Interleukin-6 induces proliferation in adult spinal cord-derived neural progenitors via the JAK2/STAT3 pathway with EGF-induced MAPK phosphorylation

Cell Proliferation

Volumn 41, Issue 3, 2008, Pages 377-392

  Kang, M K ^a   Kang, S K ^a  

^a Pusan National University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; BROXURIDINE; ENZYME INHIBITOR; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; INTERLEUKIN 6; JANUS KINASE 2; JANUS KINASE 2 INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; RAF PROTEIN; STAT3 PROTEIN; TRYPAN BLUE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL PROLIFERATION; CELL REGENERATION; CONTROLLED STUDY; ENZYME ACTIVATION; IMMUNOREACTIVITY; MOUSE; NEURAL STEM CELL; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SPINAL CORD INJURY; SPINAL CORD NERVE CELL;

ANIMALS; BROMODEOXYURIDINE; CELL PROLIFERATION; CELLS, CULTURED; DRUG SYNERGISM; ENZYME INHIBITORS; EPIDERMAL GROWTH FACTOR; HUMANS; INTERLEUKIN-6; JANUS KINASE 2; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED ICR; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; NEURONS; PHOSPHORYLATION; RECEPTOR, EPIDERMAL GROWTH FACTOR; SPINAL CORD; STAT3 TRANSCRIPTION FACTOR; STEM CELLS;

MUS;

EID: 43749093843     PISSN: 09607722     EISSN: 13652184     Source Type: Journal    
DOI: 10.1111/j.1365-2184.2008.00537.x     Document Type: Article

References (50)

