in the nervous system
72. Astrocyte responses to CNS injury
73. Quantitative aspects of reactive gliosis: A review
74. FGF-2 in the MPTP model of Parkinson's disease: Effects on astroglial cells
75. Changes in expression of ciliary neurotrophic factor (CNTF) and CNTF-receptor alpha after spinal cord injury
76. Localization of functional receptor epitopes on the structure of ciliary neurotrophic factor indicates a conserved, function-related epitope topography among helical cytokines
77. Riluzole promotes survival of rat motoneurons in vitro by stimulating trophic activity produced by spinal astrocyte monolayers
78. Neuroglial activation repertoire in the injured brain: Graded response, molecular mechanisms and cues to physiological function
79. Molecular signals for glial activation: Pro- and anti-inflammatory cytokines in the injured brain
80. The glial scar: Its bearing on axonal elongation and transplantation approaches to CNS repair
81. Ciliary neurotrophic factor: A review
82. Reactive astrocytes: Cellular and molecular cues to biological function
83. Cyclic AMP-dependent regulation of fibroblast growth factor-2 messenger RNA levels in rat cortical astrocytes: Comparison with fibroblast growth factor-1 and ciliary neurotrophic factor
84. Regulation of ciliary neurotrophic factor in cultured rat hippocampal astrocytes
85. Changes in neurotrophic factor expression and receptor activation following exposure of hippocampal neuron/astrocyte cocultures to kainic acid
86. Inhibition of neurite outgrowth on astroglial scars in vitro
87. Neurotrophic factor gene expression in astrocytes during development and following injury
88. Trophic factor production by reactive astrocytes in injured brain
89. Proliferation of astrocytes in vitro in response to cytokines. A primary role for tumor necrosis factor
90. Ciliary neurotrophic factor
91. Human CNTF and related cytokines: Effects on DRG neurone survival
92. Macrophage/Microglia regulation of astrocytic tenascin: Synergistic action of transforming growth factor-beta and basic fibroblast growth factor
93. Nuclear localization of functional FGF receptor 1 in human astrocytes suggests a novel mechanism for growth factor action
94. Growth factor regulation of cell growth and proliferation in the nervous system. A new intracrine nuclear mechanism
95. The tripartite CNTF receptor complex: Activation and signaling involves components shared with other cytokines
96. The CNS lesion scar: New vistas on an old regeneration barrier
97. Histological investigation of spinal cord lesions in the spinal hyperostotic mouse (twy/twy): Morphological changes in anterior horn cells and immunoreactivity to neurotropic factors
98. Mechanism of nerve growth factor mRNA regulation by interleukin-1 and basic fibroblast growth factor in primary cultures of rat astrocytes
99. Astrocyte hypertrophy in the Alzheimer's disease hippocampal formation
100. Regulation of oligodendrocyte cell survival and differentiation by ciliary neurotrophic factor, leukemia inhibitory factor, oncostatin M, and interleukin-6
101. Growth factors and myelin regeneration in multiple sclerosis
102. A role for ciliary neurotrophic factor as an inducer of reactive gliosis, the glial response to central nervous system injury
103. Cytokines regulate IGF binding proteins in the cns
104. Treatment of the chronically injured spinal cord with neurotrophic factors can promote axonal regeneration from supraspinal neurons