1. Ahn YH, Bae YY, Lee G, Kang MK, Kang SK (2006) Molecular insights of the injured lesions of rat spinal cords: inflammation, apoptosis, and cell survival. Biochem. Biophys. Res. Comm. 348, 560 570.
2. Bonni A, Sun Y, Nadal-Vicens M, Bhatt A, Frank DA, Rozovsky I, Stahl N, Yancopoulos GD, Greenberg ME (1997) Regulation of gliogenesis in the central nervous system by the JAK/STAT signaling pathway. Science 278, 477 483.
3. Crack PJ, Taylor JM (2005) Reactive oxygen species and the modulation of stroke. Free Radic. Biol. Med. 38, 1433 1444.
4. Darnell JE Jr Kerr IM, Stark GR (1994) Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264, 1415 1421.
5. David S, Aguayo AJ (1981) Axonal elongation into peripheral nervous system 'bride' after central nervous system injury in adult rats. Science 214, 931 933.
6. Fauconneau B, Petegnief V, Sanfeliu C, Piriou A, Planas AM (2002) Induction of heat shock proteins HSPs by sodium arsenite in cultured astrocytes and reduction of hydrogen peroxide-induced cell death. J. Neurochem. 83, 1338 1348.
7. Fukada T, Hibi M, Yamanaka Y, Takahishi-Tezuka M, Fukitani Y, Yamaguchi T, Nakajima K, Hirano T (1996) Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis. Immunity 5, 449 460.
8. Gadient RA, Otten UH (1997) Interleukin-6 (IL-6) - a molecule with both beneficial and destructive potentials. Prog. Neurobiol. 52, 379 390.
9. Gallmeier E, Schafer C, Moubarak P, Tietz A, Plossl I, Huss R, Goke B, Wagner AC (2005) JAK and STAT proteins are expressed and activated by IFN-γ in rat pancreatic acinar cells. J. Cell. Physiol. 203, 209 216.
10. Gorina R, Petegnief V, Chamnorro A, Planas AM (2005) AG490 prevent cell death after exposure of rat astrocytes to hydrogen peroxide or proinflammatory cytokines: involvement of the Jak2/STAT3 pathway. J. Neurochem. 92, 505 518.
11. Grandis JR, Drenning SD, Zeng Q, Watkins SC, Melhem MF, Endo S, Johnson DE, Huang L, He Y, Kim JD (2000) Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo. Proc. Natl. Acad. Sci. USA 97, 4227 4232.
12. Grossman SD, Rosenberg LJ, Wrathall JR (2001) Temporal-spatial pattern of acute neuronal and glial loss after spinal cord contusion. Exp. Neurol. 168, 273 282.
13. Guo D, Dunbar JD, Yang CH, Pfeffer LM, Donner DB (1998) Induction of Jak/STAT signaling by activation of the type 1 TNF receptor. J. Immunol. 160, 2742 2750.
14. Hattori R, Maulik N, Otani H, Zhu L, Cordis G, Engelman RM, Siddiqui MA, Das DK (2001) Role of STAT3 in ischemic preconditioning. J. Mol. Cell. Cardiol. 33, 1929 1936.
15. Hayashi M, Ueyama T, Nemoto K, Tamaki T, Senba E (2000) Sequential mRNA expression for immediate early genes, cytokines, and neurotrophins in spinal cord injury. J. Neurotrauma. 17, 203 218.
16. Heinrich PC, Behrmann I, Muller-Newen G, Schaper F, Graeve L (1998) Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. Biochem. J. 334, 297 314.
17. Horner PJ, Power AE, Kempermann G, Kuhn HG, Palmer TD, Winkler J, Thal LJ, Gage FH (2000) Proliferation and differentiation of progenitor cells throughout the intact adult rat spinal cord. J. Neurosci. 20, 2218 2228.
18. Hulsebosch CE (2002) Recent advances in pathophysiology and treatment of spinal cord injury. Adv. Physiol. Educ. 26, 238 255.
19. Ihle JN (2001) The Stat family in cytokine signaling. Curr. Opin. Cell Biol. 13, 211 217.
20. Ishikawa H, Tsuyama N, Obata M, Kawano MM (2006) Mitogenic signals initiated via interleukin-6 receptor complexes in cooperation with other transmembrane molecules in myelomas. J. Clin. Exp. Hematopathol. 46, 55 66.
21. Kamimura D, Ishihara K, Hirano T (2003) IL-6 signal transduction and its physiological roles: the signal orchestration model. Rev. Physiol. Biochem. Pharmacol. 149, 1 38.
22. Kim H, Hawley TS, Hawley RG, Baumann H (1998) Protein tyrosine phosphatase 2 (SHP-2) moderates signaling by gp130 but is not required for the induction of acute-phase plasma protein genes in hepatic cells. Mol. Cell. Biol. 18, 1525 1533.
23. Kitchens DL, Synder EY, Gottlieb DI (1994) FGF and EGF are mitogens for immortalized neural progenitors. J. Neurobiol. 25, 797 807.
24. Klassen HJ, Imfeld KL, Kirov II, Tai LQ, Gage FH, Young MJ, Berman MA (2003) Expression of cytokines by multipotent neural progenitor cells. Cytokine 22, 101 106.
25. Klein MA, Moller JC, Jones LL, Bluethmann H, Kreutzber GW, Raicich G (1997) mpaired neuroglial activation in interleukin-6 deficient mice. Glia 19, 227 233.
26. Kojima A, Tator CH (2000) Epidermal growth factor and fibroblast growth factor 2 cause proliferation of ependymal precursor cells in the adult rat spinal cord in vivo. J. Neuropathol. Exp. Neurol. 59, 687 697.
27. Kojima A, Tator CH (2002) Intrathecal administration of epidermal growth factor and fibroblast growth factor 2 promotes ependymal proliferation and functional recovery after spinal cord injury in adult rats. J. Neurotrauma 19, 223 238.
28. Liu X, Zhu Y, Gao W (2006) Isolation of neural stem cells from the spinal cords of low temperature preserved abortuses. J. Neurosci. Methods 157, 64 70.
29. Mansergh FC, Wride MA, Rancourt DE (2000) Neurons from stem cells: implications for understanding nervous system development and repair. Biochem. Cell Biol. 78, 613 628.
30. McTigue DM, Wei P, Stokes BT (2001) Proliferation of NG2-positivecells and altered oligodendrocyte numbers in the contused rat spinal cord. J. Neurosci. 21, 3392 3400.
31. Meydan N, Grunberger T, Dadi H, Shahar M, Arpaia E, Lapidot Z, Leeder JS, Freedman M, Cohen A, Gazit A, Levitzki A, Roifman CM (1996) Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor. Nature 379, 645 648.
32. Nakamura M, Okada S, Toyama Y, Okano H (2005) Role of IL-6 in spinal cord injury in a mouse model. Clin. Rew. Allergy Immunol. 28, 197 203.
33. Quinn SM, Walters WM, Vescovi AL, Whittemore SR (1999) Lineage restriction of neruoepithelial precursor cells from fetal human spinal cord. J. Neurosci. Res. 57, 590 602.
34. Reynolds BA, Weiss S (1992) Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science 255, 1707 1710.
35. Rosenberg LJ, Zai LJ, Wrathall JR (2005) Chronic alterations in the cellular composition of spinal cord white matter following contusion injury. Glia 49, 107 120.
36. Sakurai M, Nagata T, Abe K, Horinouchi T, Itoyama Y, Tabayashi K (2003) Oxidative damage and reduction of redox factor-1 expression after transient spinal cord ischemia in rabbits. J. Vasc. Surg. 37, 446 452.
37. Schaper F, Gendo C, Eck M, Schmitz J, Grimm C, Anhuf D, Kerr IM, Heinrich PC (1998) Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducingreceptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression. Biochem. J. 335, 557 565.
38. Schindler C, Darnell JE Jr (1995) Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu. Rev. Biochem. 64, 21 51.
39. Smith ME, van der Maesen K, Somera FP, Sobel RA (1998) Effects of phorbol myristate acetate (PMA) on functions of macrophages and microglia in vitro. Neurochem. Res. 23, 427 434.
40. Sriuranpong V, Park JI, Amornphimoltham P, Patel V, Nelkin BD, Gutkind JS (2003) Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcimona is medicated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system. Cancer Res. 63, 2948 2956.
41. Symes A, Stahl N, Reeves SA, Farruggella T, Servidei T, Gearan T, Yancopoulos G, Fink JS (1997) The protein tyrosine phosphatase SHP-2 negatively regulates ciliary neurotrophic factor induction of gene expression. Curr. Biol. 7, 697 700.
42. Taga T, Kishimoto T (1997) Gp130 and the interleukin-6 family of cytokines. Annu. Rev. Immunol. 15, 797 819.
43. Takahashi M, Arai Y, Kurosawa H, Sueyoshi N, Shirai S (2003) Ependymal cell reactions in spinal cord segments after compression injury in adult rat. J. Neuropathol. Exp. Neurol. 62, 185 194.
44. Taoka Y, Okajima K (1998) Spinal cord injury in the rat. Prog. Neurobiol. 56, 341 358.
45. Weiss S, Dunne C, Hewson J, Wohl C, Wheatley M, Peterson AC (1996) Multipotent CNS stem cells are present in the adult mammalian spinal cord and ventricular neuroaxis. J. Neurosci. 16, 7599 7609.
46. Wennerstein A, Meier X, Holmin S, Wahlberg L, Mathiesen T (2004) Proliferation, migration, and differentiation of human neural stem/progenitor cells after transplantation into a rat model of traumatic brain injury. J. Neurosurg. 100, 88 96.
47. Yamamoto S, Yamamoto N, Kitamura T, Nakamura K, Nakafuku M (2001) Proliferation of parenchymal neural progenitors in response to injury in the adult rat spinal cord. Exp. Neurol. 172, 115 127.
48. Yamauchi K, Osuka K, Takayasu M, Usuda N, Nakazawa A, Nakahara N, Yoshida M, Aoshima C, Hara M, Yoshida J (2006) Activation of JAK/STAT signaling in neruons following spinal cord injury in mice. J. Neurochem. 96, 1060 1070.
49. Zai LJ, Wrathall JR (2005) Cell proliferation and replacement following contusive spinal cord injury. Glia 50, 247 257.
50. Zai LJ, Yoo S, Wrathall JR (2005) Increased growth factor expression and cell proliferation after contusive spinal cord injury. Brain Res. 1052, 147 155.